Rheumatic Fever Treatment & Management
- Author: Mark R Wallace, MD, FACP, FIDSA; Chief Editor: Michael Stuart Bronze, MD more...
Management and prevention of acute rheumatic fever (ARF) can be divided into the following 4 approaches.
Treatment of the group A streptococcal infection that led to the disease
Although never proven to improve the one-year outcome, this is a standard practice.[1, 6] It may at least serve to reduce the spread of rheumatogenic strains.
General treatment of the acute episode
Anti-inflammatory agents are used to control the arthritis, fever, and other acute symptoms. Salicylates are the preferred agents, although other nonsteroidal agents are probably equally efficacious. Steroids are also effective but should probably be reserved for patients in whom salicylates fail. None of these anti-inflammatory agents has been shown to reduce the risk of subsequent rheumatic heart disease.
Bed rest is a traditional part of ARF therapy and is especially important in those with carditis. Patients are typically advised to rest through the acute illness and to then gradually increase activity; some clinicians monitor the patient’s ESR and restart activity only as it normalizes.[6, 1]
Intravenous immunoglobulin has not been shown to reduce the risk of rheumatic heart disease or to substantially improve the clinical course.
Chorea is usually managed conservatively in a quiet nonstimulatory environment; valproic acid is the preferred agent if sedation is needed. Intravenous immunoglobulin, steroids, and plasmapheresis have all been used successfully in refractory chorea, although conclusive evidence of their efficacy is limited.[6, 18]
Bed rest is essential in patients with cardiac involvement. Carditis resulting in heart failure is treated with conventional measures; some use corticosteroids for severe carditis, although data to support this are scant. Diuretics are the mainstay of therapy. Monitor for development of arrhythmias in patients with active myocarditis.
For details about penicillin prophylaxis, see Medication.
Surgical care is not typically indicated in ARF. Surgical intervention is required only to treat long-term valvular cardiac sequelae of ARF that cause stenosis.
Consultation with a cardiologist may be required to manage heart blocks and CHF.
Consultation with a neurologist or psychiatrist may be required to confirm the diagnosis of chorea and to assist in its management.
Consultations with an infectious disease specialist and rheumatologist may be helpful in diagnosis.
No specific dietary recommendation exists. CHF may require salt restriction.
Bed rest is a time-honored part of ARF therapy and is especially important in those with carditis. Patients are typically advised to rest through the acute illness and to then gradually increase activity; some clinicians monitor the ESR and restart activity only as it normalizes.[1, 6]
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