Approach Considerations
Despite the use of antibiotics, acute mastoiditis still remains a threat for patients with acute otitis media (AOM), especially for children younger than age 5 years. Great care is required on the part of clinicians to make an early diagnosis in order to promote adequate treatment and to prevent complications.[7]
Material for culture and sensitivity should be obtained from the ear (via tympanocentesis or myringotomy), blood, any abscess, and mastoid tissue (if it becomes available). Obtain and evaluate spinal fluid if any suggestion exists of intracranial extension of the process.
Complete blood count
A complete blood count (CBC) and sedimentation rate are obtained for baseline studies used to evaluate the efficacy of therapy. A high white blood cell count on admission may serve as a predictive factor for complicated cases.
Audiometry
In the light of the prevailing medicolegal climate, an audiometric evaluation must be obtained. Audiometry is seldom appropriate or useful for children with ASM, but it must be performed after convalescence from the acute phase and with children who have chronic mastoiditis. In the at-risk population (children < 2 y), thresholds for air and bone conduction under headphones are only rarely obtained.
Tympanocentesis/myringotomy
Tympanocentesis is a puncture of the tympanic membrane for aspiration of middle ear fluid. The tympanic membrane typically heals within several days. Send fluid for cultures, Gram stain, and acid-fast stain. It is often possible in an acute infection to convert a tympanocentesis into a myringotomy without undue discomfort by widening the needle hole with alligator forceps.
Myringotomy is a small incision of the tympanum to express fluid from the middle ear in chronic or recurrent otitis media; it often relieves discomfort associated with pressure from acute otitis media (AOM). Tympanostomy tube insertion is also performed in most cases to allow for continued drainage and so that administered therapeutic otic drops reach the middle ear.
Imaging Studies
CT scanning
CT scanning of the temporal bone is the standard for evaluation of mastoiditis, with published sensitivities ranging from 87-100%. Some argue that all suspected cases of mastoiditis warrant CT scan evaluation.[8]
The following findings are used to differentiate acute otitis media (AOM)/acute mastoiditis without osteitis, acute surgical mastoiditis (ASM), and chronic mastoiditis:
- Opacification of the mastoid air cells and middle ear by inflammatory swelling of mucosa and by collection of fluid
- Loss of sharpness or visibility of mastoid cell walls due to demineralization, atrophy, or necrosis of bony septa
- Haziness or distortion of the mastoid outline, possibly with visible defects of the tegmen or mastoid cortex
- Enhancement of areas of abscess formation
- Elevation of the periosteum of the mastoid process or posterior cranial fossa
- Osteoblastic activity in chronic mastoiditis
It is this author’s belief that in the presence of clear clinical indications of acute surgical mastoiditis, CT scanning may be omitted prior to surgical intervention, avoiding unnecessary radiation exposure as recommended by the US National Institutes of Health.[9]
MRI
Magnetic resonance imaging (MRI) is not typically the radiographic study of choice; however, it is helpful in showing inflammatory processes and differentiating certain tumors. Do not use MRI as a method of evaluating the mastoid, although it is the standard for evaluation of contiguous soft tissue, particularly the intracranial structures. However, MRI is the preferred imaging modality for the potential complications of ASM (ie, abscess formation, sinus thrombosis).
Plain radiography
In areas of the world where CT scanning is not immediately available, plain radiographs of the mastoids demonstrate clouding of the air cells with bone destruction in ASM. In the vast majority of cases, radiographs suffice to establish the diagnosis but lack the sensitivity to differentiate the stages of the disease and fail to show the petrous apex in any great detail.
Casula S, Castro JG, Espinoza LA. An unusual cause of mastoiditis that evolved into multiple ring-enhancing intracerebral lesions in a person with HIV infection. AIDS Read. Aug 2007;17(8):402-4. [Medline].
Ongkasuwan J, Valdez TA, Hulten KG, Mason EO Jr, Kaplan SL. Pneumococcal mastoiditis in children and the emergence of multidrug-resistant serotype 19A isolates. Pediatrics. Jul 2008;122(1):34-9. [Medline].
Nussinovitch M, Yoeli R, Elishkevitz K, Varsano I. Acute mastoiditis in children: epidemiologic, clinical, microbiologic, and therapeutic aspects over past years. Clin Pediatr (Phila). Apr 2004;43(3):261-7. [Medline].
Luntz M, Brodsky A, Nusem S, Kronenberg J, Keren G, Migirov L, et al. Acute mastoiditis--the antibiotic era: a multicenter study. Int J Pediatr Otorhinolaryngol. Jan 2001;57(1):1-9. [Medline].
Oestreicher-Kedem Y, Raveh E, Kornreich L, Popovtzer A, Buller N, Nageris B. Complications of mastoiditis in children at the onset of a new millennium. Ann Otol Rhinol Laryngol. Feb 2005;114(2):147-52. [Medline].
Niv A, Nash M, Slovik Y, Fliss DM, Kaplan D, Leibovitz E, et al. Acute mastoiditis in infancy: the Soroka experience: 1990-2000. Int J Pediatr Otorhinolaryngol. Nov 2004;68(11):1435-9. [Medline].
van den Aardweg MT, Rovers MM, de Ru JA, Albers FW, Schilder AG. A systematic review of diagnostic criteria for acute mastoiditis in children. Otol Neurotol. Sep 2008;29(6):751-7. [Medline].
Vazquez E, Castellote A, Piqueras J, Mauleon S, Creixell S, Pumarola F, et al. Imaging of complications of acute mastoiditis in children. Radiographics. Mar-Apr 2003;23(2):359-72. [Medline].
National Cancer Institute. Radiation Risks and Pediatric Computed Tomography (CT): A Guide for Health Care Providers. National Institutes of Health. Available at http://www.cancer.gov/cancertopics/causes/radiation/radiation-risks-pediatric-CT. Accessed October 2, 2011.
Roddy MG, Glazier SS, Agrawal D. Pediatric mastoiditis in the pneumococcal conjugate vaccine era: symptom duration guides empiric antimicrobial therapy. Pediatr Emerg Care. Nov 2007;23(11):779-84. [Medline].

