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Primary Cardiac Neoplasms Follow-up

  • Author: Mary C Mancini, MD, PhD, MMM; Chief Editor: Eric H Yang, MD  more...
Updated: Oct 14, 2015

Further Outpatient Care

Annually monitor patients who have undergone resection for cardiac tumors with echocardiography in order to assess for recurrences. With the more aggressive malignant tumors, follow up every 3-6 months.



Complications encountered after resection of cardiac tumors can include valvular insufficiency, complete heart block requiring pacemaker insertion, atrial and ventricular arrhythmias, and stroke.



Prognosis for benign tumors is excellent, matching that of the healthy population. Malignant tumors carry a dismal prognosis even in the face of complete resection. An occasional sarcoma can be resected completely, resulting in long-term survival.

Contributor Information and Disclosures

Mary C Mancini, MD, PhD, MMM Professor and Chief of Cardiothoracic Surgery, Department of Surgery, Louisiana State University School of Medicine in Shreveport

Mary C Mancini, MD, PhD, MMM is a member of the following medical societies: American Association for Thoracic Surgery, American College of Surgeons, American Surgical Association, Society of Thoracic Surgeons, Phi Beta Kappa

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Benjamin Movsas, MD 

Benjamin Movsas, MD is a member of the following medical societies: American College of Radiology, American Radium Society, American Society for Radiation Oncology

Disclosure: Nothing to disclose.

Chief Editor

Eric H Yang, MD Associate Professor of Medicine, Director of Cardiac Catherization Laboratory and Interventional Cardiology, Mayo Clinic Arizona

Eric H Yang, MD is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

Additional Contributors

Clarence Sarkodee Adoo, MD, FACP Consulting Staff, Department of Bone Marrow Transplantation, City of Hope Samaritan BMT Program

Clarence Sarkodee Adoo, MD, FACP is a member of the following medical societies: American College of Physicians-American Society of Internal Medicine, American Society of Hematology, American Society of Clinical Oncology

Disclosure: Nothing to disclose.

  1. Attar S, Lee YC, Singleton R, et al. Cardiac myxoma. Ann Thorac Surg. 1980 May. 29(5):397-405. [Medline].

  2. Burke AP, Cowan D, Virmani R. Primary sarcomas of the heart. Cancer. 1992 Jan 15. 69(2):387-95. [Medline].

  3. Butany J, Nair V, Naseemuddin A, et al. Cardiac tumours: diagnosis and management. Lancet Oncol. 2005 Apr. 6(4):219-28. [Medline].

  4. O'Neil MB Jr, Grehl TM, Hurley EJ. Cardial myxomas: a clinical diagnostic challenge. Am J Surg. 1979 Jul. 138(1):68-76. [Medline].

  5. Llombart-Cussac A, Pivot X, Contesso G, et al. Adjuvant chemotherapy for primary cardiac sarcomas: the IGR experience. Br J Cancer. 1998 Dec. 78(12):1624-8. [Medline].

  6. Basu S, Folliguet T, Anselmo M, et al. Lipomatous hypertrophy of the interatrial septum. Cardiovasc Surg. 1994 Apr. 2(2):229-31. [Medline].

  7. Smythe JF, Dyck JD, Smallhorn JF, et al. Natural history of cardiac rhabdomyoma in infancy and childhood. Am J Cardiol. 1990 Nov 15. 66(17):1247-9. [Medline].

  8. Shahian DM, Labib SB, Chang G. Cardiac papillary fibroelastoma. Ann Thorac Surg. 1995 Feb. 59(2):538-41. [Medline].

  9. Burke AP, Virmani R. Cardiac rhabdomyoma: a clinicopathologic study. Mod Pathol. 1991 Jan. 4(1):70-4. [Medline].

  10. Burke AP, Rosado-de-Christenson M, Templeton PA, et al. Cardiac fibroma: clinicopathologic correlates and surgical treatment. J Thorac Cardiovasc Surg. 1994 Nov. 108(5):862-70. [Medline].

  11. Brizard C, Latremouille C, Jebara VA, et al. Cardiac hemangiomas. Ann Thorac Surg. 1993 Aug. 56(2):390-4. [Medline].

  12. Garson A, Smith RT Jr, Moak JP, et al. Incessant ventricular tachycardia in infants: myocardial hamartomas and surgical cure. J Am Coll Cardiol. 1987 Sep. 10(3):619-26. [Medline].

  13. Jebara VA, Uva MS, Farge A, et al. Cardiac pheochromocytomas. Ann Thorac Surg. 1992 Feb. 53(2):356-61. [Medline].

  14. Lund JT, Ehman RL, Julsrud PR, et al. Cardiac masses: assessment by MR imaging. AJR Am J Roentgenol. 1989 Mar. 152(3):469-73. [Medline].

  15. Sparrow PJ, Kurian JB, Jones TR, et al. MR imaging of cardiac tumors. Radiographics. 2005 Sep-Oct. 25(5):1255-76. [Medline].

  16. Reeder GS, Khandheria BK, Seward JB, et al. Transesophageal echocardiography and cardiac masses. Mayo Clin Proc. 1991 Nov. 66(11):1101-9. [Medline].

  17. Read RC, White HJ, Murphy ML, et al. The malignant potentiality of left atrial myxoma. J Thorac Cardiovasc Surg. 1974 Dec. 68(6):857-68. [Medline].

  18. Ferrans VJ, Roberts WC. Structural features of cardiac myxomas. Histology, histochemistry, and electron microscopy. Hum Pathol. 1973 Mar. 4(1):111-46. [Medline].

  19. Murphy MC, Sweeney MS, Putnam JB Jr, et al. Surgical treatment of cardiac tumors: a 25-year experience. Ann Thorac Surg. 1990 Apr. 49(4):612-7; discussion 617-8. [Medline].

  20. Michler RE, Goldstein DJ. Treatment of cardiac tumors by orthotopic cardiac transplantation. Semin Oncol. 1997 Oct. 24(5):534-9. [Medline].

  21. Basso C, Valente M, Poletti A, et al. Surgical pathology of primary cardiac and pericardial tumors. Eur J Cardiothorac Surg. 1997 Nov. 12(5):730-7; discussion 737-8. [Medline].

  22. Thomason R, Schlegel W, Lucca M, et al. Primary malignant mesothelioma of the pericardium. Case report and literature review. Tex Heart Inst J. 1994. 21(2):170-4. [Medline].

  23. Balasundaram S, Halees SA, Duran C. Mesothelioma of the atrioventricular node: first successful follow-up after excision. Eur Heart J. 1992 May. 13(5):718-9. [Medline].

  24. Abdou M, Hayek S, Williams BR 3rd. Atrial myxoma in a patient with hypertrophic cardiomyopathy. Tex Heart Inst J. 2013. 40(4):462-4. [Medline]. [Full Text].

  25. Bhan A, Mehrotra R, Choudhary SK, et al. Surgical experience with intracardiac myxomas: long-term follow-up. Ann Thorac Surg. 1998 Sep. 66(3):810-3. [Medline].

  26. Butany J, Leong SW, Carmichael K, et al. A 30-year analysis of cardiac neoplasms at autopsy. Can J Cardiol. 2005 Jun. 21(8):675-80. [Medline].

  27. Jain D, Maleszewski JJ, Halushka MK. Benign cardiac tumors and tumorlike conditions. Ann Diagn Pathol. 2010 Jun. 14(3):215-30. [Medline].

  28. Jelic J, Milicic D, Alfirevic I, et al. Cardiac myxoma: diagnostic approach, surgical treatment and follow-up. A twenty years experience. J Cardiovasc Surg (Torino). 1996 Dec. 37(6 Suppl 1):113-7. [Medline].

  29. La Francesca S, Gregoric ID, Cohn WE, et al. Successful resection of a primary left ventricular schwannoma. Ann Thorac Surg. 2007 May. 83(5):1881-2. [Medline].

  30. Matebele MP, Peters P, Mundy J, Shah P. Cardiac tumors in adults: surgical management and follow-up of 19 patients in an Australian tertiary hospital. Interact Cardiovasc Thorac Surg. 2010 Jun. 10(6):892-5. [Medline].

  31. McAllister HA Jr. Primary tumors and cysts of the heart and pericardium. Curr Probl Cardiol. 1979 May. 4(2):1-51. [Medline].

  32. Muzzi L, Davoli G, Specchia L, et al. Primary hemangioma of the mitral valve: an unusual presentation. J Heart Valve Dis. 2007 Mar. 16(2):209-11. [Medline].

  33. Nonami A, Takenaka K, Kamezaki K, et al. Successful treatment of primary cardiac lymphoma by rituximab-CHOP and high-dose chemotherapy with autologous peripheral blood stem cell transplantation. Int J Hematol. 2007 Apr. 85(3):264-6. [Medline].

  34. Padalino MA, Basso C, Milanesi O, et al. Surgically treated primary cardiac tumors in early infancy and childhood. J Thorac Cardiovasc Surg. 2005 Jun. 129(6):1358-63. [Medline].

  35. Park KJ, Woo JS, Park JY. Left atrial myxoma presenting with unusual cystic form. Korean J Thorac Cardiovasc Surg. 2013 Oct. 46(5):362-4. [Medline]. [Full Text].

  36. Paul S, Ramanathan T, Cohen DM, et al. Primary Ewing sarcoma invading the heart: resection and reconstruction. J Thorac Cardiovasc Surg. 2007 Jun. 133(6):1667-9. [Medline].

  37. Peregud-Pogorzelska M, Kazmierczak J, Wojtarowicz A. Intracavitary mass as the initial manifestation of primary pericardial mesothelioma: a case report. Angiology. 2007 Apr-May. 58(2):255-8. [Medline].

  38. Putnam JB Jr, Sweeney MS, Colon R, et al. Primary cardiac sarcomas. Ann Thorac Surg. 1991 Jun. 51(6):906-10. [Medline].

  39. Reynen K. Cardiac myxomas. N Engl J Med. 1995 Dec 14. 333(24):1610-7. [Medline].

  40. Silverman NA. Primary cardiac tumors. Ann Surg. 1980 Feb. 191(2):127-38. [Medline].

  41. Stern MJ, Cohen MV, Fish B, et al. Clinical presentation and non-invasive diagnosis of right heart masses. Br Heart J. 1981 Nov. 46(5):552-8. [Medline].

  42. Tatli S, Lipton MJ. CT for intracardiac thrombi and tumors. Int J Cardiovasc Imaging. 2005 Feb. 21(1):115-31. [Medline].

  43. Wold LE, Lie JT. Cardiac myxomas: a clinicopathologic profile. Am J Pathol. 1980 Oct. 101(1):219-40. [Medline].

Low-power photomicrograph of cardiac myxoma (hematoxylin and eosin stain).
High-power photomicrograph showing the histology of cardiac myxoma (hematoxylin and eosin stain). Note the dark staining polygonal cells characteristic of the tumor.
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