- Author: Benjamin Kennedy, MD; Chief Editor: Jules E Harris, MD, FACP, FRCPC more...
Astrocytomas (see the image below) are CNS neoplasms in which the predominant cell type is derived from an immortalized astrocyte. Survival correlates most highly with the intrinsic properties of the astrocytoma and typically ranges from approximately 10 years from the time of diagnosis for patients with pilocytic astrocytomas to less than 1 year for patients with glioblastoma.
Signs and symptoms
Neurologic symptoms from astrocytoma development depend foremost on the site and extent of tumor growth in the CNS but may include any of the following:
Altered mental status
Nausea and vomiting
Astrocytomas of the spinal cord or brainstem are less common and present as motor/sensory or cranial nerve deficits referable to the tumor's location.
On physical examination, patients may demonstrate signs of increased ICP or localizing and lateralizing signs such as the following:
Cranial nerve palsies
Alteration of deep tendon reflexes (DTRs)
Pathologic reflexes (eg, Hoffman sign, Babinski sign)
See Clinical Presentation for more detail.
No laboratory studies are diagnostic of astrocytoma, but the following baseline laboratory studies may be obtained for general metabolic surveillance and preoperative assessment:
Basic metabolic profile
Prothrombin time (PT)
Activated partial thromboplastin time (aPTT)
MRI is considered the criterion standard imaging study
Astrocytomas are generally isointense on T1-weighted images and hyperintense on T2-weighted images
While low-grade astrocytomas uncommonly enhance on MRI, most anaplastic astrocytomas enhance with paramagnetic contrast agents
The possibility of metastatic disease must be considered in cases in which a cortically based enhancing mass is discovered, particularly if multiple lesions are identified
High-resolution MRI is now often used to provide intraoperative image guidance
A CT scan may be useful in the acute setting or when MRI is contraindicated
On CT, low-grade astrocytomas appear as poorly defined, homogeneous, low-density masses without contrast enhancement; however, slight enhancement, calcification, and cystic changes may be evident early in the course of the disease
Systemic imaging, generally consisting of a contrast-enhanced CT scan of the chest, abdomen, and pelvis, may be warranted to evaluate for the possibility of an alternate primary lesion
Anaplastic astrocytomas may appear as low-density lesions or inhomogeneous lesions, with areas of both high and low density within the same lesion; unlike low-grade lesions, partial contrast enhancement is common
May be used to rule out vascular malformations and to evaluate tumor blood supply
A normal angiographic pattern or a pattern consistent with an avascular mass that displaces normal vessels is usually observed with both low-grade and high-grade lesions
In rare instances, a tumor blush may be observed with high-grade lesions
PET, SPECT, or technetium-based imaging can permit study of tumor metabolism and brain function
PET and SPECT may be used to distinguish a solid tumor from edema, to differentiate tumor recurrence from radiation necrosis, and to localize structures
Metabolic activity of a lesion can be used to determine tumor grade; hypermetabolic lesions often correspond to higher-grade tumors
EEG may be used to evaluate and monitor epileptiform activity
ECG and chest radiographs are indicated to evaluate operative risk
CSF studies may be used to rule out other diagnoses (eg, metastasis, lymphoma, medulloblastoma)
See Workup for more detail.
There is no accepted standard of treatment for low-grade or anaplastic astrocytoma. Treatment decisions are generally best made through a team approach, including input from the involved neurosurgeon, radiation oncologist, and medical oncologist or neurologist.
Typically, anaplastic astrocytomas are treated with the following:
Some practitioners add concomitant temozolomide [2, 3]
Some smaller survival benefit has been shown with adjuvant carmustine 
Treatment of low-grade astrocytomas remains more controversial. The role of maximal surgical resection, timing of radiotherapy, and the role, timing, and appropriate agents of chemotherapy are not clear.
Stereotactic biopsy is a safe and simple method for establishing a tissue diagnosis
Tumor resection can be performed safely and is generally undertaken with the intent to cause the least possible neurologic injury to the patient
Surgical resection provides improved survival advantage and histologic diagnosis of the tumor rather than offering a cure
Total resection of an astrocytoma is often impossible because the tumors often invade eloquent regions of the brain and exhibit tumor infiltration that is only detectable on a microscopic scale
Diversion of CSF by external ventricular drain (EVD) or ventriculoperitoneal shunt (VPS) may be required to decrease ICP
Patients with an astrocytoma and a history of seizures should receive anticonvulsant therapy, with monitoring of the serum drug concentration; levetiracetam (Keppra) is often used
Prophylactic use of anticonvulsants in astrocytoma patients with no prior history of seizures has been reported but remains controversial
The use of corticosteroids, such as dexamethasone, yields rapid improvement in most patients secondary to a reduction of tumor mass effect; patients receiving corticosteroids should have concurrent prophylaxis for gastrointestinal ulcers
Treatment and prognosis for brainstem gliomas typically depends on whether the tumor is diffuse or focal. Treatment of diffuse brainstem gliomas is as follows:
No benefit of surgical resection has been shown
Corticosteroids may provide temporary benefit by reduction of edema
Irradiation and chemotherapy are sometimes used, but neither has been shown to cure or prolong survival, and radiation necrosis and chemotherapy side effects can be significant
Treatment of focal brainstem gliomas is as follows:
Surgery is often the primary treatment, although the decision to operate, the surgical approach, and the extent of resection depend on location, patient factors, and the surgeon's judgment
Obstructive hydrocephalus is common and usually treated by a separate procedure, either endoscopic third ventriculostomy or shunt placement 
Astrocytomas are central nervous system (CNS) neoplasms in which the predominant cell type is derived from an immortalized astrocyte. Two classes of astrocytic tumors are recognized: those with narrow zones of infiltration (eg, pilocytic astrocytoma, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma) and those with diffuse zones of infiltration (eg, low-grade astrocytoma, anaplastic astrocytoma, glioblastoma). Members of the latter group share various features, including the following:
The ability to arise at any site in the CNS, with a preference for the cerebral hemispheres
Clinical presentation usually in adults
Heterogeneous histopathological properties and biological behavior
Diffuse infiltration of contiguous and distant CNS structures, regardless of histological stage
An intrinsic tendency to progress to more advanced grades
See the image below.
Numerous grading schemes based on histopathologic characteristics have been devised, including the following:
Bailey and Cushing grading system
Kernohan grades I-IV
World Health Organization (WHO) grades I-IV
St. Anne/Mayo grades 1-4
The regions of a tumor that demonstrate the greatest degree of anaplasia are used to determine the histologic grade of the tumor. This practice is based on the assumption that the areas of greatest anaplasia determine disease progression.
This article focuses on the widely accepted WHO grading scheme, which relies on assessments of nuclear atypia, mitotic activity, cellularity, vascular proliferation, and necrosis. The WHO scheme is as follows:
Grade I - Corresponds to pilocytic astrocytoma
Grade II - Corresponds to low-grade (diffuse) astrocytoma
Grade III - Corresponds to anaplastic astrocytoma
Grade IV - Corresponds to glioblastoma multiforme (GBM)
This article is confined to low-grade and anaplastic astrocytomas. GBM and pilocytic astrocytoma are not discussed in this article (for more information, see Glioblastoma Multiforme).
Regional effects of astrocytomas include compression, invasion, and destruction of brain parenchyma. Arterial and venous hypoxia, competition for nutrients, release of metabolic end products (eg, free radicals, altered electrolytes, neurotransmitters), and release and recruitment of cellular mediators (eg, cytokines) disrupt normal parenchymal function. Elevated intracranial pressure (ICP) attributable to direct mass effect, increased blood volume, or increased cerebrospinal fluid (CSF) volume may mediate secondary clinical sequelae.
Neurological signs and symptoms attributable to astrocytomas result from perturbation of CNS function. Focal neurological deficits (eg, weakness, paralysis, sensory deficits, cranial nerve palsies) and seizures of various characteristics may permit localization of lesions.
Infiltrating low-grade astrocytomas grow slowly than their malignant counterparts. Doubling time for low-grade astrocytomas is estimated at 4 times that of anaplastic astrocytomas. Several years often intervene between the initial symptoms and the establishment of a diagnosis of low-grade astrocytoma. One series estimated the interval to be approximately 3.5 years.
The clinical course is marked by a gradual deterioration in half of cases, a stepwise decline in one third of cases, and a sudden deterioration in 15% of cases. Seizures, often generalized, are the initial presenting symptom in about half of patients with low-grade astrocytoma.
For patients with anaplastic astrocytomas, the growth rate and interval between onset of symptoms and diagnosis is intermediate between low-grade astrocytomas and glioblastomas. Although highly variable, a mean interval of approximately 1.5-2 years between onset of symptoms and diagnosis is frequently reported. Seizures are less common in patients with anaplastic astrocytomas than in those with low-grade lesions. Initial presenting symptoms most commonly are headache, depressed mental status, and focal neurological deficits.
The annual incidence of glioma in the United States is 5.4 cases per 100,000 population. Incidence differences are not significant between the United States and other countries.
Morbidity and mortality, as defined by the length of a patient's history and the odds of recurrence-free survival, correlate most highly with the intrinsic properties of the astrocytoma in question. Typical ranges of survival from the time of diagnosis are as follows:
Pilocytic astrocytomas (WHO grade I): 10 years
Low-grade diffuse astrocytomas (WHO grade II)  : >5 years
Anaplastic astrocytomas (WHO grade III): 2-5 years
Glioblastoma (WHO grade IV): <1 year
Although genetic determinants are recognized in astrocytoma development and progression, astrocytomas do not differ intrinsically in incidence or behavior among racial groups. Demographic and sociological factors, such as population, age, ethnic attitude toward disease, and access to care, have been reported to influence measured distributions.
No clear sex predominance has been identified in the development of pilocytic astrocytomas. A slight male predominance, with a male-to-female ratio of 1.18:1 for development of low-grade astrocytomas, has been reported. A more significant male predominance, with a male-to-female ratio of 1.87:1 for the development of anaplastic astrocytomas, has been identified.
In most cases, patients with pilocytic astrocytoma present in the first 2 decades of life. In contrast, the peak incidence of low-grade astrocytomas, representing 25% of all cases in adults, occurs in people aged 30-40 years. Ten percent of low-grade astrocytomas occur in people younger than 20 years; 60% of low-grade astrocytomas occur in people aged 20-45 years; and 30% of low-grade astrocytomas occur in people older than 45 years. The mean age of patients undergoing a biopsy of anaplastic astrocytoma is 41 years.
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