17-Hydroxyprogesterone, Urine 

Updated: Mar 28, 2014
  • Author: Muhammad Bader Hammami, MD; Chief Editor: Thomas M Wheeler, MD  more...
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Reference Range

The reference range of urinary 17-hydroxyprogesterone (17-OHPG) in children is as follows: [1, 2, 3]

  • Age 3 days to 1 year: Up to 50 ng/24 hours
  • Age 1-8 years: Up to 300 ng/24 hours

The following is the reference of urinary 17-OHPG in adults:

  • Males: Up to 2 µg/24 hours
  • Females: Up to 4.5 µg/24 hours
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Interpretation

Elevated urinary 17-hydroxyprogesterone (17-OHPG) levels are associated with the following:

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Collection and Panels

Specifics for collection and panels are as follows:

  • Specimen type: Urine
  • Collection method: 24-hour urine collection (see image below)
    Urine sample. Urine sample.
  • Specimen volume: 10 mL
  • Other instructions: Record duration and total volume
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Background

Description

An elevated level of 17-OHPG, an intermediate in the synthesis of adrenocortical hormones, is the distinguishing characteristic of 21-hydroxylase (CYP21) deficiency, the most common form of CAH.

Urine 17-OHPG is also frequently elevated in patients with PCOS or idiopathic hirsutism.

Indications/Applications

CAH is a general term for a group of inherited disorders in which a defect in cortisol biosynthesis results in overproduction of adrenocorticotropin hormone (ACTH), with secondary adrenal hyperplasia as a consequence. Classic CAH is generally recognized at birth or in early childhood because of ambiguous genitalia, salt wasting, or early virilization. Nonclassic adrenal hyperplasia is generally recognized at or after puberty because of oligomenorrhea or virilizing signs in females.

Indications for testing of urinary 17-OHPG include the following:

  • In a male child with premature sexual development
  • In females with hirsutism, other signs of virilization, oligomenorrhea, or infertility

Considerations

Patients should avoid use of corticosteroids, ACTH, estrogen, or gonadotropin medication for at least 48 hours before the start of urine collection.

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