eMedicine Specialties > Obstetrics and Gynecology > General Gynecology
Adnexal Tumors: Follow-up
Updated: Oct 16, 2008
Outcome and Prognosis
Most adnexal masses are benign; outcome and prognosis are very good. Generally, no impact on life span or quality of life is noted. In fact, most women treated for adnexal masses have no interruption in their reproductive abilities.
Those women who are found to have malignant adnexal masses fall into 3 groups, as follows:
- Women ranging in age from the late teens (y) to early 20s (y): Germ cell tumors are seen in these women. The tumors are generally confined to the ovary and are cured in 90% of women after chemotherapy.
- Women aged 40-60 years: Epithelial tumors are the most common ovarian cancer in these women. These tumors are advanced (stage III-IV) in more than 50% of women. Even after the use of chemotherapy, only 10-40% of patients survive their disease.25
- Women older than 60 years: Ovarian epithelial malignancies are common in this group of patients. Metastatic malignancies are also common. The incidence of sex-cord stromal tumors also increases in incidence in this age group, although it still accounts for only 5% of tumors. Stromal tumors are often early stage and may have an indolent course.
Future and Controversies
Future
The future holds several interesting possibilities. First, the rapid expansion of new laparoscopic equipment makes minimally invasive surgery an area that is gaining increasing importance in the treatment of adnexal masses. Second, the development of new radiologic techniques or expansion of the present techniques will allow the clinician to gain additional characterization of adnexal masses without entering the surgical suite. Third, new molecular, genetic, and biologic markers and therapies should become available that will assist in the diagnosis and treatment of adnexal masses, both benign and malignant.
Controversies
The major controversy surrounding adnexal masses is when and how to treat them. While some adnexal masses can be clearly stratified into low- or high-risk for malignancy based on clinical, laboratory, and clinical findings, currently, there are no definitive means of preoperative diagnosis with imaging or laboratory findings.
More on Adnexal Tumors |
| Overview: Adnexal Tumors |
| Workup: Adnexal Tumors |
| Treatment: Adnexal Tumors |
Follow-up: Adnexal Tumors |
| References |
| « Previous Page |
References
ACOG Practice Bulletin. Management of adnexal masses. Obstet Gynecol. Jul 2007;110(1):201-14. [Medline].
Drake J. Diagnosis and management of the adnexal mass. Am Fam Physician. May 15 1998;57(10):2471-6, 2479-80. [Medline].
Gallup DG, Talledo E. Management of the adnexal mass in the 1990s. South Med J. Oct 1997;90(10):972-81. [Medline].
Hricak H, Chen M, Coakley FV, et al. Complex adnexal masses: detection and characterization with MR imaging--multivariate analysis. Radiology. Jan 2000;214(1):39-46. [Medline].
Alcazar JL, Ruiz-Perez ML, Errasti T. Transvaginal color Doppler sonography in adnexal masses: which parameter performs best?. Ultrasound Obstet Gynecol. Aug 1996;8(2):114-9. [Medline].
Castillo G, Alcázar JL, Jurado M. Natural history of sonographically detected simple unilocular adnexal cysts in asymptomatic postmenopausal women. Gynecol Oncol. Mar 2004;92(3):965-9. [Medline].
Modesitt SC, Pavlik EJ, Ueland FR, DePriest PD, Kryscio RJ, van Nagell JR Jr. Risk of malignancy in unilocular ovarian cystic tumors less than 10 centimeters in diameter. Obstet Gynecol. Sep 2003;102(3):594-9. [Medline].
Zalel Y, Piura B, Elchalal U, Czernobilsky B, Antebi S, Dgani R. Diagnosis and management of malignant germ cell ovarian tumors in young females. Int J Gynaecol Obstet. Oct 1996;55(1):1-10. [Medline].
Barber HR, Graber EA. Gynecological tumors in childhood and adolescence. Obstet Gynecol Surv. May 1973;28(5):suppl:357-81. [Medline].
Pfeifer SM, Gosman GG. Evaluation of adnexal masses in adolescents. Pediatr Clin North Am. Jun 1999;46(3):573-92. [Medline].
Slap GB, Forke CM, Cnaan A, et al. Recognition of tubo-ovarian abscess in adolescents with pelvic inflammatory disease. J Adolesc Health. Jun 1996;18(6):397-403. [Medline].
Kinkel K, Lu Y, Mehdizade A, Pelte MF, Hricak H. Indeterminate ovarian mass at US: incremental value of second imaging test for characterization--meta-analysis and Bayesian analysis. Radiology. Jul 2005;236(1):85-94. [Medline].
Clement PB. Tumor-like lesions of the ovary associated with pregnancy. Int J Gynecol Pathol. Apr 1993;12(2):108-15. [Medline].
Chiang G, Levine D. Imaging of adnexal masses in pregnancy. J Ultrasound Med. Jun 2004;23(6):805-19. [Medline].
The role of the generalist obstetrician-gynecologist in the early detection of ovarian cancer. Gynecol Oncol. Dec 2002;87(3):237-9. [Medline].
Mol BW, Bayram N, Lijmer JG, Wiegerinck MA, Bongers MY, van der Veen F, et al. The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis. Fertil Steril. Dec 1998;70(6):1101-8. [Medline].
Devarbhavi H, Kaese D, Williams AW, Rakela J, Klee GG, Kamath PS. Cancer antigen 125 in patients with chronic liver disease. Mayo Clin Proc. Jun 2002;77(6):538-41. [Medline].
Topalak O, Saygili U, Soyturk M, Karaca N, Batur Y, Uslu T, et al. Serum, pleural effusion, and ascites CA-125 levels in ovarian cancer and nonovarian benign and malignant diseases: a comparative study. Gynecol Oncol. Apr 2002;85(1):108-13. [Medline].
Canis M, Pouly JL, Wattiez A, et al. Laparoscopic management of adnexal masses suspicious at ultrasound. Obstet Gynecol. May 1997;89(5 Pt 1):679-83. [Medline].
Russo A, Calò V, Bruno L, Rizzo S, Bazan V, Di Fede G. Hereditary ovarian cancer. Crit Rev Oncol Hematol. Jul 23 2008;[Medline].
Padilla LA, Radosevich DM, Milad MP. Limitations of the pelvic examination for evaluation of the female pelvic organs. Int J Gynaecol Obstet. Jan 2005;88(1):84-8. [Medline].
Carlson KJ, Skates SJ, Singer DE. Screening for ovarian cancer. Ann Intern Med. Jul 15 1994;121(2):124-32. [Medline].
Twickler DM, Forte TB, Santos-Ramos R, et al. The Ovarian Tumor Index predicts risk for malignancy. Cancer. Dec 1 1999;86(11):2280-90. [Medline].
DePriest PD, Gallion HH, Pavlik EJ, et al. Transvaginal sonography as a screening method for the detection of early ovarian cancer. Gynecol Oncol. Jun 1997;65(3):408-14. [Medline].
Einhorn N. Ovarian cancer. Acta Oncol. 1996;35 Suppl 7:86-92. [Medline].
Schilder JM, Thompson AM, DePriest PD, Ueland FR, Cibull ML, Kryscio RJ, et al. Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility-sparing therapy. Gynecol Oncol. Oct 2002;87(1):1-7. [Medline].
Haefner HK, Roberts JA, Schmidt R. The university experience of clinical and pathological findings of ovarian neoplasms in children and adolescents. Ped Adoles Gynecol. 1992;5:182-6.
Maiman M, Seltzer V, Boyce J. Laparoscopic excision of ovarian neoplasms subsequently found to be malignant. Obstet Gynecol. Apr 1991;77(4):563-5. [Medline].
Nezhat FR, Tazuke S, Nezhat CH, et al. Laparoscopy during pregnancy: a literature review. JSLS. Jan-Mar 1997;1(1):17-27. [Medline].
Spanos WJ. Preoperative hormonal therapy of cystic adnexal masses. Am J Obstet Gynecol. Jun 15 1973;116(4):551-6. [Medline].
Timmerman D, Bourne TH, Tailor A, et al. A comparison of methods for preoperative discrimination between malignant and benign adnexal masses: the development of a new logistic regression model. Am J Obstet Gynecol. Jul 1999;181(1):57-65. [Medline].
Further Reading
Keywords
adnexal mass, pelvic mass, ovarian mass, pelvic masses, ovarian masses, ovarian cysts, ovarian neoplasms, fallopian tube masses, fallopian tube neoplasms, follicular cyst, endometriosis, ovarian cancer, functional cysts, nonfunctional cysts, germ cell tumor, adult cystic teratoma, dermoid cyst
Follow-up: Adnexal Tumors