G6PD Deficiency Risk Factors 

Updated: Dec 03, 2014
  • Author: Buck Christensen; Chief Editor: Buck Christensen  more...
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G6PD Deficiency Risk Factors

Glucose-6-phosphatase dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in humans, affecting 400 million people worldwide. [1]

Most individuals with G6PD deficiency do not need treatment. However, they should be taught to avoid drugs and chemical exposures that can cause oxidant stress. Patients should also avoid broad beans (ie, fava beans). Favism occurs primarily in the Mediterranean variety of G6PD deficiency.

Drugs and foods that present risk in individuals with G6PD deficiency risk factors are listed below. They are based on guidelines from the G6PD Deficiency Association. [2]

The following are considered high risk:

  • Acetanilide (acetanilid)
  • Acetylphenylhydrazine (2-phynylacetohydrazide)
  • Aldesulfone sodium (sulfoxone)
  • Arsine
  • Beta-naphthol (2-naphthol)
  • Brinzolamide
  • Chloramphenicol
  • Chloroquine
  • Ciprofloxacin
  • Dapsone (diaphenylsulfone)
  • Dimercaprol
  • Dorzolamide
  • Doxorubicin
  • Furazolidone
  • Glibenclamide
  • Glucosulfone (glucosulfone sodium)
  • Isobutyl nitrite
  • Menadiol sodium sulfate (vitamin K4 sodium sulfate)
  • Menadione (menaphthone)
  • Menadione sodium bisulfite (vitamin K3 sodium bisulfite)
  • Mepacrine (quinacrine)
  • Mesalazine - 5-aminosalicylic acid (paraaminosalicylic acid)
  • Metamizole
  • Methylthioninium chloride (methylene blue)
  • Nalidixic acid
  • Naphthalene, pure (naphthalin)
  • Niridazole
  • Nitrofural (nitrofurazone)
  • Nitrofurantoin
  • O-acetylsalicylic acid (acetylsalicylic acid)
  • Oxidase, urate (urate oxidase)
  • Pamaquine
  • Pentaquine
  • Phenacetin (acetophenetidin)
  • Phenazopyridine
  • Phenylhydrazine
  • Primaquine
  • Probenecid
  • Stibophen (2-(2-oxido-3,5-disulphonatophenoxy)-1,3,2,benzodioxastibole-4-6-disulphonate)
  • Sulfacetamide
  • Sulfadimidine
  • Sulfafurazole (sulfisoxazole)
  • Sulfamethoxazole
  • Sulfanilamide (sulphanilamide)
  • Sulfapyridine
  • Sulfasalazine, salazosulfapyridine (Salazopyrin)
  • Thiazolsulfone
  • Tolonium chloride, tolonium chloride (toluidine blue)
  • Trinitrotoluene (2,4,6-trinitrotoluene)

The following are considered low risk:

  • Aminophenazone (aminopyrine)
  • Antazoline (Antistine)
  • Arginine (acido 2(S)-ammino-5-guanidilpentanoico)
  • Ascorbic acid
  • Colchicine
  • Diphenhydramine
  • Dopamine (L-dopa)
  • Isoniazid
  • Norfloxacin
  • Para-aminobenzoic acid (4-aminobenzoic acid)
  • Paracetamol (acetaminophen)
  • Phenazone (antipyrine)
  • Phenylbutazone
  • Phenytoin
  • Phytomenadione (vitamin K1)
  • Procainamide
  • Proguanil (chlorguanidine)
  • Pyrimethamine
  • Quinidine
  • Quinine
  • Streptomycin
  • Sulfacytine
  • Sulfadiazine
  • Sulfaguanidine
  • Sulfamerazine
  • Sulfamethoxypyridazine
  • Tiaprofenic acid
  • Trihexyphenidyl (benzhexol)
  • Trimethoprim
  • Tripelennamine