eMedicine Specialties > Oncology > Carcinomas of the Gastrointestinal Tract

Cholangiocarcinoma: Multimedia

Author: Peter E Darwin, MD, Associate Professor, Director of GI Endoscopy, Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine
Coauthor(s): Andrew Scott Kennedy, MD, Co-Medical Director, Wake Radiology Oncology; Jennifer Lynn Bonheur, MD, Attending Physician, Division of Gastroenterology, Lenox Hill Hospital
Contributor Information and Disclosures

Updated: Jan 8, 2009

Multimedia

Bismuth classification for perihilar cholangiocar...Media file 1: Bismuth classification for perihilar cholangiocarcinoma. Shaded areas represent tumor location.
Bismuth classification for perihilar cholangiocar...

Bismuth classification for perihilar cholangiocarcinoma. Shaded areas represent tumor location.

Tight stricture of a common hepatic duct in a pat...Media file 2: Tight stricture of a common hepatic duct in a patient presenting with jaundice. Cytologic studies confirmed cholangiocarcinoma.
Tight stricture of a common hepatic duct in a pat...

Tight stricture of a common hepatic duct in a patient presenting with jaundice. Cytologic studies confirmed cholangiocarcinoma.

Three-dimensional treatment planning uses CT scan...Media file 3: Three-dimensional treatment planning uses CT scan slices to reconstruct the patient as a volume. Shown here is the display for planning external-beam radiotherapy to the cholangiocarcinoma (green structure). A biliary catheter (red tube) runs through the tumor volume and was used to deliver brachytherapy, which was given in addition to external-beam radiotherapy. Such technology has assisted greatly in the delivery of high doses to the tumor, while sparing vital normal structures, such as the kidney and spinal cord.
Three-dimensional treatment planning uses CT scan...

Three-dimensional treatment planning uses CT scan slices to reconstruct the patient as a volume. Shown here is the display for planning external-beam radiotherapy to the cholangiocarcinoma (green structure). A biliary catheter (red tube) runs through the tumor volume and was used to deliver brachytherapy, which was given in addition to external-beam radiotherapy. Such technology has assisted greatly in the delivery of high doses to the tumor, while sparing vital normal structures, such as the kidney and spinal cord.

More on Cholangiocarcinoma

Overview: Cholangiocarcinoma
Differential Diagnoses & Workup: Cholangiocarcinoma
Treatment & Medication: Cholangiocarcinoma
Follow-up: Cholangiocarcinoma
Multimedia: Cholangiocarcinoma
References

References

  1. Douglass HO, Tepper J, Leichman L. Neoplasms of the extrahepatic bile ducts. In: Holland JF, et al, eds. Cancer Medicine. Vol 2. Philadelphia, Pa: Lea & Febiger. 1993:1455-62.

  2. Lake JR. Benign and malignant neoplasms of the gallbladder, bile ducts and ampulla. In: Sleisinger MH, Fordtran JS, eds. Gastrointestinal Disease. 5th ed. Vol 2. Philadelphia, Pa: WB Saunders. 1993:1891-1902.

  3. Lotze MT, Flickinger JC, Carr BI. Hepatobiliary neoplasms. In: Devita V, Hellman S, Rosenberg S. Cancer: Principles and Practice of Oncology. 4th. Philadelphia, Pa: Lippincott; 1993:883-907.

  4. de Groen PC, Gores GJ, LaRusso NF, et al. Biliary tract cancers. N Engl J Med. Oct 28 1999;341(18):1368-78. [Medline].

  5. Klatskin G. Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis. An unusual tumor with distinctive clinical and pathological features. Am J Med. Feb 1965;38:241-56. [Medline].

  6. Clary B, Jarnigan W, Pitt H, et al. Hilar cholangiocarcinoma. J Gastrointest Surg. Mar-Apr 2004;8(3):298-302. [Medline].

  7. American Cancer Society Statistics. Estimated New Cancer Cases and Deaths, 2007. Available at http://www.cancer.org/downloads/stt/CFF2007EstCsDths07.pdf. Accessed April 11, 2008.

  8. Biliary Tract Cancer. In: Schottenfeld D, Fraumeni J. Cancer. Epidemiology and Prevention. 3rd Edition. Oxford University Press; 2006:787-800.

  9. Chalasani N, Baluyut A, Ismail A, et al. Cholangiocarcinoma in patients with primary sclerosing cholangitis: a multicenter case-control study. Hepatology. Jan 2000;31(1):7-11. [Medline].

  10. Keiding S, Hansen SB, Rasmussen HH, et al. Detection of cholangiocarcinoma in primary sclerosing cholangitis by positron emission tomography. Hepatology. Sep 1998;28(3):700-6. [Medline].

  11. Petrowsky H, Wildbrett P, Husarik DB. Impact of Integrated PET and CT on staging and management of glabladder cancer and cholangiocarcinoma. J Hepatol. 2006;Epub Apr 19.

  12. Fritscher-Ravens A, Broering DC, Knoefel WT, et al. EUS-guided fine-needle aspiration of suspected hilar cholangiocarcinoma in potentially operable patients with negative brush cytology. Am J Gastroenterol. Jan 2004;99(1):45-51. [Medline].

  13. Ortner MA, Liebetruth J, Schreiber S, et al. Photodynamic therapy of nonresectable cholangiocarcinoma. Gastroenterology. Mar 1998;114(3):536-42. [Medline].

  14. Ortner ME, Caca K, Berr F, et al. Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study. Gastroenterology. Nov 2003;125(5):1355-63. [Medline].

  15. Simmons DT, Baron TH, Peterson BT. A Novel Endoscopic Approach to Brachytherapy in the Management of Hilar Cholangiocarcinoma. Am J Gastroenterol. 2006;Epub ahead of print.

  16. Thongprasert S, Napapan S, Charoentum C, Moonprakan S. Phase II study of gemcitabine and cisplatin as first-line chemotherapy in inoperable biliary tract carcinoma. Ann Oncol. Feb 2005;16(2):279-81. [Medline].

  17. Thongprasert S. The role of chemotherapy in cholangiocarcinoma. Ann Oncol. 2005;16 Suppl 2:ii93-6. [Medline].

  18. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology. Available at http://www.nccn.org/professionals/physician_gls/default.asp.

  19. Heimbach JK, Haddock MG, Alberts SR, et al. Transplantation for hilar cholangiocarcinoma. Liver Transpl. Oct 2004;10(10 Suppl 2):S65-8. [Medline].

  20. Gunderson LL, Willett CG. Pancreas and hepatobiliary tract. In: Perez CA, Brady LW, et al. Principles and Practice of Radiation Oncology. 1998. 3rd ed. Philadelphia, Pa: Lippincott-Raven; 1467-1488.

  21. Kew MC. Tumors of the liver. In: Zakim D, Boyer TD, eds. Hepatology. Philadelphia, Pa: WB Saunders. 1996:1513-1548.

  22. Lillemoe K, Kennedy A, Picus J. Clinical management of carcinoma of the biliary tree. In: Kelsen DP, Daly JM, Kern SE, et al. Gastrointestinal Oncology: Principles and Practices. Philadelphia, Pa: Lippincott Williams & Wilkins; 2001.

  23. Uchida M, Ishibashi M, Tomita N, et al. Hilar and suprapancreatic cholangiocarcinoma: value of 3D angiography and multiphase fusion images using MDCT. AJR Am J Roentgenol. May 2005;184(5):1572-7. [Medline].

  24. Yalcin S. Diagnosis and management of cholangiocarcinomas: a comprehensive review. Hepatogastroenterology. Jan-Feb 2004;51(55):43-50. [Medline].

Further Reading

Keywords

cholangiocarcinoma, CCC, biliary duct system, perihilar tumors, Klatskin tumors, adenocarcinoma, primary sclerosing cholangitis, PSC

Contributor Information and Disclosures

Author

Peter E Darwin, MD, Associate Professor, Director of GI Endoscopy, Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine
Peter E Darwin, MD is a member of the following medical societies: American College of Gastroenterology, American College of Physicians, and American Society for Gastrointestinal Endoscopy
Disclosure: Nothing to disclose.

Coauthor(s)

Andrew Scott Kennedy, MD, Co-Medical Director, Wake Radiology Oncology
Andrew Scott Kennedy, MD is a member of the following medical societies: Alpha Omega Alpha, American Association for Cancer Research, American Hepato-Pancreato-Biliary Association, American Society for Therapeutic Radiology and Oncology, American Society of Clinical Oncology, and Radiological Society of North America
Disclosure: Nothing to disclose.

Jennifer Lynn Bonheur, MD, Attending Physician, Division of Gastroenterology, Lenox Hill Hospital
Jennifer Lynn Bonheur, MD is a member of the following medical societies: American Gastroenterological Association, American Society for Gastrointestinal Endoscopy, New York Academy of Sciences, New York Society for Gastrointestinal Endoscopy, and Sigma Xi
Disclosure: Nothing to disclose.

Medical Editor

Michael Perry, MD, MS, MACP, Nellie B Smith Chair of Oncology Emeritus, Professor, Department of Internal Medicine, Division of Hematology and Oncology, University of Missouri/Ellis Fischel Cancer Center
Michael Perry, MD, MS, MACP is a member of the following medical societies: Alpha Omega Alpha, American Association for Cancer Research, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Medical Association, American Society of Clinical Oncology, American Society of Hematology, International Association for the Study of Lung Cancer, and Missouri State Medical Association
Disclosure: Bionumerik Consulting fee Consulting; Proactya Consulting fee Consulting; GSK Consulting fee Consulting; NovoNordisk Consulting fee Consulting; Amgen Honoraria Speaking and teaching; GSK Consulting fee Speaking and teaching

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Benjamin Movsas, MD, Vice-Chairman, Department of Radiation Oncology, Fox Chase Cancer Center
Benjamin Movsas, MD is a member of the following medical societies: American College of Radiology, American Radium Society, and American Society for Therapeutic Radiology and Oncology
Disclosure: Nothing to disclose.

CME Editor

Rajalaxmi McKenna, MD, FACP, Southwest Medical Consultants, SC, Department of Medicine, Good Samaritan Hospital, Advocate Health Systems
Rajalaxmi McKenna, MD, FACP is a member of the following medical societies: American Society of Clinical Oncology, American Society of Hematology, and International Society on Thrombosis and Haemostasis
Disclosure: Nothing to disclose.

Chief Editor

Jules E Harris, MD, Clinical Professor of Medicine, Division of Hematology/Medical Oncology, Department of Internal Medicine, University of Arizona College of Medicine at Tucson; Consulting Staff, Arizona Cancer Center
Jules E Harris, MD is a member of the following medical societies: American Association for Cancer Research, American Association for the Advancement of Science, American Association of Immunologists, American Society of Hematology, and Central Society for Clinical Research
Disclosure: GlobeImmune Salary Consulting; Amplimed Consulting fee Consulting; FibroGen Consulting fee Consulting

 
 
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