eMedicine Specialties > Oncology > Carcinomas of the Gastrointestinal Tract
Carcinoid Tumor, Intestinal: Follow-up
Updated: Jan 8, 2009
Follow-up
Further Outpatient Care
Surveillance of treated carcinoid patients depends on the initial stage at presentation and the type of treatment that was offered.
- For appendicular carcinoids that are less than 2 cm and localized to the appendix, no further follow-up is required after the patients have had an appendicectomy.
- For those patients who have had a right hemicolectomy, blood markers (5-HIAA, chromogranin A) need to be monitored at 3 months after resection along with imaging in the form of a CT scan or MRI.
- For rectal carcinoids 2 cm or less, which have been amenable to transanal excision, follow-up is required in the form of a proctoscopy at 6 and 12 months, and further investigations are warranted only if clinically indicated.
- For other people with intestinal carcinoid tumors, long-term monitoring is required. This involves blood markers every 6 months for the first 3 years and then yearly thereafter. Additional imaging is performed based on the results of the markers and clinical findings.13
Miscellaneous
Medicolegal Pitfalls
Because patients with carcinoid tumors present with a plethora of symptoms, diagnosis is usually delayed. This delay can be the basis of litigation.
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References
Oberndorfer S. Karzinoide tumoren des du¨nndarms. Frankfurt Zietschrift fur Pathologie. 1907;1:426–429.
Marshall JB, Bodnarchuk G. Carcinoid tumors of the gut. Our experience over three decades and review of the literature. J Clin Gastroenterol. Mar 1993;16(2):123-9. [Medline].
Thorson A, Biorck G, Bjorkman G, Waldenstrom J. Malignant carcinoid of the small intestine with metastases to the liver, valvular disease of the right side of the heart (pulmonary stenosis and tricuspid regurgitation without septal defects), peripheral vasomotor symptoms, bronchoconstriction, and an unusual type of cyanosis; a clinical and pathologic syndrome. Am Heart J. Jun 1954;47(5):795-817. [Medline].
Pearse AG. The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem. May 1969;17(5):303-13. [Medline].
American Cancer Society. Statistics for 2008. [Full Text].
Surveillance, Epidemiology, and End Results (SEER) Program. Public-Use Data (1973-1998), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2001, based on the November 2000 submission. Available at http://seer.cancer.gov/.
Deans GT, Spence RA. Neoplastic lesions of the appendix. Br J Surg. Mar 1995;82(3):299-306. [Medline].
Sugimoto E, Lorelius LE, Eriksson B, Oberg K. Midgut carcinoid tumours. CT appearance. Acta Radiol. Jul 1995;36(4):367-71. [Medline].
Ruszniewski P, Amouyal P, Amouyal G, Grange JD, Mignon M, Bouche O, et al. Localization of gastrinomas by endoscopic ultrasonography in patients with Zollinger-Ellison syndrome. Surgery. Jun 1995;117(6):629-35. [Medline].
Diaco DS, Hajarizadeh H, Mueller CR, Fletcher WS, Pommier RF, Woltering EA. Treatment of metastatic carcinoid tumors using multimodality therapy of octreotide acetate, intra-arterial chemotherapy, and hepatic arterial chemoembolization. Am J Surg. May 1995;169(5):523-8. [Medline].
Mani S, Modlin IM, Ballantyne G, Ahlman H, West B. Carcinoids of the rectum. J Am Coll Surg. Aug 1994;179(2):231-48. [Medline].
Carrasco CH, Charnsangavej C, Ajani J, Samaan NA, Richli W, Wallace S. The carcinoid syndrome: palliation by hepatic artery embolization. AJR Am J Roentgenol. Jul 1986;147(1):149-54. [Medline].
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp.
Ahlman H, Wangberg B, Jansson S, Friman S, Olausson M, Tylen U, et al. Interventional treatment of gastrointestinal neuroendocrine tumours. Digestion. 2000;62 Suppl 1:59-68. [Medline].
Anthony L, Johnson D, Hande K, Shaff M, Winn S, Krozely M, et al. Somatostatin analogue phase I trials in neuroendocrine neoplasms. Acta Oncol. 1993;32(2):217-23. [Medline].
Boudreaux JP, Putty B, Frey DJ, Woltering E, Anthony L, Daly I, et al. Surgical treatment of advanced-stage carcinoid tumors: lessons learned. Ann Surg. Jun 2005;241(6):839-45; discussion 845-6. [Medline].
Chen F, O'Dorisio MS, Hermann G, Hayes J, Malarkey WB, O'Dorisio TM. Mechanisms of action of long-acting analogs of somatostatin. Regul Pept. Apr 8 1993;44(3):285-95. [Medline].
Eriksson B, Orlefors H, Sundin A, Skogseid B, Langstrom B, Bergstrom M, et al. Positron emission tomography in neuroendocrine tumours. Ital J Gastroenterol Hepatol. Oct 1999;31 Suppl 2:S167-71. [Medline].
Godwin JD 2nd. Carcinoid tumors. An analysis of 2,837 cases. Cancer. Aug 1975;36(2):560-9. [Medline].
Gorden P, Comi RJ, Maton PN, Go VL. NIH conference. Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut. Ann Intern Med. Jan 1 1989;110(1):35-50. [Medline].
Hajarizadeh H, Ivancev K, Mueller CR, Fletcher WS, Woltering EA. Effective palliative treatment of metastatic carcinoid tumors with intra-arterial chemotherapy/chemoembolization combined with octreotide acetate. Am J Surg. May 1992;163(5):479-83. [Medline].
Hofland LJ, van Hagen PM, Lamberts SW. Functional role of somatostatin receptors in neuroendocrine and immune cells. Ann Med. Oct 1999;31 Suppl 2:23-7. [Medline].
Hou W, Schubert ML. Treatment of gastric carcinoids. Curr Treat Options Gastroenterol. Mar 2007;10(2):123-33. [Medline].
Krenning EP, de Jong M, Kooij PP, Breeman WA, Bakker WH, de Herder WW, et al. Radiolabelled somatostatin analogue(s) for peptide receptor scintigraphy and radionuclide therapy. Ann Oncol. 1999;10 Suppl 2:S23-9. [Medline].
Kulke MH, Mayer RJ. Carcinoid tumors. N Engl J Med. Mar 18 1999;340(11):858-68. [Medline].
Neuroendocrine Carcinoma. In: Kantarjian H, Wolff R, Koller C, eds. M D Anderson Manual of Medical Oncology. New York: McGraw-Hill; 2006:449-459.
Maroun J, Kocha W, Kvols L, Bjarnason G, Chen E, Germond C, et al. Guidelines for the diagnosis and management of carcinoid tumours. Part 1: The gastrointestinal tract. A statement from a Canadian National Carcinoid Expert Group. Curr Oncol. Apr 2006;13(2):67-76. [Medline].
McCarthy KE, Woltering EA, Espenan GD, Cronin M, Maloney TJ, Anthony LB. In situ radiotherapy with 111In-pentetreotide: initial observations and future directions. Cancer J Sci Am. Mar-Apr 1998;4(2):94-102. [Medline].
Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. Feb 15 2003;97(4):934-59. [Medline].
Modlin IM, Sandor A. An analysis of 8305 cases of carcinoid tumors. Cancer. Feb 15 1997;79(4):813-29. [Medline].
Moertel CG, Johnson CM, McKusick MA, Martin JK Jr, Nagorney DM, Kvols LK, et al. The management of patients with advanced carcinoid tumors and islet cell carcinomas. Ann Intern Med. Feb 15 1994;120(4):302-9. [Medline].
Moertel CG, Kvols LK, O'Connell MJ, Rubin J. Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin. Evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer. Jul 15 1991;68(2):227-32. [Medline].
Oberg K. Established clinical use of octreotide and lanreotide in oncology. Chemotherapy. 2001;47 Suppl 2:40-53. [Medline].
Oberg K. Interferon in the management of neuroendocrine GEP-tumors: a review. Digestion. 2000;62 Suppl 1:92-7. [Medline].
Oberg K, Stridsberg M. Chromogranins as diagnostic and prognostic markers in neuroendocrine tumours. Adv Exp Med Biol. 2000;482:329-37. [Medline].
Perry RR, Vinik AI. Endocrine tumors of the gastrointestinal tract. Annu Rev Med. 1996;47:57-68. [Medline].
Rubin J, Ajani J, Schirmer W, Venook AP, Bukowski R, Pommier R, et al. Octreotide acetate long-acting formulation versus open-label subcutaneous octreotide acetate in malignant carcinoid syndrome. J Clin Oncol. Feb 1999;17(2):600-6. [Medline].
Szilvas A, Szekely G, Szilvasi I, Sagi S, Jakab F. The importance of follow-up examinations in patients with carcinoid tumor. Hepatogastroenterology. Sep-Oct 2003;50(53):1452-3. [Medline].
Vikman S, Essand M, Cunningham JL, de la Torre M, Oberg K, Totterman TH, et al. Gene expression in midgut carcinoid tumors: potential targets for immunotherapy. Acta Oncol. 2005;44(1):32-40. [Medline].
Öberg K. Carcinoid Tumors: Current Concepts in Diagnosis and Treatment. Oncologist. 1998;3(5):339-345. [Medline].
Further Reading
Keywords
intestinal carcinoid tumor, intestinal carcinoid tumour, gastroenteropancreatic neoplasm, GEP, GEP neoplasm, well-differentiated gastrointestinal neuroendocrine cancer, GI neuroendocrine tumor, neuroendocrine tumor, neuroendocrine tumour, argentaffinoma, carcinoid syndrome, small bowel malignancy, irritable bowel syndrome, IBS, idiopathic flushing, intestinal tumor, intestinal tumour, GI tumor, GI tumour, gastrointestinal tumor, gastrointestinal tumour, intestinal malignancy, appendectomy, cancer of the appendix, carcinoid tumor of the appendix, carcinoid tumor of the small intestine, distal small bowel malignancy
Follow-up: Carcinoid Tumor, Intestinal