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Colposcopy Treatment & Management

  • Author: Stephen A Metz, MD, PhD; Chief Editor: Michel E Rivlin, MD  more...
 
Updated: Jan 02, 2015
 

Surgical Therapy

Following complete colposcopic evaluation of the cervical lesion and histologic confirmation of the diagnosis, an appropriate treatment regimen can be developed. This should be based on the extent and degree of the pathologic findings, taking into account, insomuch as possible, the individual patient’s desire for future childbearing.

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Follow-up

Regardless of the treatment modality chosen, patients undergoing therapy for preinvasive cervical lesions are at risk for recurrence. Follow-up algorithms are available from various sources, such as the American Society for Colposcopy and Cervical Pathology.

For patient education resources, see Cancer Center and Women's Health Center, as well as Colposcopy, Cervical Cancer, and Pap Smear.

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Complications

Complications from colposcopic procedures are exceedingly rare. Occasionally, bothersome bleeding can occur following biopsy. This tends to be problematic only with procedures performed during pregnancy or with large excisional procedures. Infection of biopsy sites is also exceedingly rare, although it can occur following laser ablation or LEEP procedures. The most worrisome complication is inadequate or inaccurate evaluation leading to the missed diagnosis of invasive cancer. This obviously can lead to treatment delays and poorer outcomes. Another complication is the overestimation of lesion severity by inexperienced practitioners. This can put the patient on a treatment course that may not be necessary and has the potential for adverse sequelae. Many of these sequelae center around future fertility limitations such as cervical stenosis or incompetence.

The infrequent but preventable lack of adequate evaluation is the only real controversy surrounding the procedure today. Questions concern who should perform the examination and what training requirements must be met before instituting the procedure on patients. Because of the prevalence of HPV disease and the frequency of abnormal findings on Papanicolaou tests, this becomes both an economic issue and a quality issue. Some have recommended as many as 200 supervised procedures to gain competence followed by regular performance of at least 25 procedures a year to maintain competence. The learning curve undoubtedly is practitioner-dependent, and, currently, no adequate studies have identified minimum criteria for certification. All practitioners performing this procedure should put mechanisms in place to ensure their own competence and safety.

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Future and Controversies

The colposcope can also be helpful in evaluating lesions of the vagina or vulva. The vaginal epithelium is a nonkeratinizing squamous epithelium similar to that of the exocervix. Acetowhite changes and vascular patterns can be observed that are similar to those found on the cervical portio. Because vaginal lesions do not originate in metaplastic tissue, vascular patterns previously described are not diagnostically reliable. When premalignant changes are suspected, all acetowhite lesions should be biopsied.

The vagina is more sensitive to pain than the cervix, so prebiopsy injection of local anesthesia should be considered. However, in a 2014 study involving 214 women with abnormal cervical cytologic findings that required colposcopy and directed cervical punch biopsy with/without endocervical curettage, Oz et al found no significant differences in pain scores after the colposcopic cervical biopsies with endocervical curettage between women who received 10% topical lidocaine spray and those who received placebo.[12]

The vulva is also a potential site for development of preinvasive disease. These tissues also can show acetowhite changes, but, because of the thickness of the epithelium and its keratin surface, acetic acid should be applied for a greater length of time and in a higher concentration (eg, 5%) to be effective in bringing about this change. Altered vascular patterns are uncommon on the vulva; but, when they are observed, biopsies should be performed liberally. Again, because of the sensitivity of these tissues, all biopsies should be obtained under local anesthetic.

Another use of the colposcope is in the evaluation of a victim of sexual assault. This has gained popularity, especially in the evaluation of children suspected of being assaulted. At low magnification, the colposcope can assist in identifying tissue trauma that might be too subtle to be detected by the naked eye. Careful, thorough, and gentle examination, especially of hymenal tissues, can usually be accomplished with minimal discomfort. Attached cameras for recording findings can be helpful from an evidentiary perspective.

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Contributor Information and Disclosures
Author

Stephen A Metz, MD, PhD Associate Professor, Department of Obstetrics and Gynecology, Tufts University School of Medicine; Adjunct Associate Professor, School of Public Health Sciences, University of Massachusetts; Consulting Staff, Baystate Medical Center; Private Practice, Division of Surgery, Hampden County Physician Associates

Stephen A Metz, MD, PhD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Urogynecologic Society, American Society for Colposcopy and Cervical Pathology, Society of Gynecologic Surgeons, Massachusetts Medical Society

Disclosure: Nothing to disclose.

Chief Editor

Michel E Rivlin, MD Former Professor, Department of Obstetrics and Gynecology, University of Mississippi School of Medicine

Michel E Rivlin, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Medical Association, Mississippi State Medical Association, Royal College of Surgeons of Edinburgh, Royal College of Obstetricians and Gynaecologists

Disclosure: Nothing to disclose.

Acknowledgements

Michael P Grossman, MD Consulting Staff, CNY Fertility Centers

Disclosure: Nothing to disclose.

Bophal Hong Michigan State University College of Human Medicine

Disclosure: Nothing to disclose.

Shironda Stewart Michigan State University College of Human Medicine

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Reference Salary Employment

Alissa Zuellig Michigan State University College of Human Medicine

Disclosure: Nothing to disclose.

References
  1. Noller K, Wagner A Jr. Colposcopy. Sciarra JL, ed. Gynecology and Obstetrics. Philadelphia, Pa: Lippincott, Williams and Wilkins; 2000. Vol 1:

  2. Papanicolaou G, Traut H. Diagnosis of uterine cancer by the vaginal smear. New York, NY: Commonwealth Fund; 1943.

  3. Mesher D, Tristram A, Castanon A, Beer H, Ashman S, Fielder H, et al. Single negative colposcopy: is it enough to rule out high-grade disease?. J Med Screen. 2011. 18(3):160-1. [Medline].

  4. Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA. 2002 Apr 24. 287(16):2114-9. [Medline].

  5. Verma I, Jain V, Kaur T. Application of bethesda system for cervical cytology in unhealthy cervix. J Clin Diagn Res. 2014 Sep. 8(9):OC26-30. [Medline]. [Full Text].

  6. Wright TC Jr, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D. 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. Am J Obstet Gynecol. 2007 Oct. 197(4):346-55. [Medline].

  7. García-Arteaga JD, Kybic J, Li W. Automatic colposcopy video tissue classification using higher order entropy-based image registration. Comput Biol Med. 2011 Oct. 41(10):960-70. [Medline].

  8. Freeman-Wang T, Walker P. Colposcopy in special circumstances: Pregnancy, immunocompromise, including HIV and transplants, adolescence and menopause. Best Pract Res Clin Obstet Gynaecol. 2011 Oct. 25(5):653-65. [Medline].

  9. Massad LS, Einstein MH, Huh WK, et al. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. J Low Genit Tract Dis. 2013 Apr. 17(5 Suppl 1):S1-S27. [Medline]. [Full Text].

  10. Castle PE, Smith KM, Davis TE, et al. Reliability of the Xpert HPV Assay to Detect High-Risk Human Papillomavirus DNA in a Colposcopy Referral Population. Am J Clin Pathol. 2015 Jan. 143(1):126-33. [Medline].

  11. Galaal K, Bryant A, Deane KH, Al-Khaduri M, Lopes AD. Interventions for reducing anxiety in women undergoing colposcopy. Cochrane Database Syst Rev. 2011 Dec 7. 12:CD006013. [Medline].

  12. Oz M, Korkmaz E, Cetinkaya N, Bas S, Ozdal B, Meydanl MM, et al. Comparison of Topical Lidocaine Spray With Placebo for Pain Relief in Colposcopic Procedures: A Randomized, Placebo-Controlled, Double-Blind Study. J Low Genit Tract Dis. 2014 Dec 30. [Medline].

  13. Abu J, Davies Q. Endocervical curettage at the time of colposcopic assessment of the uterine cervix. Obstet Gynecol Surv. 2005 May. 60(5):315-20. [Medline].

  14. ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists. Number 61, April 2005. Human papillomavirus. Obstet Gynecol. 2005 Apr. 105(4):905-18. [Medline].

  15. ASCUS-LSIL Triage Study (ALTS) Group. Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance. Am J Obstet Gynecol. 2003 Jun. 188(6):1383-92. [Medline].

  16. Benedet JL, Anderson GH, Boyes DA. Colposcopic accuracy in the diagnosis of microinvasive and occult invasive carcinoma of the cervix. Obstet Gynecol. 1985 Apr. 65(4):557-62. [Medline].

  17. Cooper K, Evans M, Mount S. Biology and evolution of cervical squamous intraepithelial lesions: a hypothesis with diagnostic prognostic implications. Adv Anat Pathol. 2003 Jul. 10(4):200-3. [Medline].

  18. Forsberg JG. Cervicovaginal epithelium: its origin and development. Am J Obstet Gynecol. 1973 Apr 1. 115(7):1025-43. [Medline].

  19. Ho GY, Bierman R, Beardsley L, Chang CJ, Burk RD. Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med. 1998 Feb 12. 338(7):423-8. [Medline].

  20. Melnikow J, Nuovo J, Willan AR, Chan BK, Howell LP. Natural history of cervical squamous intraepithelial lesions: a meta-analysis. Obstet Gynecol. 1998 Oct. 92(4 Pt 2):727-35. [Medline].

  21. Nucci MR, Crum CP. Redefining early cervical neoplasia: recent progress. Adv Anat Pathol. 2007 Jan. 14(1):1-10. [Medline].

  22. Stoler MH. The virology of cervical neoplasia: an HPV-associated malignancy. Cancer J. 2003 Sep-Oct. 9(5):360-7. [Medline].

  23. Wright TC Jr, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D. 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ. Am J Obstet Gynecol. 2007 Oct. 197(4):340-5. [Medline].

 
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Early metaplastic change of columnar epithelium.
Normal squamocolumnar junction. Tissue response to applied light.
Dysplastic epithelium with increased reflectance of applied light.
Human papilloma virus (HPV)–infected epithelium with increased light reflectance.
Punctation in cervical lesions. Left is fine, right is coarse (likely high grade or invasive).
Mosaicism in cervical lesions; left is fine, right is coarse (likely high grade or invasive).
 
 
 
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