Lymphogranuloma Venereum Treatment & Management
- Author: Pamela Arsove, MD, FACEP; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD more...
The complete treatment of patients with LGV includes appropriate antimicrobial coverage and drainage of infected buboes.
The recommended medical treatment for LGV involves one of the following antibiotic regimens:
Doxycycline 100 mg PO bid for 21 d
Erythromycin base 500 mg PO qid for 21 d
Doxycycline is the drug of choice in patients who are not pregnant. Pregnant and lactating females should be treated with erythromycin. HIV-positive patients should be treated the same as HIV-negative patients, although they may require prolonged treatment, with longer resolution of symptoms.
Infected patients should abstain from sexual intercourse until antibiotic therapy is completed and symptoms resolve.
Sex partners who have had contact with the patient within the past 60 days should be evaluated and treated if symptomatic. If no symptoms are present, they should be treated for exposure as follows:
Doxycycline 100 mg PO BID for 7 days
Azythromycin 1 gm PO as a single dose 
Needle aspiration or incision and drainage of involved inguinal nodes may be required for pain relief and prevention of ulcer formation. Some of the late complications of the third stage of LGV may require surgical repair.
Surgical consultation for lymphadenopathy is generally not required unless extensive buboes require further exploration. For tertiary disease, appropriate surgical consultation is indicated.
No restrictions to physical activities are required; however, patients should abstain from sexual contact until the infection resolves completely.
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