Medscape is available in 5 Language Editions – Choose your Edition here.


Catheter-Related Urinary Tract Infection 

  • Author: John L Brusch, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
Updated: Aug 18, 2015

Transmission and Pathogens

Catheter-related urinary tract infection (UTI) occurs because urethral catheters inoculate organisms into the bladder and promote colonization by providing a surface for bacterial adhesion and causing mucosal irritation.[1] The presence of a urinary catheter is the most important risk factor for bacteriuria.

Once a catheter is placed, the daily incidence of bacteriuria is 3-10%. Between 10% and 30% of patients who undergo short-term catheterization (ie, 2-4 days) develop bacteriuria and are asymptomatic. Between 90% and 100% of patients who undergo long-term catheterization develop bacteriuria. About 80% of nosocomial UTIs are related to urethral catheterization; only 5-10% are related to genitourinary manipulation.

The presence of potentially pathogenic bacteria and an indwelling catheter predisposes to the development of a nosocomial UTI. The bacteria may gain entry into the bladder during insertion of the catheter, during manipulation of the catheter or drainage system, around the catheter, and after removal.

Enteric pathogens (eg, Escherichiacoli) are most commonly responsible, but Pseudomonas species, Enterococcus species, Staphylococcus aureus, coagulase-negative staphylococci, Enterobacter species, and yeast also are known to cause infection. Proteus and Pseudomonas species are the organisms most commonly associated with biofilm growth on catheters.

Candida, especially Candida albicans, is the second-most-common organism that can cause catheter-associated urinary tract infection or asymptomatic colonization, although the isolation of fungi from urine rarely indicates active infection. The use of clinical signs such as fever, leukocytosis, and decreased renal function cannot reliably distinguish between asymptomatic funguria and actual infection.[2]

Risk factors for bacteriuria in patients who are catheterized include longer duration of catheterization, colonization of the drainage bag, diarrhea, diabetes, absence of antibiotics, female gender, renal insufficiency, errors in catheter care, catheterization late in the hospital course, and immunocompromised or debilitated states.


Guidelines for Catheter Use

The 2009 Centers for Disease Control and Prevention (CDC) guidelines for prevention of catheter-associated urinary tract infections (UTIs) recommends catheter use only for appropriate indications. Catheter use and duration should be minimized in all patients, especially those at higher risk for catheter-associated UTI (eg, women, elderly persons, and patients with impaired immunity).[3]

Catheters should be kept in place only for as long as needed. Indwelling catheters placed in patients undergoing surgery should be removed as soon as possible postoperatively. The use of urinary catheters for treatment of incontinence in patients and nursing home residents should be avoided.[3]

The 2009 CDC guidelines recommend that clinicians avoid using systemic antimicrobials routinely to prevent catheter-associated UTI in patients requiring either short- or long-term catheterization.[3]

The 2009 Infectious Diseases Society of America (IDSA) guidelines for catheter-associated UTIs state that an indwelling catheter may be used at the patient’s request in exceptional cases and when other approaches to incontinence management have been ineffective.[4]

Long-term catheterization increases patient satisfaction but also increases mechanical complications. Contraindications include bleeding disorders, previous lower abdominal surgery or irradiation, and morbid obesity. Intermittent catheterization is an option, but most patients become bacteriuric within a few weeks; the incidence of bacteriuria is 1-3% per insertion.

According to the 2009 IDSA guidelines, if an indwelling catheter has been in place for more than 2 weeks at the onset of catheter-associated UTI and remains indicated, the catheter should be replaced to promote continued resolution of symptoms and to reduce the risk of subsequent catheter-associated infection.[4]

Improved management of catheter-related UTIs was approved as a National Patient Safety Goal for 2012.[5]



Symptoms of catheter-related urinary tract infection (UTI) generally are nonspecific; most patients present with fever and leukocytosis. Significant pyuria is generally represented by more than 50 white blood cells (WBCs) per high-power field (HPF). Colony counts on a urine culture range from 100-10,000/mL.

Infections may be polymicrobial. Pyuria and elevated bacterial colony counts are seen in all patients in whom a catheter has been in place for more than a few days. In this situation, their presence is not synonymous with a UTI.

The 2009 Infectious Diseases Society of America (IDSA) guidelines define catheter-related UTI in patients whose urinary (urethral, suprapubic, or condom) catheter has been removed within the previous 48 hours by the presence of symptoms or signs compatible with UTI with no other identified source of infection along with 1000 or more colony-forming units (CFU)/mL of 1 or more bacterial species.[4]

If catheterization can be discontinued, the culture can be obtained in a voided midstream urine specimen. If an indwelling catheter has been in place for longer than 2 weeks at the onset of the UTI and is still indicated, it should be replaced, and the urine culture should be obtained from the freshly placed catheter.


Treatment & Management

In some patients with bacteriuria, removal of the catheter suffices. To reduce the risk of urinary tract infection (UTI), antibiotic treatment may be considered in patients with asymptomatic bacteriuria that persists 48 hours after removal of a short-term indwelling catheter. A specimen for urine culture should be obtained before initiation of antibiotic therapy, because of the wide spectrum of potential infecting organisms and the increased likelihood of antimicrobial resistance.[4]

In patients whose symptoms resolve promptly, 7 days is the recommended duration of antibiotic treatment. In those with a delayed response or with bacteremia, 10-14 days of treatment is recommended. In patients who are not severely ill, a 5-day regimen of a quinolone may be considered. In women older than 65 years who develop a UTI after removal of an indwelling catheter and who have no upper urinary tract symptoms, a 3-day antimicrobial regimen may be considered.[4]




Best practices should be followed for the prevention of healthcare-associated infections. Urinary tract infections (UTIs) are the most common hospital-acquired infections, with most attributed to the use of an indwelling catheter.[6]


Aseptic indwelling catheter insertion, a properly maintained closed-drainage system (with ports in the distal catheter for needle aspiration of urine), and unobstructed urine flow are essential for prevention of UTI. Because many of these infections occur in clusters, good hand washing before and after catheter care is essential.

Urinary catheters coated with silver alloy also reduce the risk of infection.[7] An alternative is to use the Lubricath (Bard Medical,  Covington, GA), which has a hydrophilic coating that decreases tissue irritation and nosocomial UTIs. It is reasonable to use these more expensive catheters in patients who are at highest risk. However, a 2012 study failed to find any advantage in the short-term use of silver alloy-coated and nitrofurantoin-impregnated catheters in reducing symptomatic urinary tract infections.[8]


Systemic antimicrobial drug therapy has repeatedly been shown to lower the risk of UTI in catheterized patients; the greatest benefit was observed in those catheterized for 3-14 days. Most hospitalized patients already are receiving antibiotics for other reasons. Disadvantages include creating resistant organisms.

The 2009 Infectious Diseases Society of America (IDSA) guidelines advise against the routine addition of antimicrobials or antiseptics to the drainage bag of patients who are catheterized in an effort to reduce the risk of catheter-associated bacteriuria or catheter-associated UTI.[4]

One adult neurological intensive care unit implemented an evidence-based "UTI bundle" focused on the avoidance of catheter insertion, maintenance of sterility, product standardization, and early catheter removal. In a 30-month period, catheter-associated UTIs signficantly decreased (from 13.3 to 4.0 infections per 1000 catheter days), with a linear relationship between catheter use rate and catheter-associated UTIs.[9]

Contributor Information and Disclosures

John L Brusch, MD, FACP Assistant Professor of Medicine, Harvard Medical School; Consulting Staff, Department of Medicine and Infectious Disease Service, Cambridge Health Alliance

John L Brusch, MD, FACP is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Chief Editor

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American Medical Association, Oklahoma State Medical Association, Southern Society for Clinical Investigation, Association of Professors of Medicine, American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.


Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Reference Salary Employment

  1. Vergidis P, Patel R. Novel approaches to the diagnosis, prevention, and treatment of medical device-associated infections. Infect Dis Clin North Am. 2012 Mar. 26(1):173-86. [Medline]. [Full Text].

  2. Padawer D, Pastukh N, Nitzan O, Labay K, Aharon I, Brodsky D, et al. Catheter-associated candiduria: Risk factors, medical interventions, and antifungal susceptibility. Am J Infect Control. 2015 Jul 1. 43 (7):e19-22. [Medline].

  3. [Guideline] Gould CV, Umscheid CA, Agarwal RK, Kuntz G, Pegues DA. Guideline for prevention of catheter-associated urinary tract infections 2009. Infect Control Hosp Epidemiol. 2010 Apr. 31(4):319-26. [Medline].

  4. [Guideline] Hooton TM, Bradley SF, Cardenas DD, Colgan R, Geerlings SE, Rice JC, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010 Mar 1. 50(5):625-63. [Medline].

  5. Approved: New infection-related National Patient Safety Goal for 2012: catheter-associated urinary tract infections pose high risk. Jt Comm Perspect. 2011 Jul. 31(7):6-7. [Medline].

  6. Munasinghe RL, Yazdani H, Siddique M, Hafeez W. Appropriateness of use of indwelling urinary catheters in patients admitted to the medical service. Infect Control Hosp Epidemiol. 2001 Oct. 22(10):647-9. [Medline].

  7. Schumm K, Lam TB. Types of urethral catheters for management of short-term voiding problems in hospitalised adults. Cochrane Database Syst Rev. 2008 Apr 16. CD004013. [Medline].

  8. Pickard R, Lam T, MacLennan G, Starr K, Kilonzo M, McPherson G, et al. Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial. Lancet. 2012 Dec 1. 380(9857):1927-35. [Medline].

  9. Titsworth WL, Hester J, Correia T, Reed R, Williams M, Guin P, et al. Reduction of catheter-associated urinary tract infections among patients in a neurological intensive care unit: a single institution's success. J Neurosurg. 2012 Jan 6. [Medline].

  10. Lo E, Nicolle L, Classen D, Arias KM, Podgorny K, Anderson DJ, et al. Strategies to prevent catheter-associated urinary tract infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008 Oct. 29 Suppl 1:S41-50. [Medline].

All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.