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Pel-Ebstein Fever: Differential Diagnoses & Workup
Updated: Jun 26, 2006
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
Differential Diagnoses
Other Problems to Be Considered
Pancreatic carcinoid tumor
Workup
Laboratory Studies
- In a patient with true Pel-Ebstein fever, the diagnosis is established by the histologic finding of HL or another lymphoma. (Other lymphomas and malignancies may be associated with fevers, but only the fever associated with HL is named Pel-Ebstein.)
- No laboratory tests are particularly useful in persons with Pel-Ebstein fever.
- In rare cases, Pel-Ebstein fever has been associated with episodic hemolysis. In these cases, hemolysis laboratory studies may be helpful in making a diagnosis.
Imaging Studies
- Imaging studies are not useful in the diagnosis of the fever; however, CT scans of the neck, chest, abdomen, and pelvis, as well as PET or gallium scans, can be useful in the diagnosis of the underlying Hodgkin lymphoma.
Procedures
- No diagnostic procedures are particularly useful in persons with Pel-Ebstein fever beyond the biopsy used to diagnose the HL or causative lymphoma.
More on Pel-Ebstein Fever |
| Overview: Pel-Ebstein Fever |
Differential Diagnoses & Workup: Pel-Ebstein Fever |
| Treatment & Medication: Pel-Ebstein Fever |
| Follow-up: Pel-Ebstein Fever |
| References |
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References
Colvett KL, Patel D, Smith JK. Multiple Beau''s lines in a patient with fever of unknown origin. South Med J. Dec 1993;86(12):1424-6. [Medline].
Dankbaar H, Willemze R, Bieger R. Bone marrow disorders in Hodgkin''s disease: cyclic pancytopenia coinciding with Pel-Ebstein fever. Neth J Med. 1983;26(3):74-6. [Medline].
Good GR, DiNubile MJ. Images in clinical medicine. Cyclic fever in Hodgkin''s disease (Pel- Ebstein fever). N Engl J Med. Feb 16 1995;332(7):436. [Medline].
Hilson AJ. Pel-Ebstein fever [letter; comment]. N Engl J Med. Jul 6 1995;333(1):66-7. [Medline].
Koopmans RP, van den Born BJ, Kersten MJ, Hart W. [Clinical reasoning and decision making in practice. A 41-year old with periodic fever of unknown origin]. Ned Tijdschr Geneeskd. Sep 13 2003;147(37):1778-83. [Medline].
McKenna W, Lampert I, Oakley C, Goldman J. Pel-Ebstein fever coinciding with cyclical haemolytic anaemia and splenomegaly in a patient with Hodgkin''s disease. Scand J Haematol. Nov 1979;23(5):378-80. [Medline].
Molina Boix M, Ortega Gonzalez G, Garcia Perez B, Perez Gracia A. [Pel-Ebstein fever, hemolytic anemia and Hodgkin''s disease (letter)]. An Med Interna. Jul 1989;6(7):388-9. [Medline].
Racchi O, Rapezzi D, Ferraris AM, Gaetani GF. Unusual bone marrow relapse of Hodgkin''s disease with typical Pel- Ebstein fever. Ann Hematol. Jul 1996;73(1):39-40. [Medline].
Reimann HA. Periodic (Pel-Ebstein) fever of lymphomas. Ann Clin Lab Sci. Jan-Feb 1977;7(1):1-5. [Medline].
Storgaard L, Karle H. Fever and haemolysis in Hodgkin''s diseases. Acta Med Scand. Apr 1975;197(4):311-6. [Medline].
Talbot TR. Cases from the Osler Medical Service at Johns Hopkins University. Hodgkin''s disease with Pel-Ebstein fevers. Am J Med. Mar 2002;112(4):312-3. [Medline].
Further Reading
Keywords
Pel-Ebstein fever, periodic fever of lymphomas, Hodgkin disease, Hodgkin's disease, HD, Hodgkin's episodic fever, Hodgkin episodic fever, B symptoms, B-type symptoms, Hodgkin lymphoma, Hodgkin's lymphoma, HL, lymphoma, lymphoma-related fever, relapsing fever, hemolysis, hemolytic anemia, periodic fever spikes
Differential Diagnoses & Workup: Pel-Ebstein Fever