eMedicine Specialties > Hematology > Stem Cells and Disorders

Lymphoma, Follicular: Multimedia

Author: Cesar O Freytes, MD, FACP, Director of Bone Marrow Transplant Program, Professor, Department of Internal Medicine, Division of Hematology, University of Texas Health Science Center at San Antonio
Coauthor(s): Julianna A Burzynski, PharmD, BCOP, BCPS, Clinical Pharmacy Specialist in Hematology/Oncology, Mayo Clinic
Contributor Information and Disclosures

Updated: Nov 3, 2009

Multimedia

Follicular lymphoma, low-power view: Note the nod...
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Media file 1: Follicular lymphoma, low-power view: Note the nodular pattern reminiscent of germinal centers. Photograph courtesy of Aamir Ehsan, MD.
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Follicular lymphoma, low-power view: Note the nod...

Follicular lymphoma, low-power view: Note the nodular pattern reminiscent of germinal centers. Photograph courtesy of Aamir Ehsan, MD.

Diffuse lymphoma: Note the absence of the nodular...
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Media file 2: Diffuse lymphoma: Note the absence of the nodular pattern observed in follicular lymphomas. Photograph courtesy of Aamir Ehsan, MD.
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Diffuse lymphoma: Note the absence of the nodular...

Diffuse lymphoma: Note the absence of the nodular pattern observed in follicular lymphomas. Photograph courtesy of Aamir Ehsan, MD.

A patient with follicular lymphoma who was diagno...
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Media file 3: A patient with follicular lymphoma who was diagnosed 6 years earlier presents to his hematologist's office because of rapidly growing lymphadenopathy and a new onset of fever, severe night sweats, and weight loss. In the past, he had been treated with chlorambucil and prednisone when his submandibular lymph nodes became large enough to make him uncomfortable. This treatment had worked well, and he has not required any treatment recently. A biopsy of an involved lymph node is obtained (see image). The diagnosis is transformation to diffuse non-Hodgkin lymphoma.
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A patient with follicular lymphoma who was diagno...

A patient with follicular lymphoma who was diagnosed 6 years earlier presents to his hematologist's office because of rapidly growing lymphadenopathy and a new onset of fever, severe night sweats, and weight loss. In the past, he had been treated with chlorambucil and prednisone when his submandibular lymph nodes became large enough to make him uncomfortable. This treatment had worked well, and he has not required any treatment recently. A biopsy of an involved lymph node is obtained (see image). The diagnosis is transformation to diffuse non-Hodgkin lymphoma.

More on Lymphoma, Follicular

Overview: Lymphoma, Follicular
Differential Diagnoses & Workup: Lymphoma, Follicular
Treatment & Medication: Lymphoma, Follicular
Follow-up: Lymphoma, Follicular
Multimedia: Lymphoma, Follicular
References
Further Reading
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References

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  25. Marcus R, Imrie K, Belch A. CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma. Blood. Feb 15 2005;105(4):1417-23.

  26. McLaughlin P, Grillo-Lopez AJ, Link BK, et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol. Aug 1998;16(8):2825-33. [Medline].

  27. Schouten HC, Qian W, Kvaloy S. High-dose therapy improves progression-free survival and survival in relapsed follicular non-Hodgkin''s lymphoma: results from the randomized European CUP trial. J Clin Oncol. Nov 1 2003;21(21):3918-27. [Medline].

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  29. Swenson WT, Wooldridge JE, Lynch CF. Improved survival of follicular lymphoma patients in the United States. J Clin Oncol. Aug 1 2005;23(22):5019-26.

  30. van Besien K, Loberiza FR, Bajorunaite R. Comparison of autologous and allogeneic hematopoietic stem cell transplantationfor follicular lymphoma. Blood. Nov 15 2003;102(10):3521-9. [Medline].

  31. van Besien K, Sobocinski KA, Rowlings PA, et al. Allogeneic bone marrow transplantation for low-grade lymphoma. Blood. Sep 1 1998;92(5):1832-6. [Medline].

  32. Witzig TE, Gordon LI, Cabanillas F. Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma. J Clin Oncol. May 15 2002;20(10):2453-63. [Medline].

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Keywords

follicular lymphoma, non-Hodgkin's lymphoma, nodular lymphomas, low-grade lymphomas, indolent lymphomas, non-Hodgkin lymphoma, lymphoid tissue, lymph nodes, spleen, bone marrow, primary extranodal lymphoma

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Contributor Information and Disclosures

Author

Cesar O Freytes, MD, FACP, Director of Bone Marrow Transplant Program, Professor, Department of Internal Medicine, Division of Hematology, University of Texas Health Science Center at San Antonio
Cesar O Freytes, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American Association for Cancer Research, American Association for the Advancement of Science, American Association of Blood Banks, American College of Physicians, American Society for Blood and Marrow Transplantation, American Society of Hematology, International Society for Experimental Hematology, and New York Academy of Sciences
Disclosure: Genzyme Grant/research funds Review panel membership; Otsuka Consulting fee Review panel membership

Coauthor(s)

Julianna A Burzynski, PharmD, BCOP, BCPS, Clinical Pharmacy Specialist in Hematology/Oncology, Mayo Clinic
Julianna A Burzynski, PharmD, BCOP, BCPS is a member of the following medical societies: American College of Clinical Pharmacy
Disclosure: Nothing to disclose.

Medical Editor

Koyamangalath Krishnan, MD, FRCP, FACP, Paul Dishner Endowed Chair of Excellence in Medicine, Professor of Medicine and Chief of Hematology-Oncology, Program Director, Hematology-Oncology Fellowship, James H Quillen College of Medicine at East Tennessee State University
Koyamangalath Krishnan, MD, FRCP, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians-American Society of Internal Medicine, American Society of Hematology, and Royal College of Physicians
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Wendy Hu, MD, Consulting Staff, Department of Hematology/Oncology and Bone Marrow Transplantation, Huntington Memorial Medical Center
Wendy Hu, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Physicians, American Society for Blood and Marrow Transplantation, American Society of Hematology, and Physicians for Social Responsibility
Disclosure: Nothing to disclose.

CME Editor

Rajalaxmi McKenna, MD, FACP, Southwest Medical Consultants, SC, Department of Medicine, Good Samaritan Hospital, Advocate Health Systems
Rajalaxmi McKenna, MD, FACP is a member of the following medical societies: American Society of Clinical Oncology, American Society of Hematology, and International Society on Thrombosis and Haemostasis
Disclosure: Nothing to disclose.

Chief Editor

Emmanuel C Besa, MD, Professor, Department of Medicine, Division of Hematologic Malignancies, Kimmel Cancer Center, Thomas Jefferson University
Emmanuel C Besa, MD is a member of the following medical societies: American Association for Cancer Education, American College of Clinical Pharmacology, American Federation for Medical Research, American Society of Hematology, and New York Academy of Sciences
Disclosure: Nothing to disclose.

 
 
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