eMedicine Specialties > Hematology > Stem Cells and Disorders

Myeloproliferative Disease: Follow-up

Author: Haleem J Rasool, MD, FACP, Hematologist Oncologist, Department of Oncology, Franciscan Skemp Healthcare
Coauthor(s): Dale Groshek, BS, PA-C, Cancer Center, Department of Radiation Oncology, Franciscan Skemp Healthcare, La Crosse
Contributor Information and Disclosures

Updated: Feb 13, 2008

Follow-up

Complications

  • Patients are at risk of both thrombotic and hemorrhagic events. 
    • Thrombotic and hemorrhagic events are particularly common in polycythemia vera (PV) and essential thrombocythemia (ET). Thrombosis is the cause of death in 30-40% of patients.
    • A particularly serious thrombotic event that may be associated with polycythemia vera is Budd-Chiari syndrome, which is due to hepatic venous or inferior venal caval thrombosis.
  • Patients are at risk of developing secondary acute leukemia from their underlying disorder as well as their treatment.

Miscellaneous

Medicolegal Pitfalls

When suspecting polycythemia in patients with iron deficiency, replenish iron before conducting red blood cell mass studies; otherwise, some cases of true polycythemia may be missed.

 


More on Myeloproliferative Disease

Overview: Myeloproliferative Disease
Differential Diagnoses & Workup: Myeloproliferative Disease
Treatment & Medication: Myeloproliferative Disease
Follow-up: Myeloproliferative Disease
Multimedia: Myeloproliferative Disease
References

References

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  2. Baxter EJ, Scott LM, Campbell PJ. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. Mar 19-25 2005;365(9464):1054-61. [Medline].

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  4. Mesa RA, Powell H, Lasho T, Dewald G, McClure R, Tefferi A. JAK2(V617) and leukemic transformation in myelofirbrosis with myeloid metaplasia. Leuk Res. 2006/11;30 (11):1457-60.

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  6. O'Brien SG, Guilhot F, Larson RA. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. Mar 13 2003;348(11):994-1004. [Medline].

  7. Kaplan ME, Mack K, Goldberg JD. Long-term management of polycythemia vera with hydroxyurea: a progress report. Semin Hematol. Jul 1986;23(3):167-71. [Medline].

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  11. Johansson P, Kutti J, Andreasson B. Trends in the incidence of chronic Philadelphia chromosome negative (Ph-) myeloproliferative disorders in the city of Goteborg, Sweden, during 1983-99. J Intern Med. Aug 2004;256(2):161-5.

  12. Kralovics R, Passamonti F, Buser AS. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. Apr 28 2005;352(17):1779-90. [Medline].

  13. Kutti J, Ridell B. Epidemiology of the myeloproliferative disorders: essential thrombocythaemia, polycythaemia vera and idiopathic myelofibrosis. Pathol Biol (Paris). Mar 2001;49(2):164-6. [Medline].

  14. Levine RL, Wadleigh M, Cools J. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. Apr 2005;7(4):387-97. [Medline].

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  16. Pardanani A, Brockman SR, Paternoster SF. FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia. Blood. Nov 15 2004;104(10):3038-45. [Medline][Full Text].

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Further Reading

Keywords

MPD, polycythemia vera, PV, polycythemia rubra vera, primary thrombocythemia, PT, agnogenic myeloid metaplasia, AMM, chronic myelogenous leukemia, chronic myeloid leukemia, CML, myelofibrosis, MF, acute leukemia, myelodysplastic syndrome, essential thrombocythemia, ET, Budd-Chiari syndrome, chronic idiopathic myelofibrosis, CIM, chronic neutrophilic leukemia, CNL, chronic eosinophilic leukemia, CEL, hypereosinophilic syndrome, HES

Contributor Information and Disclosures

Author

Haleem J Rasool, MD, FACP, Hematologist Oncologist, Department of Oncology, Franciscan Skemp Healthcare
Haleem J Rasool, MD, FACP is a member of the following medical societies: American College of Physicians-American Society of Internal Medicine and American Society of Hematology
Disclosure: Nothing to disclose.

Coauthor(s)

Dale Groshek, BS, PA-C, Cancer Center, Department of Radiation Oncology, Franciscan Skemp Healthcare, La Crosse
Disclosure: Nothing to disclose.

Medical Editor

Koyamangalath Krishnan, MD, FRCP, FACP, Paul Dishner Endowed Chair of Excellence in Medicine, Professor of Medicine and Chief of Hematology-Oncology, Program Director, Hematology-Oncology Fellowship, James H Quillen College of Medicine at East Tennessee State University
Koyamangalath Krishnan, MD, FRCP, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians-American Society of Internal Medicine, American Society of Hematology, and Royal College of Physicians
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Troy H Guthrie, Jr, MD, Director of Cancer Institute, Baptist Medical Center
Troy H Guthrie, Jr, MD is a member of the following medical societies: American Federation for Medical Research, American Medical Association, American Society of Hematology, Florida Medical Association, Medical Association of Georgia, and Southern Medical Association
Disclosure: Nothing to disclose.

CME Editor

Rajalaxmi McKenna, MD, FACP, Southwest Medical Consultants, SC, Department of Medicine, Good Samaritan Hospital, Advocate Health Systems
Rajalaxmi McKenna, MD, FACP is a member of the following medical societies: American Society of Clinical Oncology, American Society of Hematology, and International Society on Thrombosis and Haemostasis
Disclosure: Nothing to disclose.

Chief Editor

Emmanuel C Besa, MD, Professor, Department of Medicine, Division of Hematologic Malignancies, Kimmel Cancer Center, Thomas Jefferson University
Emmanuel C Besa, MD is a member of the following medical societies: American Association for Cancer Education, American College of Clinical Pharmacology, American Federation for Medical Research, American Society of Hematology, and New York Academy of Sciences
Disclosure: Nothing to disclose.

 
 
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