Antiglomerular Basement Membrane Disease: Multimedia

References

1. Lerner RA, Glassock RJ, Dixon FJ. The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med. Dec 1 1967;126(6):989-1004. [Medline].

2. Sinico RA, Radice A, Corace C, et al. Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: a comparison of different assays. Nephrol Dial Transplant. Feb 2006;21(2):397-401. [Medline].

3. Lockwood CM, Rees AJ, Pearson TA, et al. Immunosuppression and plasma-exchange in the treatment of Goodpasture's syndrome. Lancet. Apr 3 1976;1(7962):711-5. [Medline].

4. Wang XP, Fogo AB, Colon S, et al. Distinct epitopes for anti-glomerular basement membrane alport alloantibodies and goodpasture autoantibodies within the noncollagenous domain of alpha3(IV) collagen: a janus-faced antigen. J Am Soc Nephrol. Dec 2005;16(12):3563-71. [Medline].

5. Kashtan CE. Renal transplantation in patients with Alport syndrome. Pediatr Transplant. Sep 2006;10(6):651-7. [Medline].

6. Borza DB, Bondar O, Colon S, et al. Goodpasture autoantibodies unmask cryptic epitopes by selectively dissociating autoantigen complexes lacking structural reinforcement: novel mechanisms for immune privilege and autoimmune pathogenesis. J Biol Chem. Jul 22 2005;280(29):27147-54. [Medline].

7. Borza DB. Autoepitopes and alloepitopes of type IV collagen: role in the molecular pathogenesis of anti-GBM antibody glomerulonephritis. Nephron Exp Nephrol. 2007;106(2):e37-43. [Medline]. [Full Text].

8. Butkowski RJ, Langeveld JP, Wieslander J, et al. Localization of the Goodpasture epitope to a novel chain of basement membrane collagen. J Biol Chem. Jun 5 1987;262(16):7874-7. [Medline].

9. Bygren P, Freiburghaus C, Lindholm T, et al. Goodpasture's syndrome treated with staphylococcal protein A immunoadsorption. Lancet. Dec 7 1985;2(8467):1295-6. [Medline].

10. Cameron JS. Recurrent renal disease after renal transplantation. Curr Opin Nephrol Hypertens. Nov 1994;3(6):602-7. [Medline].

11. Collard HR, Schwarz MI. Diffuse alveolar hemorrhage. Clin Chest Med. Sep 2004;25(3):583-92, vii. [Medline].

12. Goodpasture EW. The significance of certain pulmonary lesions in relation to the etiology of influenza. Am J Med Sci. 1919;158:863-70.

13. Gunnarsson A, Hellmark T, Wieslander J. Molecular properties of the Goodpasture epitope. J Biol Chem. Oct 6 2000;275(40):30844-8. [Medline].

14. Hudson BG. The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family. J Am Soc Nephrol. Oct 2004;15(10):2514-27. [Medline].

15. Hudson BG, Tryggvason K, Sundaramoorthy M, et al. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N Engl J Med. Jun 19 2003;348(25):2543-56. [Medline].

16. Hudson BG, Wieslander J, Wisdom BJ Jr, et al. Goodpasture syndrome: molecular architecture and function of basement membrane antigen. Lab Invest. Sep 1989;61(3):256-69. [Medline].

17. Jung C, Karpouzas G, Stringer WW. Dyspnea, hemoptysis, and perihilar infiltrates in a 35-year-old man. Chest. Apr 2005;127(4):1437-41. [Medline].

18. Khandelwal M, McCormick BB, Lajoie G, et al. Recurrence of anti-GBM disease 8 years after renal transplantation. Nephrol Dial Transplant. Feb 2004;19(2):491-4. [Medline].

19. Larsson LA, Freiburghaus C, Nilsson IM. Plasma regeneration system for extensive immunoadsorption. Prog Artificial Organs. 1985;902-4.

20. Levy JB, Hammad T, Coulthart A, et al. Clinical features and outcome of patients with both ANCA and anti-GBM antibodies. Kidney Int. Oct 2004;66(4):1535-40. [Medline].

21. Levy JB, Turner AN, Rees AJ, et al. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann Intern Med. Jun 5 2001;134(11):1033-42. [Medline].

22. Mathew TH. Recurrence of disease following renal transplantation. Am J Kidney Dis. Aug 1988;12(2):85-96. [Medline].

23. Miner JH. Renal basement membrane components. Kidney Int. Dec 1999;56(6):2016-24. [Medline].

24. Pirson Y, Goffin E, Squiffet JP. Outcome of anti-GBM nephritis after renal transplantation [abstract]. J Am Soc Nephrol. 1993;4:955.

25. Reynolds J, Moss J, Duda MA, et al. The evolution of crescentic nephritis and alveolar haemorrhage following induction of autoimmunity to glomerular basement membrane in an experimental model of Goodpasture's disease. J Pathol. May 2003;200(1):118-29. [Medline].

26. Saus J, Wieslander J, Langeveld JP, et al. Identification of the Goodpasture antigen as the alpha 3(IV) chain of collagen IV. J Biol Chem. Sep 15 1988;263(26):13374-80. [Medline].

27. Saxena R, Bygren P, Butkowski R, et al. Specificity of kidney-bound antibodies in Goodpasture's syndrome. Clin Exp Immunol. Oct 1989;78(1):31-6. [Medline].

28. Saxena R, Isaksson B, Bygren P, et al. A rapid assay for circulating anti-glomerular basement membrane antibodies in Goodpasture syndrome. J Immunol Methods. Mar 10 1989;118(1):73-8. [Medline].

29. Short AK, Esnault VL, Lockwood CM. ANCA and anti-GBM antibodies in RPGN. Adv Exp Med Biol. 1993;336:441-4. [Medline].

30. Simpson IJ, Doak PB, Williams LC, et al. Plasma exchange in Goodpasture's syndrome. Am J Nephrol. 1982;2(6):301-11. [Medline].

31. Sinico RA, Radice A, Corace C, et al. Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: a comparison of different assays. Nephrol Dial Transplant. Feb 2006;21(2):397-401. [Medline].

32. Stanton MC, Tange JD. Goodpasture's syndrome (pulmonary haemorrhage associated with glomerulonephritis). Australas Ann Med. May 1958;7(2):132-44. [Medline].

33. Wang XP, Fogo AB, Colon S, et al. Distinct epitopes for anti-glomerular basement membrane alport alloantibodies and goodpasture autoantibodies within the noncollagenous domain of alpha3(IV) collagen: a janus-faced antigen. J Am Soc Nephrol. Dec 2005;16(12):3563-71. [Medline].

34. Wieslander J, Bygren P, Heinegård D. Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome. Proc Natl Acad Sci U S A. Mar 1984;81(5):1544-8. [Medline].

35. Wu J, Arends J, Borillo J, et al. A self T cell epitope induces autoantibody response: mechanism for production of antibodies to diverse glomerular basement membrane antigens. J Immunol. Apr 1 2004;172(7):4567-74. [Medline].

Further Reading

Keywords

antiglomerular basement membrane disease, anti-glomerular basement membrane disease, anti-GBM disease, Goodpasture syndrome, Goodpasture's syndrome, glomerular basement membrane, GBM, anti-GBM nephritis, renal failure, kidney failure, glomerulonephritis, lung hemorrhage, lung bleeding, pulmonary hemorrhage, glomerulonephritides, Alport syndrome, Alport's syndrome, kidney transplantation, kidney transplants, plasmapheresis, renal transplantation, renal transplant, fatal lung hemorrhage

Contributor Information and Disclosures

Author

Ramesh Saxena, MD, PhD, Associate Professor, Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center
Ramesh Saxena, MD, PhD is a member of the following medical societies: American Medical Association, American Society of Nephrology, and International Society of Nephrology
Disclosure: e-medicine Honoraria authoring review articles

Medical Editor

Chike Magnus Nzerue, MD, Associate Dean for Clinical Affairs, Meharry Medical College
Chike Magnus Nzerue, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Society of Nephrology, and National Kidney Foundation
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Christie P Thomas, MB, BS, FRCP, FASN, FAHA, Professor, Department of Internal Medicine, Division of Nephrology, University of Iowa Hospitals and Clinics; Director of Transplantation Services, Veterans Affairs Medical Center
Christie P Thomas, MB, BS, FRCP, FASN, FAHA is a member of the following medical societies: American College of Physicians, American Federation for Medical Research, American Heart Association, American Society of Nephrology, American Society of Transplantation, American Thoracic Society, International Society of Nephrology, and Royal College of Physicians
Disclosure: Nothing to disclose.

CME Editor

Rebecca J Schmidt, DO, FACP, FASN, Professor of Medicine, Section Chief, Department of Medicine, Section of Nephrology, West Virginia University School of Medicine
Rebecca J Schmidt, DO, FACP, FASN is a member of the following medical societies: American College of Osteopathic Internists, American College of Physicians, American Medical Association, American Society of Nephrology, International Society of Nephrology, National Kidney Foundation, Renal Physicians Association, and West Virginia State Medical Association
Disclosure: Abbott Grant/research funds Speaking and teaching; Genzyme Honoraria Consulting; Roche Honoraria Consulting

Chief Editor

Vecihi Batuman, MD, FACP, FASN, Professor of Medicine, Section of Nephrology-Hypertension, Tulane University School of Medicine; Chief, Medicine Service, Southeast Louisiana Veterans Health Care System
Vecihi Batuman, MD, FACP, FASN is a member of the following medical societies: American College of Physicians, American Society of Hypertension, American Society of Nephrology, and International Society of Nephrology
Disclosure: Nothing to disclose.