Factor XI Deficiency Medication
- Author: Jamie E Siegel, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP more...
To achieve a FXI level of 50%, a patient needs to have half of their plasma volume replaced.
Directed-donor fresh frozen plasma can be arranged for elective procedures, but a large volume of plasma will need to be stored to transfuse for the required 7-14 days after surgery. One study has demonstrated that solvent detergent fresh frozen plasma has a half-life of 45 hours, while a second study has shown that FXI is decreased in the product.
Plasma is the fluid compartment of blood containing the soluble clotting factors. Octaplas is a solvent detergent treated, pooled FFP.
May consider prophylactic administration with antifibrinolytics prior to minor procedures (eg, dental).
Inhibits fibrinolysis via inhibition of plasminogen activator substances and, to a lesser degree, through antiplasmin activity. Main problem is that the thrombi that form during treatment are not lysed, and effectiveness is uncertain.
Alternative to aminocaproic acid. Inhibits fibrinolysis by displacing plasminogen from fibrin.
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