eMedicine Specialties > Obstetrics and Gynecology > Medical Problems in Pregnancy

Antiphospholipid Antibody Syndrome and Pregnancy: Follow-up

Author: Teresa G Berg, MD, FACOG, Associate Professor, Program Director, Director of the Perinatal Diagnostic Center, Department of Obstetrics and Gynecology, University of Nebraska Medical Center
Contributor Information and Disclosures

Updated: Aug 11, 2008

Follow-up

Further Inpatient Care

Institute inpatient care as appropriate for the clinical findings.

Further Outpatient Care

Institute outpatient care as appropriate for clinical findings. Grief support may be indicated for families who experience perinatal losses.

Miscellaneous

Special Concerns

  • Regarding corticosteroid therapy, administer supplementation to cover the labor or cesarean delivery in patients currently receiving steroids or those recently treated with these drugs.
  • No evidence indicates adverse effects related to breastfeeding, although breastfeeding is not recommended if high doses of cytotoxic or immunosuppressive agents are required.
  • Pregnancy in itself is not harmful to the mother or the baby unless the added work related to the newborn and the emotional stress in the family prove to be too much for a particular patient. Therapeutic abortions are generally not indicated in pregnant women with autoimmune disease.
  • Epidural anesthetic is not recommended if the mother has a marked drop in the maternal platelet count.
  • The use of forceps or the vacuum extractor should be individualized.
 
Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous authors Stella Nowicki, DDS; Gregory Locksmith, MD; and Bogdan Nowicki, MD, PhD to the development and writing of this article.



More on Antiphospholipid Antibody Syndrome and Pregnancy

Overview: Antiphospholipid Antibody Syndrome and Pregnancy
Differential Diagnoses & Workup: Antiphospholipid Antibody Syndrome and Pregnancy
Treatment & Medication: Antiphospholipid Antibody Syndrome and Pregnancy
Follow-up: Antiphospholipid Antibody Syndrome and Pregnancy
References

References

  1. Asherson RA, Khamashta MA, Ordi-Ros J, Derksen RH, Machin SJ, Barquinero J, et al. The "primary" antiphospholipid syndrome: major clinical and serological features. Medicine (Baltimore). Nov 1989;68(6):366-74. [Medline].

  2. Kochenour NK, Branch DW, Rote NS, et al. A new postpartum syndrome associated with antiphospholipid antibodies. Obstet Gynecol. Mar 1987;69(3 Pt 2):460-8. [Medline].

  3. Cowchock FS, Reece EA, Balaban D, et al. Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol. May 1992;166(5):1318-23. [Medline].

  4. Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum. Jul 1999;42(7):1309-11. [Medline].

  5. Asherson RA, Cervera R, Piette J-C et al. Catastrophic antiphospholipid syndrome: Clinical and laboratory features of 50 patients. Medicine. 1918;77:195.

  6. Berman J, Girardi G, Salmon JE. TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss. J Immunol. Jan 1 2005;174(1):485-90. [Medline].

  7. Blank M, Cohen J, Toder V, Shoenfeld Y. Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc Natl Acad Sci U S A. Apr 15 1991;88(8):3069-73. [Medline].

  8. Blank M, Shoenfeld Y, Cabilly S, et al. Prevention of experimental antiphospholipid syndrome and endothelial cell activation by synthetic peptides. Proc Natl Acad Sci U S A. Apr 27 1999;96(9):5164-8. [Medline].

  9. Bocciolone L, Meroni P, Parazzini F, et al. Antiphospholipid antibodies and risk of intrauterine late fetal death. Acta Obstet Gynecol Scand. May 1994;73(5):389-92. [Medline].

  10. Branch DW, Hatasaka HH. Antiphospholipid antibodies and infertility: fact or fallacy. Lupus. 1998;7 Suppl 2:S90-4. [Medline].

  11. Branch DW, Scott JR, Kochenour NK, Hershgold E. Obstetric complications associated with the lupus anticoagulant. N Engl J Med. Nov 21 1985;313(21):1322-6. [Medline].

  12. Branch DW, Silver R, Pierangeli S, et al. Antiphospholipid antibodies other than lupus anticoagulant and anticardiolipin antibodies in women with recurrent pregnancy loss, fertile controls, and antiphospholipid syndrome. Obstet Gynecol. Apr 1997;89(4):549-55. [Medline].

  13. Caligaris-Cappio F, Bertero MT, Converso M, et al. Circulating levels of soluble CD30, a marker of cells producing Th2- type cytokines, are increased in patients with systemic lupus erythematosus and correlate with disease activity. Clin Exp Rheumatol. May-Jun 1995;13(3):339-43. [Medline].

  14. Casali P, Schettino EW. Structure and function of natural antibodies. Curr Top Microbiol Immunol. 1996;210:167-79. [Medline].

  15. Christiansen OB, Ulcova-Gallova Z, Mohapeloa H, Krauz V. Studies on associations between human leukocyte antigen (HLA) class II alleles and antiphospholipid antibodies in Danish and Czech women with recurrent miscarriages. Hum Reprod. Dec 1998;13(12):3326-31. [Medline].

  16. de Groot PG, Horbach DA, Derksen RH. Protein C and other cofactors involved in the binding of antiphospholipid antibodies: relation to the pathogenesis of thrombosis. Lupus. Oct 1996;5(5):488-93. [Medline].

  17. Derksen RH, Khamashta MA, Branch DW. Management of the obstetric antiphospholipid syndrome. Arthritis Rheum. Apr 2004;50(4):1028-39. [Medline].

  18. Gharavi EE, Chaimovich H, Cucurull E, et al. Induction of antiphospholipid antibodies by immunization with synthetic viral and bacterial peptides. Lupus. 1999;8(6):449-55. [Medline].

  19. Hagiwara E, Gourley MF, Lee S, Klinman DK. Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-gamma- secreting cells in the peripheral blood. Arthritis Rheum. Mar 1996;39(3):379-85. [Medline].

  20. Harris EN, Pierangeli SS, Gharavi AE. Diagnosis of the antiphospholipid syndrome: a proposal for use of laboratory tests. Lupus. 1998;7 Suppl 2:S144-8. [Medline].

  21. Hayem G, Kassis N, Nicaise P, et al. Systemic lupus erythematosus-associated catastrophic antiphospholipid syndrome occurring after typhoid fever: a possible role of Salmonella lipopolysaccharide in the occurrence of diffuse vasculopathy- coagulopathy. Arthritis Rheum. May 1999;42(5):1056-61. [Medline].

  22. Ikematsu W, Luan FL, La Rosa L, et al. Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c mice. Arthritis Rheum. Jun 1998;41(6):1026-39. [Medline].

  23. Jablonowska B, Selbing A, Palfi M, et al. Prevention of recurrent spontaneous abortion by intravenous immunoglobulin: a double-blind placebo-controlled study. Hum Reprod. Mar 1999;14(3):838-41. [Medline].

  24. Khamashta MA, Cuadrado MJ, Mujic F, et al. The management of thrombosis in the antiphospholipid-antibody syndrome. N Engl J Med. Apr 13 1995;332(15):993-7. [Medline].

  25. Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GR. The management of thrombosis in the antiphospholipid-antibody syndrome. N Engl J Med. Apr 13 1995;332(15):993-7. [Medline].

  26. Kutteh WH. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol. May 1996;174(5):1584-9. [Medline].

  27. Lockshin MD, Druzin ML, Goei S, et al. Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N Engl J Med. Jul 18 1985;313(3):152-6. [Medline].

  28. Machin SJ. Platelets and antiphospholipid antibodies. Lupus. Oct 1996;5(5):386-7. [Medline].

  29. Matsuura E, Igarashi Y, Fujimoto M, et al. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol. Jun 15 1992;148(12):3885-91. [Medline].

  30. McFarland HF. Complexities in the treatment of autoimmune disease. Science. Dec 20 1996;274(5295):2037-8. [Medline].

  31. Oshiro BT, Silver RM, Scott JR, et al. Antiphospholipid antibodies and fetal death. Obstet Gynecol. Apr 1996;87(4):489-93. [Medline].

  32. Pal D, Dalal BS, Haldar KK, et al. The prevalence of hepatitis D in hepatitis B patients--a hospital based study. Indian J Public Health. Jan-Mar 1996;40(1):22-3. [Medline].

  33. Pierro E, Cirino G, Bucci MR, et al. Antiphospholipid antibodies inhibit prostaglandin release by decidual cells of early pregnancy: possible involvement of extracellular secretory phospholipase A2. Fertil Steril. Feb 1999;71(2):342-6. [Medline].

  34. Piona A, La Rosa L, Tincani A, et al. Placental thrombosis and fetal loss after passive transfer of mouse lupus monoclonal or human polyclonal anti-cardiolipin antibodies in pregnant naive BALB/c mice. Scand J Immunol. May 1995;41(5):427-32. [Medline].

  35. Puri V, Bookman A, Yeo E, et al. Antiphospholipid antibody syndrome associated with hepatitis C infection. J Rheumatol. Feb 1999;26(2):509-10. [Medline].

  36. Rai R, Cohen H, Dave M, Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ. Jan 25 1997;314(7076):253-7. [Medline].

  37. Richaud-Patin Y, Alcocer-Varela J, Llorente L. High levels of TH2 cytokine gene expression in systemic lupus erythematosus. Rev Invest Clin. Jul-Aug 1995;47(4):267-72. [Medline].

  38. Roubey RA, Eisenberg RA, Harper MF, Winfield JB. "Anticardiolipin" autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding. J Immunol. Jan 15 1995;154(2):954-60. [Medline].

  39. Segal R, Bermas BL, Dayan M, et al. Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1/T helper cell 2-type cytokines in disease. J Immunol. Mar 15 1997;158(6):3009-16. [Medline].

  40. Silver RM, Porter TF, van Leeuween I, et al. Anticardiolipin antibodies: clinical consequences of "low titers". Obstet Gynecol. Apr 1996;87(4):494-500. [Medline].

  41. Sletnes KE, Wisloff F, Moe N, Dale PO. Antiphospholipid antibodies in pre-eclamptic women: relation to growth retardation and neonatal outcome. Acta Obstet Gynecol Scand. Feb 1992;71(2):112-7. [Medline].

  42. Spinnato JA, Clark AL, Pierangeli SS, Harris EN. Intravenous immunoglobulin therapy for the antiphospholipid syndrome in pregnancy. Am J Obstet Gynecol. Feb 1995;172(2 Pt 1):690-4. [Medline].

  43. Tincani A, Spatola L, Prati E, et al. The anti-beta2-glycoprotein I activity in human anti-phospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native beta2-glycoprotein I and preserved during species' evolution. J Immunol. Dec 15 1996;157(12):5732-8. [Medline].

  44. Van Es JH, Aanstoot H, Gmelig-Meyling FH, et al. A human systemic lupus erythematosus-related anti-cardiolipin/single- stranded DNA autoantibody is encoded by a somatically mutated variant of the developmentally restricted 51P1 VH gene. J Immunol. Sep 15 1992;149(6):2234-40. [Medline].

  45. Vogt E, Ng AK, Rote NS. A model for the antiphospholipid antibody syndrome: monoclonal antiphosphatidylserine antibody induces intrauterine growth restriction in mice. Am J Obstet Gynecol. Feb 1996;174(2):700-7. [Medline].

  46. Yetman DL, Kutteh WH. Antiphospholipid antibody panels and recurrent pregnancy loss: prevalence of anticardiolipin antibodies compared with other antiphospholipid antibodies. Fertil Steril. Oct 1996;66(4):540-6. [Medline].

Further Reading

Keywords

antiphospholipid syndrome, APS, lupus anticoagulant, LAC, anticardiolipin antibodies, aCL, autoimmune disease, systemic lupus erythematosus, lupus, SLE,  lupus erythematosus, LE, fetal loss, thrombosis, autoimmune thrombocytopenia, infertility, pregnancy complications, fetal mortality, fetal morbidity, maternal morbidity, spontaneous abortion, prematurity, stillbirth, fetal growth restriction, FGR, fetal growth retardation

Contributor Information and Disclosures

Author

Teresa G Berg, MD, FACOG, Associate Professor, Program Director, Director of the Perinatal Diagnostic Center, Department of Obstetrics and Gynecology, University of Nebraska Medical Center
Teresa G Berg, MD, FACOG is a member of the following medical societies: American Institute of Ultrasound in Medicine, Association of Professors of Gynecology and Obstetrics, Central Association of Obstetricians and Gynecologists, and Society for Maternal-Fetal Medicine
Disclosure: Nothing to disclose.

Medical Editor

Bruce A Meyer, MD, MBA, Vice President for Medical Affairs, Associate Dean for Health System Affairs and Director of the Faculty Practice Plan, Professor, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical School
Bruce A Meyer, MD, MBA is a member of the following medical societies: American College of Obstetricians and Gynecologists, American College of Physician Executives, American Institute of Ultrasound in Medicine, Association of Professors of Gynecology and Obstetrics, Massachusetts Medical Society, Medical Group Management Association, and Society for Maternal-Fetal Medicine
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

CME Editor

Frederick B Gaupp, MD, Consulting Staff, Department of Family Practice, Hancock Medical Center
Frederick B Gaupp, MD is a member of the following medical societies: American Academy of Family Physicians
Disclosure: Nothing to disclose.

Chief Editor

Carl V Smith, MD, The Distinguished Chris J and Marie A Olson Chair of Obstetrics and Gynecology, Professor, Department of Obstetrics and Gynecology, University of Nebraska Medical Center
Carl V Smith, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Institute of Ultrasound in Medicine, American Medical Association, Arkansas Medical Society, Association of Professors of Gynecology and Obstetrics, Central Association of Obstetricians and Gynecologists, Council of University Chairs of Obstetrics and Gynecology, Nebraska Medical Association, and Society for Maternal-Fetal Medicine
Disclosure: Nothing to disclose.

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.