Therapeutic Drug Levels 

Updated: Jul 31, 2015
  • Author: Abimbola Farinde, PharmD, PhD; more...
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Therapeutic Drug Levels

Table 1. Therapeutic Drug Levels [1] (Open Table in a new window)

Drug Therapeutic Range
Acetaminophen 10-25 μg/mL
Amikacin Nonbacteremic gram-negative infection (urinary tract infection, synergism with beta-lactams): 15-30 μg/mL Serious gram-negative infection (bacteremia, pneumonia, sepsis): 25-40 μg/mL
Amitriptyline 120-150 ng/mL
Carbamazepine 4-12 μg/mL
Chloramphenicol Meningitis: 15-25 μg/mL Other infections: 10-20 μg/mL  
Desipramine 100-300 ng/mL
Digoxin 0.8-2 ng/mL
Disopyramide 2-4 μg/mL
Ethosuximide 40-100 μg/mL
Flecainide Adults: 0.2-1 μg/mL Children: 0.2-0.8 μg/mL
Gentamicin 5-10 μg/mL
Imipramine 150-250 ng/mL
Kanamycin 15-30 μg/mL
Lidocaine 1.5-5 μg/mL
Lithium Relapse prevention for bipolar disorder: 0.6-1 mEq/L Acute mania: 0.8-1.2 mEq/L Elderly patients: 0.4-0.8 mEq/L
Methotrexate High-dose regimens result in 0.1-1 μmol/L 24-72 h postinfusion Toxic levels: >0.2 μmol/L (low-dose); >1 μmol/L (high-dose)
Nortriptyline 50-150 ng/mL
Phenobarbital Adults: 10-40 μg/mL Infants/children: 15-30 μg/mL
Phenytoin Total phenytoin levels: 10-20 μg/mL
Primidone 5-12 μg/mL
Procainamide Procainamide: 4-8 μg/mL N-acetylprocainamide: 4-8 μg/mL
Quinidine 2-5 μg/mL
Salicylate Antiplatelet/analgesia/antipyretic: ~100 μg/mL Mild toxic effects observed with anti-inflammatory dose levels of 150-300 μg/mL
Sirolimus 5-15 μg/L (whole blood)
Tacrolimus 5-20 μg/L (whole blood)
Theophylline Adults: 5-15 μg/mL Children: 5-10 μg/mL Neonatal apnea: 6-11 μg/mL
Tobramycin Life-threatening infection: 8-10 μg/mL Serious infection: 6-8 μg/mL Urinary tract infection: 4-6 μg/mL Synergy for infections caused by gram-positive organisms: 3-5 μg/mL
Valproic acid Epilepsy (total): 50-100 μg/mL Mania (total): 50-125 μg/mL Free: 6-22 μg/mL
Cyclosporine 50-125 microgram/L (serum or plasma) 150-400microgram/L (whole blood)