eMedicine Specialties > Infectious Diseases > Viral Infections
Human Herpesvirus Type 6: Follow-up
Updated: Oct 8, 2008
Follow-up
Further Inpatient Care
- Infants infected with human herpesvirus 6 (HHV-6) who present with findings such as febrile seizures or CNS involvement require hospitalization.
- About 13% of infants with acute HHV-6 infection require hospitalization.
Miscellaneous
Medicolegal Pitfalls
Ganciclovir can worsen bone marrow suppression in patients who have undergone bone marrow transplant. Foscarnet may be used, but renal function and calcium levels need to be monitored closely.
More on Human Herpesvirus Type 6 |
| Overview: Human Herpesvirus Type 6 |
| Differential Diagnoses & Workup: Human Herpesvirus Type 6 |
| Treatment & Medication: Human Herpesvirus Type 6 |
Follow-up: Human Herpesvirus Type 6 |
| References |
| « Previous Page |
References
Merk J, Schmid FX, Fleck M, et al. Fatal pulmonary failure attributable to viral pneumonia with human herpes virus 6 (HHV6) in a young immunocompetent woman. J Intensive Care Med. Sep-Oct 2005;20(5):302-6. [Medline].
Singh N. Infections with Human Herpesvirus 6, 7, and 8 after hematopoietic stem cell or solid organ transplantation. In: Bowden R, Ljungman P, Paya C. Transplant Infections. 2nd. Philadelphia: Lippincott Williams & Wilkins; 2004:365-374.
Kunisaki Y, Goto H, Kitagawa K, et al. Salazosulfapyridine induced hypersensitivity syndrome associated with reactivation of humanherpes virus 6. Intern Med. Feb 2003;42(2):203-7. [Medline].
Hasegawa A, Yasukawa M, Sakai I, et al. Transcriptional down-regulation of CXC chemokine receptor 4 induced by impaired association of transcription regulator YY1 with c-Myc in human herpesvirus 6-infected cells. J Immunol. Jan 15 2001;166(2):1125-31. [Medline].
Challoner PB, Smith KT, Parker JD, et al. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci U S A. Aug 1 1995;92(16):7440-4. [Medline].
Tejada-Simon MV, Zang YC, Hong J, et al. Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis. Ann Neurol. Feb 2003;53(2):189-97. [Medline].
Mori T, Mihara A, Yamazaki R, et al. Myelitis associated with human herpes virus 6 (HHV-6) after allogeneic cord blood transplantation. Scand J Infect Dis. 2007;39(3):276-8. [Medline].
Burns WH, Sandford GR. Susceptibility of human herpesvirus 6 to antivirals in vitro. J Infect Dis. Sep 1990;162(3):634-7. [Medline].
Chapnick EK, Lutwick LI. Human Herpesvirus 6 (HHV-6). Infectious Disease Practice. 1995;19:91-94.
Cirone M, Cuomo L, Zompetta C, et al. Human herpesvirus 6 and multiple sclerosis: a study of T cell cross-reactivity to viral and myelin basic protein antigens. J Med Virol. Oct 2002;68(2):268-72. [Medline].
Cone RW, Huang ML, Corey L, et al. Human herpesvirus 6 infections after bone marrow transplantation: clinical and virologic manifestations. J Infect Dis. Feb 1999;179(2):311-8. [Medline].
Dockrell DH, Smith TF, Paya CV. Human herpesvirus 6. Mayo Clin Proc. Feb 1999;74(2):163-70. [Medline].
Fox JD, Briggs M, Ward PA, et al. Human herpesvirus 6 in salivary glands. Lancet. Sep 8 1990;336(8715):590-3. [Medline].
Fujita H, Maruta A, Tomita N, et al. Human herpesvirus-6-associated exanthema in a patient with acute lymphocytic leukaemia. Br J Haematol. Mar 1996;92(4):947-9. [Medline].
Gutierrez J, Vergara MJ, Guerrero M, et al. Multiple sclerosis and human herpesvirus 6. Infection. Jun 2002;30(3):145-9. [Medline].
Hashimoto K, Yasukawa M, Tohyama M. Human herpesvirus 6 and drug allergy. Curr Opin Allergy Clin Immunol. Aug 2003;3(4):255-60. [Medline].
Hukin J, Farrell K, MacWilliam LM, et al. Case-control study of primary human herpesvirus 6 infection in children with febrile seizures. Pediatrics. Feb 1998;101(2):E3. [Medline].
Janoly-Dumenil A, Galambrun C, Basset T, et al. Human herpes virus-6 encephalitis in a paediatric bone marrow recipient: successful treatment with pharmacokinetic monitoring and high doses of ganciclovir. Bone Marrow Transplant. Dec 2006;38(11):769-70. [Medline].
Kimberlin DW, Whitley RJ. Human herpesvirus-6: neurologic implications of a newly-described viral pathogen. J Neurovirol. Oct 1998;4(5):474-85. [Medline].
Knox KK, Carrigan DR. Disseminated active HHV-6 infections in patients with AIDS. Lancet. Mar 5 1994;343(8897):577-8. [Medline].
Liedtke W, Malessa R, Faustmann PM, et al. Human herpesvirus 6 polymerase chain reaction findings in human immunodeficiency virus associated neurological disease and multiple sclerosis. J Neurovirol. Sep 1995;1(3-4):253-8. [Medline].
Singh N, Carrigan DR. Human herpesvirus-6 in transplantation: an emerging pathogen. Ann Intern Med. Jun 15 1996;124(12):1065-71. [Medline].
Swanborg RH, Whittum-Hudson JA, Hudson AP. Infectious agents and multiple sclerosis--are Chlamydia pneumoniae and human herpes virus 6 involved?. J Neuroimmunol. Mar 2003;136(1-2):1-8. [Medline].
Tokimasa S, Hara J, Osugi Y, et al. Ganciclovir is effective for prophylaxis and treatment of human herpesvirus-6 in allogeneic stem cell transplantation. Bone Marrow Transplant. Apr 2002;29(7):595-8. [Medline].
Tyler KL. Human herpesvirus 6 and multiple sclerosis: the continuing conundrum. J Infect Dis. May 1 2003;187(9):1360-4. [Medline].
Villoslada P, Juste C, Tintore M, et al. The immune response against herpesvirus is more prominent in the early stages of MS. Neurology. Jun 24 2003;60(12):1944-8. [Medline].
Volin L, Lautenschlager I, Juvonen E, et al. Human herpesvirus 6 antigenaemia in allogeneic stem cell transplant recipients: impact on clinical course and association with other beta-herpesviruses. Br J Haematol. Sep 2004;126(5):690-6. [Medline].
Yamanishi K. Human herpesvirus 6 and human herpesvirus 7. In: Clinical Virology. First ed. New York, NY: Churchill Livingston; 1997:471-81 TEXTBOOK.
Zerr DM, Corey L, Kim HW, et al. Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation. Clin Infect Dis. Apr 1 2005;40(7):932-40. [Medline].
Further Reading
Keywords
human herpesvirus 6, human herpesvirus type 6, HHV-6, HHV6, human herpes virus 6, HHV-6A, HHV-6B, roseola infantum, exanthema subitum, sixth disease
Follow-up: Human Herpesvirus Type 6