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Tympanoplasty

  • Author: Brian Kip Reilly, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
 
Updated: Mar 02, 2016
 

Background

Tympanoplasty is a surgical technique to repair a defect in the tympanic membrane with the placement of a graft, either medial or lateral to the tympanic membrane annulus. The goal of this surgical procedure is not only to close the perforation but also to improve hearing. The success of the operation depends on the ability to eradicate disease from the middle ear (eg, inflamed granulation tissue and cholesteatoma). Various techniques have been developed and refined, and a number of grafting materials are available. Both the lateral and medial grafting techniques are detailed below.

Tympanoplasty is a safe and effective outpatient procedure used to both eradicate disease from the middle ear and restore hearing and middle ear function.[1, 2] A number of surgical approaches and grafting techniques are available for use by the surgeon. Paramount to success are the preoperative assessment, good hemostasis intraoperatively, and thoughtful surgical planning with careful placement of the graft.

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Pathology

Perforations are most problematic when they cause both conductive hearing loss and chronic otorrhea. Although most perforations heal spontaneously, those that persist after dry ear precautions, ototopical drops, or myringoplasty should be considered for surgical repair. Tympanic membrane perforations can arise as sequelae of acute otitis media or chronic otitis media with or without cholesteatoma, as a complication of PE tube insertion, or as a result of barotrauma to the ear. Smaller perforations of the tympanic membrane can result in low-frequency hearing loss, while larger perforations can cause high-frequency and low-frequency hearing loss. Chronic infections and cholesteatoma can also result from perforations of the tympanic membrane.[3, 4] A perforation is a significant risk for the development of otitis when swimming in lakes, rivers, oceans, or pools.

Cholesteatoma

Cholesteatoma is an epidermal inclusion cyst that contains desquamated keratin and accounts for much of the morbidity of otomastoiditis. The in-growth of squamous cells into the middle ear through a perforation can result in an acquired cholesteatoma. Chronic otitis media can occur with or without cholesteatoma, and both varieties can present challenges to the clinician and barriers to the success of a tympanoplasty.

A complete discussion on the etiology and pathophysiology of cholesteatoma is beyond the scope of this article, but multiple theories exist on its etiology. One of the more common theories about how cholesteatomas form involves retraction of the pars flaccida from negative middle ear pressure, resulting in invagination of squamous epithelium into the middle ear and mastoid. Another theory suggests that cholesteatoma arises from ingrowth of epithelium through a perforation of the tympanic membrane.

The 2 other most popular theories involve hyperplasia of the basal layer of the tympanic membrane and metaplasia of middle ear mucosa. A number of complications of cholesteatoma are related to growth and bony erosion, including hearing loss (via erosion of ossicles and/or cochlea), labyrinthitis or labyrinthine fistula, facial nerve paresis, and intracranial complications.

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Indications

Although most perforations heal spontaneously, those that persist after dry ear precautions, ototopical drops, or myringoplasty should be considered for surgical repair.

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Contraindications

Operating on an actively infected ear is contraindicated.

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Technical Considerations

Tympanic Membrane

An understanding of the tympanic membrane anatomy is critical to successful repair. Tympanoplasty technique mandates an understanding of the layers. The tympanic membrane typically consists of the following 3 layers:

  • Lateral epithelial layer
  • Middle fibrous layer
  • Medial mucosal layer

The outer epithelial layer is composed of stratified squamous epithelium, which is continuous with the skin of the external auditory canal. This is significant because in-growth of this outer epithelial portion through the perforation can result in an epithelial cyst called an acquired cholesteatoma. Untreated, this cyst then releases destructive enzymes that can enlarge the size of the perforation and ultimately cause ossicular erosion. The lateral grafting technique that is discussed later in this text requires that this entire epithelial layer be stripped from the drum remnant prior to placement of the graft so as to avoid iatrogenic cholesteatoma formation.

The middle fibrous layer is composed of connective tissue consisting of outer radial fibers and inner circular fibers. It provides strength to the drum. A healed perforation is also commonly deficient of this middle fibrous layer. The epithelial and endothelial layers regenerate creating a “dimeric” membrane. This miscalculation can be corrected when carefully examined under binocular microscopy. Because this middle layer is absent in the pars flaccida superiorly, the posterior-superior aspect of the drum can be drawn inward toward the middle ear as a retraction pocket.

The inner layer of the tympanic membrane consists of simple cuboidal and columnar epithelium cells. This layer is identical to the mucosal lining of the rest of the middle ear mucosal tissue and is considered to be critical to ensure healing of tympanic membrane perforations, and the surgeon often abrades or rasps the undersurface of the tympanic membrane remnant to stimulate regrowth.

Annulus

The peripheral edge of the tympanic membrane is rimmed by a dense fibrous layer called the annulus, which is essentially a thickening of the pars tensa. Successful elevation of the annulus is critical for medial grafting technique. The annulus is deficient superiorly at the “12 o’clock” location. This area is the notch of Rivinus and can guide the surgeon to a natural plane to elevate the annulus.

Ear Canal

The ear canal has bone in the medial component (inner one-third). The lateral portion, which extends into the pinna, is composed of cartilage. The boney/cartilaginous interface is located at the medial two-thirds junction. Most incisions that are made to raise a tympanomeatal flap or perform either an endaural or transcanal approaches are made at this location as well. The superiorly placed vascular strip is another critical area within the ear canal. This region is demarcated by the tympanosquamous suture line superiorly and the tympanomastoid junction line inferiorly. Canal incisions are often made along these junctions.

Middle Ear

The middle ear is an air-filled space bordered by the bony labyrinth of the inner ear medially, the tympanic membrane laterally, and the cranium superiorly. This space contains the ossicles, nerves (facial nerve, chorda tympani, Jacobsen nerve), small muscles (stapedius and tensor tympani), ligaments, and blood vessels. The petrous portion of the internal carotid artery and the internal jugular vein, which are both in proximity to the middle ear space, can be dehiscent and should be noted on any preoperative imaging. Rarely, middle ear pathology can involve these structures.

In order for successful grafting of the tympanic membrane to improve hearing, an intact ossicular chain must be present. The malleus transmits energy from the tympanic membrane to the incus, which itself is connected to the stapes superstructure resting on the oval window. Diarthrodial joints connect the 3 ossicles and allow the transmission of acoustic energy from the tympanic membrane to the inner ear. The incudostapedial joint is the most fragile and, hence, has the highest likelihood to require repair.

Mastoid

The middle ear communicates with the mastoid air cells via the mastoid antrum. The temporal bone air cells are usually pneumatized by 3 years of age. However, the air cells can remain underdeveloped and sclerotic in patients with persistent eustachian tube dysfunction. A poorly pneumatized or fluid-filled mastoid bone predisposes a patient to require a more extensive tympanomastoidectomy to improve the chances of successful graft placement.

Eustachian Tube

The eustachian tube connects the middle ear with the nasopharynx and allows pressure equilibration in the middle ear. Enlarged adenoids or biofilms within this lymphoid tissue are hypothesized to predispose a patient to persistent middle ear disease. This bony-cartilaginous tube is approximately 45° from the horizontal in adults but only 10° from horizontal in infants. In addition, the infant eustachian tube is about 50% of the adult length.

Inner Ear

The inner ear is composed of the cochlea, which is the end-organ for hearing, and the vestibular organs. The vestibular organs include the utricle, saccule, and the 3 semicircular canals and are involved in balance.

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Outcomes

The indications and outcomes vary depending on the specific clinical problem. Success rates of tympanic membrane closure vary greatly in the literature (35-98%) but are usually greater than 80% and depend largely on the size and location of the perforation, surgical technique, and overall health of the middle ear.[5, 6, 7]

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Complications

Complications of the surgery include recurrence of the perforation, tympanic membrane retraction, otorrhea, cholesteatoma development, persistence or worsening of any conductive hearing loss, sensorineural hearing loss (rare), and taste disturbances. Post-auricular incisions are at risk for hematoma, and a mastoid pressure dressing is recommended for the first postoperative night. Outcomes can be optimized by a proper and detailed preoperative assessment and the careful construction of an effective surgical plan.

The graft can fail because of infection, failure to pack the graft securely in place, technical error, failure to clear mastoid and middle ear disease, and because of a concurrent undetected cholesteatoma. Excising all tympanosclerosis at the edge of the perforation so as to allow vascularized perimeters to incorporate the graft is critical.

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Contributor Information and Disclosures
Author

Brian Kip Reilly, MD Assistant Professor of Otolaryngology and Pediatrics, Department of Otolaryngology, Children's National Medical Center, George Washington University School of Medicine

Brian Kip Reilly, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery

Disclosure: Nothing to disclose.

Coauthor(s)

Michael E McCormick, MD Assistant Professor, Department of Otolaryngology and Communications Sciences, Division of Pediatric Otolaryngology, Medical College of Wisconsin and Children's Hospital of Wisconsin

Michael E McCormick, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American Academy of Pediatrics, American Medical Association, American Society of Pediatric Otolaryngology, Society for Ear, Nose and Throat Advances in Children

Disclosure: Nothing to disclose.

Chief Editor

Arlen D Meyers, MD, MBA Professor of Otolaryngology, Dentistry, and Engineering, University of Colorado School of Medicine

Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Cerescan;RxRevu;SymbiaAllergySolutions<br/>Received income in an amount equal to or greater than $250 from: Symbia<br/>Received from Allergy Solutions, Inc for board membership; Received honoraria from RxRevu for chief medical editor; Received salary from Medvoy for founder and president; Received consulting fee from Corvectra for senior medical advisor; Received ownership interest from Cerescan for consulting; Received consulting fee from Essiahealth for advisor; Received consulting fee from Carespan for advisor; Received consulting fee from Covidien for consulting.

References
  1. Verhoeff M. Chronic suppurative otitis media: A review. Int J Ped Oto. 70(1):1-12.

  2. Webb B, Chang CYJ. Efficacy of Tympanoplasty without mastoidectomy for Chronic Superative Otitis Media. Arch of Otolaryngol Head and Neck Surg. 2008/11. 1155-1158.

  3. Haynes DS, Harley DH. Surgical management of chronic otitis media: beyond tympanotomy tubes. Otolaryngol Clin North Am. 2002 Aug. 35(4):827-39. [Medline].

  4. Prescott CAJ. Chronic otitis media(COM) – A personal philosophy. Int J Ped Oto. 2006. 70:1317-1320.

  5. Adams ME and El-Kashlan HK. Tympanoplasty and Ossiculoplasty. Cummings CW et al (Eds). Otolaryngology: Head & Neck Surgery. 5th Edition. Philadelphia, PA: Mosby-Elsevier; 2010.

  6. Sarkar S, Roychoudhury A, Roychaudhuri BK. Tympanoplasty in children. Eur Arch Otorhinolaryngol. 2009 May. 266(5):627-33. [Medline].

  7. Hardman J, Muzaffar J, Nankivell P, Coulson C. Tympanoplasty for Chronic Tympanic Membrane Perforation in Children: Systematic Review and Meta-analysis. Otol Neurotol. 2015 Jun. 36 (5):796-804. [Medline].

  8. Aggarwal R, Saeed SR, Green KJ. Myringoplasty. J Laryngol Otol. 2006 Jun. 120(6):429-32. [Medline].

  9. Chang CYJ. Chronic Disorders of the Middle Ear and Mastoid (Tympanic Membrane Perforations and Cholesteatoma. Mitchell RB. Pediatric Otolaryngology for the Clinician. New York, NY: Springer; 2009.

  10. Lin AC, Messner AH. Pediatric tympanoplasty: factors affecting success. Curr Opin Otolaryngol Head Neck Surg. 2008 Feb. 16(1):64-8. [Medline].

  11. Wehrs RE. Grafting techniques. Otolaryngol Clin North Am. 1999 Jun. 32(3):443-55. [Medline].

  12. Wright D, Safranek S. Treatment of otitis media with perforated tympanic membrane. Am Fam Physician. 2009 Apr 15. 79(8):650, 654. [Medline].

  13. Kartush JM, Michaelides EM, Becvarovski Z, LaRouere MJ. Over-under tympanoplasty. Laryngoscope. 2002 May. 112(5):802-7. [Medline].

  14. Seiden AM et al. Functional Disorders. Otolaryngology: The Essentials.

  15. Luetje III CM. Reconstruction of the Tympanic Membrane and Ossicular Chain. Bailey BJ. Head & Neck Surgery – Otolaryngology. 4th Edition. Philadelphia, PA: Lippincott Williams & Wilkins; 2006.

  16. Dornhoffer JL. Cartilage tympanoplasty. Otolaryngol Clin North Am. 2006 Dec. 39(6):1161-76. [Medline].

  17. Wasson JD, Papadimitriou CE, Pau H. Myringoplasty: impact of perforation size on closure and audiological improvement. J Laryngol Otol. 2009 Sep. 123(9):973-7. [Medline].

 
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Basic otologic instruments.
Forceps.
Otologic instruments.
Rimming of perforation with Rosen needle.
Canalplasty to remove anterior bony ledge allowing unobstructed view of perforation.
Underlay graft in place underneath perforation, with tympanomeatal flaps unfolded.
Lateral graft being tucked in over annulus.
 
 
 
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