Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

Bladder Stones

  • Author: Joseph Basler, MD, PhD; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
 
Updated: Nov 11, 2014
 

Background

Bladder (vesical) calculi are stones or calcified materials that are present in the bladder (or in a bladder substitute that functions as a urinary reservoir). They are usually associated with urinary stasis but can form in healthy individuals without evidence of anatomic defects, strictures, infections, or foreign bodies. The presence of upper urinary tract calculi is not necessarily a predisposition to the formation of bladder stones.

Bladder calculi are an uncommon cause of illness in most Western countries, but they result in specific symptoms and are a significant source of discomfort. This article discusses the diagnosis and current management techniques for vesical calculus disease.

The incidence of bladder stones in children is slowly declining, even in endemic areas. This is mostly due to improved nutrition, better prenatal and postnatal care, and improved awareness of the problem in the endemic areas. In the 21st century, the incidence of this disease in children will probably continue to decline, and the disease will largely become a disease of adults.

Aggressive treatment of lower urinary tract symptoms with alpha-blockers and 5-alpha-reductase inhibitors should further decrease the overall incidence of bladder stones by improving bladder emptying. Removal of bladder stones will continue to progress toward minimally invasive techniques, thus decreasing hospital stay and recovery times. Continued advances in surgical equipment and the ability to downsize without the sacrifice of effectiveness could eventually render open surgery for stones obsolete.

In addition, continued aggressive management of neurogenic bladder, specifically in the pediatric neurogenic bladder population, may lead to a rise in both the incidence of struvite stones and the development of creative and minimally invasive surgical techniques for augmented bladders.

For patient education resources, see the Kidneys and Urinary System Center and the Procedures Center, as well as Cystoscopy, Intravenous Pyelogram, and Blood in the Urine.

Next

Anatomy

In men, the main anatomic problem that leads to vesical obstruction is prostatic enlargement. The prostate forms a ringlike growth around the vesical neck and, when hypertrophic, can significantly impede the flow of urine. Stasis due to this blockage is responsible for the deposition of layer upon layer of new stone material.

In women, voiding dysfunction and urinary stasis can occur but are less commonly associated with calculi. Typical anatomic findings include cystoceles, enteroceles, or findings of previous urethral surgery, all of which contribute to elevated residuals. With rare exceptions, any foreign body that cannot escape the bladder is calcified and eventually forms a stone.

Previous
Next

Pathophysiology

Most vesical calculi are formed de novo within the bladder, but some initially may have formed within the kidneys as a dissociated Randall plaque or on a sloughed papilla and subsequently may have passed into the bladder, where additional deposition of crystals cause the stone to grow.

However, most renal stones that are small enough to pass through the ureters are also small enough to pass through a normally functioning bladder and an unobstructed urethra. In older men with bladder stones composed of uric acid, the stone most likely formed in the bladder. Stones composed of calcium oxalate are usually initially formed in the kidney.

In adults, the most common type of vesical stone (seen in more than 50% of cases) is composed of uric acid. Less frequently, bladder calculi are composed of calcium oxalate, calcium phosphate, ammonium urate, cysteine, or magnesium ammonium phosphate (when associated with infection).[1, 2] Perhaps surprisingly, patients with uric acid bladder calculi rarely ever have a documented history of gout or hyperuricemia. In many cases, the core is composed of one chemical, and layers of different chemicals form around this core.

In children, stones are composed mainly of ammonium acid urate, calcium oxalate, or an impure mixture of ammonium acid urate and calcium oxalate with calcium phosphate.[3] The common link among endemic areas relates to feeding infants human breast milk and polished rice. These foods are low in phosphorus, ultimately leading to high ammonia excretion. These children also usually have a high intake of oxalate-rich vegetables (increased oxalate crystalluria) and animal protein (low dietary citrate).[4, 5, 3]

In patients with spinal cord injuries (SCIs), bladder stones are often composed of struvite or calcium phosphate.

Vesical calculi may be single or multiple, especially in the presence of bladder diverticula, and can be small or large enough to occupy the entire bladder. They range from soft to extremely hard, with surfaces ranging from smooth and faceted to jagged and spiculated (“jack” stones; see the image below). In general, most vesical calculi are mobile within the bladder, though some stones are fixed when they form on a suture, on the intravesical portion of a papillary tumor, or on retained stents.

Two delicate "jack" stones removed before open pro Two delicate "jack" stones removed before open prostatectomy.

In regions where vesical lithiasis is endemic among children, stone formation is more common among boys younger than 11 years and among people from low socioeconomic backgrounds, is not usually associated with renal calculi, and is relatively less likely to reoccur after treatment (in comparison with upper urinary tract calculi).[6]

Previous
Next

Etiology

Bladder outlet obstruction remains the most common cause of bladder calculi in adults. Prostatic enlargement, elevation of the bladder neck, and high postvoid residual urine volume cause stasis, which leads to crystal nucleation and accretion. This ultimately results in overt calculi. In addition, patients who have static urine and develop urinary tract infections are more likely to form bladder calculi.

In a study of patients with SCIs (newly acquired neurogenic bladders) who were monitored for more than 8 years, 36% developed bladder calculi. Subsequent reports indicated that as a consequence of better care of SCI patients, this rate has dropped to less than 10%. In a retrospective study of 93 SCI patients with bladder stones, Bartel and colleagues found that indwelling catheters were associated with a higher risk of developing bladder stones and a higher risk of recurrence of bladder stones than intermittent catheterization or reflex micturition.[7]

Bladder inflammation secondary to external beam radiation or schistosomiasis can also predispose to vesical calculi.[8] The dystrophic calcifications that develop from radiotherapy-related bladder and prostate damage may serve as a nidus for stone formation. Congenital or acquired vesical diverticula may serve a reservoir of urinary stasis, leading to stone formation. Other rare anatomic abnormalities implicated as contributors to stasis and stone formation include sliding inguinal hernias containing the urinary bladder.[9]

Multiple risk factors predispose to bladder stones in pediatric patients undergoing bladder augmentation. Mathoera et al, in a study of 89 pediatric patients who had undergone bladder augmentation and presented with bladder calculi, found that cloacal malformations, vaginal reconstructions, ureteral reimplantations, and bladder neck surgery were all associated with higher risk for stone formation.[10] Antibiotic prophylaxis for recurrent infections decreased struvite stone formation but did not significantly reduce overall stone formation.

Other etiologic factors for bladder stone formation include foreign bodies in the bladder that act as a nidus for stone formation. These may be subclassified into iatrogenic and noniatrogenic bodies.

Iatrogenic bodies include suture material, shattered Foley catheter balloons, eggshell calcifications that form on a catheter balloon, staples, ureteral stents, migrating contraceptive devices, erosions of surgical implants, and prostatic urethral stents.[11, 12, 13, 14, 15] Stones on suture material may have an early presentation if sutures were originally placed within the bladder lumen, or they may have a delayed presentation if they are caused by erosion through the bladder wall.[16]

Noniatrogenic bodies include objects placed into the bladder by the patients for recreational and various other reasons.[17]

Metabolic abnormalities are not a significant cause of stone formation in patients with urinary diversions. In this group of patients, the stones are primarily composed of calcium and struvite. In rare cases, medications (eg, viral protease inhibitors) may be the source for bladder calculus formation.[18]

In a prospective, comparative analysis of 57 men undergoing surgery for bladder outlet obstruction secondary to benign prostatic hyperplasia, 27 of whom had bladder calculi, Childs and colleagues found that patients with calculi were more likely to have a history of renal stone disease and gout and were more likely to have lower urinary pH and magnesium and higher uric acid supersaturation on 24-hour urine studies, suggesting that multiple factors, including metabolic abnormalities, may contribute to the pathogenesis of bladder calculi.[19]

In general, if an otherwise healthy person in the United States or Europe is found to have a bladder stone, a complete urologic evaluation must be undertaken to find a cause for urinary stasis. Potential causes include benign prostatic hyperplasia, urethral stricture, neurogenic bladder, diverticula, and congenital anomalies such as ureterocele and bladder neck contracture. In females, examples include an incontinence repair that is too tight, cystoceles, and bladder diverticula.[20]

Previous
Next

Epidemiology

Since the 19th century, the incidence of primary bladder calculi in the United States and Western Europe has been steadily and significantly declining as a consequence of improved diet, better nutrition, and infection control. In these countries, vesical calculi affect adults, with a steadily declining frequency in children. In the Western hemisphere, vesical calculi primarily affect men who are usually older than 50 years and have associated bladder outlet obstruction.

However, the incidence of bladder calculi in less developed countries and areas such as Thailand, Burma, Indonesia, the Middle East, and North Africa remains relatively high. Although vesical lithiasis is becoming less common in these populations, it remains a disease that affects children, among whom the disease is far more common in boys than in girls.[21]

In 1977, Van Reen published a symposium on idiopathic urinary bladder stone disease.[5] Unfortunately, the worldwide data are insufficient to provide a definitive and accurate picture of the frequency of bladder calculi, mostly because of poor hospital records in developing regions of the world. Although several studies have been done in countries with a high incidence of the disease, the reporting is not uniform.

Previous
 
 
Contributor Information and Disclosures
Author

Joseph Basler, MD, PhD Thomas P Ball Residency Education Professor, Urology Residency Program Director, Department of Urology, University of Texas Health Science Center at San Antonio; Chief, Section of Urology, Audie Murphy Veterans Affairs Hospital

Joseph Basler, MD, PhD is a member of the following medical societies: American Urological Association, Society of University Urologists, SWOG, Texas Medical Association, Society for Basic Urologic Research, Society of Urologic Oncology

Disclosure: Nothing to disclose.

Coauthor(s)

Joel A Leon-Becerril, MD 

Joel A Leon-Becerril, MD is a member of the following medical societies: American Medical Association, Pan American Trauma Society

Disclosure: Nothing to disclose.

Chief Editor

Bradley Fields Schwartz, DO, FACS Professor of Urology, Director, Center for Laparoscopy and Endourology, Department of Surgery, Southern Illinois University School of Medicine

Bradley Fields Schwartz, DO, FACS is a member of the following medical societies: American College of Surgeons, Society of Laparoendoscopic Surgeons, Society of University Urologists, Association of Military Osteopathic Physicians and Surgeons, American Urological Association, Endourological Society

Disclosure: Nothing to disclose.

Acknowledgements

Christopher H Cantrill, MD Resident Physician, Department of Urology, University of Texas Health Sciences Center at San Antonio

Christopher H Cantrill, MD is a member of the following medical societies: American Association of Clinical Urologists, American Urological Association, and Endourological Society

Disclosure: Nothing to disclose.

Aldo Ghobriel, MD Staff Physician, Department of Surgery, Division of Urology, University of Texas Health Sciences Center at San Antonio

Aldo Ghobriel, MD is a member of the following medical societies: American Medical Association and American Urological Association

Disclosure: Nothing to disclose.

Leonard Gabriel Gomella, MD, FACS The Bernard W Godwin Professor of Prostate Cancer Chairman, Department of Urology, Associate Director of Clinical Affairs, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University

Leonard Gabriel Gomella, MD, FACS is a member of the following medical societies: American Association for Cancer Research, American College of Surgeons, American Medical Association, American Society for Laser Medicine and Surgery, American Urological Association, Sigma Xi, Society for Basic Urologic Research, Society of University Urologists, and Society of Urologic Oncology

Disclosure: GSK Consulting fee Consulting; Astra Zeneca Honoraria Speaking and teaching; Watson Pharmaceuticals Consulting fee Consulting

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

References
  1. Douenias R, Rich M, Badlani G, Mazor D, Smith A. Predisposing factors in bladder calculi. Review of 100 cases. Urology. 1991 Mar. 37(3):240-3. [Medline].

  2. Hammad FT, Kaya M, Kazim E. Bladder calculi: did the clinical picture change?. Urology. 2006 Jun. 67(6):1154-8. [Medline].

  3. Kamoun A, Daudon M, Abdelmoula J, Hamzaoui M, Chaouachi B, Houissa T, et al. Urolithiasis in Tunisian children: a study of 120 cases based on stone composition. Pediatr Nephrol. 1999 Nov. 13(9):920-5; discussion 926. [Medline].

  4. Hodgkinson A. Composition of urinary tract calculi from some developing countries. Urol Int. 1979. 34(1):26-35. [Medline].

  5. Van Reen R. Geographical and nutritional aspects of endemic stones. Urinary Calculus. Littleton, Mass: PSG Publishing Co; 1981.

  6. Bakane BC, Nagtilak SB, Patil B. Urolithiasis: a tribal scenario. Indian J Pediatr. 1999 Nov-Dec. 66(6):863-5. [Medline].

  7. Bartel P, Krebs J, Wöllner J, Göcking K, Pannek J. Bladder stones in patients with spinal cord injury: a long-term study. Spinal Cord. 2014 Apr. 52(4):295-7. [Medline].

  8. Ho K, Segura J. Lower Urinary Tract Calculi. Wein A, Kavoussi L, Novick A, Partin A, Peters C. Campbell-Walsh Urology. 9th. Philadelphia, Pa: Saunders Elsevier; 2007. 3: 2663-73.

  9. Ng AC, Leung AK, Robson WL. Urinary bladder calculi in a sliding vesical-inguinal-scrotal hernia diagnosed preoperatively by plain abdominal radiography. Adv Ther. 2007 Sep-Oct. 24(5):1016-9. [Medline].

  10. Mathoera RB, Kok DJ, Nijman RJ. Bladder calculi in augmentation cystoplasty in children. Urology. 2000 Sep 1. 56(3):482-7. [Medline].

  11. Rub R, Madeb R, Morgenstern S, Ben-Chaim J, Avidor Y. Development of a large bladder calculus on sutures used for pubic bone closure following extrophy repair. World J Urol. 2001 Aug. 19(4):261-2. [Medline].

  12. Godbole P, Mackinnon AE. Expanded PTFE bladder neck slings for incontinence in children: the long-term outcome. BJU Int. 2004 Jan. 93(1):139-41. [Medline].

  13. Eichel L, Allende R, Mevorach RA, Hulbert WC, Rabinowitz R. Bladder calculus formation and urinary retention secondary to perforation of a normal bladder by a ventriculoperitoneal shunt. Urology. 2002 Aug. 60(2):344. [Medline].

  14. Hick EJ, Hernández J, Yordán R, Morey AF, Avilés R, García CR. Bladder calculus resulting from the migration of an intrauterine contraceptive device. J Urol. 2004 Nov. 172(5 Pt 1):1903. [Medline].

  15. Rafique M. Vesical calculus formation on permanent sutures. J Coll Physicians Surg Pak. 2005 Jun. 15(6):373-4. [Medline].

  16. Arunkalaivanan AS, Smith AR. Bladder calculus after laparoscopic colposuspension. J Obstet Gynaecol. 2002 Jan. 22(1):101. [Medline].

  17. Lau S, Zammit P, Bikhchandani J, Buchholz NP. The unbreakable bladder stone--Munchhausen's tale. Urol Int. 2006. 77(3):284-5. [Medline].

  18. Russinko PJ, Agarwal S, Choi MJ, Kelty PJ. Obstructive nephropathy secondary to sulfasalazine calculi. Urology. 2003 Oct. 62(4):748. [Medline].

  19. Childs MA, Mynderse LA, Rangel LJ, Wilson TM, Lingeman JE, Krambeck AE. Pathogenesis of bladder calculi in the presence of urinary stasis. J Urol. 2013 Apr. 189(4):1347-51. [Medline]. [Full Text].

  20. Mizuno K, Kamisawa H, Hamamoto S, Okamura T, Kohri K. Bilateral single-system ureteroceles with multiple calculi in an adult woman. Urology. 2008 Aug. 72(2):294-5. [Medline].

  21. Huffman JL, Ginsberg DA. Calculi in the Bladder and Urinary Diversions. Coe FL, Favus MJ, Pak CY, Parks JH, Preminger GM, eds. Kidney Stones: Medical and Surgical Management. Philadelphia, Pa: Lippincott-Raven; 1996. 1025-34.

  22. Su CM, Lin HY, Li CC, Chou YH, Huang CH. Bladder stone in a woman after cesarean section: a case report. Kaohsiung J Med Sci. 2003 Jan. 19(1):42-4. [Medline].

  23. Huang WC, Yang JM. Sonographic appearance of a bladder calculus secondary to a suture from a bladder neck suspension. J Ultrasound Med. 2002 Nov. 21(11):1303-5. [Medline].

  24. Webb M, Fong W. A large bladder calculus and severe vesicoureteric reflux as seen on Tc-99m MAG3 renography. Clin Nucl Med. 2002 Nov. 27(11):803-4. [Medline].

  25. Losty P, Surana R, O'Donnell B. Limitations of extracorporeal shock wave lithotripsy for urinary tract calculi in young children. J Pediatr Surg. 1993 Aug. 28(8):1037-9. [Medline].

  26. Bhatia V, Biyani CS. Vesical lithiasis: open surgery versus cystolithotripsy versus extracorporeal shock wave therapy. J Urol. 1994 Mar. 151(3):660-2. [Medline].

  27. Bapat SS. Endoscopic removal of bladder stones in adults. Br J Urol. 1977 Nov. 49(6):527-30. [Medline].

  28. Shokeir AA. Transurethral cystolitholapaxy in children. J Endourol. 1994 Apr. 8(2):157-9; discussion 159-60. [Medline].

  29. Ikari O, Netto NR Jr, D'Ancona CA, Palma PC. Percutaneous treatment of bladder stones. J Urol. 1993 Jun. 149(6):1499-500. [Medline].

  30. Wollin TA, Singal RK, Whelan T, Dicecco R, Razvi HA, Denstedt JD. Percutaneous suprapubic cystolithotripsy for treatment of large bladder calculi. J Endourol. 1999 Dec. 13(10):739-44. [Medline].

  31. Paez E, Reay E, Murthy LN, Pickard RS, Thomas DJ. Percutaneous treatment of calculi in reconstructed bladder. J Endourol. 2007 Mar. 21(3):334-6. [Medline].

  32. Franzoni DF, Decter RM. Percutaneous vesicolithotomy: an alternative to open bladder surgery in patients with an impassable or surgically ablated urethra. J Urol. 1999 Sep. 162(3 Pt 1):777-8. [Medline].

  33. BARNES RW, BERGMAN RT, WORTON E. Litholapaxy vs. cystolithotomy. J Urol. 1963 May. 89:680-1. [Medline].

  34. Nseyo UO, Rivard DJ, Garlick WB, Bennett AH. Management of bladder stones: should transurethral prostatic resection be performed in combination with cystolitholapaxy?. Urology. 1987 Mar. 29(3):265-7. [Medline].

  35. Tugcu V, Polat H, Ozbay B, Gurbuz N, Eren GA, Tasci AI. Percutaneous versus transurethral cystolithotripsy. J Endourol. 2009 Feb. 23(2):237-41. [Medline].

 
Previous
Next
 
Multiple laminated bladder calculi in patient with neurogenic bladder.
Endoscopic view of spiculated "jack" stone with erythematous bladder mucosa in background.
Large calculus visible on plain film of intravenous pyelogram performed for hematuria.
Ex vivo photograph of bladder stone.
Two delicate "jack" stones removed before open prostatectomy.
Bladder stone accretion on matrix. Patient had history of urinary tract infections and presented with irritative voiding symptoms and microscopic hematuria. Upper-tract evaluation findings were normal, but cystoscopy demonstrated calculus. Upon laser treatment of stone, soft matrix core was encountered beneath glistening outer core. Exposed matrix core is visible in crevices.
Bladder stone accretion on matrix. Patient had history of urinary tract infections and presented with irritative voiding symptoms and microscopic hematuria. Upper-tract evaluation findings were normal, but cystoscopy demonstrated calculus. Upon laser treatment of stone, soft matrix core was encountered beneath glistening outer core. Exposed matrix core is visible in crevices.
Laser destruction of stone. Note small lacuna generated in stone as result of laser energy. At lower power settings, stone can be quickly reduced to dust.
Layered nature of bladder calculus exposed as laser strips away surface.
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.