Cardiobacterium Medication
- Author: Kerry O Cleveland, MD; Chief Editor: Michael Stuart Bronze, MD more...
Medication Summary
The goals of pharmacotherapy are to eradicate the infection, to reduce morbidity, and to prevent complications.
Antibiotics
Class Summary
Empiric antimicrobial therapy should cover all likely pathogens in the context of the clinical setting.
Ceftriaxone (Rocephin)
Third-generation cephalosporin with broad gram-negative and gram-positive activity.
Mechanism of action is binding to penicillin-binding proteins. Cefotaxime may be used instead.
Ampicillin (Omnipen, Marcillin)
Interferes with bacterial cell wall synthesis during active multiplication, causing bactericidal activity against susceptible organisms.
Gentamicin (Garamycin)
Synergistic activity when used with beta-lactam for gram-negative bacteria. Inhibits protein synthesis by binding to the 30S ribosomal subunits.
Ampicillin and sulbactam (Unasyn)
Drug combination of beta-lactamase inhibitor with ampicillin. Interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms.
Covers skin, enteric flora, and anaerobes. Not ideal for nosocomial pathogens.
Ciprofloxacin (Cipro)
Fluoroquinolone that inhibits bacterial DNA synthesis and, consequently, growth, by inhibiting DNA gyrase and topoisomerases, which are required for replication, transcription, and translation of genetic material. Quinolones have broad activity against gram-positive and gram-negative aerobic organisms. Has no activity against anaerobes.
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