Malignant Lesions of the Fallopian Tube and Broad Ligament Treatment & Management
- Author: Hetal B Gor, MD, FACOG; Chief Editor: Warner K Huh, MD more...
Medical Care
Medical care for fallopian tube and broad ligament malignancy depends on frozen section and pathology results, as follows:
Stage 0 - Carcinoma in situ
- Negative cytology results - No further treatment
- Positive cytology results - Intraperitoneal platin-based chemotherapy
Stage I
- Negative cytology results - No treatment or short-term cisplatin therapy
- Positive cytology results - Intraperitoneal cisplatin but is associated with more toxicity or short-term platin-based and taxol-based chemotherapy
Stage II-IV
- Bulky residual disease or positive nodes - Three cycles of neoadjuvant chemotherapy taxol-based and platinum-based, debulking followed by 3 more cycles of chemotherapy.
- No residual disease, negative nodes - Six cycles of taxol-based and platin-based chemotherapy
Treatment of broad ligament malignancy is similar to that for fallopian tube malignancy except in young patients, in whom wide local excision can be adequate.
Surgical Care
Surgical care includes (1) total abdominal hysterectomy with bilateral salpingo-oophorectomy, (2) omentectomy and peritoneal washing, and (3) selective pelvic and para-aortic lymphadenectomy.
Consultations
- Gynecologic oncologist
- Medical oncologist
- Surgical pathologist
- Social worker
Orthmann EG. Primareskarzinom in Einertuberkulosen. Ztschr Geburtsh Gynaek. 1888;15:212.
Kalir T, Rahaman J, Hagopian G, Demopoulos R, Cohen C, Burstein DE. Immunohistochemical detection of glucose transporter GLUT1 in benign and malignant fallopian tube epithelia, with comparison to ovarian carcinomas. Arch Pathol Lab Med. May 2005;129(5):651-4. [Medline].
Alvarado-Cabrero I, Young RH, Vamvakas EC. Carcinoma of the fallopian tube: a clinicopathological study of 105 cases with observations on staging and prognostic factors. Gynecol Oncol. Mar 1999;72(3):367-79. [Medline].
Aslani M, Scully RE. Primary carcinoma of the broad ligament. Report of four cases and review of the literature. Cancer. Oct 1 1989;64(7):1540-5. [Medline].
Ben-Hur H, Dgani R, Ben-Arie A. Diagnostic dilemmas and current therapy of Fallopian tube cancer. Eur J Gynaecol Oncol. 1999;20(2):108-9. [Medline].
Berek J, Hacker N, eds. Practical Gynecologic Oncology. 3rd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:546.
Danforth DN, Scott JR. Diseases of the ovary and fallopian tubes. In: Danforth DN, Scott JR, Di Saia PJ, Hammond CB, Spellacy WN, eds. Danforth's Obstetrics & Gynecology. 8th ed. Philadelphia, Pa: Lippincott Raven; 1999:889.
Dieste MC, Lynch GR, Gordon A. Malignant fibrous histiocytoma of the broad ligament: a case report and literature review. Gynecol Oncol. Oct 1987;28(2):225-9. [Medline].
Disaia PJ, Creasman WT. Fallopian tube cancer. In: Creasman WT, Doherty M, Disaia PJ, Dinh TV, Hannigan EV, eds. Clinical Gynecologic Oncology. 5th ed. St. Louis, Mo: Mosby-Year Book; 1997:375-80.
Dunton CJ, Neufeld J. Complete response to topotecan of recurrent fallopian tube carcinoma. Gynecol Oncol. Jan 2000;76(1):128-9. [Medline].
Fedele L, Cittadini E, Bortolozzi G. Successful in vitro fertilization and embryo transfer after limited surgical treatment for tubal adenocarcinoma. Cancer. Oct 1 1989;64(7):1546-7. [Medline].
Kurjak A, Kupesic S, Jacobs I. Preoperative diagnosis of the primary fallopian tube carcinoma by three- dimensional static and power Doppler sonography. Ultrasound Obstet Gynecol. Mar 2000;15(3):246-51. [Medline].
Latner AL, Turner GA. Effect of aprotinin on immunological resistance in tumour-bearing animals. Br J Cancer. May 1976;33(5):535-8. [Medline].
Loverro G, Cormio G, Renzulli G. Serous papillary cystadenoma of borderline malignancy of the broad ligament. Eur J Obstet Gynecol Reprod Biol. Aug 1997;74(2):211-3. [Medline].
Navani SS, Alvarado-Cabrero I, Young RH. Endometrioid carcinoma of the fallopian tube: a clinicopathologic analysis of 26 cases. Gynecol Oncol. Dec 1996;63(3):371-8. [Medline].
Ricci JV. One Hundred Years of Gynecology. Philadelphia, Pa: Blackiston; 1945.
Rose PG, Shrigley R, Wiesner GL. Germline BRCA2 mutation in a patient with fallopian tube carcinoma: a case report. Gynecol Oncol. May 2000;77(2):319-20. [Medline].
Rosen AC, Ausch C, Hafner E. A 15-year overview of management and prognosis in primary fallopian tube carcinoma. Austrian Cooperative Study Group for Fallopian Tube Carcinoma. Eur J Cancer. Oct 1998;34(11):1725-9. [Medline].
Rosen AC, Ausch C, Klein M. p53 expression in fallopian tube carcinomas. Cancer Lett. Aug 1 2000;156(1):1-7. [Medline].

