- Author: KoKo Aung, MD, MPH, FACP; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD more...
Bacillary angiomatosis is a vascular, proliferative form of Bartonella infection that occurs primarily in immunocompromised persons. While the disorder is treatable and curable, it may be life threatening if untreated. Bacillary angiomatosis is the second-most-common cause of angiomatous skin lesions in persons infected with the human immunodeficiency virus (HIV). Multiple lesions often demonstrate more than 1 morphologic appearance. Black patients, in particular, may bear the plaque form (see the image below).
Signs and symptoms
Patients with bacillary angiomatosis commonly have a history of HIV infection, organ transplantation, leukemia, or chemotherapy. Inoculation bartonellosis may be evident in immunocompetent individuals as a pyogenic granuloma–like nodule at the site of a cat scratch or at a burn site.[2, 3]
Cutaneous lesions due to bacillary angiomatosis may take one of the following forms:
Solitary or multiple red, purple, flesh-colored, or colorless papules (hemangiomalike lesions) varying in size from 1 mm to several centimeters
Nodules, often covered with a fine, tightly adherent scale
Large, friable, pedunculated, or polypoid exophytic masses
Hyperpigmented, hyperkeratotic, indurated plaques, typically on the extremities and often overlying osseous defects
Lesions can also occur in the oral mucosa, tongue, oropharynx, nose, penis, and anus. Bone pain, frequently in the forearms or legs, can also occur.
Visceral involvement associated with bacillary angiomatosis may be asymptomatic or may cause the following symptoms:
Fever, chills, malaise, night sweats, anorexia, and weight loss
Symptoms of peliosis hepatis: Abdominal pain, nausea, and vomiting
Jaundice secondary to biliary obstruction caused by external compression of periportal lymph nodes
Intra-abdominal mass and gastrointestinal bleeding
Symptoms of colonic bacillary angiomatosis: Abdominal cramps, tenesmus, and bloody diarrhea
Symptoms of CNS bacillary angiomatosis: Psychiatric symptoms, such as exacerbation of depression or new-onset psychosis; personality changes, including anxiety and irritability; headache; trigeminal neuralgia; seizures; and back pain
Difficulty breathing secondary to laryngeal obstruction
The diagnosis of cutaneous bacillary angiomatosis and extracutaneous disease is most often based on clinical features coupled with biopsies of lesions. Histology reveals vascular proliferation with the presence of neutrophils adjacent to the blood vessels and masses of bacteria, which can be demonstrated by modified silver staining (Warthin-Starry silver stain). Detection of Bartonella DNA in tissue specimens by polymerase chain reaction (PCR) assay or of Bartonella antigens by immunohistochemical methods is diagnostic.
Radiography can be used to find bone lesions; chest radiography can reveal pulmonary parenchymal nodules.
Computed tomography (CT) scanning of the brain can detect intracerebral bacillary angiomatosis. CT scanning and magnetic resonance imaging (MRI) can be used in the diagnosis of peliosis hepatis, while chest and abdominal CT scans may reveal mediastinal, retroperitoneal, or mesenteric lymph node enlargement.
Biopsy: Specimens of skin, subcutaneous or mucosal lesions, or, in cases of peliosis hepatis, the liver are diagnostic
Endoscopy: With gastrointestinal involvement, may reveal ulcerated nodules of the mucosa of the stomach, small intestine, or large intestine
Bronchoscopy: With lung involvement, may reveal polypoid lesions
Bacillary angiomatosis can be cured in most patients with antibiotics. Clinical experience strongly favors the use of erythromycin or a tetracycline derivative in this disorder.
Cryotherapy, electrodesiccation and curettage, and surgical excision of solitary cutaneous lesions can be useful as adjunctive therapy.
The reader is referred to the 2014 guidelines published by the Infectious Diseases Society of America (IDSA) for the treatment of bacillary angiomatosis (see Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America).
Bacillary angiomatosis is a vascular, proliferative form of Bartonella infection that occurs primarily in immunocompromised persons. It was first described in 1983 in a patient infected with the human immunodeficiency virus (HIV). The disease has since been described in patients following organ transplantation and in other individuals with a weakened immune system, although it is occasionally reported in immunocompetent patients. Initially, bacillary angiomatosis was called epithelioid angiomatosis, because of its histologic appearance (see the image below). (See Pathophysiology and Etiology.)
In 1990, Relman et al identified a visible but uncultivable bacillus from affected tissues of patients with bacillary angiomatosis. The gram-negative organism was later named Bartonella (formerly Rochalimaea) henselae. A similar bacterium, B quintana, has also been detected in and cultured from lesions caused by bacillary angiomatosis.
The systemic nature of the disease became evident when postmortem examinations showed nodules in the larynx, gastrointestinal tract, peritoneum, and diaphragm.
Bacillary angiomatosis often responds to therapy with oral erythromycin, although other oral antibiotics and antituberculosis medications, including tetracycline, other macrolides, trimethoprim-sulfamethoxazole, ciprofloxacin, and rifampin, may also be effective. While the disorder is treatable and curable, it may be life threatening if untreated. The disease is the second-most-common cause of angiomatous skin lesions in persons infected with HIV. (See Treatment and Medication.)
Immunocompromised patients and their caregivers should be advised to avoid cat contact and to control flea infestations in cats.
B henselae and B quintana are small gram-negative rods in the family Bartonellaceae. Bartonella, Rickettsia, Ehrlichia, and Afipia species all are part of the alpha-2 subgroup of the Alphaproteobacteria.
Bacillary angiomatosis can affect almost any organ system, although it most commonly affects skin and subcutaneous tissue. Subcutaneous lesions may erode into underlying bones (ie, osseous bacillary angiomatosis), especially the tibia, fibula, and radius. Involvement of ribs and vertebrae has been described. Rarely, skeletal muscles may be involved, resulting in pyomyositis. Mucous membranes of the conjunctiva, upper airway, and perineum (anus and penis) may also be affected. Bacillary angiomatosis may be accompanied by disseminated visceral disease (peliosis), mainly in the liver (peliosis hepatis), spleen, and lymph nodes.
Other internal organs that may be involved include the following:
Extrinsic compression of the common bile duct by enlarged peripancreatic, celiac, and portohepatic nodes has been reported.
The pathogenesis of bacillary angiomatosis includes early blood-borne dissemination of organisms. Bartonella organisms readily attach to and may enter erythrocytes. They avoid opsonization and host phagocytosis by unknown mechanisms and become persistent within the intravascular compartment.
An angiogenic factor may be responsible for the vascular proliferation observed in patients with bacillary angiomatosis, because a similar factor mediates vasoproliferation in verruca peruana, the second stage of Bartonella bacilliformis infection. Moreover, deoxyribonucleic acid (DNA) hybridization, 16S ribosomal ribonucleic acid (rRNA) sequence homology, cellular fatty acid profiles, and cytosine and guanine content studies have shown that B henselae and B quintana are closely related to Bartonella bacilliformis.
The specific Bartonella species, B henselae or B quintana, can affect the location of bacillary angiomatosis, as follows:
Cutaneous lesions: Result almost equally from B henselae and B quintana infections
Subcutaneous lesions: Usually caused by B quintana infection
Osseous lesions: Usually caused by B quintana infection
Visceral involvement: Almost exclusively caused by B henselae infection
Neurologic disorders: Associated more frequently with B quintana infection than with B henselae
Domestic cats (Felis domesticus) are the reservoirs of B henselae, which may be transmitted via cat bites or scratches or, potentially, by bites from cat fleas (Ctenocephalides felis). Kittens are more frequently associated with transmission of B henselae than are older cats. Humans appear to be the only reservoir of B quintana; the human body louse, Pediculus humanus, is the transmission vector.
Risk factors for bacillary angiomatosis include the following:
HIV infection [11, 12]
Chronic lymphocytic leukemia
Additional risk factors for bacillary angiomatosis associated with B henselae infection include the following:
Additional risk factors for bacillary angiomatosis associated with B quintana infection include the following:
Low socioeconomic status
Exposure to body and hair lice
Bacillary angiomatosis was reported in a patient who was HIV-seronegative but had idiopathic thrombocytopenic purpura, had undergone splenectomy, and had been administered long-term systemic prednisone. Although not taken from the same patient, see the image below.
Another report described an immunocompetent child with infected facial wound, in the vicinity of which bacillary angiomatosis lesions had developed. Similar lesions also appeared at the donor site of the skin graft, which was grafted on the facial wound. A case of bacillary angiomatosis presenting as a pyogenic granuloma of the hand in an otherwise apparently healthy man was recently reported from Saudi Arabia.
Multiple leg ulcers caused by bacillary angiomatosis without a history of direct contact with cats in an adult immunocompetent man has also been reported.
A case of bacillary angiomatosis in an HIV-negative patient who had chronic hepatitis B but no other immunosuppressive status was reported from Turkey, suggesting that immunologic differences secondary to chronic hepatitis B could have led to an increased risk for the disease.
Occurrence in the United States
The exact incidence of bacillary angiomatosis is not known, but the disease has been reported in almost all states. Reports have been especially high in Florida, Texas, New York, and northern California (San Francisco area), each of which has a high frequency of HIV infection.
Bacillary angiomatosis is reported less commonly in Europe than in North America, which may imply that either diagnoses are missed or that Europe has a minimal reservoir of bacilli. Cases have also been reported in Africa, Peru, Argentina, Brazil,[18, 19] Turkey, Saudi Arabia, and Australia. In 2008, Thailand reported its first case of bacillary angiomatosis associated with B henselae.
Race-, sex-, and age-related demographics
Approximately 40% of US patients with bacillary angiomatosis are white, 40% are black, and 20% are of Hispanic origin.
Approximately 90% of US patients with bacillary angiomatosis are men, probably because a disproportionate number of patients infected with HIV are also men.
A wide age range exists among patients with bacillary angiomatosis, from infancy to old age. The age range was 26-52 years in one early series of patients with acquired immunodeficiency syndrome (AIDS). Although bacillary angiomatosis is extremely rare in children, it was reported in a boy aged 12 years with acute leukemia who was undergoing chemotherapy and in a 6-year-old immunocompetent girl.
The prognosis of bacillary angiomatosis is excellent; antibiotics are curative in most patients, with lesions resolving completely after treatment. Hyperpigmentation or slight induration at the site of a lesion may persist indefinitely. Relapses can occur after cessation of therapy and are common in immunocompromised hosts.
Overall prognosis depends on early detection and treatment and on the degree of immunosuppression. Treatment may be more difficult and requires a longer duration of therapy if the diagnosis is delayed. Untreated bacillary angiomatosis may be progressive and life threatening.
Bacillary angiomatosis may cause disease of many different organs, including the heart, brain, liver, and spleen, if not treated promptly. Complications include the following:
Biliary obstruction and jaundice
Laryngeal obstruction and asphyxiation
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