Lymphocytic Choriomeningitis Workup
- Author: Rupal M Mody, MD, MPH; Chief Editor: Burke A Cunha, MD more...
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- Lymphocytic choriomeningitis virus (LCMV) infection is initially diagnosed based on a suggestive history that is confirmed by various laboratory investigations.
- Leukopenia and thrombocytopenia may be observed early in the course of illness.
- LCMV can be isolated from the blood early in the course and, later, from the CSF. LCMV may be isolated from the blood or CSF in either cell culture or the intracerebral inoculation of weanling mice (the most reliable method).
- Immunohistochemical staining and reverse transcription-polymerase chain reaction (RT-PCR) of tissues may be useful.
See the list below:
- Acute lymphocytic choriomeningitis (LCM) can also be diagnosed via detection of immunoglobulin M (IgM) antibodies by enzyme-linked immunosorbent assay (ELISA) from serum or CSF. This is the preferred diagnostic test.
- Less than 25% of patients with LCMV infection have depressed CSF glucose levels.
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|Diagnosis||Season||Usual Source||Relative Bradycardia||Pharyngitis||Diarrhea||Parotitis||Orchitis||CSF Glucose level|
|LCM||Fall/winter||Mouse, hamster||+||+/-||-||+/-||+/-||Normal or decreased|
|Typhoid fever||Year-round||Food, water||+||+||+ (late)||-||-||Normal|
|Mumps||Winter/spring||Person||-||-||-||+||+/-||Normal or decreased|