Myelophthisic Anemia Differential Diagnoses
- Author: Emmanuel C Besa, MD; Chief Editor: Koyamangalath Krishnan more...
Diagnostic Considerations
The leukoerythroblastic picture, the characteristic laboratory changes associated with myelophthisic anemia, is characterized by the following (see the image below):
- Nucleated red blood cells and teardrop forms
- Giant platelets
- Immature white blood cells (eg, myelocytes, metamyelocytes, occasionally promyelocytes and myeloblasts) in the peripheral blood smear
This blood film at 1000X magnification demonstrates a leukoerythroblastic blood picture with the presence of precursor cells of the myeloid and erythroid lineage. In addition, anisocytosis, poikilocytosis, and polychromasia can be seen. Courtesy of U. Woermann, MD, Division of Instructional Media, Institute for Medical Education, University of Bern, Switzerland.
Go to Anemia, Chronic Anemia, Megaloblastic Anemia, Myelophthisic Anemia, Hemolytic Anemia, and Sideroblastic Anemias for complete information on these topics.
Differential Diagnoses
- Agnogenic Myeloid Metaplasia With Myelofibrosis
- Breast Cancer
- Gaucher Disease
- Lung Cancer, Non-Small Cell
- Lung Cancer, Oat Cell (Small Cell)
- Prostate Cancer: Metastatic and Advanced Disease
- Sarcoidosis
- Tuberculosis
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