eMedicine Specialties > Infectious Diseases > Bacterial Infections

Yersinia Enterocolitica: Follow-up

Author: Zartash Zafar Khan, MD, Fellow in Infectious Diseases, University of Oklahoma Health Science Center
Coauthor(s): Michelle R Salvaggio, MD, Assistant Professor, Department of Internal Medicine, Section of Infectious Diseases, University of Oklahoma College of Medicine; Medical Director of Infectious Diseases Institute, University of Oklahoma Health Sciences Center; Mark H Johnston, MD, Associate Professor of Medicine, Uniformed Services University of Health Sciences; Consulting Staff, Lancaster Gastroenterology Inc; Gregory J Martin, MD, Director, Infectious Diseases Clinical Research Program (IDCRP) Associate Professor of Medicine, Uniformed Services University, Bethesda, MD
Contributor Information and Disclosures

Updated: Apr 9, 2009

Follow-up

Further Inpatient Care

  • Admit patients with evidence of severe dehydration, malnourishment, or septicemia.
  • Carefully monitor patients who are immunocompromised or patients with conditions that place them at risk for septicemia (eg, alcoholism, cirrhosis, iron overload syndromes, conditions that require deferoxamine therapy, diabetes, malnourishment), using a low threshold for admission and treatment with supportive measures and antibiotic therapy.

Inpatient & Outpatient Medications

  • Yersiniosis has been treated successfully with antibiotics.
  • Avoid antidiarrheal medications.

Deterrence/Prevention

  • Instruct patients and at-risk individuals about appropriate hygiene methods and signs and symptoms of infection.
  • Encourage public awareness of Y enterocolitica outbreaks and modes of transmission.
  • Hand washing and control of environmental cross-contamination are principal measures in reducing the spread of enteric pathogens in daycares, health care setting, pet care facilities, and within households.
  • In blood banks, donors should be inquired about any recent symptoms of gastroenteritis.
  • Unwashed raw vegetables, uncooked meats (especially pork), and unpasteurized milk should be avoided.

Complications

  • Y enterocolitica infection carries a low mortality rate, but patients with significant comorbidities are at risk of bacteremia, with a reported case fatality rate approaching 50%.
  • Reactive arthritis can last 1-4 months.

Prognosis

  • Yersiniosis is usually either self-limited or is responsive to therapy; however, reinfection is possible.
  • Septicemia is rare but does carry a substantial case fatality rate.

Patient Education

  • Educate patients and individuals at risk of infection about appropriate hygiene methods and signs or symptoms of infection.
  • Encourage public awareness of outbreaks, modes of transmission, and ways to prevent transmission.

Miscellaneous

Medicolegal Pitfalls

  • Exercise caution in differentiating yersiniosis from inflammatory bowel disease, specifically Crohn disease. Performing stool cultures and ruling out infectious etiologies prior to initiating immunomodulatory therapy for inflammatory bowel disease should be a general practice.

Special Concerns

  • Patients with conditions that place them at risk for Y enterocolitica septicemia (eg, elderly patients, patients who are chronically ill, patients with iron overload, patients with chronic hemolysis, patients on deferoxamine therapy, patients who are immunocompromised) should be monitored closely and admitted for antibiotic therapy at the first sign of disseminated disease.
  • In the event of acute outbreaks, attempt to isolate persons who have been in contact with the index patient.
 
Acknowledgments

This article was reviewed by Michelle R. Salvaggio, MD, FACP, Assistant Professor, Associate Fellowship Director of Infectious Diseases, University of Oklahoma Health Science Center.

The authors and editors of eMedicine gratefully acknowledge the contributions of previous coauthor Brooks D Cash, MD, FACP, to the development and writing of this article.



More on Yersinia Enterocolitica

Overview: Yersinia Enterocolitica
Differential Diagnoses & Workup: Yersinia Enterocolitica
Treatment & Medication: Yersinia Enterocolitica
Follow-up: Yersinia Enterocolitica
Multimedia: Yersinia Enterocolitica
References

References

  1. Bercovier H, Brenner DJ, Ursing J, Steigerwalt AG, Fanning GR, Alonso JM, et al. Characterization of Yersinia enterocolitica sensu stricto. Current Microbiology. 1980;4:201-6.

  2. Bottone EJ. Yersinia enterocolitica: a panoramic view of a charismatic microorganism. CRC Crit Rev Microbiol. 1977;5(2):211-41. [Medline].

  3. Schleifstein J, Coleman, MB. An unidentified microorganism resembling B. lignieresi and Pasteurella pseudotuberculosis, pathogenic for man. New York State Journal of Medicine. 1939;39:1749-53.

  4. Zheng H, Sun Y, Lin S, Mao Z, Jiang B. Yersinia enterocolitica infection in diarrheal patients. Eur J Clin Microbiol Infect Dis. Aug 2008;27(8):741-52. [Medline].

  5. Young VB, Falkow S, Schoolnik GK. The invasin protein of Yersinia enterocolitica: internalization of invasin-bearing bacteria by eukaryotic cells is associated with reorganization of the cytoskeleton. J Cell Biol. Jan 1992;116(1):197-207. [Medline].

  6. Handley SA, Newberry RD, Miller VL. Yersinia enterocolitica invasin-dependent and invasin-independent mechanisms of systemic dissemination. Infect Immun. Dec 2005;73(12):8453-5. [Medline].

  7. Bradford WD, Noce PS, Gutman LT. Pathologic features of enteric infection with Yersinia enterocolitica. Arch Pathol. Jul 1974;98(1):17-22. [Medline].

  8. Aho K, Ahvonen P, Lassus A, Sievers K, Tiilikainen A. HL-A 27 in reactive arthritis. A study of Yersinia arthritis and Reiter's disease. Arthritis Rheum. Sep-Oct 1974;17(5):521-6. [Medline].

  9. Yersinia enterocolitica. Available at http://www.foodsafety.gov/~mow/chap5.html.

  10. Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food--10 states, 2007. MMWR Morb Mortal Wkly Rep. Apr 11 2008;57(14):366-70. [Medline].

  11. Jacobs J, Jamaer D, Vandeven J, Wouters M, Vermylen C, Vandepitte J. Yersinia enterocolitica in donor blood: a case report and review. J Clin Microbiol. May 1989;27(5):1119-21. [Medline].

  12. Bottone EJ. Yersinia enterocolitica: the charisma continues. Clin Microbiol Rev. Apr 1997;10(2):257-76. [Medline].

  13. Helms M, Simonsen J, Mølbak K. Foodborne bacterial infection and hospitalization: a registry-based study. Clin Infect Dis. Feb 15 2006;42(4):498-506. [Medline].

  14. Metchock B, Lonsway DR, Carter GP, Lee LA, McGowan JE Jr. Yersinia enterocolitica: a frequent seasonal stool isolate from children at an urban hospital in the southeast United States. J Clin Microbiol. Dec 1991;29(12):2868-9. [Medline].

  15. You Y, Fu C, Zeng X, Fang D, Yan X, Sun B, et al. A novel DNA microarray for rapid diagnosis of enteropathogenic bacteria in stool specimens of patients with diarrhea. J Microbiol Methods. Dec 2008;75(3):566-71. [Medline].

  16. Kojima M, Morita Y, Shimizu K, Yoshida T, Yamada I, Togo T, et al. Immunohistological findings of suppurative granulomas of Yersinia enterocolitica appendicitis: a report of two cases. Pathol Res Pract. 2007;203(2):115-9. [Medline].

  17. Noble RC. Failure of cefotaxime in the treatment of Yersinia enterocolitica sepsis despite in vitro susceptibility. Current Therapeutic Research, Clinical and Experimental. 1989;46(4):692-4.

  18. Lal M, Kaur H, Gupta LK. Y.enterocolitica gastroenteritis - A prospective study. Indian J Med Microbiol. Jul-Sep 2003;21(3):186-8. [Medline].

  19. Black RE, Slome S. Yersinia enterocolitica. Infect Dis Clin North Am. Sep 1988;2(3):625-41. [Medline].

  20. Caplan LM, Dobson ML, Dorkin H. Yersinia enterocolitica septicemia. Am J Clin Pathol. Feb 1978;69(2):189-92. [Medline].

  21. Chatzipanagiotou S, Kyriazi Z, Ioannidis A, et al. Detection of chromosomal- and plasmid-encoded virulence-associated epidemiological markers in Yersinia enterocolitica strains isolated from clinical cases: a comparative study. Mol Diagn. 2004;8(2):131-2. [Medline].

  22. Cover TL, Aber RC. Yersinia enterocolitica. N Engl J Med. Jul 6 1989;321(1):16-24. [Medline].

  23. Cunha BA. Pseudoappendicitis. Infectious Disease Practice. 1995;19:56.

  24. Guerrant RL, Van Gilder T, Steiner TS, et al. Practice guidelines for the management of infectious diarrhea. Clin Infect Dis. Feb 1 2001;32(3):331-51. [Medline].

  25. Lian CJ, Hwang WS, Kelly JK, Pai CH. Invasiveness of Yersinia enterocolitica lacking the virulence plasmid: an in-vivo study. J Med Microbiol. Nov 1987;24(3):219-26. [Medline].

  26. Lian CJ, Pai CH. Inhibition of human neutrophil chemiluminescence by plasmid-mediated outer membrane proteins of Yersinia enterocolitica. Infect Immun. Jul 1985;49(1):145-51. [Medline].

  27. Makinen M, Niemela S, Lehtola J, Karttunen TJ. Collagenous colitis and Yersinia enterocolitica infection. Dig Dis Sci. Jun 1998;43(6):1341-6. [Medline].

  28. Matsumoto T, Iida M, Matsui T, et al. Endoscopic findings in Yersinia enterocolitica enterocolitis. Gastrointest Endosc. Nov-Dec 1990;36(6):583-7. [Medline].

  29. O'Loughlin EV, Gall DG, Pai CH. Yersinia enterocolitica: mechanisms of microbial pathogenesis and pathophysiology of diarrhoea. J Gastroenterol Hepatol. Mar-Apr 1990;5(2):173-9. [Medline].

  30. Papaioannou CA, Varvarigos N, Karatsolis G, Papaioannou N, Draganigos A, Katsantouris C, et al. Yersinia Enterocolitica Endocarditis. Hellenic J Cardiol [serial online]. 2003;44:Available at http://www.hellenicjcardiol.com/archive/full_text/2003/6/2003_6_427.pdf.

  31. Portnoy DA, Moseley SL, Falkow S. Characterization of plasmids and plasmid-associated determinants of Yersinia enterocolitica pathogenesis. Infect Immun. Feb 1981;31(2):775-82. [Medline].

  32. Rose FB, Camp CJ, Antes EJ. Family outbreak of fatal Yersinia enterocolitica pharyngitis. Am J Med. Mar 23 1987;82(3 Spec No):636-7. [Medline].

  33. Stuart RC, Leahy AL, Cafferkey MT, Stephens RB. Yersinia enterocolitica infection and toxic megacolon. Br J Surg. Jul 1986;73(7):590. [Medline].

Further Reading

Keywords

Yersinia enterocolitica, Y enterocolitica, Yersinia enterocolitis, yersiniosis, acute bacterial gastroenteritis, bacterial gastroenteritis, gastroenteritis, food poisoning, food contamination, water contamination, mesenteric adenitis, enterocolitis

Contributor Information and Disclosures

Author

Zartash Zafar Khan, MD, Fellow in Infectious Diseases, University of Oklahoma Health Science Center
Zartash Zafar Khan, MD is a member of the following medical societies: American College of Physicians, Infectious Diseases Society of America, and International Society for Infectious Diseases
Disclosure: Nothing to disclose.

Coauthor(s)

Michelle R Salvaggio, MD, Assistant Professor, Department of Internal Medicine, Section of Infectious Diseases, University of Oklahoma College of Medicine; Medical Director of Infectious Diseases Institute, University of Oklahoma Health Sciences Center
Michelle R Salvaggio, MD is a member of the following medical societies: American College of Physicians and Infectious Diseases Society of America
Disclosure: Merck Honoraria Speaking and teaching

Mark H Johnston, MD, Associate Professor of Medicine, Uniformed Services University of Health Sciences; Consulting Staff, Lancaster Gastroenterology Inc
Mark H Johnston, MD is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, American Gastroenterological Association, and Christian Medical & Dental Society
Disclosure: Nothing to disclose.

Gregory J Martin, MD, Director, Infectious Diseases Clinical Research Program (IDCRP) Associate Professor of Medicine, Uniformed Services University, Bethesda, MD
Gregory J Martin, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Society of Tropical Medicine and Hygiene, and Infectious Diseases Society of America
Disclosure: Nothing to disclose.

Medical Editor

Thomas Herchline, MD, Professor of Medicine, Wright State University Boonshoft School of Medicine; Medical Director, Public Health, Dayton and Montgomery County, Ohio
Thomas Herchline, MD is a member of the following medical societies: American College of Physicians, American Society for Microbiology, and Infectious Diseases Society of America
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Richard B Brown, MD, FACP, Chief, Division of Infectious Diseases, Baystate Medical Center; Professor, Department of Internal Medicine, Tufts University School of Medicine
Richard B Brown, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Chest Physicians, American College of Physicians, American Medical Association, American Society for Microbiology, Infectious Diseases Society of America, and Massachusetts Medical Society
Disclosure: Nothing to disclose.

CME Editor

Eleftherios Mylonakis, MD, Clinical and Research Fellow, Department of Internal Medicine, Division of Infectious Diseases, Massachusetts General Hospital
Eleftherios Mylonakis, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Physicians, American Society for Microbiology, and Infectious Diseases Society of America
Disclosure: Nothing to disclose.

Chief Editor

Burke A Cunha, MD, Professor of Medicine, State University of New York School of Medicine at Stony Brook; Chief, Infectious Disease Division, Winthrop-University Hospital
Burke A Cunha, MD is a member of the following medical societies: American College of Chest Physicians, American College of Physicians, and Infectious Diseases Society of America
Disclosure: Nothing to disclose.

 
 
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