Medication Summary
The goals of pharmacotherapy are to reduce morbidity and to prevent complications.
Analgesics
Class Summary
Generally, the usual pain medications (eg, aspirin with codeine, acetaminophen with codeine) may be used to relieve pain. Many patients with rhabdomyomas are asymptomatic; these patients rarely require strong pain medication.
Aspirin 325 mg with codeine 30 mg (Empirin with Codeine)
Provides adequate pain relief. However, discontinue aspirin several days before any surgical treatment is undertaken to prevent excessive bleeding.
Codeine/acetaminophen (Tylenol #2)
Indicated for the treatment of mild to moderate pain. Acetaminophen can be used safely before surgery.
Acetaminophen (Tylenol, Feverall, Tempra)
DOC for pain in patients with documented hypersensitivity to aspirin or NSAIDs, with upper GI disease, or who are taking oral anticoagulants.
Oxycodone and acetaminophen (Percocet, Tylox)
Drug combination indicated for the relief of moderate to severe pain.
Hansen T, Katenkamp D. Rhabdomyoma of the head and neck: morphology and differential diagnosis. Virchows Arch. Nov 2005;447(5):849-54. [Medline].
Bjorndal Sorensen K, Godballe C, Ostergaard B, Krogdahl A. Adult extracardiac rhabdomyoma: light and immunohistochemical studies of two cases in the parapharyngeal space. Head Neck. Mar 2006;28(3):275-9. [Medline].
Iversen UM. Two cases of benign vaginal rhabdomyoma. Case reports. APMIS. Jul-Aug 1996;104(7-8):575-8. [Medline].
Kelekci S, Yazicioglu HF, Yilmaz B, Aygün M, Omeroglu RE. Cardiac rhabdomyoma with tuberous sclerosis: a case report. J Reprod Med. Jul 2005;50(7):550-2. [Medline].
Jozwiak S, Domanska-Pakiela D, Kwiatkowski DJ, Kotulska K. Multiple cardiac rhabdomyomas as a sole symptom of tuberous sclerosis complex: case report with molecular confirmation. J Child Neurol. Dec 2005;20(12):988-9. [Medline].
Ashfaq R, Timmons CF. Rhabdomyomatous mesenchymal hamartoma of skin. Pediatr Pathol. Sep-Oct 1992;12(5):731-5. [Medline].
Delides A, Petrides N, Banis K. Multifocal adult rhabdomyoma of the head and neck: a case report and literature review. Eur Arch Otorhinolaryngol. Jun 2005;262(6):504-6. [Medline].
Webb DW, Thomas RD, Osborne JP. Cardiac rhabdomyomas and their association with tuberous sclerosis. Arch Dis Child. 1993;68(3):367-70. [Medline].
Tiberio D, Franz DN, Phillips JR. Regression of a cardiac rhabdomyoma in a patient receiving everolimus. Pediatrics. May 2011;127(5):e1335-7. [Medline].
Bastian BC, Brocker EB. Adult rhabdomyoma of the lip. Am J Dermatopathol. Feb 1998;20(1):61-4. [Medline].
Bosi G, Lintermans JP, Pellegrino PA, et al. The natural history of cardiac rhabdomyoma with and without tuberous sclerosis. Acta Paediatr. Aug 1996;85(8):928-31. [Medline].
Burke A, Virmani R. Pediatric heart tumors. Cardiovasc Pathol. Jul-Aug 2008;17(4):193-8. [Medline].
Campanacci M. Bone and Soft Tissue Tumors. New York, NY: Springer-Verlag; 1986.
Furihata M, Fujimori T, Imura J, Ono Y, Furihata T, Shimoda M. Malignant stromal tumor, so called "gastrointestinal stromal tumor", with rhabdomyomatous differentiation occurring in the gallbladder. Pathol Res Pract. 2005;201(8-9):609-13. [Medline].
Gunther T, Schreiber C, Noebauer C, Eicken A, Lange R. Treatment strategies for pediatric patients with primary cardiac and pericardial tumors: a 30-year review. Pediatr Cardiol. Nov 2008;29(6):1071-6. [Medline].
Koutsimpelas D, Weber A, Lippert BM, Mann WJ. Multifocal adult rhabdomyoma of the head and neck: a case report and literature review. Auris Nasus Larynx. Jun 2008;35(2):313-7. [Medline].
Lapner PC, Chou S, Jimenez C. Perianal fetal rhabdomyoma: case report. Pediatr Surg Int. Sep 1997;12(7):544-7. [Medline].
Motara F, Cilliers AM, Papeta L, Adams PE, Ntsinjana H, Vanderdonck K, et al. A giant rhabdomyoma in a neonate with tuberous sclerosis. Cardiovasc J Afr. Sep-Oct 2008;19(5 Suppl):S24-5. [Medline].
O'Callaghan FJ, Clarke AC, Joffe H, et al. Tuberous sclerosis complex and Wolff-Parkinson-White syndrome. Arch Dis Child. Feb 1998;78(2):159-62. [Medline].
Tanda F, Rocca PC, Bosincu L. Rhabdomyoma of the tunica vaginalis of the testis: a histologic, immunohistochemical, and ultrastructural study. Mod Pathol. Jun 1997;10(6):608-11. [Medline].

