eMedicine Specialties > Infectious Diseases > Bacterial Infections
Ehrlichiosis: Follow-up
Updated: Feb 5, 2009
Follow-up
Deterrence/Prevention
- In endemic ehrlichiosis areas, proper precautions should be taken when traveling through tick-infested wooded areas by minimizing exposed areas of skin with proper clothing and diethyltoluamide (DEET).
- After returning from wooded and/or tick-infested areas, individuals should check themselves carefully for ticks. If found, ticks should be removed carefully and a physician should be consulted.
Prognosis
- Ehrlichiosis carries an excellent prognosis in healthy hosts.
- Ehrlichiosis carries an estimated mortality rate of 1-5%. The likelihood of mortality is much greater in immunocompromised hosts.
Patient Education
- Educate patients in endemic ehrlichiosis areas to take proper precautions when traveling through wooded and/or tick-infested areas (see Deterrence/Prevention).
- For excellent patient education resources, visit eMedicine's Bites and Stings Center. Also, see eMedicine's patient education article Ticks.
Miscellaneous
Medicolegal Pitfalls
- Clinicians should remember that doxycycline is the preferred antimicrobial agent for all treatable tick-borne infectious diseases.
- Avoid using chloramphenicol in patients with possible ehrlichiosis because it is ineffective in both human monocytic ehrlichiosis (HME) and human granulocytic anaplasmosis (HGA).
More on Ehrlichiosis |
| Overview: Ehrlichiosis |
| Differential Diagnoses & Workup: Ehrlichiosis |
| Treatment & Medication: Ehrlichiosis |
Follow-up: Ehrlichiosis |
| Multimedia: Ehrlichiosis |
| References |
| « Previous Page | Next Page » |
References
Everett ED, Evans KA, Henry RB, et al. Human ehrlichiosis in adults after tick exposure. Diagnosis using polymerase chain reaction. Ann Intern Med. May 1 1994;120(9):730-5. [Medline].
Aguero-Rosenfeld ME, Horowitz HW, Wormser GP, et al. Human granulocytic ehrlichiosis: a case series from a medical center in New York State. Ann Intern Med. Dec 1 1996;125(11):904-8. [Medline].
Anderson BE, Dawson JE, Jones DC, et al. Ehrlichia chaffeensis, a new species associated with human ehrlichiosis. J Clin Microbiol. Dec 1991;29(12):2838-42. [Medline].
Bakken JS. Human granulocytic ehrlichiosis in the United States. Infect Med. 1996;10:877-889.
Bakken JS, Dumler JS. Ehrlichiosis. In: Cunha BA, ed. Tickborne Infectious Diseases: Diagnosis and Management. New York, NY: Marcel Dekker; 2000:139-168.
Bakken JS, Dumler JS, Chen SM, et al. Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging?. JAMA. Jul 20 1994;272(3):212-8. [Medline].
Bakken JS, Krueth J, Tilden RL, et al. Serological evidence of human granulocytic ehrlichiosis in Norway. Eur J Clin Microbiol Infect Dis. Oct 1996;15(10):829-32. [Medline].
Bakken JS, Krueth J, Wilson-Nordskog C, et al. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA. Jan 17 1996;275(3):199-205. [Medline].
Bakken JS, Krueth JK, Lund T, et al. Exposure to deer blood may be a cause of human granulocytic ehrlichiosis. Clin Infect Dis. Jul 1996;23(1):198. [Medline].
Brouqui P, Dumler JS, Lienhard R, et al. Human granulocytic ehrlichiosis in Europe. Lancet. Sep 16 1995;346(8977):782-3. [Medline].
Brouqui P, Raoult D. Susceptibility of ehrlichia to antibiotics. In: Raoult D, ed. Antimicrobial Agents and Intracellular Pathogens. Boca Raton, Fla: CRC Press; 1993:182-199.
Brouqui P, Raoult D. In vitro antibiotic susceptibility of the newly recognized agent of ehrlichiosis in humans, Ehrlichia chaffeensis. Antimicrob Agents Chemother. Dec 1992;36(12):2799-803. [Medline].
Carpenter CF, Gandhi TK, Kong LK, et al. The incidence of ehrlichial and rickettsial infection in patients with unexplained fever and recent history of tick bite in central North Carolina. J Infect Dis. Sep 1999;180(3):900-3. [Medline].
[Guideline] Chapman AS, Bakken JS, Folk SM, Paddock CD, Bloch KC, Krusell A, et al. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals. MMWR Recomm Rep. Mar 31 2006;55:1-27. [Medline].
Chen SM, Dumler JS, Bakken JS, et al. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J Clin Microbiol. Mar 1994;32(3):589-95. [Medline].
Cunha BA. Antibiotic Essentials. 7th ed. Royal Oak, Michigan: Physicians Press; 2008.
Dawson JE, Fishbein DB, Eng TR, et al. Diagnosis of human ehrlichiosis with the indirect fluorescent antibody test: kinetics and specificity. J Infect Dis. Jul 1990;162(1):91-5. [Medline].
Dhand A, Nadelman RB, Aguero-Rosenfeld M, et al. Human granulocytic anaplasmosis during pregnancy: case series and literature review. Clin Infect Dis. Sep 1 2007;45(5):589-93. [Medline].
Dumler JS, Asanovich KM, Bakken JS, et al. Serologic cross-reactions among Ehrlichia equi, Ehrlichia phagocytophila, and human granulocytic Ehrlichia. J Clin Microbiol. May 1995;33(5):1098-103. [Medline].
Dumler JS, Bakken JS. Ehrlichial diseases of humans: emerging tick-borne infections. Clin Infect Dis. May 1995;20(5):1102-10. [Medline].
Dumler JS, Bakken JS. Human ehrlichioses: newly recognized infections transmitted by ticks. Annu Rev Med. 1998;49:201-13. [Medline].
Dumler JS, Bakken JS. Human granulocytic ehrlichiosis in Wisconsin and Minnesota: a frequent infection with the potential for persistence. J Infect Dis. Apr 1996;173(4):1027-30. [Medline].
Dumler JS, Madigan JE, Pusterla N, et al. Ehrlichioses in humans: epidemiology, clinical presentation, diagnosis, and treatment. Clin Infect Dis. Jul 15 2007;45 Suppl 1:S45-51. [Medline].
Dumler JS, Sutker WL, Walker DH. Persistent infection with Ehrlichia chaffeensis. Clin Infect Dis. Nov 1993;17(5):903-5. [Medline].
Eng TR, Fishbein DB. Epidemiologic factors, clinical findings, and vaccination status of rabies in cats and dogs in the United States in 1988. National Study Group on Rabies. J Am Vet Med Assoc. Jul 15 1990;197(2):201-9. [Medline].
Fishbein DB, Dawson JE, Robinson LE. Human ehrlichiosis in the United States, 1985 to 1990. Ann Intern Med. May 1 1994;120(9):736-43. [Medline].
Fishbein DB, Kemp A, Dawson JE, et al. Human ehrlichiosis: prospective active surveillance in febrile hospitalized patients. J Infect Dis. Nov 1989;160(5):803-9. [Medline].
Graf PC, Chretien JP, Ung L, et al. Prevalence of seropositivity to spotted fever group rickettsiae and Anaplasma phagocytophilum in a large, demographically diverse US sample. Clin Infect Dis. Jan 1 2008;46(1):70-7. [Medline].
Hamburg BJ, Storch GA, Micek ST, et al. The importance of early treatment with doxycycline in human ehrlichiosis. Medicine (Baltimore). Mar 2008;87(2):53-60. [Medline].
Hamilton KS, Standaert SM, Kinney MC. Characteristic peripheral blood findings in human ehrlichiosis. Mod Pathol. May 2004;17(5):512-7. [Medline].
Hardalo CJ, Quagliarello V, Dumler JS. Human granulocytic ehrlichiosis in Connecticut: report of a fatal case. Clin Infect Dis. Oct 1995;21(4):910-4. [Medline].
Harkess JR. Ehrlichiosis. Infect Dis Clin North Am. Mar 1991;5(1):37-51. [Medline].
Horowitz HW, Aguero-Rosenfeld M, Dumler JS, et al. Reinfection with the agent of human granulocytic ehrlichiosis. Ann Intern Med. Sep 15 1998;129(6):461-3. [Medline].
Horowitz HW, Raffalli J, Nadelman RB, et al. Saddleback fever due to human granulocytic ehrlichiosis. Lancet. Feb 28 1998;351(9103):650. [Medline].
IJdo JW, Zhang Y, Hodzic E, et al. The early humoral response in human granulocytic ehrlichiosis. J Infect Dis. Sep 1997;176(3):687-92. [Medline].
Lotric-Furlan S, Petrovec M, Avsic-Zupanc T, et al. Clinical distinction between human granulocytic ehrlichiosis and the initial phase of tick-borne encephalitis. J Infect. Jan 2000;40(1):55-8. [Medline].
Maeda K, Markowitz N, Hawley RC, et al. Human infection with Ehrlichia canis, a leukocytic rickettsia. N Engl J Med. Apr 2 1987;316(14):853-6. [Medline].
Magnarelli LA, Stafford KC 3rd, Mather TN, et al. Hemocytic rickettsia-like organisms in ticks: serologic reactivity with antisera to Ehrlichiae and detection of DNA of agent of human granulocytic ehrlichiosis by PCR. J Clin Microbiol. Oct 1995;33(10):2710-4. [Medline].
Magnarelli LA. Ehrlichiosis. a veterinary problem with growing epidemiologic importance. Clin Microbiol Newsletter. 1990;12:145-147.
Martin GS, Christman BW, Standaert SM. Rapidly fatal infection with Ehrlichia chaffeensis. N Engl J Med. Sep 2 1999;341(10):763-4. [Medline].
Marty AM, Dumler JS, Imes G, et al. Ehrlichiosis mimicking thrombotic thrombocytopenic purpura. Case report and pathological correlation. Hum Pathol. Aug 1995;26(8):920-5. [Medline].
McDade JE. Ehrlichiosis--a disease of animals and humans. J Infect Dis. Apr 1990;161(4):609-17. [Medline].
Morais JD, Dawson JE, Greene C, et al. First European case of ehrlichiosis. Lancet. Sep 7 1991;338(8767):633-4. [Medline].
Nadelman RB, Horowitz HW, Hsieh TC, et al. Simultaneous human granulocytic ehrlichiosis and Lyme borreliosis. N Engl J Med. Jul 3 1997;337(1):27-30. [Medline].
Nutt AK, Raufman J. Gastrointestinal and hepatic manifestations of human ehrlichiosis: 8 cases and a review of the literature. Dig Dis. 1999;17(1):37-43. [Medline].
Oteo JA, Blanco JR, Martinez de Artola V, et al. First report of human granulocytic ehrlichiosis from southern Europe (Spain). Emerg Infect Dis. Jul-Aug 2000;6(4):430-2. [Medline].
Paddock CD, Childs JE. Ehrlichia chaffeensis: a prototypical emerging pathogen. Clin Microbiol Rev. Jan 2003;16(1):37-64. [Medline].
Paddock CD, Sumner JW, Shore GM, et al. Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis. J Clin Microbiol. Oct 1997;35(10):2496-502. [Medline].
Parola P, Raoult D. Ticks and tickborne bacterial diseases in humans: an emerging infectious threat. Clin Infect Dis. Mar 15 2001;32(6):897-928. [Medline].
Patel RG, Byrd MA. Near fatal acute respiratory distress syndrome in a patient with human ehrlichiosis. South Med J. Mar 1999;92(3):333-5. [Medline].
Perez M, Rikihisa Y, Wen B. Ehrlichia canis-like agent isolated from a man in Venezuela: antigenic and genetic characterization. J Clin Microbiol. Sep 1996;34(9):2133-9. [Medline].
Petrovec M, Lotric Furlan S, Zupanc TA, et al. Human disease in Europe caused by a granulocytic Ehrlichia species. J Clin Microbiol. Jun 1997;35(6):1556-9. [Medline].
Pierard D, Levtchenko E, Dawson JE, et al. Ehrlichiosis in Belgium. Lancet. Nov 4 1995;346(8984):1233-4. [Medline].
Prince LK, Shah AA, Martinez LJ, et al. Ehrlichiosis: making the diagnosis in the acute setting. South Med J. Aug 2007;100(8):825-8. [Medline].
Rabinstein A, Tikhomirov V, Kaluta A, et al. Recurrent and prolonged fever in asplenic patients with human granulocytic ehrlichiosis. QJM. Mar 2000;93(3):198-201. [Medline].
Ratnasamy N, Everett ED, Roland WE, et al. Central nervous system manifestations of human ehrlichiosis. Clin Infect Dis. Aug 1996;23(2):314-9. [Medline].
Rikihisa Y. Clinical and biological aspects of infection caused by Ehrlichia chaffeensis. Microbes Infect. Apr 1999;1(5):367-76. [Medline].
Rikihisa Y. The tribe Ehrlichieae and ehrlichial diseases. Clin Microbiol Rev. Jul 1991;4(3):286-308. [Medline].
Rikihisa Y, Zhi N, Wormser GP, et al. Ultrastructural and antigenic characterization of a granulocytic ehrlichiosis agent directly isolated and stably cultivated from a patient in New York state. J Infect Dis. Jan 1997;175(1):210-3. [Medline].
Roland WE, McDonald G, Caldwell CW, et al. Ehrlichiosis--a cause of prolonged fever. Clin Infect Dis. Apr 1995;20(4):821-5. [Medline].
Schutze GE. Ehrlichiosis. Pediatr Infect Dis J. Jan 2006;25(1):71-2. [Medline].
Stone JH, Dierberg K, Aram G, et al. Human monocytic ehrlichiosis. JAMA. Nov 10 2004;292(18):2263-70. [Medline].
Strle F. Human granulocytic ehrlichiosis in Europe. Int J Med Microbiol. Apr 2004;293 Suppl 37:27-35. [Medline].
Sumption KJ, Wright DJ, Cutler SJ, et al. Human ehrlichiosis in the UK. Lancet. Dec 2 1995;346(8988):1487-8. [Medline].
Telford SR 3rd, Dawson JE, Katavolos P, et al. Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proc Natl Acad Sci U S A. Jun 11 1996;93(12):6209-14. [Medline].
Thomas LD, Hongo I, Bloch KC, et al. Human ehrlichiosis in transplant recipients. Am J Transplant. Jun 2007;7(6):1641-7. [Medline].
Varde S, Beckley J, Schwartz I. Prevalence of tick-borne pathogens in Ixodes scapularis in a rural New Jersey County. Emerg Infect Dis. Jan-Mar 1998;4(1):97-9. [Medline].
Weaver RA, Virella G, Weaver A. Ehrlichiosis with severe pulmonary manifestations despite early treatment. South Med J. Mar 1999;92(3):336-9. [Medline].
Further Reading
Keywords
ehrlichiosis, human monocytic ehrlichiosis, HME, human granulocytic anaplasmosis, HGA, human granulocytic ehrlichiosis, HGE, spotless Rocky Mountain spotted fever, Ehrlichia, Ehrlichia chaffeensis, E chaffeensis, Erlichia ewingii, E ewingii, Anaplasma phagocytophilum, A phagocytophilum, morulae
Follow-up: Ehrlichiosis