Rickettsialpox

Updated: Jun 30, 2017
  • Author: Pradeep Kumar Mada, MD, MRCP(UK); Chief Editor: Mark R Wallace, MD, FACP, FIDSA  more...
  • Print
Overview

Background

Rickettsialpox is a mild, self-limited, zoonotic febrile illness characterized by eschar formation at the location of a mite bite, followed by the onset of systemic symptoms and a more generalized papulovesicular rash. The causative agent is Rickettsia akari, a member of the spotted-fever group of rickettsiae. [1, 2]

Next:

Pathophysiology

R akari is an obligate intracellular gram-negative coccobacillus. Its vector is the colorless mite Liponyssoides sanguineus (formerly Allodermanyssus sanguineus), which is found on mice (most commonly the house mouse [Mus musculus]) and other rodents. These hosts serve as the reservoir for the disease. A sanguineus will bite humans when murine hosts are scarce. About 7-10 days after the painless bite, a papular skin lesion appears at the bite location and becomes vesicular with a surrounding area of erythema. An eschar forms and slowly heals. About 3-7 days after the initial skin lesion develops, patients may suddenly develop high-grade fever, chills, headaches, and myalgias with subsequent development of a sparse generalized papulovesicular rash.

Rickettsialpox is mild and self-limited and usually persists for about a week.

Previous
Next:

Epidemiology

Frequency

United States

Rickettsialpox occurs primarily in urban areas, where the density of mites, mice, and humans is high. Huebner et al first isolated and named rickettsialpox in 1946 in New York City. [3]

Rickettsialpox has been reported primarily in the northeastern and midwest United States (Boston, Mass; West Hartford, Conn; Philadelphia, Pa; Pittsburgh, Pa; and Cleveland, Ohio). Cases have also been reported in North Carolina, Arkansas, and Utah. [4, 5, 6] R akari–like organisms have also been identified in wild rodents in Orange County, California. [7]

Although the prevalence of confirmed cases is very low, several reports suggest the disease is more common than previously thought. Serologic evidence of rickettsialpox exposure was found in 16% of 631 intravenous drug users in inner-city Baltimore, MD, and in 9% of 204 intravenous drug users in Harlem, NY. [8, 9] In addition, between 2001 and 2003, the number of clinical samples submitted to the Centers for Disease Control and Prevention (CDC) increased following the anthrax bioterror attack, reflecting an increased awareness of eschar-associated febrile illness. [10] Prior to this, these clinical syndromes may have been misdiagnosed, or perhaps the infected persons did not seek medical attention. Consequently, rickettsialpox is widely believed to be an underrecognized and underreported clinical entity.

In 2007, about 14 cases of rickettsialpox were reported New York City (a rate of approximately 1.7 cases per 1,000,000 persons). Case reports increased in of 2001 and continued in 2002, following the anthrax attacks in New York City, New Jersey, Washington, D.C., and Florida. [11]

International

Internationally, rickettsialpox has been described in South Africa, Costa Rica, France, Italy, Turkey, Croatia, the Ukraine, Russia, and Korea. [4, 12, 13]

A case report from 2012 described the first case of rickettsialpox in the Netherlands wherein the patient did not have any contact with mice or other animals and the cause of transmission unclear. [14] There have been case reports of rickettsialpox in Mexico and suspected cases identified by serologic assays in Albania, Bosnia Herzegovina, Central African Republic, France, Germany, and Turkey. [15]

Mortality/Morbidity

Rickettsialpox is a benign, self-limited disease. No fatalities have been reported. The incubation period varies from 10-21 days. Rickettsialpox usually resolves within 14-21 days; however, headache and lassitude may persist for another 1-2 weeks.

Sex

Rickettsialpox has no sexual predilection.

Age

Rickettsialpox has no age predilection. It has been reported in patients aged 6 months to 72 years.

Previous