Epidural Abscess Treatment & Management
- Author: Mark R Wallace, MD, FACP, FIDSA; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD more...
Spinal epidural abscess
A combined medical-surgical approach, with emergent surgical decompression and drainage of purulent material, has been the standard approach to spinal epidural abscess. Antibiotic-based therapy, sometimes combined with CT-directed needle aspiration, has traditionally been used only in patients who are determined to be at prohibitively high risk of surgery or who have a fixed paralysis that lasts more than 48-72 hours and that is presumed to be irreversible.
In recent years, wider use of antibiotic-based, nonsurgical therapy for spinal epidural abscess has been advocated,[16, 17, 18] condemned,[19, 20] and cautiously discussed.[13, 21, 22, 23, 24] The current literature on the subject consists largely of small case series and remains inadequate to resolve the controversy.[1, 2]
If medical therapy is to be used as initial therapy for spinal epidural abscess and surgery held in reserve, a number of caveats apply, as follows:
The patient should have no neurological deficits.
A culture-proven microbiological diagnosis should be available (from blood culture or aspiration).
Stringent follow-up by both the primary team and neurosurgeons must be available and emergent surgery available, if needed.
The physicians caring for the patient must be aware that rapid deterioration may occur at any time (the first 72 hours being most risky) and that even prompt rescue surgery may leave the patient with a neurological deficit that might have been avoided with surgery at first diagnosis. Failure rates with medical management in one recent study were 41%, with some these failures termed "catastrophic". 
Risk factors for failure of medical therapy include neurological deficit, diabetes, bacteremia, age older than 65 years, and MRSA as the causative organism. [23, 24] Patients with multiple risk factors for failure of medical therapy should have the traditional combined medical/surgical approach, with the surgery performed soon after diagnosis.
A follow-up MRI is necessary within 2-4 weeks to evaluate for improvement with medical therapy.
Empirical antibiotic therapy should include coverage of gram-positive cocci, particularly staphylococci (including MRSA), and gram-negative bacilli. Vancomycin has been the standard agent for gram-positive infections, although linezolid, daptomycin, ceftaroline, or tigecycline could be considered. The third- and fourth-generation cephalosporins and meropenem offer excellent gram-positive (except MRSA) and gram-negative coverage in addition to CNS penetration.
Pending cultures, a combination of agents (vancomycin plus cefepime or similar) is needed. Additional coverage may be needed if some of the less-common etiologic agents (see Causes) are suspected. Always tailor coverage once culture data are available; for example, nafcillin is a much better drug for MSSA infections than vancomycin. Note that failures due to the development of resistance have occurred when daptomycin alone was used for MRSA spinal epidural abscess. Experience with ceftaroline for these infections is extremely limited, but this maybe a useful second-line MRSA agent.
Intracranial epidural abscess
A combined medical-surgical approach is used for intracranial epidural abscess. A craniotomy is usually performed. Empiric antibiotic therapy is similar to that described for spinal epidural abscess; since many of these infections result from prior interventions, the possibility of more-resistant nosocomial organisms must be considered. Vancomycin plus cefepime or meropenem would be good starting choices, with metronidazole added to the cefepime if anaerobes are a major concern.
Prompt decompression is used to manage intracranial epidural abscess, as it is uniformly considered a neurosurgical emergency.
As discussed in detail above, most patients with spinal epidural abscess require urgent decompressive laminectomy; other surgical techniques may be preferred in certain situations. In some patients without neurologic deficits, medical therapy might be cautiously attempted, recognizing that disastrous outcomes may ensue from this conservative approach (see Medical Therapy). CT-guided drainage might be helpful in some cases of posterior spinal epidural abscess, but the literature on this is scant.
Emergent consultation with a neurosurgeon is mandatory for surgical decompression and drainage of purulent material in patients with intracranial epidural abscess. Emergent surgical intervention is needed in most patients with spinal epidural abscess, and prompt consultation and tight follow-up are mandatory in those in whom surgery is deferred (see Treatment). Consultation with an infectious disease specialist is strongly recommended for both diagnostic and therapeutic assistance.
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