Dysphagia Medication

Updated: May 02, 2017
  • Author: Nam-Jong Paik, MD, PhD; Chief Editor: Consuelo T Lorenzo, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to prevent complications and reduce morbidity.

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Histamine H2 Antagonists

Class Summary

These agents are used prophylactically to prevent complications.

Cimetidine (Tagamet)

Cimetidine inhibits histamine at H2 receptors of gastric parietal cells, which results in reduced gastric acid secretion, gastric volume, and hydrogen concentrations.

Ranitidine (Zantac)

Ranitidine inhibits histamine stimulation of the H2 receptor in gastric parietal cells, which, in turn, reduces gastric acid secretion, gastric volume, and hydrogen ion concentrations.

Famotidine (Pepcid)

Famotidine competitively inhibits histamine at the H2 receptor of gastric parietal cells, resulting in reduced gastric acid secretion, gastric volume, and hydrogen ion concentrations.

Nizatidine (Axid)

Nizatidine competitively inhibits histamine at the H2 receptor of the gastric parietal cells, resulting in reduced gastric acid secretion, gastric volume, and reduced hydrogen concentrations.

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Proton Pump Inhibitors

Class Summary

Proton pump inhibitors inhibit gastric acid secretion by inhibition of the H+ -K+ -ATPase enzyme system in the gastric parietal cells. They are used prophylactically in cases not responsive to H2-antagonist therapy.

Omeprazole (Prilosec)

Omeprazole decreases gastric acid secretion by inhibiting the parietal cell H+/K+-adenosine triphosphate (ATP) pump at the secretory surface of gastric parietal cells.

Lansoprazole (Prevacid)

Lansoprazole decreases gastric acid secretion by inhibiting the parietal cell H+/K+-ATP pump at the secretory surface of gastric parietal cells.

Rabeprazole (AcipHex)

Rabeprazole decreases gastric acid secretion by inhibiting the parietal cell H+/K+-ATP pump at the secretory surface of gastric parietal cells.

Pantoprazole (Protonix)

Pantoprazole decreases gastric acid secretion by inhibiting the parietal cell H+/K+-ATP pump at the secretory surface of gastric parietal cells.

Esomeprazole (Nexium)

Esomeprazole inhibits gastric acid secretion by inhibiting the H+/K+-ATPase enzyme system at the secretory surface of gastric parietal cells at the secretory surface of gastric parietal cells.

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