Malignant Carcinoid Syndrome Differential Diagnoses
- Author: Luigi Santacroce, MD; Chief Editor: Jules E Harris, MD more...
Differential Diagnoses
- Anaphylaxis
- Angioedema
- Intestinal Motility Disorders
- Irritable Bowel Syndrome
- Ogilvie Syndrome
- Tumor Lysis Syndrome
- Urticaria
Bendelow J, Apps E, Jones LE, et al. Carcinoid syndrome. Eur J Surg Oncol. Mar 2008;34(3):289-96. [Medline].
Feldman JM. Carcinoid tumors and syndrome. Semin Oncol. Sep 1987;14(3):237-46. [Medline].
Feldman JM. Carcinoid tumors and the carcinoid syndrome. Curr Probl Surg. Dec 1989;26(12):835-85. [Medline].
Lubarsch O. Ueber den primaren Krebs des Ileum, nebst Bemerhunge uber das gleichzeitge Vorkommen von Krebs und Tuberculose. Virchows Arch. 1888;111:280-317.
Oberndorfer S. Uber die "kleinen Dunndarm Carcinome". Verh Dtsch Ges Pathol. 1907;11:113—6.
Erspamer V, Asero B. Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-Hydroxytryptamine. Nature. 1952;169:800-1.
Gosset A, Masson P. Tumeurs endocinne de l'appendice. Presse Med. 1914;22:237-40.
Masson, P. Carcinoids (argentaffin-cell tumors) and nerve hyperplasia of appendicular mucosa. Am J Patholol. 1928;4:181-212.
Ahlman H. Midgut carcinoid tumors. Surg Annu. 1986;18:65-93. [Medline].
Papadogias D, Makras P, Kossivakis K, et al. Carcinoid syndrome and carcinoid crisis secondary to a metastatic carcinoid tumour of the lung: a therapeutic challenge. Eur J Gastroenterol Hepatol. Dec 2007;19(12):1154-9. [Medline].
Bonaros N, Muller S, Bonatti J, et al. Primary ovarian carcinoid heart disease curatively treated with a two-stage procedure. Thorac Cardiovasc Surg. Oct 2007;55(7):467-9. [Medline].
Chaowalit N, Connolly HM, Schaff HV, et al. Carcinoid heart disease associated with primary ovarian carcinoid tumor. Am J Cardiol. May 15 2004;93(10):1314-5. [Medline].
Bhattacharyya S, Davar J, Dreyfus G, et al. Carcinoid heart disease. Circulation. Dec 11 2007;116(24):2860-5. [Medline].
Cunningham JL, Janson ET, Agarwal S, Grimelius L, Stridsberg M. Tachykinins in endocrine tumors and the carcinoid syndrome. Eur J Endocrinol. Sep 2008;159(3):275-82. [Medline].
Russo S, Boon JC, Kema IP, Willemse PH, den Boer JA, Korf J, et al. Patients with carcinoid syndrome exhibit symptoms of aggressive impulse dysregulation. Psychosom Med. May-Jun 2004;66(3):422-5. [Medline]. [Full Text].
Quaedvlieg PF, Visser O, Lamers CB, Janssen-Heijen ML, Taal BG. Epidemiology and survival in patients with carcinoid disease in The Netherlands. An epidemiological study with 2391 patients. Ann Oncol. Sep 2001;12(9):1295-300. [Medline]. [Full Text].
Berge T, Linell F. Carcinoid tumours. Frequency in a defined population during a 12-year period. Acta Pathol Microbiol Scand A. Jul 1976;84(4):322-30. [Medline].
Wilson HM. Chronic subacute bowel obstruction caused by carcinoid tumour misdiagnosed as irritable bowel syndrome: a case report. Cases J. Jan 22 2009;2(1):78. [Medline].
Metcalfe DD. Differential diagnosis of the patient with unexplained flushing/anaphylaxis. Allergy Asthma Proc. 2000;21(1):21-4. [Medline].
Kleyn CE, Lai-Cheong JE, Bell HK. Cutaneous manifestations of internal malignancy: diagnosis and management. Am J Clin Dermatol. 2006;7(2):71-84. [Medline].
Monsegu J, Algayres JP, Ciribilli JM, et al. [Tricuspid insufficiency disclosing carcinoid syndrome]. Rev Med Interne. 1994;15(9):593-6. [Medline].
Shah GM, Shah RG, Veillette H, Kirkland JB, Pasieka JL, Warner RR. Biochemical assessment of niacin deficiency among carcinoid cancer patients. Am J Gastroenterol. Oct 2005;100(10):2307-14. [Medline].
Banzali FM Jr, Tiwari AK, Frantz R, et al. Valvular heart disease caused by carcinoid syndrome: emphasis on the use of intraoperative transesophageal echocardiography. J Cardiothorac Vasc Anesth. Dec 2007;21(6):855-7. [Medline].
Kulke MH, Freed E, Chiang DY, Philips J, Zahrieh D, Glickman JN, et al. High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chromosomes Cancer. Jul 2008;47(7):591-603. [Medline].
Granerus G, Lindell SE, Waldenstrom J, et al. Histamine metabolism in carcinoidosis. Lancet. Jun 4 1966;1(7449):1267-8. [Medline].
Campana D, Nori F, Piscitelli L, Morselli-Labate AM, Pezzilli R, Corinaldesi R, et al. Chromogranin A: is it a useful marker of neuroendocrine tumors?. J Clin Oncol. May 20 2007;25(15):1967-73. [Medline].
Bhattacharyya S, Toumpanakis C, Caplin ME, Davar J. Usefulness of N-terminal pro-brain natriuretic peptide as a biomarker of the presence of carcinoid heart disease. Am J Cardiol. Oct 1 2008;102(7):938-42. [Medline].
Sinzinger H, Renner F, Granegger S. Unsuccessful iodine-131 MIBG imaging of carcinoid tumors and apudomas. J Nucl Med. Jul 1986;27(7):1221-2. [Medline].
Garg S, Bourantas CV, Nair RK, Alamgir F. Carcinoid syndrome diagnosed by echocardiography. Int J Cardiol. Feb 11 2009;[Medline].
Bastarrika G, Cao MG, Cano D, et al. Magnetic resonance imaging diagnosis of carcinoid heart disease. J Comput Assist Tomogr. Nov-Dec 2005;29(6):756-9. [Medline].
Sinha V, Dyer P, Shuvro RC, Geh JI, Karandikar S. Case of carcinoid crisis following a fine-needle biopsy of hepatic metastasis. Eur J Gastroenterol Hepatol. Jan 2009;21(1):101-3. [Medline].
Joensuu H, Kumpulainen E, Grohn P. Treatment of metastatic carcinoid tumour with recombinant interferon alfa. Eur J Cancer. 1992;28A(10):1650-3. [Medline].
[Best Evidence] Rinke A, Müller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, et al. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol. Oct 1 2009;27(28):4656-63. [Medline].
Pavel ME, Hainsworth JD, Baudin E, et al. Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study. Lancet. Dec 10 2011;378(9808):2005-12. [Medline].
Hodul P, Malafa M, Choi J, et al. The role of cytoreductive hepatic surgery as an adjunct to the management of metastatic neuroendocrine carcinomas. Cancer Control. Jan 2006;13(1):61-71. [Medline].
Eller R, Frazee R, Roberts J. Gastrointestinal carcinoid tumors. Am Surg. Jul 1991;57(7):434-7. [Medline].
Farndon JR. The carcinoid syndrome: methods of treatment and recent experience with hepatic artery ligation and infusion. Clin Oncol. Dec 1977;3(4):365-75. [Medline].
Codd JE, Drozda J, Merjavy J. Palliation of carcinoid heart disease. Arch Surg. Sep 1987;122(9):1076-7. [Medline].
Bhattacharyya S, Davar J, Dreyfus G, Caplin ME. Carcinoid heart disease. Circulation. Dec 11 2007;116(24):2860-5. [Medline].
Chambers AJ, Pasieka JL, Dixon E, Rorstad O. The palliative benefit of aggressive surgical intervention for both hepatic and mesenteric metastases from neuroendocrine tumors. Surgery. Oct 2008;144(4):645-51; discussion 651-3. [Medline].
Bernheim AM, Connolly HM, Rubin J, Møller JE, Scott CG, Nagorney DM, et al. Role of hepatic resection for patients with carcinoid heart disease. Mayo Clin Proc. Feb 2008;83(2):143-50. [Medline].
Gregor M. Therapeutic principles in the management of metastasising carcinoid tumors: drugs for symptomatic treatment. Digestion. 1994;55 Suppl 3:60-3. [Medline].
Kleyn CE, Lai-Cheong JE, Bell HK. Cutaneous manifestations of internal malignancy: diagnosis and management. Am J Clin Dermatol. 2006;7(2):71-84. [Medline].
Ramage JK, Davies AH, Ardill J, et al. Guidelines for the management of gastroenteropancreatic neuroendocrine (includingcarcinoid) tumours. Gut. Jun 2005;54 Suppl 4:iv:1-16. [Medline].
Patients, Caregivers, and Friends. The Carcinoid Foundation. Available at www.carcinoid.org/index.shtml. Accessed September 27, 2009.
Jabbour-Khoury S, Dabbous A, al-Jazzar M, et al. Anesthetic management of a patient having a carcinoid syndrome. Middle East J Anesthesiol. Oct 2003;17(3):435-47. [Medline].
Anderson AS, Krauss D, Lang R. Cardiovascular complications of malignant carcinoid disease. Am Heart J. Oct 1997;134(4):693-702. [Medline].
Anthony LB, Martin W, Delbeke D, et al. Somatostatin receptor imaging: predictive and prognostic considerations. Digestion. 1996;57 Suppl 1:50-3. [Medline].
Bhattacharyya S, Toumpanakis C, Caplin ME, et al. Analysis of 150 patients with carcinoid syndrome seen in a single year at one institution in the first decade of the twenty-first century. Am J Cardiol. Feb 1 2008;101(3):378-81. [Medline].
Bourgault C, Bergeron S, Bogaty P, et al. A most unusual acute coronary syndrome. Can J Cardiol. Apr 2006;22(5):429-32. [Medline].
de Diego C, Marcos Alberca P, Cabrera JA, et al. Pathognomonic echocardiographic features of carcinoid syndrome. Clin Cardiol. Mar 2006;29(3):134. [Medline].
[Guideline] de Herder WW, O'Toole D, Rindi G. ENETS Consensus Guidelinesfor the Diagnosis and Treatment of Neuroendocrine Gastrointestinal TumorsPart 2 - Midgut and Hindgut Tumors. Neuroendocrinology. 2008;87.
Di Lucca J, Mahé E, Saiag P. [Severe acrocyanosis in carcinoid syndrome]. Ann Dermatol Venereol. Nov 2007;134(11):895-6. [Medline].
Farling PA, Durairaju AK. Remifentanil and anaesthesia for carcinoid syndrome. Br J Anaesth. Jun 2004;92(6):893-5. [Medline].
Feldman JM. Histaminuria from histamine-rich foods. Arch Intern Med. Nov 1983;143(11):2099-102. [Medline].
Frilling A, Rogiers X, Knofel WT, et al. Liver transplantation for metastatic carcinoid tumors. Digestion. 1994;55 Suppl 3:104-6. [Medline].
González O, Alberca MT, Santonja C. Echocardiographic diagnosis of carcinoid disease: exceptional evolution after ovarian tumor resection without cardiac surgery. Eur J Echocardiogr. Dec 2007;8(6):497-500. [Medline].
Hodgson HJ. Controlling the carcinoid syndrome. BMJ. Nov 12 1988;297(6658):1213-4. [Medline].
Jaber WA, Klarich KW. Images in cardiovascular medicine. Carcinoid heart disease. Circulation. Feb 21 2006;113(7):e160-1. [Medline].
Jagernauth S, Patel A, Baig K, et al. Fungal endocarditis of the eustachian valve in carcinoid heart disease: a case report. J Heart Valve Dis. Nov 2007;16(6):631-3. [Medline].
Lee KJ, Connolly HM, Pellikka PA. Carcinoid pulmonary valvulopathy evaluated by real-time 3-dimensional transthoracic echocardiography. J Am Soc Echocardiogr. Apr 2008;21(4):407.e1-2. [Medline].
Majeed F, Porter TR, Tarantolo S, et al. Carcinoid crisis and reversible right ventricular dysfunction after embolization in untreated carcinoid syndrome. Eur J Echocardiogr. Oct 2007;8(5):386-9. [Medline].
Mansencal N, Mitry E, Forissier JF, et al. Assessment of patent foramen ovale in carcinoid heart disease. Am Heart J. May 2006;151(5):1129.e1-6. [Medline].
Maton PN. The carcinoid syndrome. JAMA. Sep 16 1988;260(11):1602-5. [Medline].
Merino J, Zuluaga A, Gutierrez-Tejero F, et al. Pure testicular carcinoid associated with intratubular germ cell neoplasia. J Clin Pathol. Dec 2005;58(12):1331-3. [Medline].
Mignon M. Natural history of neuroendocrine enteropancreatic tumors. Digestion. 2000;62 Suppl 1:51-8. [Medline].
[Best Evidence] Moller JE, Pellikka PA, Bernheim AM, et al. Prognosis of carcinoid heart disease: analysis of 200 cases over two decades. Circulation. Nov 22 2005;112(21):3320-7. [Medline].
Mollet NR, Dymarkowski S, Bogaert J. MRI and CT revealing carcinoid heart disease. Eur Radiol. Dec 2003;13 Suppl 4:L14-8. [Medline].
Park SB, Kim JK, Cho KS. Imaging findings of a primary bilateral testicular carcinoid tumor associated with carcinoid syndrome. J Ultrasound Med. Mar 2006;25(3):413-6. [Medline].
Robertson RG, Geiger WJ, Davis NB. Carcinoid tumors. Am Fam Physician. 2006;74(3):429-34. [Full Text].
Rorstad O. Prognostic indicators for carcinoid neuroendocrine tumors of the gastrointestinal tract. J Surg Oncol. Mar 1 2005;89(3):151-60. [Medline].
Rosenberg JM, Welch JP. Ileal tumor causing carcinoid syndrome without hepatic metastases. Arch Surg. Apr 1984;119(4):485. [Medline].
Shapiro RS, Shafir M, Sung M, et al. Cryotherapy of metastatic carcinoid tumors. Abdom Imaging. May-Jun 1998;23(3):314-7. [Medline].
Somak R, Shramana M, Vijay S, et al. Primary carcinoid tumor of the ovary: a case report. Arch Gynecol Obstet. Jan 2008;277(1):79-82. [Medline].
Stella M, Decian F, Mithieux F, et al. Ileal carcinoid with liver metastasis presenting after ten years with abdominal mass and right heart failure: report of a case. Tumori. Jan-Feb 2006;92(1):83-5. [Medline].
van der Horst-Schrivers AN, Wymenga AN, Links TP, et al. Complications of midgut carcinoid tumors and carcinoid syndrome. Neuroendocrinology. 2004;80 Suppl 1:28-32. [Medline].
Yeo CJ, Couse NF, Zinner MJ. Serotonin and substance P stimulate intestinal secretion in the isolated perfused ileum. Surgery. Jan 1989;105(1):86-92. [Medline].
Zeitlin IJ. Kinin release in the carcinoid syndrome. Lancet. Nov 1971;2(7732):1040. [Medline].

