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Luteinizing Hormone Deficiency Follow-up

  • Author: Nichole M Barker, DO; Chief Editor: Richard Scott Lucidi, MD, FACOG  more...
 
Updated: Oct 30, 2014
 

Further Outpatient Care

Kallmann syndrome: Patients require lifelong hormonal therapy and specific treatment to achieve fertility.

Hypogonadotropic hypogonadism: Patients with stress-related hypothalamic dysfunction can often regain gonadal function after weight gain or stress reduction. Patients with genetic or idiopathic hypogonadotropic hypogonadism require lifelong hormonal therapy and specific treatment to achieve fertility.

Pituitary dysfunction: Pituitary microadenomas (≤1 cm) often resolve spontaneously. Pituitary macroadenomas (>1 cm) are usually persistent and require at least annual imaging to detect enlargement. Most causes of panhypopituitarism are irreversible and patients require lifelong hormonal therapy and specific treatment to achieve fertility.

Luteal phase deficiency: When pregnancy is desired, hormone therapy is required for ovulation induction or luteal support. No long-term health risks are associated with this condition.

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Complications

LH deficiency results in infertility and decreased sex hormones if untreated. Complications associated with the secondary lack of estrogen or testosterone can be avoided by replacement hormone therapy. Hypothalamic and pituitary anomalies can result in other hormonal deficiencies (eg, thyroid, adrenal) that can adversely affect health.

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Prognosis

Most causes of LH deficiency are irreversible. However, with appropriate hormone replacement therapy, fertility and a normal life expectancy can be anticipated.

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Patient Education

Patients need to be educated about the incidence, pathophysiology, and treatment of their specific condition.

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Contributor Information and Disclosures
Author

Nichole M Barker, DO Physician in Reproductive Endocrinology and Infertility, Seattle Reproductive Medicine

Nichole M Barker, DO is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Society for Reproductive Medicine

Disclosure: Nothing to disclose.

Coauthor(s)

Allen Donald Seftel, MD Professor of Urology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School; Head, Division of Urology, Director, Urology Residency Training Program, Cooper University Hospital

Allen Donald Seftel, MD is a member of the following medical societies: American Urological Association

Disclosure: Received consulting fee from lilly for consulting; Received consulting fee from abbott for consulting; Received consulting fee from auxilium for consulting; Received consulting fee from actient for consulting; Received honoraria from journal of urology for board membership; Received consulting fee from endo for consulting.

William W Hurd, MD, MSc, MPH Professor and Director, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center

William W Hurd, MD, MSc, MPH is a member of the following medical societies: American College of Surgeons, American Gynecological and Obstetrical Society, AAGL, Society of Reproductive Surgeons, Alpha Omega Alpha, American College of Obstetricians and Gynecologists, American Medical Association, American Society for Reproductive Medicine, Society for Reproductive Investigation

Disclosure: Nothing to disclose.

Rebecca Flyckt, MD Associate Staff, Reproductive Endocrinology and Infertility, Cleveland Clinic

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Chief Editor

Richard Scott Lucidi, MD, FACOG Associate Professor of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine

Richard Scott Lucidi, MD, FACOG is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Society for Reproductive Medicine

Disclosure: Nothing to disclose.

Acknowledgements

MRI of pituitary adenoma courtesy of Kristine Blackham, MD, University Hospitals Case Medical Center, Department of Radiology

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Basal body temperature (BBT) chart.
MRI of pituitary macroadenoma.
 
 
 
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