eMedicine Specialties > Nephrology > Tubulointerstitial Diseases of the Kidney
Nephritis, Interstitial: Multimedia
Updated: Nov 11, 2009
Multimedia
 | Media file 1: Kidney biopsy. This is an example of acute interstitial nephritis. The renal cortex shows a diffuse interstitial, predominantly mononuclear, inflammatory infiltrate with no changes to the glomerulus. Tubules in the center of the field are separated by inflammation and edema, as compared with the more normal architecture in the right lower area (periodic acid-Schiff, 40 X). |
 | Media file 2: Kidney biopsy. Shown here is an example of acute interstitial nephritis. The diagnosis is based on the active inflammatory infiltrate on the right with unaffected glomeruli. Interstitial edema and fibrosis are present on the left side of the field, where some tubules show thickened basement membrane (hematoxylin and eosin, 20 X). |
 | Media file 3: Kidney biopsy. This image shows acute interstitial nephritis. The interstitium is expanded by mononuclear inflammatory infiltrate and edema. Acute tubular damage is present; some tubules are distended and contain granular casts (hematoxylin and eosin, 40 X). |
 | Media file 4: Kidney biopsy in interstitial nephritis. Acute crescentic glomerulonephritis. The glomerular tuft is compressed by the proliferation of epithelial cells, forming a crescent. The interstitium shows mononuclear inflammatory infiltrate and edema (periodic acid-Schiff, 40 X). |
 | Media file 5: Kidney biopsy. This image shows acute interstitial nephritis. The mononuclear inflammatory infiltrate contains abundant eosinophils, suggesting an allergic etiology. Severe tubular damage is observed (hematoxylin and eosin, 40 X). |
 | Media file 6: Kidney biopsy. This image shows acute interstitial nephritis. The inflammatory infiltrate forms an ill-defined granuloma, suggesting allergic or infectious etiologies. A partially destroyed tubule is present (periodic acid-Schiff, 40 X). |
 | Media file 7: Kidney biopsy. This image shows chronic tubulointerstitial nephritis. The interstitium is expanded by fibrosis, with distortion of tubules and periglomerular fibrosis. Glomeruli do not show pathologic changes (hematoxylin and eosin, 20 X). |
 | Media file 8: Kidney biopsy in interstitial nephritis. This image shows a cholesterol microembolism. The 2 arterioles in the center are occluded by elongated crystals (hematoxylin and eosin, 20 X). |
 | Media file 9: Kidney biopsy in interstitial nephritis. This image shows a cholesterol microembolism. The arteriole in the center of the field has a thickened wall. The lumen is occluded by elongated spaces, corresponding to dissolved crystals surrounded by cellular reaction. The 2 glomeruli flanking the arteriole are sclerotic and hardly recognizable (hematoxylin and eosin, 40 X). |
More on Nephritis, Interstitial |
| Overview: Nephritis, Interstitial |
| Differential Diagnoses & Workup: Nephritis, Interstitial |
| Treatment & Medication: Nephritis, Interstitial |
| Follow-up: Nephritis, Interstitial |
 Multimedia: Nephritis, Interstitial |
| References |
| Further Reading |
| « Previous Page |
References
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Further Reading
Related eMedicine topics:
Acute Renal Failure
Alport Syndrome [Nephrology]
Alport Syndrome [Pediatrics: General Medicine]
Goodpasture Syndrome [Nephrology]
Goodpasture Syndrome [Pediatrics: General Medicine]
Hypersensitivity Nephropathy
Lead Nephropathy
Nephritis
Nephritis, Lupus
Papillary Necrosis [Radiology]
Papillary Necrosis [Urology]
Renal Failure, Acute
Clinical guidelines:
ACR Appropriateness Criteria® renal failure. American College of Radiology - Medical Specialty Society. 1995 (revised 2008). 10 pages. NGC:007019
K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease. National Kidney Foundation - Disease Specific Society. 2004 May. 290 pages. NGC:003985
Clinical trials:
Abatacept and Cyclophosphamide Combination Therapy for Lupus Nephritis (ACCESS)
Etanercept for the Treatment of Lupus Nephritis
Immune System Related Kidney Disease
Study of Systemic Lupus Erythematosus
Keywords
interstitial nephritis, nephritis, kidney disease, obstructive uropathy, acute interstitial nephritis, nephritis lupus, analgesic nephropathy, end-stage renal disease, tubulointerstitial diseases, tubulointerstitial nephritis, acute tubulointerstitial nephritis, chronic tubulointerstitial nephritis, lithium nephropathy, cyclosporine-induced nephropathy, tacrolimus-induced nephropathy, lead nephropathy, atherosclerotic kidney disease, cholesterol microembolic disease, Balkan endemic nephropathy, Chinese herb nephropathy
