eMedicine Specialties > Neurosurgery > Spine

Skull Base Tumors: Multimedia

Author: Todd C Hankinson, MD, MBA, Resident in Neurological Surgery, Department of Neurological Surgery, Neurological Institute of New York, Columbia University
Coauthor(s): Jeffrey N Bruce, MD, Edgar M Housepian Professor of Neurological Surgery Research, Professor of Neurological Surgery, Director of Brain Tumor Tissue Bank, Director of Bartoli Brain Tumor Laboratory, Department of Neurosurgery, Columbia University College of Physicians and Surgeons; Grant P Sinson, MD, Associate Professor, Department of Neurosurgery, Medical College of Wisconsin; G Timothy Reiter, MD, Assistant Professor, Department of Neurosurgery, Penn State College of Medicine; Director, Department of Spinal Neurosurgery and Neurotrauma, Penn State Hershey Medical Center
Contributor Information and Disclosures

Updated: May 29, 2007

Multimedia

Osteoma. CT scan with axial bone windows and coro...Media file 1: Osteoma. CT scan with axial bone windows and coronal plane reconstruction that demonstrates a fibrous osteoma that involves the right orbit and the floor of the anterior cranial fossa.
Osteoma. CT scan with axial bone windows and coro...

Osteoma. CT scan with axial bone windows and coronal plane reconstruction that demonstrates a fibrous osteoma that involves the right orbit and the floor of the anterior cranial fossa.

Intracranial plasmacytoma. Sagittal and axial T1-...Media file 2: Intracranial plasmacytoma. Sagittal and axial T1-weighted MRI with contrast enhancement demonstrate a right-sided plasmacytoma of the petrous bone. This tumor was treated through a far lateral approach and suboccipital craniotomy following a superselective embolization of feeding arteries.
Intracranial plasmacytoma. Sagittal and axial T1-...

Intracranial plasmacytoma. Sagittal and axial T1-weighted MRI with contrast enhancement demonstrate a right-sided plasmacytoma of the petrous bone. This tumor was treated through a far lateral approach and suboccipital craniotomy following a superselective embolization of feeding arteries.

Paraganglioma. Contrast-enhanced MRI scan of the ...Media file 3: Paraganglioma. Contrast-enhanced MRI scan of the axial (left) and coronal (right) planes that demonstrates a paraganglioma (glomus jugulare) at the right cerebellopontine angle. Extension out of the jugular foramen into the extracranial soft tissue is visible (right).
Paraganglioma. Contrast-enhanced MRI scan of the ...

Paraganglioma. Contrast-enhanced MRI scan of the axial (left) and coronal (right) planes that demonstrates a paraganglioma (glomus jugulare) at the right cerebellopontine angle. Extension out of the jugular foramen into the extracranial soft tissue is visible (right).

Paraganglioma. Arterial phase external carotid ar...Media file 4: Paraganglioma. Arterial phase external carotid artery angiograms of the patient in Image 3. Pre-embolization imaging (left) demonstrates the rich vascularity of the tumor. Postembolization imaging (right) demonstrates that the arterial feeding vessels have been significantly reduced.
Paraganglioma. Arterial phase external carotid ar...

Paraganglioma. Arterial phase external carotid artery angiograms of the patient in Image 3. Pre-embolization imaging (left) demonstrates the rich vascularity of the tumor. Postembolization imaging (right) demonstrates that the arterial feeding vessels have been significantly reduced.

Esthesioneuroblastoma. A 39-year-old man presente...Media file 5: Esthesioneuroblastoma. A 39-year-old man presented with 1 month of decreased vision, left facial numbness, and swelling. Physical examination demonstrated left-sided exophthalmos and blindness. He was also unable to smell. Contrast-enhanced T1-weighted MRI demonstrated a large lesion that originated in the paranasal sinuses and extended through the cribriform plate into the anterior cranial fossa. He underwent a bifrontal craniotomy for resection of this tumor.
Esthesioneuroblastoma. A 39-year-old man presente...

Esthesioneuroblastoma. A 39-year-old man presented with 1 month of decreased vision, left facial numbness, and swelling. Physical examination demonstrated left-sided exophthalmos and blindness. He was also unable to smell. Contrast-enhanced T1-weighted MRI demonstrated a large lesion that originated in the paranasal sinuses and extended through the cribriform plate into the anterior cranial fossa. He underwent a bifrontal craniotomy for resection of this tumor.

Clival chondrosarcoma. Contrast-enhanced T1-weigh...Media file 6: Clival chondrosarcoma. Contrast-enhanced T1-weighted MRI in the coronal plane. This tumor involved the clivus and posterior clinoid and encroached on the optic chiasm in the suprasellar region. It was subtotally resected through a frontotemporal craniotomy with a zygomatic osteotomy.
Clival chondrosarcoma. Contrast-enhanced T1-weigh...

Clival chondrosarcoma. Contrast-enhanced T1-weighted MRI in the coronal plane. This tumor involved the clivus and posterior clinoid and encroached on the optic chiasm in the suprasellar region. It was subtotally resected through a frontotemporal craniotomy with a zygomatic osteotomy.

Chordoma. T1-weighted MRI with contrast that demo...Media file 7: Chordoma. T1-weighted MRI with contrast that demonstrates an enhancing mass that replaced the clivus and invaded the right cavernous sinus. This lesion was subtotally resected using a sublabial approach. The patient was then treated with gamma knife radiosurgery (GKRS).
Chordoma. T1-weighted MRI with contrast that demo...

Chordoma. T1-weighted MRI with contrast that demonstrates an enhancing mass that replaced the clivus and invaded the right cavernous sinus. This lesion was subtotally resected using a sublabial approach. The patient was then treated with gamma knife radiosurgery (GKRS).

Fibrous dysplasia. Coronal reconstruction of none...Media file 8: Fibrous dysplasia. Coronal reconstruction of nonenhanced CT scan that demonstrates fibrous dysplasia of the right orbit with extension into the floor of the anterior fossa. This lesion was completely resected using a multidisciplinary team and a craniofacial approach that included a bifrontal craniotomy
Fibrous dysplasia. Coronal reconstruction of none...

Fibrous dysplasia. Coronal reconstruction of nonenhanced CT scan that demonstrates fibrous dysplasia of the right orbit with extension into the floor of the anterior fossa. This lesion was completely resected using a multidisciplinary team and a craniofacial approach that included a bifrontal craniotomy

Vestibular schwannoma. T1-weighted MRI scan that ...Media file 9: Vestibular schwannoma. T1-weighted MRI scan that demonstrates a large left-sided vestibular schwannoma in a 19-year-old woman with neurofibromatosis type II. Also present on the left is a vagal (tenth nerve) schwannoma. A residual tumor from a right-sided vestibular schwannoma, which was previously operated on, is visible. These lesions were resected through a retrosigmoid approach and suboccipital craniectomy.
Vestibular schwannoma. T1-weighted MRI scan that ...

Vestibular schwannoma. T1-weighted MRI scan that demonstrates a large left-sided vestibular schwannoma in a 19-year-old woman with neurofibromatosis type II. Also present on the left is a vagal (tenth nerve) schwannoma. A residual tumor from a right-sided vestibular schwannoma, which was previously operated on, is visible. These lesions were resected through a retrosigmoid approach and suboccipital craniectomy.

Hypoglossal schwannoma. Precontrast (left) and Po...Media file 10: Hypoglossal schwannoma. Precontrast (left) and Postcontrast (right) T1-weighted MRI scans that demonstrate a right-sided schwannoma of the hypoglossal (XII) nerve. This tumor was completely resected using an extreme lateral approach and suboccipital craniectomy.
Hypoglossal schwannoma. Precontrast (left) and Po...

Hypoglossal schwannoma. Precontrast (left) and Postcontrast (right) T1-weighted MRI scans that demonstrate a right-sided schwannoma of the hypoglossal (XII) nerve. This tumor was completely resected using an extreme lateral approach and suboccipital craniectomy.

Foramen magnum meningioma. Contrast-enhanced T1-w...Media file 11: Foramen magnum meningioma. Contrast-enhanced T1-weighted MRI scans that demonstrate a ventral, left-sided meningioma at the foramen magnum. This tumor was completely resected using a far lateral approach and suboccipital craniotomy with C1 laminectomy.
Foramen magnum meningioma. Contrast-enhanced T1-w...

Foramen magnum meningioma. Contrast-enhanced T1-weighted MRI scans that demonstrate a ventral, left-sided meningioma at the foramen magnum. This tumor was completely resected using a far lateral approach and suboccipital craniotomy with C1 laminectomy.

Multiple skull base meningiomas. Contrast-enhance...Media file 12: Multiple skull base meningiomas. Contrast-enhanced T1-weighted MRI in the coronal (above) and sagittal (below) planes demonstrates a large left-sided petroclival meningioma and a right-sided meningioma at the foramen magnum. After shunt placement to treat hydrocephalus, the petroclival tumor was resected using a presigmoid approach. The foramen magnum tumor was subsequently resected.
Multiple skull base meningiomas. Contrast-enhance...

Multiple skull base meningiomas. Contrast-enhanced T1-weighted MRI in the coronal (above) and sagittal (below) planes demonstrates a large left-sided petroclival meningioma and a right-sided meningioma at the foramen magnum. After shunt placement to treat hydrocephalus, the petroclival tumor was resected using a presigmoid approach. The foramen magnum tumor was subsequently resected.

Right sphenoid wing meningioma with intraorbital ...Media file 13: Right sphenoid wing meningioma with intraorbital involvement. Contrast-enhanced T1-weighted sagittal MRI scan. This tumor manifested as slowly progressive unilateral vision loss and mild proptosis on the right. It was resected using a frontotemporal craniotomy with orbitozygomatic osteotomy. Note the right sphenoid hyperostosis, which is best seen on the axial image (Image 14).
Right sphenoid wing meningioma with intraorbital ...

Right sphenoid wing meningioma with intraorbital involvement. Contrast-enhanced T1-weighted sagittal MRI scan. This tumor manifested as slowly progressive unilateral vision loss and mild proptosis on the right. It was resected using a frontotemporal craniotomy with orbitozygomatic osteotomy. Note the right sphenoid hyperostosis, which is best seen on the axial image (Image 14).

Right sphenoid wing meningioma with intraorbital ...Media file 14: Right sphenoid wing meningioma with intraorbital involvement. Contrast-enhanced T1-weighted axial MRI scan (same patient as Image 13). This tumor manifested as slowly progressive unilateral vision loss and mild proptosis on the right side. It was resected using a frontotemporal craniotomy with orbitozygomatic osteotomy. Note the right sphenoid hyperostosis.
Right sphenoid wing meningioma with intraorbital ...

Right sphenoid wing meningioma with intraorbital involvement. Contrast-enhanced T1-weighted axial MRI scan (same patient as Image 13). This tumor manifested as slowly progressive unilateral vision loss and mild proptosis on the right side. It was resected using a frontotemporal craniotomy with orbitozygomatic osteotomy. Note the right sphenoid hyperostosis.

Meningioma of the tuberculum sella. Contrast-enha...Media file 15: Meningioma of the tuberculum sella. Contrast-enhanced T1-weighted MRI scan that demonstrates a meningioma in a patient who presented with headaches and slowly progressive visual loss. Note the broad dural base, best appreciated on the sagittal image (right). This lesion was completely removed using a frontotemporal craniotomy with orbital osteotomy.
Meningioma of the tuberculum sella. Contrast-enha...

Meningioma of the tuberculum sella. Contrast-enhanced T1-weighted MRI scan that demonstrates a meningioma in a patient who presented with headaches and slowly progressive visual loss. Note the broad dural base, best appreciated on the sagittal image (right). This lesion was completely removed using a frontotemporal craniotomy with orbital osteotomy.

Hemangiopericytoma. Contrast enhanced T1-weighted...Media file 16: Hemangiopericytoma. Contrast enhanced T1-weighted MRI scans that demonstrates a large hemangiopericytoma originating from the floor of the anterior fossa in a young man with progressive headaches, blurred vision, and papilledema. This tumor was subtotally resected through a frontotemporal craniotomy with orbital osteotomy.
Hemangiopericytoma. Contrast enhanced T1-weighted...

Hemangiopericytoma. Contrast enhanced T1-weighted MRI scans that demonstrates a large hemangiopericytoma originating from the floor of the anterior fossa in a young man with progressive headaches, blurred vision, and papilledema. This tumor was subtotally resected through a frontotemporal craniotomy with orbital osteotomy.

Adenoid cystic carcinoma. A T1-weighted image fro...Media file 17: Adenoid cystic carcinoma. A T1-weighted image from an MRI scan that demonstrates a tumor (red arrow) that involves the ethmoid sinuses and cribriform plate.
Adenoid cystic carcinoma. A T1-weighted image fro...

Adenoid cystic carcinoma. A T1-weighted image from an MRI scan that demonstrates a tumor (red arrow) that involves the ethmoid sinuses and cribriform plate.

Adenoid cystic carcinoma. Extension of the tumor ...Media file 18: Adenoid cystic carcinoma. Extension of the tumor into the middle fossa anterior to the temporal lobe (blue arrow).
Adenoid cystic carcinoma. Extension of the tumor ...

Adenoid cystic carcinoma. Extension of the tumor into the middle fossa anterior to the temporal lobe (blue arrow).

Petroclival meningioma. Contrast-enhanced T1-weig...Media file 19: Petroclival meningioma. Contrast-enhanced T1-weighted and a T2-weighted (upper right) MRI scan that demonstrates a large left-sided petroclival meningioma. This tumor was near totally resected using a presigmoid approach. The patient subsequently underwent gamma knife radiosurgery (GKRS) for the treatment of the residual tumor.
Petroclival meningioma. Contrast-enhanced T1-weig...

Petroclival meningioma. Contrast-enhanced T1-weighted and a T2-weighted (upper right) MRI scan that demonstrates a large left-sided petroclival meningioma. This tumor was near totally resected using a presigmoid approach. The patient subsequently underwent gamma knife radiosurgery (GKRS) for the treatment of the residual tumor.

Skull base tumors. Sagittal enhanced T1-weighted ...Media file 20: Skull base tumors. Sagittal enhanced T1-weighted image from an MRI scan that shows a hypointense mass (blue arrow) anterior to the brainstem.
Skull base tumors. Sagittal enhanced T1-weighted ...

Skull base tumors. Sagittal enhanced T1-weighted image from an MRI scan that shows a hypointense mass (blue arrow) anterior to the brainstem.

Skull base tumors. Axial T2-weighted image from a...Media file 21: Skull base tumors. Axial T2-weighted image from an MRI scan that demonstrates a hyperintense mass (blue arrow) anterior to and compressing the brainstem.
Skull base tumors. Axial T2-weighted image from a...

Skull base tumors. Axial T2-weighted image from an MRI scan that demonstrates a hyperintense mass (blue arrow) anterior to and compressing the brainstem.

Squamous cell carcinoma. Venous phase of a cerebr...Media file 22: Squamous cell carcinoma. Venous phase of a cerebral angiogram that demonstrates filling of the right transverse sinus (red arrow) but no filling of the left transverse sinus (blue arrow).
Squamous cell carcinoma. Venous phase of a cerebr...

Squamous cell carcinoma. Venous phase of a cerebral angiogram that demonstrates filling of the right transverse sinus (red arrow) but no filling of the left transverse sinus (blue arrow).

Squamous cell carcinoma. Balloon test occlusion w...Media file 23: Squamous cell carcinoma. Balloon test occlusion with the balloon inflated in the right transverse sinus (red arrow).
Squamous cell carcinoma. Balloon test occlusion w...

Squamous cell carcinoma. Balloon test occlusion with the balloon inflated in the right transverse sinus (red arrow).

Squamous cell carcinoma. Venous phase of a cerebr...Media file 24: Squamous cell carcinoma. Venous phase of a cerebral angiogram with the balloon occluding the right transverse sinus (red arrow).
Squamous cell carcinoma. Venous phase of a cerebr...

Squamous cell carcinoma. Venous phase of a cerebral angiogram with the balloon occluding the right transverse sinus (red arrow).

Gamma knife radiosurgery plan. This patient prese...Media file 25: Gamma knife radiosurgery plan. This patient presented with adenoid cystic carcinoma of the right lacrimal gland. The tumor metastasized to the right middle fossa and cavernous sinus.
Gamma knife radiosurgery plan. This patient prese...

Gamma knife radiosurgery plan. This patient presented with adenoid cystic carcinoma of the right lacrimal gland. The tumor metastasized to the right middle fossa and cavernous sinus.

Radiation necrosis. The same patient from Image 2...Media file 26: Radiation necrosis. The same patient from Image 25 subsequently developed tumor recurrence and underwent right orbital exenteration and further gamma knife radiosurgery (GKRS). He presented 18 months later with new headaches and seizures. Contrast-enhanced T1-weighted and T2 FLAIR (center) MRI demonstrate radiation necrosis at the site of previous radiation therapy.
Radiation necrosis. The same patient from Image 2...

Radiation necrosis. The same patient from Image 25 subsequently developed tumor recurrence and underwent right orbital exenteration and further gamma knife radiosurgery (GKRS). He presented 18 months later with new headaches and seizures. Contrast-enhanced T1-weighted and T2 FLAIR (center) MRI demonstrate radiation necrosis at the site of previous radiation therapy.

Giant pituitary adenoma. Contrast-enhanced MRI sc...Media file 27: Giant pituitary adenoma. Contrast-enhanced MRI scan that demonstrates a very large pituitary adenoma with significant suprasellar extension. Large tumors of the sellar and suprasellar region may require a combined craniotomy and trans-sphenoidal approach to achieve complete resection.
Giant pituitary adenoma. Contrast-enhanced MRI sc...

Giant pituitary adenoma. Contrast-enhanced MRI scan that demonstrates a very large pituitary adenoma with significant suprasellar extension. Large tumors of the sellar and suprasellar region may require a combined craniotomy and trans-sphenoidal approach to achieve complete resection.

More on Skull Base Tumors

Overview: Skull Base Tumors
Workup: Skull Base Tumors
Treatment: Skull Base Tumors
Follow-up: Skull Base Tumors
Multimedia: Skull Base Tumors
References

References

  1. Schwartz TH, Rhiew R, Isaacson SR, Orazi A, Bruce JN. Association between intracranial plasmacytoma and multiple myeloma: clinicopathological outcome study. Neurosurgery. Nov 2001;49(5):1039-44; discussion 1044-5. [Medline].

  2. Greenberg M. Handbook of Neurosurgery. 5th Edition. New York: Thieme; 2001:447.

  3. Burger PC. Surgical Pathology of the Nervous System and its Coverings. 4th ed. New York: Churchill-Livingstone; 2002:p. 15.

  4. Van Havenbergh T, Carvalho G, Tatagiba M, Plets C, Samii M. Natural history of petroclival meningiomas. Neurosurgery. Jan 2003;52(1):55-62; discussion 62-4. [Medline].

  5. Pieper DR, LaRouere M, Jackson IT. Operative management of skull base malignancies: choosing the appropriate approach. Neurosurg Focus. May 15 2002;12(5):e6. [Medline].

  6. Origitano TC, Petruzzelli GJ, Vandevender D, Emami B. Management of malignant tumors of the anterior and anterolateral skull base. Neurosurg Focus. May 15 2002;12(5):e7. [Medline].

  7. McGrew BM, Jackson CG, Redtfeldt RA. Lateral skull base malignancies. Neurosurg Focus. May 15 2002;12(5):e8. [Medline].

  8. Kryzanski JT, Annino DJ Jr, Heilman CB. Complication avoidance in the treatment of malignant tumors of the skull base. Neurosurg Focus. May 15 2002;12(5):e11. [Medline].

  9. Pollock BE. Stereotactic radiosurgery for intracranial meningiomas: indications and results. Neurosurg Focus. May 15 2003;14(5):e4. [Medline].

  10. Kondziolka D, Lunsford LD, Flickinger JC. Comparison of management options for patients with acoustic neuromas. Neurosurg Focus. May 15 2003;14(5):e1. [Medline].

  11. Witt TC. Stereotactic radiosurgery for pituitary tumors. Neurosurg Focus. May 15 2003;14(5):e10. [Medline].

  12. Osborn A.G. Diagnostic Neuroradiology. St. Louis, Mosby. 1994;1st Ed:p.550.

  13. Cavallo LM, Messina A, Cappabianca P, Esposito F, de Divitiis E, Gardner P, et al. Endoscopic endonasal surgery of the midline skull base: anatomical study and clinical considerations. Neurosurg Focus. Jul 15 2005;19(1):E2. [Medline].

  14. Sekhar LN, Swamy NK, Jaiswal V, Rubinstein E, Hirsch WE Jr, Wright DC. Surgical excision of meningiomas involving the clivus: preoperative and intraoperative features as predictors of postoperative functional deterioration. J Neurosurg. Dec 1994;81(6):860-8. [Medline].

  15. Van Tuyl R, Gussack GS. Prognostic factors in craniofacial surgery. Laryngoscope. Mar 1991;101(3):240-4. [Medline].

  16. Chang CY, O'Rourke DK, Cass SP. Update on skull base surgery. Otolaryngol Clin North Am. Jun 1996;29(3):467-501. [Medline].

  17. D'Ambrosio AL, Bruce JN. Treatment of meningioma: an update. Curr Neurol Neurosci Rep. May 2003;3(3):206-14. [Medline].

  18. Jackson IT. Craniofacial osteotomies to facilitate the resection of tumors of the skull base. Neurosurgery. 1996;II:1585-602.

  19. Kokkino AJ, Abdel Aziz KM, Tew JM Jr. Honored guest presentation: contemporary treatment of skull base meningiomas. Clin Neurosurg. 2000;46:554-74. [Medline].

  20. Levine PA, McLean WC, Cantrell RW. Esthesioneuroblastoma: the University of Virginia experience 1960-1985. Laryngoscope. Jul 1986;96(7):742-6. [Medline].

  21. Levine PA, Scher RL, Jane JA, Persing JA, Newman SA, Miller J, et al. The craniofacial resection--eleven-year experience at the University of Virginia: problems and solutions. Otolaryngol Head Neck Surg. Dec 1989;101(6):665-9. [Medline].

  22. Liu JK, Gottfried ON, Couldwell WT. Surgical management of posterior petrous meningiomas. Neurosurg Focus. Jun 15 2003;14(6):e7. [Medline].

  23. Long DM. Surgical approaches to the skull base: an overview. Neurosurgery. II:1573-84.

  24. Ragel B, Jensen RL. Pathophysiology of Meningiomas. Seminars in Neurosurgery. 2003;14 (3).

  25. Rosenberg AE, Nielsen GP, Keel SB, Renard LG, Fitzek MM, Munzenrider JE, et al. Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol. Nov 1999;23(11):1370-8. [Medline].

  26. Sampson JH, Wilkins RH. Paragangliomas of the carotid body and temporal bone. Neurosurgery. 1996;II:1559-72.

  27. Scher RL, Richtsmeier WJ. Craniofacial resection of anterior skull base tumors. Neurosurgery. 1996;II:1603-10.

  28. Sekhar LN, Chanda A. Neurological Surgery. In: “Chordoma and Chondrosarcomaâ€ï¿½. 5th ed. Elsevier, Phildelphia: 2004.

  29. Sekhar LN, Gay E, Wright DC. Chordomas and chondrosarcomas of the cranial base. Neurosurgery. 1996;II:1529-44.

  30. Wanebo JE, Bristol RE, Porter RR, Coons SW, Spetzler RF. Management of cranial base chondrosarcomas. Neurosurgery. Feb 2006;58(2):249-55; discussion 249-55. [Medline].

Further Reading

Keywords

skull base tumors, brain tumor, skull base surgery, skull-base tumor, skull-base surgery, brain surgery, skull-base mass, skull base mass, brain mass, meningioma, intracranial tumor, schwannoma, chondrosarcoma, chordoma, metastatic bone lesion, osteoma, en plaque tumor, en masse tumor, neurinoma, neurilemoma, acoustic neuroma, anterior cranial fossa tumor, juvenile angiofibroma, esthesioneuroblastoma, inverted papilloma, lymphomas, nasopharyngeal carcinoma, orbital glioma, orbital tumor, orbital mass, rhabdomyosarcoma, osteogenic sarcoma, ossifying fibroma, esthesioneuroblastoma, olfactory neuroblastoma, nasopharyngeal carcinoma, middle cranial base tumor, pituitary adenoma, craniopharyngioma, temporal bone tumor, cholesteatoma, enchondroma, posterior cranial fossa tumor, epidermoid tumor, dermoid tumor, chondroma, glomus tumor, paraganglioma

Contributor Information and Disclosures

Author

Todd C Hankinson, MD, MBA, Resident in Neurological Surgery, Department of Neurological Surgery, Neurological Institute of New York, Columbia University
Todd C Hankinson, MD, MBA is a member of the following medical societies: American Association of Neurological Surgeons, American Medical Association, and Congress of Neurological Surgeons
Disclosure: Nothing to disclose.

Coauthor(s)

Jeffrey N Bruce, MD, Edgar M Housepian Professor of Neurological Surgery Research, Professor of Neurological Surgery, Director of Brain Tumor Tissue Bank, Director of Bartoli Brain Tumor Laboratory, Department of Neurosurgery, Columbia University College of Physicians and Surgeons
Jeffrey N Bruce, MD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Neurological Surgeons, Congress of Neurological Surgeons, New York Academy of Sciences, North American Skull Base Society, Society for Neuro-Oncology, and Southwestern Oncology Group
Disclosure: NIH Grant/research funds Other

Grant P Sinson, MD, Associate Professor, Department of Neurosurgery, Medical College of Wisconsin
Grant P Sinson, MD is a member of the following medical societies: American Association of Neurological Surgeons and American Medical Association
Disclosure: Nothing to disclose.

G Timothy Reiter, MD, Assistant Professor, Department of Neurosurgery, Penn State College of Medicine; Director, Department of Spinal Neurosurgery and Neurotrauma, Penn State Hershey Medical Center
G Timothy Reiter, MD is a member of the following medical societies: American Association of Neurological Surgeons
Disclosure: Nothing to disclose.

Medical Editor

Michael G Nosko, MD, PhD, Chief, Division of Neurosurgery, Director of Neurovascular Surgery, Medical Director of Neuroscience Unit, Associate Professor, Department of Surgery, University of Medicine and Dentistry at New Jersey
Michael G Nosko, MD, PhD is a member of the following medical societies: Academy of Medicine of New Jersey, Alpha Omega Alpha, American Association of Neurological Surgeons, American College of Surgeons, American Heart Association, American Medical Association, New York Academy of Sciences, and Society of Critical Care Medicine
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Allen R Wyler, MD, Former Medical Director, Northstar Neuroscience, Inc
Allen R Wyler, MD is a member of the following medical societies: American Academy of Neurological and Orthopaedic Surgeons, American Association of Neurological Surgeons, and Society of Neurological Surgeons
Disclosure: Nothing to disclose.

CME Editor

Paolo Zamboni, MD, Professor of Surgery, Chief of Day Surgery Unit, Chair of Vascular Diseases Center, University of Ferrara, Italy
Paolo Zamboni, MD is a member of the following medical societies: American Venous Forum and New York Academy of Sciences
Disclosure: Nothing to disclose.

Chief Editor

Allen R Wyler, MD, Former Medical Director, Northstar Neuroscience, Inc
Allen R Wyler, MD is a member of the following medical societies: American Academy of Neurological and Orthopaedic Surgeons, American Association of Neurological Surgeons, and Society of Neurological Surgeons
Disclosure: Nothing to disclose.

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.