eMedicine Specialties > Hematology > Red Blood Cells and Disorders

Myelophthisic Anemia: Treatment & Medication

Author: Emmanuel C Besa, MD, Professor, Department of Medicine, Division of Hematologic Malignancies, Kimmel Cancer Center, Thomas Jefferson University
Coauthor(s): Ulrich Woermann, MD, Consulting Staff, Division of Instructional Media, Institute for Medical Education, University of Bern, Switzerland
Contributor Information and Disclosures

Updated: Jan 4, 2008

Treatment

Medical Care

  • Treat the underlying disease and provide supportive measures for symptomatic patients.
  • Treat anemia with packed red blood cell transfusions. Rarely, patients have low erythropoietin levels and may respond to supplemental erythropoietin therapy.
  • Patients with other cytopenias generally do not need treatment unless bleeding or infection is present.

Consultations

  • Hematologist
  • Oncologist

More on Myelophthisic Anemia

Overview: Myelophthisic Anemia
Differential Diagnoses & Workup: Myelophthisic Anemia
Treatment & Medication: Myelophthisic Anemia
Follow-up: Myelophthisic Anemia
Multimedia: Myelophthisic Anemia
References

References

  1. Delsol G, Guiu-Godfrin B, Guiu M, Pris J, Corberand J, Fabre J. Leukoerythroblastosis and cancer frequency, prognosis, and physiopathologic significance. Cancer. Sep 1979;44(3):1009-13. [Medline].

  2. Weick JK, Hagedorn AB, Linman JW. Leukoerythroblastosis. Diagnostic and prognostic significance. Mayo Clin Proc. Feb 1974;49(2):110-3. [Medline].

  3. Brochamer WL Jr, Keeling MM. The bone marrow biopsy, osteoscan, and peripheral blood in non-hematopoietic cancer. Cancer. Aug 1977;40(2):836-40. [Medline].

  4. Makoni SN, Laber DA. Clinical spectrum of myelophthisis in cancer patients. Am J Hematol. May 2004;76(1):92-3. [Medline].

  5. Bodem CR, Hamory BH, Taylor HM, Kleopfer L. Granulomatous bone marrow disease. A review of the literature and clinicopathologic analysis of 58 cases. Medicine (Baltimore). Nov 1983;62(6):372-83. [Medline].

  6. Shamdas GJ, Ahmann FR, Matzner MB, Ritchie JM. Leukoerythroblastic anemia in metastatic prostate cancer. Clinical and prognostic significance in patients with hormone-refractory disease. Cancer. Jun 1 1993;71(11):3594-600. [Medline].

  7. Jandl JH. Blood. In: Pathophysiology. Oxford, England: Blackwell Scientific; 1991:104-5.

Further Reading

Keywords

myelophthisis, secondary myelofibrosis, marrow infiltration, marrow granuloma, infiltrative myelopathy, nonhematopoietic cells, cytopenia, thrombocytopenia, neutropenia, pancytopenia, anemia, metastatic carcinomas, metastatic cancer, lung cancer, breast cancer, prostate cancer, lymphoproliferative malignancies, lymphoproliferative cancers, lymphomas, disseminated granulomatous diseases, miliary tuberculosis, Gaucher disease

Contributor Information and Disclosures

Author

Emmanuel C Besa, MD, Professor, Department of Medicine, Division of Hematologic Malignancies, Kimmel Cancer Center, Thomas Jefferson University
Emmanuel C Besa, MD is a member of the following medical societies: American Association for Cancer Education, American College of Clinical Pharmacology, American Federation for Medical Research, American Society of Clinical Oncology, American Society of Hematology, and New York Academy of Sciences
Disclosure: Nothing to disclose.

Coauthor(s)

Ulrich Woermann, MD, Consulting Staff, Division of Instructional Media, Institute for Medical Education, University of Bern, Switzerland
Disclosure: Nothing to disclose.

Medical Editor

Koyamangalath Krishnan, MD, FRCP, FACP, Dishner Endowed Chair of Excellence in Medicine, Professor of Medicine and Chief of Hematology-Oncology, Program Director, Hematology-Oncology Fellowship, James H Quillen College of Medicine at East Tennessee State University
Koyamangalath Krishnan, MD, FRCP, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians-American Society of Internal Medicine, American Society of Clinical Oncology, American Society of Hematology, and Royal College of Physicians
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

CME Editor

Rajalaxmi McKenna, MD, FACP, Consulting Staff, Department of Medicine, Southwest Medical Consultants, SC, Good Samaritan Hospital, Advocate Health Systems
Rajalaxmi McKenna, MD, FACP is a member of the following medical societies: American Society of Clinical Oncology, American Society of Hematology, and International Society on Thrombosis and Haemostasis
Disclosure: Nothing to disclose.

Chief Editor

Koyamangalath Krishnan, MD, FRCP, FACP, Dishner Endowed Chair of Excellence in Medicine, Professor of Medicine and Chief of Hematology-Oncology, Program Director, Hematology-Oncology Fellowship, James H Quillen College of Medicine at East Tennessee State University
Koyamangalath Krishnan, MD, FRCP, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians-American Society of Internal Medicine, American Society of Clinical Oncology, American Society of Hematology, and Royal College of Physicians
Disclosure: Nothing to disclose.

 
 
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