eMedicine Specialties > Nephrology > Acid-Base, Fluid, and Electrolyte Disorders

Syndrome of Inappropriate Secretion of Antidiuretic Hormone: Follow-up

Author: Sonali Deshmukh, MBBS, Consulting Staff, Omaha Nephrology, Nebraska
Coauthor(s): Christie P Thomas, MB, BS, FRCP, FASN, FAHA, Professor, Department of Internal Medicine, Division of Nephrology, University of Iowa Hospitals and Clinics; Director of Transplantation Services, Veterans Affairs Medical Center
Contributor Information and Disclosures

Updated: May 28, 2009

Follow-up

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Medicolegal Pitfalls

  • Consult a nephrologist to help with the management of patients presenting with hyponatremia and mental status changes.
 


More on Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Overview: Syndrome of Inappropriate Secretion of Antidiuretic Hormone
Differential Diagnoses & Workup: Syndrome of Inappropriate Secretion of Antidiuretic Hormone
Treatment & Medication: Syndrome of Inappropriate Secretion of Antidiuretic Hormone
Follow-up: Syndrome of Inappropriate Secretion of Antidiuretic Hormone
References
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References

  1. Schwartz WB, Bennett W, Curelop S, et al. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. 1957. J Am Soc Nephrol. Dec 2001;12(12):2860-70. [Medline].

  2. Clayton JA, Le Jeune IR, Hall IP. Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome. QJM. Aug 2006;99(8):505-11. [Medline].

  3. Decaux G. Is asymptomatic hyponatremia really asymptomatic?. Am J Med. Jul 2006;119(7 Suppl 1):S79-82. [Medline].

  4. Wong F, Blei AT, Blendis LM, et al. A vasopressin receptor antagonist (VPA-985) improves serum sodium concentration in patients with hyponatremia: a multicenter, randomized, placebo-controlled trial. Hepatology. Jan 2003;37(1):182-91. [Medline].

  5. Adrogué HJ, Madias NE. Hyponatremia. N Engl J Med. May 25 2000;342(21):1581-9. [Medline].

  6. Arieff AI, Llach F, Massry SG. Neurological manifestations and morbidity of hyponatremia: correlation with brain water and electrolytes. Medicine (Baltimore). Mar 1976;55(2):121-9. [Medline].

  7. Bichet DG, Razi M, Lonergan M, et al. Hemodynamic and coagulation responses to 1-desamino[8-D-arginine] vasopressin in patients with congenital nephrogenic diabetes insipidus. N Engl J Med. Apr 7 1988;318(14):881-7. [Medline].

  8. Decaux G. Long-term treatment of patients with inappropriate secretion of antidiuretic hormone by the vasopressin receptor antagonist conivaptan, urea, or furosemide. Am J Med. May 2001;110(7):582-4. [Medline].

  9. Decaux G, Brimioulle S, Genette F, et al. Treatment of the syndrome of inappropriate secretion of antidiuretic hormone by urea. Am J Med. Jul 1980;69(1):99-106. [Medline].

  10. Decaux G, Genette F. Urea for long-term treatment of syndrome of inappropriate secretion of antidiuretic hormone. Br Med J (Clin Res Ed). Oct 24 1981;283(6299):1081-3. [Medline].

  11. Decaux G, Prospert F, Penninckx R, et al. 5-year treatment of the chronic syndrome of inappropriate secretion of ADH with oral urea. Nephron. 1993;63(4):468-70. [Medline].

  12. Gerbes AL, Gulberg V, Gines P, et al. Therapy of hyponatremia in cirrhosis with a vasopressin receptor antagonist: a randomized double-blind multicenter trial. Gastroenterology. Apr 2003;124(4):933-9. [Medline].

  13. Gross P. Treatment of severe hyponatremia. Kidney Int. Dec 2001;60(6):2417-27. [Medline].

  14. Gross P, Verbalis J, Berl T. Hyponatremia management with a once-daily, oral vasopressin V2 receptor antagonist for up to one year: first report of the tolvaptan SALT2 study [oral presentation]. Presented at the ASN Congress. November 11, 2005.

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  21. Rose BD, Post TW, eds. Clinical Physiology of Acid-Base and Electrolyte Disorders. 5th ed. New York: McGraw-Hill; 2000.

  22. [Best Evidence] Schrier RW, Gross P, Gheorghiade M, Berl T, Verbalis JG, Czerwiec FS, et al. Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med. Nov 16 2006;355(20):2099-112. [Medline]. [Full Text].

  23. Seldin DW, Giebisch GH, eds. The Kidney: Physiology and Pathophysiology. Vol 1. Philadelphia: Lippincott-Raven; 1991:1133-74.

  24. Serradeil-Le Gal C, Wagnon J, Valette G, et al. Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. [Medline].

  25. Soupart A, Decaux G. Therapeutic recommendations for management of severe hyponatremia: current concepts on pathogenesis and prevention of neurologic complications. Clin Nephrol. Sep 1996;46(3):149-69. [Medline].

  26. Sterns RH. Severe symptomatic hyponatremia: treatment and outcome. A study of 64 cases. Ann Intern Med. Nov 1987;107(5):656-64. [Medline].

  27. Sterns RH. The treatment of hyponatremia: first, do no harm. Am J Med. Jun 1990;88(6):557-60. [Medline].

  28. Verbalis JG. AVP receptor antagonists as aquaretics: review and assessment of clinical data. Cleve Clin J Med. Sep 2006;73 Suppl 3:S24-33. [Medline].

  29. Verbalis JG. Vasopressin V2 receptor antagonists. J Mol Endocrinol. Aug 2002;29(1):1-9. [Medline].

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Further Reading

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Keywords

syndrome of inappropriate secretion of antidiuretic hormone, syndrome of inappropriate secretion of ADH, SIADH, ADH, antidiuretic hormone, antidiuretic hormone disorder, arginine vasopressin, AVP, hyponatremia, low serum osmolality, expanded extracellular volume, water balance, impaired water excretion, dilutional hyponatremia

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Contributor Information and Disclosures

Author

Sonali Deshmukh, MBBS, Consulting Staff, Omaha Nephrology, Nebraska
Sonali Deshmukh, MBBS is a member of the following medical societies: American Society of Nephrology
Disclosure: Nothing to disclose.

Coauthor(s)

Christie P Thomas, MB, BS, FRCP, FASN, FAHA, Professor, Department of Internal Medicine, Division of Nephrology, University of Iowa Hospitals and Clinics; Director of Transplantation Services, Veterans Affairs Medical Center
Christie P Thomas, MB, BS, FRCP, FASN, FAHA is a member of the following medical societies: American College of Physicians, American Federation for Medical Research, American Heart Association, American Society of Nephrology, American Society of Transplantation, American Thoracic Society, International Society of Nephrology, and Royal College of Physicians
Disclosure: Genzyme Grant/research funds Other

Medical Editor

Chike Magnus Nzerue, MD, Associate Dean for Clinical Affairs, Meharry Medical College
Chike Magnus Nzerue, MD is a member of the following medical societies: American Association for the Advancement of Science, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Society of Nephrology, and National Kidney Foundation
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Eleanor Lederer, MD, Consulting Staff, Louisville VA Hospital; Professor of Medicine, Director of Nephrology Training Program, Kidney Disease Program, University of Louisville School of Medicine; Director, Metabolic Stone Clinic
Eleanor Lederer, MD is a member of the following medical societies: American Association for the Advancement of Science, American Federation for Medical Research, American Society for Biochemistry and Molecular Biology, American Society for Bone and Mineral Research, American Society of Nephrology, American Society of Transplantation, International Society of Nephrology, Kentucky Medical Association, National Kidney Foundation, and Phi Beta Kappa
Disclosure: Nothing to disclose.

CME Editor

Rebecca J Schmidt, DO, FACP, FASN, Professor of Medicine, Section Chief, Department of Medicine, Section of Nephrology, West Virginia University School of Medicine
Rebecca J Schmidt, DO, FACP, FASN is a member of the following medical societies: American College of Osteopathic Internists, American College of Physicians, American Medical Association, American Society of Nephrology, International Society of Nephrology, National Kidney Foundation, Renal Physicians Association, and West Virginia State Medical Association
Disclosure: Abbott Grant/research funds Speaking and teaching; Genzyme Honoraria Consulting; Amgen Honoraria Speaking and teaching; Ortho Biotech Honoraria Speaking and teaching

Chief Editor

Vecihi Batuman, MD, FACP, FASN, Professor of Medicine, Section of Nephrology-Hypertension, Tulane University School of Medicine; Chief, Medicine Service, Southeast Louisiana Veterans Health Care System
Vecihi Batuman, MD, FACP, FASN is a member of the following medical societies: American College of Physicians, American Society of Hypertension, American Society of Nephrology, and International Society of Nephrology
Disclosure: Nothing to disclose.

 
 
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