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Mastoiditis

  • Author: PP Devan, MBBS, MS; Chief Editor: Arlen D Meyers, MD, MBA  more...
 
Updated: May 04, 2016
 

Background

A purist's definition of mastoiditis includes all inflammatory processes of the mastoid air cells of the temporal bone. As the mastoid is contiguous to and an extension of the middle ear cleft, virtually every child or adult with acute otitis media (AOM) or chronic middle ear inflammatory disease has mastoiditis. In most cases, the symptomatology of the middle ear predominates (eg, fever, pain, conductive hearing loss), and the disease within the mastoid is not considered a separate entity (see the image below).[17] (See Etiology and Presentation.)

Mastoiditis with subperiosteal abscess. Note the l Mastoiditis with subperiosteal abscess. Note the loss of the skin crease and the pointed abscess.

Acute mastoiditis is associated with AOM. In some patients, the infection spreads beyond the mucosa of the middle ear cleft, and they develop osteitis within the mastoid air-cell system or periosteitis of the mastoid process, either directly by bone erosion through the cortex or indirectly via the emissary vein of the mastoid. These patients have acute surgical mastoiditis (ASM), an intratemporal complication of otitis media. (See Etiology.)

Chronic mastoiditis is most commonly associated with chronic suppurative otitis media and particularly with cholesteatoma formation. Cholesteatomas are benign aggregates of squamous epithelium that can grow and alter normal structure and function of surrounding soft tissue and bone. This destructive process is accelerated in the presence of active infection by the secretion of osteolytic enzymes by the epithelial tissue. (See Etiology.)

Progression of mastoiditis

Mastoiditis progresses in the following 5 stages and may be arrested at any point (see Presentation and Workup):

  • Hyperemia of the mucosal lining of the mastoid air cells
  • Transudation and exudation of fluid and/or pus within the cells
  • Necrosis of bone by loss of vascularity of the septa
  • Cell wall loss with coalescence into abscess cavities
  • Extension of the inflammatory process to contiguous areas

Patient education

Warn patients and their families of possible cosmetic deformity following mastoid surgery.

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Etiology

As with most infectious processes, consider host and microbial factors when evaluating surgical mastoiditis. Host factors include mucosal immunology, temporal bone anatomy, and systemic immunity. Microbial factors include protective coating, antimicrobial resistance, and ability to penetrate local tissue or vessels (ie, invasive strains). As the clearance of the mastoid is dependent upon a patent antrum, resolution is unlikely unless this anatomical isthmus opens by control of mucosal swelling, which otherwise creates a reservoir for infection.

Host factors

Most children presenting with acute surgical mastoiditis (ASM) are younger than age 2 years and have little history of otitis media. This is an age at which the immune system is relatively immature, particularly with regard to its ability to respond to challenges from polysaccharide antigens.

Host anatomical factors may have a role. The mastoid develops from a narrow outpouching of the posterior epitympanum (ie, the aditus ad antrum). Pneumatization occurs shortly after birth, once the middle ear becomes aerated, and this process is complete by age 10 years. Mastoid air cells are created by invasion of epithelium-lined sacs between spicules of new bone and by degeneration and redifferentiation of existing bone marrow spaces.

Other areas of the temporal bone pneumatize similarly, including the petrous apex and the zygomatic root. The antrum, as with the mastoid air cells, is lined with respiratory epithelium that swells when infection is present. Blockage of the antrum by inflamed mucosa entraps infection within the air cells by inhibiting drainage and precluding reaeration from the middle-ear side.

Persistent acute infection within the mastoid cavity may lead to a rarifying osteitis, which destroys the bony trabeculae that form the mastoid cells (hence the term coalescent mastoiditis). Essentially, coalescent mastoiditis is an empyema of the temporal bone that, unless its progress is arrested, drains either through the natural antrum to give spontaneous resolution or creates further complication by draining unnaturally to the mastoid surface, petrous apex, or intracranial spaces. Other temporal bone structures or nearby structures, such as the facial nerve, labyrinth, and venous sinuses, may become involved.

A retrospective study by Adams et al indicated that children with autism spectrum disorder have an increased likelihood of developing middle ear infections and otitis-related complications, including a more than two-fold greater chance of developing mastoiditis.[19]

Microbial factors

Reported pathogens in mastoiditis include the following:

  • Streptococcus pneumoniae – Most frequently isolated pathogen in acute mastoiditis, prevalence of approximately 25%
  • Group A beta-hemolytic streptococci
  • Staphylococcus aureus
  • Streptococcus pyogenes
  • Moraxella catarrhalis
  • Haemophilus influenzae
  • Pseudomonas aeruginosa
  • Mycobacterium species
  • Aspergillus fumigatus and other fungi
  • Nocardia asteroides - Case report [1]

Because acute otitis media (AOM) is the antecedent disease, the most common etiologic agent causing surgical mastoiditis is Streptococcus pneumoniae, followed by Haemophilus influenzae and group A Streptococcus pyogenes (GAS). Each of these bacteria has invasive forms and is recovered most often from children presenting with ASM. More than half of the Streptococcus pneumoniae recovered are of serotype 19, followed by serotypes 23 and 3.

The literature and the authors' experience indicate that a high frequency of multidrug-resistant Streptococcus pneumoniae (MDRSP) is now associated with ASM, and this may alter selection of antimicrobials (40-50% penicillin resistant, approximately 25% ceftriaxone resistant). Treatment of AOM with antimicrobials in the previous month increases the frequency of MDRSP.[2]

Gram-negative organisms and Staphylococcus aureus are recovered more frequently from patients with chronic mastoiditis.

Half of children admitted with acute mastoiditis have no previous history of recurrent AOM. In those children, Streptococcus pneumoniae has been the leading pathogen, while Pseudomonas aeruginosa has been more prevalent in children with recurrent AOM.

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Epidemiology

Incidence of surgical mastoiditis from acute otitis media is reported as 0.004% in the United States.[3] Some fear that untreated otitis media increases the risk of acute mastoiditis and is the cause of higher incidences in developing countries and very young children.[4, 5]

The Inuit population has a high predilection for middle-ear disease and, as a likely consequence, mastoiditis.

Rates of antibiotic treatment for otitis in the Netherlands, Norway, and Denmark were 31%, 67%, and 76%, respectively. The incidence of mastoiditis was approximately 4 cases per 100,000 children per year over 5 years.

Acute mastoiditis is a disease of the very young. Most patients present when younger than age 2 years, with a median age of 12 months. However, it can occur in persons of any age.

A retrospective review of pediatric patients in Colorado found that despite an initial drop in the incidence of acute mastoiditis in children under age 2 years following the introduction of heptavalent pneumococcal conjugate vaccine (PCV7), the incidence rose again to pre-PCV7 levels within a few years. The study, by Halgrimson et al, examined pediatric inpatient data from 1999-2008 for documented cases of acute mastoiditis or patients who had undergone mastoidectomy.[6]

The investigators found that the annual incidence of acute mastoiditis in children under age 2 years dropped from 11.0 per 100,000 population in 2001, a year after PCV7 was introduced, to 4.5 per 100,000 population in 2003. By 2008, however, the incidence had again risen, to 12.0 per 100,000 population. An increase in the prevalence of S pneumoniae isolates nonsusceptible to penicillin also occurred in Colorado, from 0% between 1999 and 2004 to 38% between 2005 and 2008. Halgrimson and colleagues suggested that the presence of non-PCV7 pneumococcal serotypes and a rise in pneumococcal antibiotic resistance may have caused the incidence of acute mastoiditis to increase.[6]

Another study, however, found that the introduction of pneumococcal conjugate vaccines may have led to a national reduction in pediatric mastoiditis rates. The study, by Marom et al, looked at insurance claims from a nationwide managed health care plan to analyze health care visits associated with otitis media in children aged 6 years or younger. The investigators found that between 2008 and 2011, mastoiditis rates decreased from 61 per 100,000 child-years to 37 per 100,000 child-years.[7]

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Prognosis

Expect patients with acute surgical mastoiditis (ASM) to recover completely provided that the facial nerve, vestibule, and intracranial structures are not involved. Cosmetic deformity of the operated ear can usually be prevented with judicious placement of the incision and the development of flaps to pull the ears posteriorly when replaced.

Conductive hearing loss should resolve provided that the ossicular chain remains intact. Conduct testing after otorrhea has ended and the ear has healed.

Extension of the infectious process of mastoiditis can include the following:

  • Posterior extension to the sigmoid sinus (causing thrombosis)
  • Posterior extension to the occipital bone to create an osteomyelitis of calvaria or a Citelli abscess
  • Superior extension to the posterior cranial fossa, subdural space, and meninges
  • Anterior extension to the zygomatic root
  • Lateral extension to form a subperiosteal abscess
  • Inferior extension to form a Bezold abscess
  • Medial extension to the petrous apex
  • Intratemporal involvement of the facial nerve and/or labyrinth

Complications

Complications of mastoiditis include the following:

  • Hearing loss
  • Facial nerve palsy
  • Cranial nerve involvement
  • Osteomyelitis
  • Petrositis
  • Gradenigo syndrome - Otitis media, retro-orbital pain, and abducens palsy
  • Intracranial extension - Meningitis, cerebral abscess, epidural abscess, subdural empyema
  • Sigmoid sinus thrombosis
  • Abscess formation - Citelli abscess (extension to occipital bone, calvaria), subperiosteal abscess (abscess between the periosteum and mastoid bone, resulting in the typical appearance of a protruding ear; see the image below), and Bezold's abscess (abscess of soft tissues that track along the sternomastoid sheath; Bezold abscesses are very rare complications and are usually found only in adults with a well-pneumatized mastoid tip)

See the image below.

Mastoiditis with subperiosteal abscess. Note the l Mastoiditis with subperiosteal abscess. Note the loss of the skin crease and the pointed abscess.

Meningitis and facial nerve paralysis are possible in mastoiditis. Approximately 7% of patients may develop intracranial complications related to acute mastoiditis. These complications can include sigmoid sinus thrombosis, epidural abscess, and meningitis. Persistent otalgia or otorrhea with associated neurologic symptoms in a patient taking oral antibiotics are ominous signs that suggest a complication.

Otogenic meningitis is the most common intracranial complication of neglected otitis media. In the Western world, such complications seldom occur in children and adolescents and are extremely rare in adults. The current use of antibiotics and of more sophisticated surgery has greatly diminished the incidence of otogenic meningitis; however, this has resulted in physicians having less experience with diagnosis and treatment of this complication. Emergency surgical treatment is mandatory.

In a study done by Luntz et al of 223 consecutive cases of acute mastoiditis, 16 patients presented with complications, including cerebellar abscess, perisinus empyema, subdural abscess or empyema, extradural abscess, cavernous sinus thrombosis, lateral sinus thrombosis, bacterial meningitis, labyrinthitis, petrositis, and facial nerve palsy.[8]

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Contributor Information and Disclosures
Author

PP Devan, MBBS, MS Professor and Head, Dept of ENT, A J Institute of Medical Sciences, Mangalore, India

Disclosure: Nothing to disclose.

Coauthor(s)

John D Donaldson, MD, FRCSC, FACS Pediatric Otolaryngologist, Chief of Surgery, Galisano Children's Hospital, Lee Memorial Health System

John D Donaldson, MD, FRCSC, FACS is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American Society of Pediatric Otolaryngology, American Academy of Pediatrics, American College of Surgeons

Disclosure: Nothing to disclose.

Chief Editor

Arlen D Meyers, MD, MBA Professor of Otolaryngology, Dentistry, and Engineering, University of Colorado School of Medicine

Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Cerescan;RxRevu;SymbiaAllergySolutions<br/>Received income in an amount equal to or greater than $250 from: Symbia<br/>Received from Allergy Solutions, Inc for board membership; Received honoraria from RxRevu for chief medical editor; Received salary from Medvoy for founder and president; Received consulting fee from Corvectra for senior medical advisor; Received ownership interest from Cerescan for consulting; Received consulting fee from Essiahealth for advisor; Received consulting fee from Carespan for advisor; Received consulting fee from Covidien for consulting.

Acknowledgements

Karin S Chase, MD Assistant Clinical Instructor and Resident Physician, Department of Emergency Medicine, State University of New York Downstate Medical Center/Kings County Hospital

Karin S Chase, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, and Emergency Medicine Residents Association

Disclosure: Nothing to disclose.

Christopher I Doty, MD, FACEP, FAAEM Assistant Professor of Emergency Medicine, Residency Program Director, Department of Emergency Medicine, Kings County Hospital Center, State University of New York Downstate Medical Center

Christopher I Doty, MD, FACEP, FAAEM is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, Council of Emergency Medicine Residency Directors, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Gerard J Gianoli, MD Clinical Associate Professor, Department of Otolaryngology-Head and Neck Surgery, Tulane University School of Medicine; Vice President, The Ear and Balance Institute; Chief Executive Officer, Ponchartrain Surgery Center

Gerard J Gianoli, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Neurotology Society, American Otological Society, Society of University Otolaryngologists-Head and Neck Surgeons, and Triological Society

Disclosure: Vesticon, Inc. None Board membership

Alyssa K Hamman, MD Research Assistant, Division of Emergency Medicine, Stanford University

Alyssa K Hamman, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Medical Association, and Colorado Medical Society

Disclosure: Nothing to disclose.

Eric M Kardon, MD, FACEP Attending Emergency Physician, Georgia Emergency Medicine Specialists; Physician, Division of Emergency Medicine, Athens Regional Medical Center

Eric M Kardon, MD, FACEP is a member of the following medical societies: American College of Emergency Physicians

Disclosure: Nothing to disclose.

John C Li, MD Private Practice in Otology and Neurotology; Medical Director, Balance Center

John C Li, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Medical Association, American Neurotology Society, American Tinnitus Association, Florida Medical Association, and North American Skull Base Society

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Senior Pharmacy Editor, eMedicine

Disclosure: eMedicine Salary Employment

Jeter (Jay) Pritchard Taylor III, MD Compliance Officer, Attending Physician, Emergency Medicine Residency, Department of Emergency Medicine, Palmetto Health Richland, University of South Carolina School of Medicine; Medical Director, Department of Emergency Medicine, Palmetto Health Baptist

Jeter (Jay) Pritchard Taylor III, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

N Ewen Wang, MD Consulting Staff, Department of Surgery, Division of Emergency Medicine, Stanford University Hospital

Disclosure: Nothing to disclose.

References
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  5. Palma S, Bovo R, Benatti A, Aimoni C, Rosignoli M, Libanore M, et al. Mastoiditis in adults: a 19-year retrospective study. Eur Arch Otorhinolaryngol. 2013 Apr 16. [Medline].

  6. Halgrimson WR, Chan KH, Abzug MJ, et al. Incidence of acute mastoiditis in Colorado children in the pneumococcal conjugate vaccine era. Pediatr Infect Dis J. 2014 May. 33(5):453-7. [Medline].

  7. Marom T, Tan A, Wilkinson GS, et al. Trends in otitis media-related health care use in the United States, 2001-2011. JAMA Pediatr. 2014 Jan. 168(1):68-75. [Medline]. [Full Text].

  8. Luntz M, Brodsky A, Nusem S, Kronenberg J, Keren G, Migirov L, et al. Acute mastoiditis--the antibiotic era: a multicenter study. Int J Pediatr Otorhinolaryngol. 2001 Jan. 57(1):1-9. [Medline].

  9. Oestreicher-Kedem Y, Raveh E, Kornreich L, Popovtzer A, Buller N, Nageris B. Complications of mastoiditis in children at the onset of a new millennium. Ann Otol Rhinol Laryngol. 2005 Feb. 114(2):147-52. [Medline].

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  13. National Cancer Institute. Radiation Risks and Pediatric Computed Tomography (CT): A Guide for Health Care Providers. National Institutes of Health. Available at http://www.cancer.gov/cancertopics/causes/radiation/radiation-risks-pediatric-CT. Accessed: October 2, 2011.

  14. Saat R, Laulajainen-Hongisto AH, Mahmood G, et al. MR imaging features of acute mastoiditis and their clinical relevance. AJNR Am J Neuroradiol. 2015 Feb. 36 (2):361-7. [Medline].

  15. Enoksson F, Groth A, Hultcrantz M, Stalfors J, Stenfeldt K, Hermansson A. Subperiosteal abscesses in acute mastoiditis in 115 Swedish children. Int J Pediatr Otorhinolaryngol. 2015 Jul. 79 (7):1115-20. [Medline].

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Mastoiditis with subperiosteal abscess. Note the loss of the skin crease and the pointed abscess.
Cortical mastoidectomy in a densely sclerosed mastoid.
Preoperative preparation of the patient.
Draping the surgical area.
Injection of the area with 2% Xylocaine and 1:100,000 adrenaline to reduce bleeding.
Marking the incision site.
Placement of the incision, a few mm behind the postauricular sulcus.
Deepening the incision down to the bone.
Elevation of the periosteum to expose the mastoid cortex to the mastoid tip.
Mastoid drilling in progress with simultaneous saline irrigation.
Creation of the initial groove and the vertical line.
Exposure of the antrum and exenteration of the mastoid air cells.
Curetting the aditus to enlarge it.
Further exposure.
Healed postaural scar.
Extent of cortical mastoidectomy in a well-pneumatized mastoid.
 
 
 
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