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Malignant Hypertension 

  • Author: John D Bisognano, MD, PhD, FACP, FACC; Chief Editor: Vecihi Batuman, MD, FACP, FASN  more...
 
Updated: Dec 03, 2015
 

Hypertensive Emergencies

A hypertensive emergency is a condition in which elevated blood pressure results in target organ damage.[1] The systems primarily involved include the central nervous system, the cardiovascular system, and the renal system. Malignant hypertension and accelerated hypertension are both hypertensive emergencies, with similar outcomes and therapies. In order to diagnose malignant hypertension, papilledema (as seen in the image below) must be present.[2]  However, Cremer et al consider the presence of retinopathy as but one of various potential presentations for acute hypertension with multiorgan damage.[1] Therefore, they have proposed a "more modern" definition for malignant hypertension, in which hypertensive emergencies, in the absence of retinopathy, be based on the criteria of acute elevated blood pressure accompanied by damage to a minimum of three different target organs.[1]

Papilledema. Note the swelling of the optic disc, Papilledema. Note the swelling of the optic disc, with blurred margins.

Up to 1% of patients with essential hypertension develop malignant hypertension, but the reason some patients develop malignant hypertension whereas others do not is unknown. The characteristic vascular lesion is fibrinoid necrosis of arterioles and small arteries, which causes the clinical manifestations of end-organ damage. Red blood cells are damaged as they flow through vessels obstructed by fibrin deposition, resulting in microangiopathic hemolytic anemia.

In a retrospective study that evaluated hospital admissions data from the Nationwide Inpatient Sample for malignant hypertension, hypertensive encephalopathy, and essential hypertension, Polgreen et al found an increasing trend for malignant hypertension and hypertensive encephalopathy between the years 2000 and 2011, with a dramatic increase after 2007.[3] However, there was no corresponding dramatic increase seen in morbidity for both conditions, which the investigators believed might have resulted from coding changes in diagnostic-related groups in 2007. Mortality declined significantly for patients with malignant hypertension, but there was no change for those with hypertensive encephalopathy.[3]

Another pathologic process is the dilatation of cerebral arteries following a breakthrough of the normal autoregulation of cerebral blood flow. Under normal conditions, cerebral blood flow is kept constant by cerebral vasoconstriction in response to increases in blood pressure. In patients without hypertension, flow is kept constant over a mean pressure of 60-120 mm Hg. In patients with hypertension, flow is constant over a mean pressure of 110-180 mm Hg because of arteriolar thickening. When blood pressure is raised above the upper limit of autoregulation, arterioles dilate. This results in hyperperfusion and cerebral edema, which cause the clinical manifestations of hypertensive encephalopathy.

Other causes of malignant hypertension include any form of secondary hypertension; complications of pregnancy; use of cocaine, monoamine oxidase inhibitors (MAOIs), or oral contraceptives; and the withdrawal of alcohol, beta-blockers, or alpha-stimulants. Renal artery stenosis, pheochromocytoma (most pheochromocytomas can be localized using computed tomography (CT) scanning of the adrenals), aortic coarctation, and hyperaldosteronism are also secondary causes of hypertension. In addition, both hyperthyroidism and hypothyroidism can cause hypertension.

The following conditions should also be considered when making the diagnosis: stroke, intracranial mass, head injury, epilepsy or postictal state, connective-tissue disease (especially lupus with cerebral vasculitis), drug overdose or withdrawal, cocaine or amphetamine ingestion, acute anxiety, and thrombotic thrombocytopenic purpura.[4, 5]

Because malignant hypertension-induced thrombotic microangiopathy may mimic thrombocytopenic purpura, the possibility exists that plasma exchange rather than antihypertensive agents might initially be administered to patients. In a literature review, Khanal et al reported that factors that are more likely to be present in malignant hypertension-induced thrombotic microangiopathy are: a previous history of hypertension, high mean arterial pressure, significant renal impairment but relatively modest thrombocytopenia, and lack of severe ADAMTS-13 gene deficiency (activity <10%) at diagnosis.[5]

For more information, see Hypertension.

Accelerated hypertension and hypertensive urgency

Accelerated hypertension is defined as a recent significant increase over baseline blood pressure that is associated with target organ damage. This is usually seen as vascular damage on funduscopic examination, such as flame-shaped hemorrhages or soft exudates, but without papilledema.

Hypertensive urgency must be distinguished from hypertensive emergency. Urgency is defined as severely elevated blood pressure (ie, systolic >220 mm Hg or diastolic >120 mm Hg) with no evidence of target organ damage.

Hypertensive emergencies require immediate therapy to decrease blood pressure within minutes to hours.[6] In contrast, no evidence suggests a benefit from rapidly reducing blood pressure in patients with hypertensive urgency. In fact, such aggressive therapy may harm the patient, resulting in cardiac, renal, or cerebral hypoperfusion. This article discusses hypertensive emergency, but therapy for hypertensive urgency is discussed briefly.

Patient education

Patients must be taught an appropriate diet for long-term management, and upon discharge, patients should not only know the signs and symptoms that should prompt immediate notification of a physician but also know the proper dosing and adverse effects of their medications.

For patient education resources, see the Diabetes Center as well as High Blood Pressure.

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Evaluation

The history should include screening for symptoms of malignant hypertension, focusing on the cardiac, renal, and central nervous systems. Underlying medical disorders should be reviewed, including the possibility of eclampsia. The patient's medications and other drugs should be thoroughly reviewed[7] ; agents that may cause a hypertensive emergency include cocaine, MAOIs, and oral contraceptives; the withdrawal of beta-blockers, alpha-stimulants (eg, clonidine), or alcohol also may cause hypertensive emergency.

In one review, the most common presentations of hypertensive emergencies at an emergency department were chest pain (27%), dyspnea (22%), and neurologic deficit (21%).

A thorough physical examination should be conducted, with the focus on the cardiovascular and central nervous systems and on the retinal examination.

Cardiovascular system

The cardiac presentation of malignant hypertension is angina and/or myocardial infarction, congestive heart failure, or pulmonary edema. Orthostatic symptoms may be prominent.

The heart's initial response to systemic hypertension is to develop concentric left ventricular hypertrophy. Eventually, the left ventricle becomes dilatated. This is reflected on physical examination by a fourth heart sound initially, followed by the typical changes of dilated cardiomyopathy.

Blood pressure must be checked in both arms to screen for aortic dissection or coarctation. If coarctation is suspected, blood pressure also should be measured in the legs. Furthermore, screen for carotid or renal bruits; palpate the precordium, looking for sustained left ventricular lift; and auscultate for a third or fourth heart sound or murmurs.

The patient's volume status must also be assessed with orthostatic vital signs, examination of the jugular veins, assessment of the liver size, and investigation for peripheral edema and pulmonary rales.

Central nervous system

Neurologic presentations are occipital headache, cerebral infarction or hemorrhage, visual disturbance, or hypertensive encephalopathy (a symptom complex of severe hypertension, headache, vomiting, visual disturbance, mental status changes, seizure, and retinopathy with papilledema). Focal signs and symptoms are uncommon and may indicate another process, such as cerebral infarct or hemorrhage.

A complete neurologic examination is needed to screen for localizing signs. Note that focal neurologic signs might not be attributable to encephalopathy; focal signs mandate screening for cerebral hemorrhage, infarct, or the presence of a mass.

Renal, gastrointestinal, and ophthalmologic systems

Renal disease may present as oliguria or any of the typical features of renal failure. Gastrointestinal symptoms are nausea and vomiting; in addition, diffuse arteriolar damage can result in microangiopathic hemolytic anemia.

Patients may complain of blurred vision. A funduscopic examination may reveal flame-shaped retinal hemorrhages, soft exudates, or papilledema (see the following images).[8]

Hypertensive retinopathy. Note the flame-shaped he Hypertensive retinopathy. Note the flame-shaped hemorrhages, soft exudates, and early disc blurring.
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Workup for Malignant Hypertension

Laboratory studies

Initial laboratory studies include a complete blood cell (CBC) count and electrolytes (including calcium), blood urea nitrogen (BUN), creatinine, glucose, coagulation profile, and urinalysis. Other laboratory studies are indicated only as directed by the initial workup. These may include measurements for cardiac enzymes, urinary catecholamines, and thyroid-stimulating hormone (TSH), and 24-hour urine collection for vanillylmandelic acid (VMA) and catecholamines.

Renal function should be evaluated through urinalysis, complete chemistry profile, and CBC count. Expected findings include elevated BUN and creatinine, hyperphosphatemia, hyperkalemia or hypokalemia, glucose abnormalities, acidosis, hypernatremia, and evidence of microangiopathic hemolytic anemia and azotemic oliguric renal failure. Urinalysis may reveal proteinuria, microscopic hematuria, and red blood cell or hyaline casts.

Diffuse intrarenal ischemia results in increased levels of plasma renin, angiotensin II, and aldosterone, with resulting hypovolemia and hypokalemia. Sodium depletion is common and may be severe.[9]

Radiologic studies

Routine screening consists of a chest radiograph, which is useful for assessment of cardiac enlargement, pulmonary edema, or involvement of other thoracic structures, such as rib notching with aortic coarctation or a widened mediastinum with aortic dissection. Other studies, such as head CT scanning, transesophageal echocardiogram (TEE), and renal angiography, are indicated only as directed by the initial workup.

Electrocardiography

An ECG is an essential part of the evaluation to screen for ischemia, infarct, or evidence of electrolyte abnormalities or drug overdose. In the earliest stages of malignant hypertension, electrocardiogram and echocardiogram reveal left atrial enlargement and left ventricular hypertrophy.

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Medical Management

Patients with malignant hypertension are usually admitted to an intensive care unit for continuous cardiac monitoring, frequent assessment of neurologic status and urine output, and administration of intravenous antihypertensive medications and fluids. Patients typically have altered blood pressure autoregulation, and overzealous reduction of blood pressure to reference range levels may result in organ hypoperfusion.

In patients with stroke, cardiac compromise, or renal failure, appropriate consultation should be considered. In institutions with specialists in hypertension, prompt consultation may improve the overall control of blood pressure.

Hypertensive urgencies do not mandate admission to a hospital. The goal of therapy is with these cases is to reduce blood pressure within 24 hours, which can be achieved as an outpatient.

For more information, see Hypertension.

Pharmacotherapy

The initial goal of therapy is to reduce the mean arterial pressure by approximately 25% over the first 24-48 hours. An intra-arterial line is helpful for continuous monitoring of blood pressure. Sodium and volume depletion may be severe, and volume expansion with isotonic sodium chloride solution must be considered.[6] Secondary causes of hypertension should be investigated.

No trials exist comparing the efficacy of various agents in the treatment of malignant hypertension. Drugs are chosen based on their rapidity of action, ease of use, special situations, and convention.

The most commonly used intravenous drug is nitroprusside. An alternative for patients with renal insufficiency is intravenous fenoldopam. Labetalol is another common alternative, providing easy transition from intravenous to oral dosing. However, a trial by Peacock et al demonstrated that intravenous calcium blockers (eg, nicardipine) could be useful in quickly and safely reducing blood pressure to target levels and seemed more effective than intravenous labetalol.[10]

Beta-blockade can be accomplished intravenously with esmolol or metoprolol. Also available parenterally are diltiazem, verapamil, and enalapril. Hydralazine is reserved for use in pregnant patients, whereas phentolamine is the drug of choice for a pheochromocytoma crisis. Oral medications should be initiated as soon as possible in order to ease transition to an outpatient setting.

Diet and Activity

In patients with stroke, cardiac compromise, or renal failure, appropriate consultation should be considered. In institutions with specialists in hypertension, prompt consultation may improve the overall control of blood pressure.

Activity is limited to bedrest until the patient is stable. Patients should be able to resume normal activity as outpatients once their blood pressure has been controlled.

Complications

Overzealous reduction of blood pressure can result in organ hypoperfusion, and target organ damage can be missed without a thorough evaluation. Note that enalapril has an unpredictable response in hypovolemic patients, with a possible uncontrolled drop in blood pressure.

Special Concerns

Properly diagnosing hypertensive emergency and urgency is essential to proper triage and treatment; however, reducing blood pressure too rapidly can result in patient harm. In addition, all patients should be carefully assessed for secondary causes of hypertension, and upon discharge, patients should have close follow-up care. They should know the signs and symptoms that necessitate immediate notification of a physician.

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Surgical Therapy

A therapy under clinical trial involves implantation of a carotid baroreflex stimulator. Early phase III results from the Rheos Pivotal Trial on continuous carotid baroreceptor pacing for resistant hypertesion with a first-generation device were equivocal on safety and efficacy, but initial results with a miniaturized second-generation device appear promising in patients with heart failure.[11] A phase III trial with the second-generation device for resistant hypertension has been registered.[11]

Initially, patients treated for malignant hypertension are instructed to fast until stable. Once stable, all patients should obtain good long-term care of their hypertension, including a diet that is low in salt. If indicated, the patient should follow a diet that can induce weight loss.

For more information, see Hypertension.

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Prognosis and Prevention

In a retrospective analysis of 197 patients with malignant hypertension, Gonzalez et al found that 5 and 10 years after presentation, the chances of renal survival were 84% and 72%, respectively.[12] The investigators examined data from patients diagnosed between 1974 and 2007 and reported predictors of renal outcome included whether or not the patient was diagnosed between 1974 and 1985, the existence of previous chronic renal impairment, the degree of proteinuria and the amount of renal function at baseline, the presence of microhematuria, systolic and diastolic blood pressure values, and the proteinuria value during follow-up.[12] However, after multivariate analysis, the only significant risk factor was found to be the mean proteinuria value during follow-up.[12] At 5 and 10 years after presentation, the chances of renal survival in patients with a mean proteinuria value less than 0.5 g/24 h were 100% and 95%, respectively.[12]

Before the advent of effective therapy, the life expectancy of those affected by malignant hypertension was less than 2 years, with most deaths resulting from stroke, renal failure, or heart failure. The survival rate at 1 year was less than 25%, and at 5 years, it was less than 1%. However, with current therapy, including dialysis, the survival rate at 1 year is greater than 90%, and at 5 years, it is 80%. The most common cause of death is cardiovascular, with stroke and renal failure also common.

A British study that examined survival statistics over the course of 40 years in patients with malignant hypertension found an even higher 5-year survival rate.[13] Reviewing information from 446 patients with malignant hypertension, the authors determined that before 1977, the 5-year survival rate was 32%, whereas for patients who were diagnosed between 1997 and 2006, the 5-year rate was 91%. The investigators suggested that the change was associated with lower targets for and tighter control of patients' blood pressure, along with the availability of additional classes of antihypertensive medications.[13] The authors also found age, baseline creatinine level, and follow-up systolic blood pressure to be independent predictors of survival.

A study by Amraoui et al found a higher all-cause mortality rate in patients with malignant hypertension than in persons who were normotensive or hypertensive, even though the cardiovascular risk profile for the malignant hypertension patients was more favorable than that for the hypertensive controls. The study, which compared 120 patients with a history of malignant hypertension with 120 normotensive and 120 hypertensive persons, found that the malignant hypertension patients had lower total cholesterol, low-density lipoprotein cholesterol, and body mass index values than did the hypertensive controls. However, the median estimated glomerular filtration rate was higher in the normotensive and hypertensive controls than in the malignant hypertension group. Annual all-cause mortality per 100 patient-years was 2.6 for the patients with malignant hypertension, compared with 0.2 and 0.5 for the normotensive and hypertensive controls, respectively.[14]

Prevention

The best way to prevent further episodes of hypertensive emergencies is to ensure that the patient has close outpatient follow-up for hypertension treatment. This can usually be accomplished by a general medicine or family practice physician, but referral to a hypertension specialist should also be considered for patients who require complex drug therapy or additional secondary workup.

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Contributor Information and Disclosures
Author

John D Bisognano, MD, PhD, FACP, FACC Professor of Medicine, Director of Outpatient Cardiology, Department of Medicine, Cardiology Division, University of Rochester Medical Center

John D Bisognano, MD, PhD, FACP, FACC is a member of the following medical societies: American College of Cardiology, American College of Physicians-American Society of Internal Medicine

Disclosure: Nothing to disclose.

Chief Editor

Vecihi Batuman, MD, FACP, FASN Huberwald Professor of Medicine, Section of Nephrology-Hypertension, Tulane University School of Medicine; Chief, Renal Section, Southeast Louisiana Veterans Health Care System

Vecihi Batuman, MD, FACP, FASN is a member of the following medical societies: American College of Physicians, American Society of Hypertension, American Society of Nephrology, International Society of Nephrology

Disclosure: Nothing to disclose.

Acknowledgements

George R Aronoff, MD Director, Professor, Departments of Internal Medicine and Pharmacology, Section of Nephrology, Kidney Disease Program, University of Louisville School of Medicine

George R Aronoff, MD is a member of the following medical societies: American Federation for Medical Research, American Society of Nephrology, Kentucky Medical Association, and National Kidney Foundation

Disclosure: Nothing to disclose.

L Michael Prisant, MD, FACC, FAHA Cardiologist, Emeritus Professor of Medicine, Medical College of Georgia

L Michael Prisant, MD, FACC, FAHA is a member of the following medical societies: American College of Cardiology, American College of Chest Physicians, American College of Clinical Pharmacology, American College of Forensic Examiners, American College of Physicians, American Heart Association, and American Medical Association

Disclosure: Boehringer-Ingelheim Honoraria Speaking and teaching

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

References
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  2. Rodriguez MA, Kumar SK, De Caro M. Hypertensive crisis. Cardiol Rev. 2010 Mar-Apr. 18(2):102-7. [Medline].

  3. Polgreen LA, Suneja M, Tang F, Carter BL, Polgreen PM. Increasing trend in admissions for malignant hypertension and hypertensive encephalopathy in the United States. Hypertension. 2015 May. 65 (5):1002-7. [Medline].

  4. Patel A, Patel H, Patel A. Thrombotic thrombocytopenic purpura: the masquerader. South Med J. 2009 May. 102(5):504-9. [Medline].

  5. Khanal N, Dahal S, Upadhyay S, Bhatt VR, Bierman PJ. Differentiating malignant hypertension-induced thrombotic microangiopathy from thrombotic thrombocytopenic purpura. Ther Adv Hematol. 2015 Jun. 6 (3):97-102. [Medline].

  6. Pergolini MS. The management of hypertensive crises: a clinical review. Clin Ter. 2009 Mar-Apr. 160(2):151-7. [Medline].

  7. Calhoun DA, Jones D, Textor S, et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008 Jun. 51(6):1403-19. [Medline].

  8. Shukla D, Ramchandani B, Vignesh TP, Rajendran A, Neelakantan N. Localized serous retinal detachment of macula as a marker of malignant hypertension. Ophthalmic Surg Lasers Imaging. 2010 Mar 9. 1-7. [Medline].

  9. Lopes AA. End-stage renal disease due to diabetes in racial/ethnic minorities and disadvantaged populations. Ethn Dis. 2009 Spring. 19(1 Suppl 1):S1-47-51. [Medline].

  10. Peacock WF, Varon J, Baumann BM, et al. CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department. Crit Care. 2011. 15(3):R157. [Medline].

  11. Victor RG. Carotid baroreflex activation therapy for resistant hypertension. Nat Rev Cardiol. 2015 Aug. 12(8):451-63. [Medline].

  12. Gonzalez R, Morales E, Segura J, Ruilope LM, Praga M. Long-term renal survival in malignant hypertension. Nephrol Dial Transplant. 2010 Oct. 25(10):3266-72. [Medline].

  13. Lane DA, Lip GY, Beevers DG. Improving survival of malignant hypertension patients over 40 years. Am J Hypertens. 2009 Nov. 22(11):1199-204. [Medline].

  14. Amraoui F, Van Der Hoeven NV, Van Valkengoed IG, et al. Mortality and cardiovascular risk in patients with a history of malignant hypertension: a case-control study. J Clin Hypertens (Greenwich). 2014 Feb. 16(2):122-6. [Medline].

  15. Filippone JD, Sloand JA, Illig KA, Bisognano JD. Electrical stimulation of the carotid sinus for the treatment of resistant hypertension. Curr Hypertens Rep. 2006 Oct. 8(5):420-4. [Medline].

 
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Papilledema. Note the swelling of the optic disc, with blurred margins.
Hypertensive retinopathy. Note the flame-shaped hemorrhages, soft exudates, and early disc blurring.
 
 
 
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