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Campylobacter Infections

  • Author: Mahmud H Javid, MBBS; Chief Editor: Michael Stuart Bronze, MD  more...
 
Updated: May 20, 2016
 

Background

Campylobacter infections are among the most common bacterial infections in humans. They produce both diarrheal and systemic illnesses. In industrialized regions, enteric Campylobacter infections produce an inflammatory, sometimes bloody, diarrhea or dysentery syndrome.

Campylobacter jejuni (see image below) is usually the most common cause of community-acquired inflammatory enteritis. In developing regions, the diarrhea may be watery.

Scanning electron microscope image of Campylobacte Scanning electron microscope image of Campylobacter jejuni, illustrating its corkscrew appearance and bipolar flagella. Source: Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia.

Infections with Campylobacter -like organisms can produce an enterocolitis/proctocolitis syndrome in homosexual males, who are at increased risk for Helicobacter cinaedi and Helicobacter fennelliae infections. C jejuni infections may also produce serious bacteremic conditions in individuals with AIDS. Most reported bacteremias have been due to Campylobacter fetus fetus infection. Campylobacter lari, which is found in healthy seagulls, has also been reported to produce mild recurrent diarrhea in children. Campylobacter upsaliensis may cause diarrhea or bacteremia, while Campylobacter hyointestinalis, which has biochemical characteristics similar to those of C fetus, causes occasional bacteremia in immunocompromised individuals.

Campylobacter organisms may also be an important cause of traveler's diarrhea, especially in Thailand and surrounding areas of Southeast Asia. In a study of American military personnel deployed in Thailand, more than half of those with diarrhea were found to be infected with Campylobacter species.

These organisms are related to Helicobacter pylori, which was previously known as Campylobacter pylori. No reservoir other than the human gastric mucosa has been identified for H pylori.

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Pathophysiology

The known routes of Campylobacter transmission include fecal-oral, person-to-person sexual contact, unpasteurized raw milk and poultry ingestion, and waterborne (ie, through contaminated water supplies). Exposure to sick pets, especially puppies, has also been associated with Campylobacter outbreaks.

Transmission of Campylobacter organisms to humans usually occurs via infected animals and their food products. Most human infections result from the consumption of improperly cooked or contaminated foodstuffs. Chickens may account for 50-70% of human Campylobacter infections. Most colonized animals develop a lifelong carrier state.

The infectious dose is 1000-10,000 bacteria. Campylobacter infection has occurred after ingestion of 500 organisms by a volunteer; however, a dose of less than 10,000 organisms is not a common cause of illness. Campylobacter species are sensitive to hydrochloric acid in the stomach, and antacid treatment can reduce the amount of inoculum needed to cause disease.

Symptoms of Campylobacter infection begin after an incubation period of up to a week. The sites of tissue injury include the jejunum, the ileum, and can extend to involve the colon and rectum. C jejuni appears to invade and destroy epithelial cells. C jejuni are attracted to mucus and fucose in bile, and the flagella may be important in both chemotaxis and adherence to epithelial cells or mucus. Adherence may also involve lipopolysaccharides or other outer membrane components. Such adherence would promote gut colonization. PEB 1 is a superficial antigen that appears to be a major adhesin and is conserved among C jejuni strains.

Some strains of C jejuni produce a heat-labile, choleralike enterotoxin, which is important in the watery diarrhea observed in infections. Infection with the organism produces diffuse, bloody, edematous, and exudative enteritis. The inflammatory infiltrate consists of neutrophils, mononuclear cells, and eosinophils. Crypt abscesses develop in the epithelial glands, and ulceration of the mucosal epithelium occurs.

Cytotoxin production has been reported in Campylobacter strains from patients with bloody diarrhea. In a small number of cases, the infection is associated with hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura through a poorly understood mechanism. Endothelial cell injury, mediated by endotoxins or immune complexes, is followed by intravascular coagulation and thrombotic microangiopathy in the glomerulus and the gastrointestinal mucosa.

Campylobacter species also produce the bacterial toxin cytolethal distending toxin (CDT), which produces a cell block at the G2 stage preceding mitosis. CDT inhibits cellular and humoral immunity via destruction of immune response cells and necrosis of epithelial-type cells and fibroblasts involved in the repair of lesions. This leads to slow healing and results in disease symptoms.[1]

In patients with HIV infection, Campylobacter infections may be more common, may cause prolonged or recurrent diarrhea, and may be more commonly associated with bacteremia and antibiotic resistance.

C fetus is covered with a surface S-layer protein that functions like a capsule and disrupts c3b binding to the organisms, resulting in both serum and phagocytosis resistance.

C jejuni infections also show recurrence in children and adults with immunoglobulin deficiencies. Acute C jejuni infection confers short-term immunity. Patients develop specific immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA) antibodies in serum; IgA antibodies also develop in intestinal secretions. The severity and persistence of C jejuni infections in individuals with AIDS and hypogammaglobulinemia indicates that both cell-mediated and humoral immunity are important in preventing and terminating infection.

The oral cavity contains numerous Campylobacter species, such as Campylobacter concisus, that have been associated with a subtype of inflammatory bowel disease.[2, 3]

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Epidemiology

Frequency

United States

An estimated 2 million cases of Campylobacter enteritis occur annually, accounting for 5-7% of cases of gastroenteritis. Campylobacter organisms have a large animal reservoir, with up to 100% of poultry, including chickens, turkeys, and waterfowl having asymptomatic intestinal infections. The major reservoirs of C fetus are cattle and sheep. Nonetheless, the incidence of Campylobacter infections has been declining. Changes in the incidence of culture-confirmed Campylobacter infections have been monitored by the Foodborne Diseases Active Surveillance Network (FoodNet) since 1996. In 2010, Campylobacter incidence showed a 27% decrease compared with 1996-1998. In 2010, the incidence was 13.6 cases per 100,000 population, and this did not change significantly compared with 2006-2008.[4]

International

C jejuni infections are extremely common worldwide, although exact figures are not available, particularly in low- and middle-income countries. In high-income countries, the incidence has been estimated to be 4.4-9.3 per 1000 population.[5] New Zealand reported the highest national campylobacteriosis rate, which peaked in May 2006 at 400 per 100,000 population.[6]

Mortality/Morbidity

Campylobacter infections are usually self-limited and rarely cause mortality. Exact figures are unavailable, but occasional deaths have been attributed to Campylobacter infections, typically in elderly or immunocompromised persons and secondary to volume depletion in young, previously healthy individuals.

Race

Campylobacter infections have no clear racial predilection.

Sex

Campylobacter organisms are isolated more frequently from males than females. Homosexual men appear to be at increased risk for infection with atypical Campylobacter species such as Helicobacter cinaedi and Helicobacter fennelliae.

Age

Campylobacter infections can occur in all age groups.

Studies show a peak incidence in children younger than 1 year and in persons aged 15-29 years. The age-specific attack rate is highest in young children. In the United States, the highest incidence of Campylobacter infection in 2010 was in children younger than 5 years and was 24.4 cases per 100,000 population,[4] However, the rate of fecal cultures positive for Campylobacter species is greatest in adults and older children.

Asymptomatic Campylobacter infection is uncommon in adults.

In developing countries, Campylobacter infection is very common in the first 5 years of life. Asymptomatic infection is also more common. In Bangladesh, up to 39% of all children younger than 2 years have asymptomatic infection.

For additional information on pediatric Campylobacter infections, see Campylobacter Infections.

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Contributor Information and Disclosures
Author

Mahmud H Javid, MBBS Consultant in Infectious Diseases, Shifa International Hospital, Pakistan

Mahmud H Javid, MBBS is a member of the following medical societies: Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Coauthor(s)

Shadab Hussain Ahmed, MD, AAHIVS, FACP, FIDSA Professor of Clinical Medicine, The School of Medicine at Stony Brook University Medical Center; Adjunct Clinical Associate Professor, Department of Medicine, New York College of Osteopathic Medicine of New York Institute of Technology; Attending Physician, Department of Medicine, Division of Infectious Diseases, Director of HIV Prevention Services, Administrative HIV Designee, Nassau University Medical Center

Shadab Hussain Ahmed, MD, AAHIVS, FACP, FIDSA is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American Medical Association, Oklahoma State Medical Association, Southern Society for Clinical Investigation, Association of Professors of Medicine, American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Chief Editor

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American Medical Association, Oklahoma State Medical Association, Southern Society for Clinical Investigation, Association of Professors of Medicine, American College of Physicians, Infectious Diseases Society of America

Disclosure: Nothing to disclose.

References
  1. Smith JL, Bayles DO. The contribution of cytolethal distending toxin to bacterial pathogenesis. Crit Rev Microbiol. 2006 Oct-Dec. 32 (4):227-48. [Medline].

  2. Zhang L. Oral Campylobacter species: Initiators of a subgroup of inflammatory bowel disease?. World J Gastroenterol. 2015 Aug 21. 21 (31):9239-44. [Medline].

  3. Kaakoush NO, Mitchell HM, Man SM. Role of emerging Campylobacter species in inflammatory bowel diseases. Inflamm Bowel Dis. 2014 Nov. 20 (11):2189-97. [Medline].

  4. Vital signs: incidence and trends of infection with pathogens transmitted commonly through food--foodborne diseases active surveillance network, 10 U.S. sites, 1996-2010. MMWR Morb Mortal Wkly Rep. 2011 Jun 10. 60(22):749-55. [Medline].

  5. World Health Organization. "The global view of campylobacteriosis: report of an expert consultation, Utrecht, Netherlands, 9-11 July 2012." (2013). [Full Text].

  6. Baker M, Wilson N, Ikram R, Chambers S, Shoemack P, Cook G. Regulation of chicken contamination is urgently needed to control New Zealand's serious campylobacteriosis epidemic. N Z Med J. 2006. 119(1243):U2264. [Medline].

  7. Gillespie IA, O'brien SJ, Frost JA, Tam C, Tompkins D, Neal KR. Investigating vomiting and/or bloody diarrhoea in Campylobacter jejuni infection. J Med Microbiol. 2006 Jun. 55(Pt 6):741-6. [Medline].

  8. Pacanowski J, Lalande V, Lacombe K, Boudraa C, Lesprit P, Legrand P, et al. Campylobacter bacteremia: clinical features and factors associated with fatal outcome. Clin Infect Dis. 2008 Sep 15. 47(6):790-6. [Medline].

  9. Davis L, DiRita V. Growth and laboratory maintenance of Campylobacter jejuni. Curr Protoc Microbiol. 2008 Aug. Chapter 8:Unit 8A.1.1-8A.1.7. [Medline].

  10. Nakari UM, Puhakka A, Siitonen A. Correct identification and discrimination between Campylobacter jejuni and C. coli by a standardized hippurate test and species-specific polymerase chain reaction. Eur J Clin Microbiol Infect Dis. 2008 Jul. 27(7):513-8. [Medline].

  11. Schmidt-Ott R, Brass F, Scholz C, Werner C, Gross U. Improved serodiagnosis of Campylobacter jejuni infections using recombinant antigens. J Med Microbiol. 2005 Aug. 54(Pt 8):761-7. [Medline].

  12. Lin S, Wang X, Zheng H, Mao Z, Sun Y, Jiang B. Direct detection of Campylobacter jejuni in human stool samples by real-time PCR. Can J Microbiol. 2008 Sep. 54(9):742-7. [Medline].

  13. Tolcin R, LaSalvia MM, Kirkley BA, Vetter EA, Cockerill FR 3rd, Procop GW. Evaluation of the Alexon-trend ProSpecT Campylobacter microplate assay. J Clin Microbiol. 2000 Oct. 38(10):3853-5. [Medline]. [Full Text].

  14. Bessède E, Delcamp A, Sifré E, Buissonnière A, Mégraud F. New methods for detection of campylobacters in stool samples in comparison to culture. J Clin Microbiol. 2011 Mar. 49(3):941-4. [Medline]. [Full Text].

  15. Tissari P, Rautelin H. Evaluation of an enzyme immunoassay-based stool antigen test to detect Campylobacter jejuni and Campylobacter coli. Diagn Microbiol Infect Dis. 2007 Jun. 58 (2):171-5. [Medline].

  16. Couturier BA, Couturier MR, Kalp KJ, Fisher MA. Detection of non-jejuni and -coli Campylobacter species from stool specimens with an immunochromatographic antigen detection assay. J Clin Microbiol. 2013 Jun. 51 (6):1935-7. [Medline].

  17. Gómez-Camarasa C, Gutiérrez-Fernández J, Rodríguez-Granger JM, Sampedro-Martínez A, Sorlózano-Puerto A, Navarro-Marí JM. Evaluation of the rapid RIDAQUICK Campylobacter® test in a general hospital. Diagn Microbiol Infect Dis. 2014 Feb. 78 (2):101-4. [Medline].

  18. Fitzgerald C, Patrick M, Gonzalez A, Akin J, Polage CR, Gillim-Ross L, et al. Multicenter Evaluation of Clinical Diagnostic Methods for Detection and Isolation of Campylobacter spp. from Stool. J Clin Microbiol. 2016 May. 54 (5):1209-15. [Medline].

  19. Cochennec F, Gazaigne L, Lesprit P, Desgranges P, Allaire E, Becquemin JP. Aortoiliac aneurysms infected by Campylobacter fetus. J Vasc Surg. 2008 Oct. 48(4):815-20. [Medline].

  20. Gilbert DN, Moellering RC Jr, eds. The Sanford Guide To Antimicrobial Therapy 2007. 37th ed. Antimicrobial Therapy, Inc.; 2007. 15. [Full Text].

  21. Bardon J, Kolar M, Cekanova L, Hejnar P, Koukalova D. Prevalence of Campylobacter jejuni and its Resistance to Antibiotics in Poultry in the Czech Republic. Zoonoses Public Health. 2008 Sep 2. [Medline].

  22. Hannula M, Hänninen ML. Effects of low-level ciprofloxacin challenge in the in vitro development of ciprofloxacin resistance in Campylobacter jejuni. Microb Drug Resist. 2008 Sep. 14(3):197-201. [Medline].

  23. Price LB, Johnson E, Vailes R, Silbergeld E. Fluoroquinolone-resistant campylobacter isolates from conventional and antibiotic-free chicken products. Environ Health Perspect. 2005 May. 113(5):557-60. [Medline].

  24. Hormeño L, Palomo G, Ugarte-Ruiz M, Porrero MC, Borge C, Vadillo S, et al. Identification of the main quinolone resistance determinant in Campylobacter jejuni and Campylobacter coli by MAMA-DEG PCR. Diagn Microbiol Infect Dis. 2016 Mar. 84 (3):236-9. [Medline].

  25. Taylor NM, Davies RH, Ridley A, Clouting C, Wales AD, Clifton-Hadley FA. A survey of fluoroquinolone resistance in Escherichia coli and thermophilic Campylobacter spp. on poultry and pig farms in Great Britain. J Appl Microbiol. 2008 Nov. 105(5):1421-31. [Medline].

  26. Meng CY, Smith BL, Bodhidatta L, Richard SA, Vansith K, Thy B, et al. Etiology of diarrhea in young children and patterns of antibiotic resistance in Cambodia. Pediatr Infect Dis J. 2011 Apr. 30(4):331-5. [Medline].

  27. Pandey P, Bodhidatta L, Lewis M, Murphy H, Shlim DR, Cave W, et al. Travelers' diarrhea in Nepal: an update on the pathogens and antibiotic resistance. J Travel Med. 2011 Mar-Apr. 18(2):102-8. [Medline].

  28. Mandal BK, Ellis ME, Dunbar EM, Whale K. Double-blind placebo-controlled trial of erythromycin in the treatment of clinical campylobacter infection. J Antimicrob Chemother. 1984 Jun. 13(6):619-23. [Medline].

  29. Burch KL, Saeed K, Sails AD, Wright PA. Successful treatment by meropenem of Campylobacter jejuni meningitis in a chronic alcoholic following neurosurgery. J Infect. 1999 Nov. 39(3):241-3. [Medline].

  30. Shioyama M, Mitui Y, Ueda H, Takada K, Kureshiro J, Kitaguchi M, et al. [Bacterial meningitis with Campylobacter fetus manifesting chronic clinical course]. Rinsho Shinkeigaku. 2006 Oct. 46(10):699-701. [Medline].

  31. Kato H, Wakasugi H, Mukuta T, Furukawa M, Yokota M, Yamada Y, et al. Campylobacter fetus subspecies fetus meningitis with chronic alcoholism and diabetes mellitus. Jpn J Med. 1990 Sep-Oct. 29(5):542-4. [Medline].

  32. Rao KV, Ralston RA. Meningitis due to Campylobacter fetus intestinalis in a kidney transplant recipient. A case report. Am J Nephrol. 1987. 7(5):402-3. [Medline].

  33. Davis KR, Dunn AC, Burnett C, McCullough L, Dimond M, Wagner J, et al. Campylobacter jejuni Infections Associated with Raw Milk Consumption - Utah, 2014. MMWR Morb Mortal Wkly Rep. 2016 Apr 1. 65 (12):301-5. [Medline].

  34. van Asselt ED, de Jong AE, de Jonge R, Nauta MJ. Cross-contamination in the kitchen: estimation of transfer rates for cutting boards, hands and knives. J Appl Microbiol. 2008 Nov. 105(5):1392-401. [Medline].

  35. de Jong AE, Verhoeff-Bakkenes L, Nauta MJ, de Jonge R. Cross-contamination in the kitchen: effect of hygiene measures. J Appl Microbiol. 2008 Aug. 105(2):615-24. [Medline].

  36. Wagenaar JA, Mevius DJ, Havelaar AH. Campylobacter in primary animal production and control strategies to reduce the burden of human campylobacteriosis. Rev Sci Tech. 2006 Aug. 25(2):581-94. [Medline].

  37. Lecuit M, Abachin E, Martin A. Immunoproliferative small intestinal disease associated with Campylobacter jejuni. N Engl J Med. 2004 Jan 15. 350(3):239-48. [Medline].

  38. Kosunen TU, Kauranen O, Martio J, et al. Reactive arthritis after campylobacter jejuni enteritis in patients with HLA-B27. Lancet. 1980 Jun 14. 1(8181):1312-3. [Medline].

  39. Pönkä A, Martio J, Kosunen TU. Reiter's syndrome in association with enteritis due to Campylobacter fetus ssp. jejuni. Ann Rheum Dis. 1981 Aug. 40(4):414-5. [Medline].

  40. Kuperman-Shani A, Vaknin Z, Mendlovic S, Zaidenstein R, Melcer Y, Maymon R. Campylobacter coli infection causing second trimester intrauterine growth restriction (IUGR): a case report and review of the literature. Prenat Diagn. 2015 Dec. 35 (12):1258-61. [Medline].

  41. Mishu B, Blaser MJ. Role of infection due to Campylobacter jejuni in the initiation of Guillain-Barre syndrome. Clin Infect Dis. 1993 Jul. 17(1):104-8. [Medline].

  42. Mishu B, Ilyas AA, Koski CL, et al. Serologic evidence of previous Campylobacter jejuni infection in patients with the Guillain-Barre syndrome. Ann Intern Med. 1993 Jun 15. 118(12):947-53. [Medline].

  43. Schmidt-Ott R, Schmidt H, Feldmann S, Brass F, Krone B, Gross U. Improved serological diagnosis stresses the major role of Campylobacter jejuni in triggering Guillain-Barré syndrome. Clin Vaccine Immunol. 2006 Jul. 13(7):779-83. [Medline].

  44. Baker MG, Kvalsvig A, Zhang J, Lake R, Sears A, Wilson N. Declining Guillain-Barré syndrome after campylobacteriosis control, New Zealand, 1988–2010. Emerg Infect Dis. Feb 2012.

  45. Harvala H, Rosendal T, Lahti E, Engvall EO, Brytting M, Wallensten A, et al. Epidemiology of Campylobacter jejuni infections in Sweden, November 2011-October 2012: is the severity of infection associated with C. jejuni sequence type?. Infect Ecol Epidemiol. 2016. 6:31079. [Medline].

  46. Kogawa S, Furukawa K. [Campylobacter jejuni meningitis in an immunocompetent adult male]. Rinsho Shinkeigaku. 2010 Apr. 50(4):262-4. [Medline].

  47. Kitamura S, Matsumura N, Ohtake N, Kita M, Konishi I. Tubo-ovarian abscess with endometrial cyst probably infected by Campylobacter fetus: Two cases. J Obstet Gynaecol Res. 2016 Apr 14. [Medline].

  48. Ailes E, Demma L, Hurd S, Hatch J, Jones TF, Vugia D, et al. Continued decline in the incidence of Campylobacter infections, FoodNet 1996-2006. Foodborne Pathog Dis. 2008 Jun. 5(3):329-37. [Medline].

  49. Allos BM. Campylobacter jejuni Infections: update on emerging issues and trends. Clin Infect Dis. 2001 Apr 15. 32(8):1201-6. [Medline].

  50. Blaser MJ. Campylobacter fetus--emerging infection and model system for bacterial pathogenesis at mucosal surfaces. Clin Infect Dis. 1998 Aug. 27(2):256-8. [Medline].

  51. Blaser MJ, Wells JG, Feldman RA, et al. Campylobacter enteritis in the United States. A multicenter study. Ann Intern Med. 1983 Mar. 98(3):360-5. [Medline].

  52. Butzler JP. Campylobacter, from obscurity to celebrity. Clin Microbiol Infect. 2004 Oct. 10(10):868-76. [Medline].

  53. Caldwell DB, Wang Y, Lin J. Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni. Antimicrob Agents Chemother. 2008 Nov. 52(11):3947-54. [Medline].

  54. Carbone KM, Heinrich MC, Quinn TC. Thrombophlebitis and cellulitis due to Campylobacter fetus ssp. fetus. Report of four cases and a review of the literature. Medicine (Baltimore). 1985 Jul. 64(4):244-50. [Medline].

  55. Crushell E, Harty S, Sharif F, Bourke B. Enteric campylobacter: purging its secrets?. Pediatr Res. 2004 Jan. 55(1):3-12. [Medline].

  56. Drake AA, Gilchrist MJ, Washington JA 2nd, et al. Diarrhea due to Campylobacter fetus subspecies jejuni. A clinical review of 63 cases. Mayo Clin Proc. 1981 Jul. 56(7):414-23. [Medline].

  57. Fennell CL, Totten PA, Quinn TC, et al. Characterization of Campylobacter-like organisms isolated from homosexual men. J Infect Dis. 1984 Jan. 149(1):58-66. [Medline].

  58. Francioli P, Herzstein J, Grob JP, et al. Campylobacter fetus subspecies fetus bacteremia. Arch Intern Med. 1985 Feb. 145(2):289-92. [Medline].

  59. Friis LM, Pin C, Pearson BM, Wells JM. In vitro cell culture methods for investigating Campylobacter invasion mechanisms. J Microbiol Methods. 2005 May. 61(2):145-60. [Medline].

  60. Giesendorf BA, Quint WG. Detection and identification of Campylobacter spp. using the polymerase chain reaction. Cell Mol Biol (Noisy-le-grand). 1995 Jul. 41(5):625-38. [Medline].

  61. Kosunen TU, Ponka A, Kauranen O, et al. Arthritis associated with Campylobacter jejuni enteritis. Scand J Rheumatol. 1981. 10(2):77-80. [Medline].

  62. Mee AS, Shield M, Burke M. Campylobacter colitis: differentiation from acute inflammatory bowel disease. J R Soc Med. 1985 Mar. 78(3):217-23. [Medline].

  63. Pasternak J, Bolivar R, Hopfer RL, et al. Bacteremia caused by Campylobacter-like organisms in two male homosexuals. Ann Intern Med. 1984 Sep. 101(3):339-41. [Medline].

  64. Perlman DM, Ampel NM, Schifman RB, et al. Persistent Campylobacter jejuni infections in patients infected with the human immunodeficiency virus (HIV). Ann Intern Med. 1988 Apr. 108(4):540-6. [Medline].

  65. Robinson DA. Infective dose of Campylobacter jejuni in milk. Br Med J (Clin Res Ed). 1981 May 16. 282(6276):1584. [Medline].

  66. Taylor DN, Blaser MJ. The epidemiology of Helicobacter pylori infection. Epidemiol Rev. 1991. 13:42-59. [Medline].

  67. Taylor DN, Blaser MJ, Echeverria P, et al. Erythromycin-resistant Campylobacter infections in Thailand. Antimicrob Agents Chemother. 1987 Mar. 31(3):438-42. [Medline].

  68. Taylor DN, McDermott KT, Little JR, et al. Campylobacter enteritis from untreated water in the Rocky Mountains. Ann Intern Med. 1983 Jul. 99(1):38-40. [Medline].

  69. Taylor DN, Perlman DM, Echeverria PD, et al. Campylobacter immunity and quantitative excretion rates in Thai children. J Infect Dis. 1993 Sep. 168(3):754-8. [Medline].

  70. Tee W, Mijch A. Campylobacter jejuni bacteremia in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients: comparison of clinical features and review. Clin Infect Dis. 1998 Jan. 26(1):91-6. [Medline].

  71. Tee W, Mijch A, Wright E, Yung A. Emergence of multidrug resistance in Campylobacter jejuni isolates from three patients infected with human immunodeficiency virus. Clin Infect Dis. 1995 Sep. 21(3):634-8. [Medline].

  72. Walker RI, Caldwell MB, Lee EC, et al. Pathophysiology of Campylobacter enteritis. Microbiol Rev. 1986 Mar. 50(1):81-94. [Medline].

  73. Wassenaar TM, Blaser MJ. Pathophysiology of Campylobacter jejuni infections of humans. Microbes Infect. 1999 Oct. 1(12):1023-33. [Medline].

  74. Yamashita K, Aoki Y, Hiroshima K. Pyogenic vertebral osteomyelitis caused by Campylobacter fetus subspecies fetus. A case report. Spine. 1999 Mar 15. 24(6):582-4. [Medline].

  75. Castaño-Rodríguez N, Kaakoush NO, Lee WS, Mitchell HM. Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis. Gut. 2015 Oct 27. [Medline].

  76. Laprade N, Cloutier M, Lapen DR, Topp E, Wilkes G, Villemur R, et al. Detection of virulence, antibiotic resistance and toxin (VAT) genes in Campylobacter species using newly developed multiplex PCR assays. J Microbiol Methods. 2016 May. 124:41-7. [Medline].

 
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Scanning electron microscope image of Campylobacter jejuni, illustrating its corkscrew appearance and bipolar flagella. Source: Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia.
 
 
 
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