Platelet Disorders: Multimedia

References

1. [Guideline] George JN, Woolf SH, Raskob GE, et al. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood. Jul 1 1996;88(1):3-40. [Medline]. [Full Text].

2. McMillan R. Classical management of refractory adult immune (idiopathic) thrombocytopenic purpura. Blood Rev. Mar 2002;16(1):51-5. [Medline].

3. Cines DB, Bussel JB. How I treat idiopathic thrombocytopenic purpura (ITP). Blood. Oct 1 2005;106(7):2244-51. [Medline]. [Full Text].

4. Tarantino MD. Treatment options for chronic immune (idiopathic) thrombocytopenia purpura in children. Semin Hematol. Jan 2000;37(1 suppl 1):35-41. [Medline].

5. Blanchette VS, Price V. Childhood chronic immune thrombocytopenic purpura: unresolved issues. J Pediatr Hematol Oncol. Dec 2003;25 suppl 1:S28-33. [Medline].

6. Buchanan GR, Journeycake JM, Adix L. Severe chronic idiopathic thrombocytopenic purpura during childhood: definition, management, and prognosis. Semin Thromb Hemost. Dec 2003;29(6):595-603. [Medline].

7. Skupski DW, Bussel JB. Alloimmune thrombocytopenia. Clin Obstet Gynecol. Jun 1999;42(2):335-48. [Medline].

8. Gramatges MM, Fani P, Nadeau K, Pereira S, Jeng MR. Neonatal alloimmune thrombocytopenia and neutropenia associated with maternal human leukocyte antigen antibodies. Pediatr Blood Cancer. Jul 2009;53(1):97-9. [Medline].

9. Rizvi MA, Shah SR, Raskob GE, George JN. Drug-induced thrombocytopenia. Curr Opin Hematol. Sep 1999;6(5):349-53. [Medline].

10. Amiral J, Meyer D. Heparin-induced thrombocytopenia: diagnostic tests and biological mechanisms. Baillieres Clin Haematol. Jun 1998;11(2):447-60. [Medline].

11. Moake JL. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. Arch Pathol Lab Med. Nov 2002;126(11):1430-3. [Medline]. [Full Text].

12. Clemetson KJ, Clemetson JM. Molecular abnormalities in Glanzmann's thrombasthenia, Bernard-Soulier syndrome, and platelet-type von Willebrand's disease. Curr Opin Hematol. Sep 1994;1(5):388-93. [Medline].

13. Imbach P. Refractory idiopathic immune thrombocytopenic purpura in children: current and future treatment options. Paediatr Drugs. 2003;5(12):795-801. [Medline].

14. Kojouri K, Vesely SK, Terrell DR, George JN. Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications. Blood. Nov 1 2004;104(9):2623-34. [Medline]. [Full Text].

15. Vesely SK, Perdue JJ, Rizvi MA, Terrell DR, George JN. Management of adult patients with persistent idiopathic thrombocytopenic purpura following splenectomy: a systematic review. Ann Intern Med. Jan 20 2004;140(2):112-20. [Medline].

16. Blanchette V, Imbach P, Andrew M, et al. Randomised trial of intravenous immunoglobulin G, intravenous anti-D, and oral prednisone in childhood acute immune thrombocytopenic purpura. Lancet. Sep 10 1994;344(8924):703-7. [Medline].

17. Jackson S, Beck PL, Pineo GF, Poon MC. Helicobacter pylori eradication: novel therapy for immune thrombocytopenic purpura? A review of the literature. Am J Hematol. Feb 2005;78(2):142-50. [Medline]. [Full Text].

18. Treepongkaruna S, Sirachainan N, Kanjanapongkul S, et al. Absence of platelet recovery following Helicobacter pylori eradication in childhood chronic idiopathic thrombocytopenic purpura: a multi-center randomized controlled trial. Pediatr Blood Cancer. Jul 2009;53(1):72-7. [Medline].

19. [Best Evidence] Bussel JB, Provan D, Shamsi T, et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. Lancet. Feb 21 2009;373(9664):641-8. [Medline].

20. [Best Evidence] Kuter DJ, Bussel JB, Lyons RM, et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet. Feb 2 2008;371(9610):395-403. [Medline].

21. Jacobs P, Wood L, Novitzky N. Intravenous gammaglobulin has no advantages over oral corticosteroids as primary therapy for adults with immune thrombocytopenia: a prospective randomized clinical trial. Am J Med. Jul 1994;97(1):55-9. [Medline].

22. Lippi G, Favaloro EJ, Salvagno GL, Franchini M. Laboratory assessment and perioperative management of patients on antiplatelet therapy: from the bench to the bedside. Clin Chim Acta. Jul 2009;405(1-2):8-16. [Medline].

23. [Best Evidence] Michael M, Elliott EJ, Ridley GF, Hodson EM, Craig JC. Interventions for haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura. Cochrane Database Syst Rev. Jan 21 2009;CD003595. [Medline].

24. [Guideline] Nichols WL, Rick ME, Ortel TL, et al. Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines. Am J Hematol. Jun 2009;84(6):366-70. [Medline].

25. Schwartz RS. Immune thrombocytopenic purpura--from agony to agonist. N Engl J Med. Nov 29 2007;357(22):2299-301. [Medline].

26. Shehata N, Burrows R, Kelton JG. Gestational thrombocytopenia. Clin Obstet Gynecol. Jun 1999;42(2):327-34. [Medline].

Further Reading

Related eMedicine Topics

• Bernard-Soulier Syndrome [in the Pediatrics: General Medicine section]
• Disseminated Intravascular Coagulation [in the Hematology section]
• Disseminated Intravascular Coagulation [in the Emergency Medicine section]
• Glanzmann Thrombasthenia
• Thrombasthenia [in the Pediatrics: General Medicine section]
• Thrombocytosis, Essential
• Thrombocytosis, Secondary

• The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders
• Once-Daily Oral E5501 Tablets Used in Subjects With Chronic Liver Diseases and Thrombocytopenia Prior to Elective Surgical or Diagnostic Procedures
• Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
• Study of ADAMTS-13 Activity, Von Willebrand Factor and Platelet-Monocyte Aggregation in Coronary Artery Disease
• Study of Megakaryocytes From Patients With Abnormal Platelet Vesicles
• A Study to Find How Safe and Effective GAMMAPLEX® is in Subjects With Chronic Idiopathic Thrombocytopenic Purpura (ITP)
• Unrelated Hematopoietic Stem Cell Transplantation (HSCT) for Genetic Diseases of Blood Cells

• Guideline on the assessment of bleeding risk prior to surgery or invasive procedures. British Committee for Standards in Haematology - Professional Association. 2007. 25 pages. NGC:006183
• The management of malignant thrombocytosis in Philadelphia chromosome-negative myeloproliferative disease: guideline recommendations. Program in Evidence-based Care - State/Local Government Agency [Non-U.S.]. 2008 Jan 15. 30 pages. NGC:006430
• Thrombocytopenia. Finnish Medical Society Duodecim - Professional Association. 2001 Apr 30 (revised 2007 Apr 27). Various pagings. NGC:005827
• Treatment and prevention of heparin-induced thrombocytopenia. American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). American College of Chest Physicians - Medical Specialty Society. 2004 Sep (revised 2008 Jun). 41 pages. NGC:006664

Keywords

platelet disorders, thrombocytopathy, autoimmune thrombocytopenia, alloimmune thrombocytopenia, drug-induced thrombocytopenia, thrombotic thrombocytopenic purpura, TTP, blood disorders, blood platelet disorders, bleeding disorders, hematologic disorders, hemostatic disorders, clotting disorders, thrombasthenia, thrombocytosis,

hemostatic plug, prolonged bleeding time, petechiae, purpura, immune thrombocytopenic purpura, ITP, posttransfusion purpura, post-transfusion purpura, neonatal alloimmune thrombocytopenia, hemolytic uremic syndrome, HUS, von Willebrand disease, vWD, Bernard-Soulier syndrome, Glanzmann thrombasthenia, diffuse intravascular coagulation, disseminated intravascular coagulation, DIC, gray platelet syndrome, platelet storage pool deficiency

Contributor Information and Disclosures

Author

Perumal Thiagarajan, MD, Professor, Department of Pathology and Medicine, Baylor College of Medicine; Director, Transfusion Medicine and Hematology Laboratory, Michael E DeBakey Veterans Affairs Medical Center
Perumal Thiagarajan, MD is a member of the following medical societies: American College of Physicians, American Heart Association, American Society for Biochemistry and Molecular Biology, American Society for Clinical Investigation, American Society of Hematology, Association of American Physicians, and Royal College of Physicians
Disclosure: Nothing to disclose.

Medical Editor

Karen Seiter, MD, Professor, Department of Internal Medicine, Division of Oncology/Hematology, New York Medical College
Karen Seiter, MD is a member of the following medical societies: American Association for Cancer Research, American College of Physicians, and American Society of Hematology
Disclosure: Novartis Honoraria Speaking and teaching; Celgene Honoraria Speaking and teaching; Schering Honoraria Speaking and teaching

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Ronald A Sacher, MB, BCh, MD, FRCPC, Professor, Internal Medicine and Pathology, Director, Hoxworth Blood Center, University of Cincinnati Academic Health Center
Ronald A Sacher, MB, BCh, MD, FRCPC is a member of the following medical societies: American Society of Hematology
Disclosure: Glaxo Smith Kline Honoraria Speaking and teaching; Talecris Honoraria Board membership

CME Editor

Rajalaxmi McKenna, MD, FACP, Consulting Staff, Department of Medicine, Southwest Medical Consultants, SC, Good Samaritan Hospital, Advocate Health Systems
Rajalaxmi McKenna, MD, FACP is a member of the following medical societies: American Society of Clinical Oncology, American Society of Hematology, and International Society on Thrombosis and Haemostasis
Disclosure: Nothing to disclose.

Chief Editor

Emmanuel C Besa, MD, Professor, Department of Medicine, Division of Hematologic Malignancies, Kimmel Cancer Center, Thomas Jefferson University
Emmanuel C Besa, MD is a member of the following medical societies: American Association for Cancer Education, American College of Clinical Pharmacology, American Federation for Medical Research, American Society of Hematology, and New York Academy of Sciences
Disclosure: Nothing to disclose.