eMedicine Specialties > Hematology > Coagulation, Hemostasis, and Disorders
Factor II: Differential Diagnoses & Workup
Updated: Dec 2, 2008
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
Differential Diagnoses
Other Problems to Be Considered
Actinic purpura
Aspirin administration
Corticosteroid administration
Ehlers-Danlos syndrome
Gardner-Diamond syndrome (autoerythrocyte sensitization syndrome)
Henoch-Schönlein purpura
Pseudoxanthoma elasticum
Schwartzman phenomenon
von Willebrand disease
Waterhouse-Friderichsen syndrome
Workup
Laboratory Studies
Prothrombin time (PT) is prolonged in patients with factor II deficiency.
- Activated partial thromboplastin time (aPTT) is prolonged in patients with factor II deficiency.
- Bleeding time is within reference ranges in patients with factor II deficiency.
- Functional and antigenic factor II levels
- Functional and antigenic levels are decreased in hypoprothrombinemia.
- In dysprothrombinemia, functional levels are decreased; antigenic levels are within reference ranges to slightly decreased levels.
- Assays for other clotting factors
- In isolated factor II deficiency, assays of other clotting factors should reveal normal levels.
- In factor II deficiency due to liver disease, vitamin K deficiency, or vitamin K antagonist use, assays of other clotting factors reveal a decrease in the level of all vitamin K–dependent factors (ie, factor II, factor VII, factor IX, factor X, protein C).
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Differential Diagnoses & Workup: Factor II |
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| Follow-up: Factor II |
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References
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Further Reading
Related eMedicine Topics
Keywords
factor II, acquired factor II deficiency, inherited factor II deficiency, deficiency of factor II, prothrombin deficiency, hypoprothrombinemia, FII, F II, prothrombin, vitamin K–dependent proenzyme, vitamin K deficiency, prothrombin abnormality, clotting, coagulation, coagulation disorder, blood coagulation cascade, dysprothrombinemia, prothrombin complex concentrates, prothrombin 20210a, thrombophilia
Differential Diagnoses & Workup: Factor II