17-Ketosteroids 

Updated: Feb 12, 2014
  • Author: Rajaa Almourani, MD; Chief Editor: Thomas M Wheeler, MD  more...
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Reference Range

The reference range of urinary 17-ketosteroids is as follows [1] :

  • Males: 10-20 mg (34-69 µmol)/24 h
  • Females: 5-15 mg (17-52 µmol)/24 h
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Interpretation

Increases in levels of 24-hour urinary 17-ketosteroids are associated with the following:

Decreases in levels of 24-hour urinary 17-ketosteroids are associated with the following:

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Collection and Panels

Specifics for collection and panels are as follows:

  • Specimen type: Urine (see image below)
    Urine sample. Urine sample.
  • Collection method: 24-hour urine collection
  • Other instructions: Record duration and total volume
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Background

Description

The 17-ketosteroids are breakdown products of androgens. Examples of 17-ketosteroids include androstenedione, androsterone, estrone, and dehydroepiandrosterone.

Indications/Applications

Newer tests have superseded 17-ketosteroid testing, and the assay is seldom used now.

Considerations

Drugs that can increase 17-ketosteroids measurements include the following:

  • Antibiotics (eg, penicillin, oxacillin)
  • Chlorpromazine
  • Ethinamate
  • Meprobamate
  • Phenaglycodol
  • Nalidixic acid
  • Spironolactone

Drugs that can decrease 17-ketosteroids measurements include the following:

  • Progestational agents
  • Carbamazepine
  • Cephalothin
  • Propoxyphene
  • Reserpine
  • Glucose
  • Chlordiazepoxide
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