- Author: Gagandeep Randhawa, MBBS; Chief Editor: David Bienenfeld, MD more...
Bulimia nervosa is an eating disorder with 5 key characteristics as noted by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM5).
- Recurrent episodes of binge eating. Eating more than the average person in a 2-hour period, accompanied by a sense of loss of control.
- Repetitive inappropriate compensatory behaviors to avoid weight gain such as excessive exercise, fasting, laxative use, and diuretic use.
- This eating behavior occurs at least once a week for a period of 3 months.
- Body shape and weight influence self-evaluation.
- This does not occur specifically with episodes of anorexia nervosa.
Signs and symptoms
Patients with bulimia nervosa may experience the following symptoms:[2, 3, 4]
General - Dizziness, lightheadedness, palpitations (due to dehydration, orthostatic hypotension, possibly hypokalemia), dry skin
Gastrointestinal symptoms - Pharyngeal irritation, abdominal pain (more common among persons who self-induce vomiting), blood in vomitus (from esophageal irritation; more rarely, from actual tears, which may be fatal), difficulty swallowing, bloating, flatulence, constipation, obstipation, and gastroesophageal reflux disease (GERD) 
Reproductive symptoms - Amenorrhea occurs in up to 50% of women with bulimia nervosa; significant proportion of remaining patients have irregular periods; many more will have menstrual irregularity and scanty periods
Uncommon symptoms, or in most severe cases
- Water and electrolytes - Dehydration, hypokalemia, hypochloremia, metabolic alkalosis
- Cardiac - Edema; EKG changes such as QT prolongation, increased PR interval, increased P wave amplitude, widened QRS, depressed ST segment
- Gastrointestinal - Gastric dilation, Barrett's esophagus
- Pulmonary symptoms - aspiration pneumonitis (uncommon), pneumomediastinum (rare)
Physical findings may include the following:
Cutaneous manifestations, including sudden, diffuse hair loss, acne, dry skin, nail dystrophy, and scarring resulting from cutting, burning, and other self-induced trauma
Bradycardia or tachycardia, hypothermia, and hypotension (often associated with dehydration)
Clinical obesity; morbid obesity is rare
See Clinical Presentation for more detail.
Lab studies that may be used for diagnosis include:
Comprehensive blood chemistry panel
Complete blood count (CBC)
Urine toxicology screen
Because of the potential for arrhythmias and cardiomyopathy as possible complications of bulimia nervosa, an electrocardiogram (ECG) should be performed in patients who are very thin, complaining of palpitations, or have other signs or symptoms of cardiovascular concern.
Because of the potential for osteoporosis, a dual-energy radiographic absorptiometry (DEXA) scan may be useful, particularly for patients with irregular menses, who have mood disorders, and/or who smoke cigarettes.
See Workup for more detail.
Core nonpharmacologic interventions for bulimia nervosa include the following:
Cognitive-behavioral therapy (CBT)
Interpersonal psychotherapy (IPT)
Nutritional rehabilitation counseling
Pharmacologic agents used in the treatment of bulimia nervosa include the following:
Fluoxetine (Prozac) - Approved by the FDA for the treatment of bulimia nervosa
Other antidepressants - As a group, antidepressants are the mainstay of pharmacotherapy for bulimia nervosa;  they may help patients with substantial concurrent symptoms of depression, anxiety, obsessions, or certain impulse disorder symptoms
Mood stabilizers - Topiramate, lithium, and valproic acid have been associated with adverse effects that can make these agents difficult to use in patients with bulimia nervosa; lithium has not been demonstrated to be effective for bulimia nervosa per se
See Treatment for more detail.
Bulimia nervosa is an eating disorder delineated in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Among the eating disorders, bulimia nervosa and anorexia nervosa are far more common in young females, while binge-eating disorder, the most common eating disorder overall, is more common in adults.
Bulimia nervosa includes regularly occurring compensatory behaviors that are intended to rid the body of the excess calories consumed during eating binges. Bulimia nervosa is distinguished from the recently delineated syndrome of binge-eating disorder, in which no regular or consistent compensatory behavior accompanies the bingeing episodes. Although the DSM-5 describes that compensatory behaviors may include purging and/or nonpurging behaviors (see below), in contrast to earlier DSM editions, DSM-5 no longer maintains specific purging and nonpurging subtypes. The frequent association of cigarette smoking with bulimia nervosa may at times reflect compensatory behavior, in that nicotine use appears to suppress, whereas smoking cessation provokes, weight gain in some individuals.
In up to 60% of cases, patients with bulimia nervosa report prior histories of anorexia nervosa. In contrast to individuals with uncomplicated binge-eating disorder who tend to be obese, people with bulimia nervosa are more typically of normal weight, although some degree of overlap between nonpurging bulimia nervosa and binge-eating disorder is seen. The natural history of eating disorders is such that individuals may pass through several diagnoses over time, with some meeting criteria for anorexia nervosa, bulimia nervosa, and binge-eating disorder at various points. The development of anorexia nervosa in individuals who initially present with bulimia nervosa is possible, although less common.
Bulimia nervosa is characterized by frequent episodes of binge eating associated with emotional distress and a sense of loss of control.
Binge eating: Eating, in a discrete period of time (eg, 2 hours) an amount of food that is significantly larger than is typical for most people during the same defined period. This behavior is associated with a perceived loss of control of eating during this time.
Overeating episode: The consumption of an unusually large amount of food in a defined period, without concomitant perception of loss of control.
Subjective bulimic episode: The consumption of objectively minimal amounts of food in a defined period with a perception of loss of control.
Compensatory behaviors used by individuals with bulimia nervosa include self-induced vomiting, laxative abuse, excessive exercise generally experienced as being joyless and/or compulsive, episodes of fasting or strict dieting, diuretic abuse, use of appetite suppressants, failure to use insulin in those with type I diabetes, and/or the use of medications intended to speed up metabolism (eg, thyroid hormone). DSM-5 diagnostic criteria require episodes of binge eating that occur at least once weekly for 3 months. Individuals with bulimia nervosa are also dissatisfied with their body shape, weight, or both.
Anorexia nervosa and bulimia nervosa are characterized by abnormalities in eating behaviors associated with a fear of weight gain and usually some degree of body image distortion (believing one looks much fatter than is actually the case). These are accompanied by associated abnormalities in mood and in perceptions of hunger and satiety. Disordered eating and weight control efforts can manifest as dietary restriction, binge eating, and/or other compensatory behaviors intended to prevent weight gain, as noted above.
For more information, see Medscape's Eating Disorders Resource Center.
Diagnostic criteria for bulimia nervosa
DMS-5 diagnostic criteria for 307.51 (F50.2) bulimia nervosa are as follows:
Recurrent episodes of binge eating: An episode of binge eating is characterized by both (1) eating, in a discrete period of time (eg, within any 2-hour period), an amount of food that is definitely larger than what most individuals would eat in a similar period of time under similar circumstances and (2) a sense of lack of control over eating during the episode (eg, a feeling that one cannot stop eating or control what or how much one is eating)
Recurrent inappropriate compensatory behaviors in order to prevent weight gain, such as self-induced vomiting; misuse of laxatives, diuretics, or other medications; fasting; or excessive exercise
The binge eating and inappropriate compensatory behaviors both occur, on average, at least once a week for 3 months
Self-evaluation is unduly influenced by body shape and weight
The disturbance does not occur exclusively during episodes of anorexia nervosa
Specify if either of the following applies:
In partial remission: After full criteria for bulimia nervosa were previously met, some, but not all, of the criteria have been met for a sustained period of time
In full remission: After full criteria for bulimia nervosa were previously met, none of the criteria has been met for a sustained period of time
Specify current severity. The minimum level of severity is based on the frequency of inappropriate compensatory behaviors. The level of severity may be increased to reflect other symptoms and the degree of functional disability. Specify current severity as follows:
Mild: An average of 1-3 episodes of inappropriate compensatory behaviors per week
Moderate: An average of 4-7 episodes of inappropriate compensatory behaviors per week
Severe: An average of 8–13 episodes of inappropriate compensatory behaviors per week
Extreme: An average of 14 or more episodes of inappropriate compensatory behaviors per week
A 21-year-old woman is brought into an outpatient clinic by her mother, who complains that her daughter has been demonstrating unusual eating patterns since she moved back home 6 months ago. Her mother observes her to eat large amounts of food, such as desserts, when she is alone, often finding food wrappers hidden in her daughter’s room. She is worried that her daughter may be engaging in vomiting after these episodes of heavy eating. She often isolates herself in the bathroom for 10-20 minutes after a large meal. This case will be discussed in the Clinical History section.
Other problems to be considered
Binge-eating disorder (BED)
BED is characterized by frequent and recurrent binge eating episodes without consistent compensatory behaviors. It is the most common eating disorder overall, with a lifetime prevalence of 2.8%. Binge-eating disorder is known to have several comorbidities with other psychiatric disorders, and is strongly associated with severe obesity. The lifetime prevalence for binge-eating disorder in men is 2%, while the male prevalence of bulimia nervosa is 0.5% and anorexia nervosa is 0.3%. This makes binge-eating disorder the most common eating disorder not only in the general population, but in men, as well.
Night eating syndrome (NES)
NES has only recently been defined and recognized. It is characterized by the consumption of large amounts of food (>20% of the total calorie intake) after evening meals. It is typically associated with early morning drowsiness and anorexia. No significant overlap is seen between binge-eating disorder or bulimia nervosa and night eating disorder.
Several eating disorder syndromes have been described in association with disturbances in disturbances in sleep and circadian patterns. These disorders are diagnosed under the DSM-5 “Other Specified Feeding or Eating Disorders” category.
NES is distinct from sleep-related eating disorder (SRED), another syndrome in which eating and sleep disturbances have been linked. NES and SRED are quite different. NES could be considered an abnormality in the circadian rhythm of meal timing with a normal circadian timing of sleep onset, ie, with individuals eating a substantial part of their daily intake in the evening, after usual dinnertime, before they go to sleep. Conversely, the feeding behavior in SRED is characterized by recurrent episodes of eating after an arousal from nighttime sleep with or without amnesia.
In addition to eating other foods, in SRED episodes, patients will sometimes eat foods that are ordinarily unpalatable, eg, raw flour and raw bacon have been described. Both conditions are often relentless and chronic. SRED is frequently associated with other sleep disorders, in particular parasomnias, eg, sleep-walking. Case reports have linked some cases of SRED to the use of certain psychotropic medications, including tricyclic antidepressants, anticholinergics, lithium, triazolam, olanzapine, risperidone, and zolpidem. Early studies have suggested that the anti-seizure medication topiramate may be an effective treatment for SRED.
Bulimia nervosa is thought to be significantly underrecognized. In the United States, the prevalence of bulimia nervosa is 1%. Lifetime prevalence is 0.5% for males and 1.5% for females. Those who are diagnosed with bulimia nervosa spend approximately 8.3 years with an episode. Approximately 65.3% of patients with bulimia have a body mass index (BMI) between 18.5-29.9 and only 3.5% have a BMI less than 18.5.
Bulimia nervosa is more common among those whose occupation or hobbies require gaining and/or losing weight rapidly, such as wrestlers and competitive bodybuilders. Athletes in certain sports (eg, runners and gymnasts, are particularly prone to eating disorders. The female athlete triad of eating disorders, hypothalamic amenorrhea, and osteoporosis is now well recognized and is particularly common in sports where slimness and body shape are of great importance, such as gymnastics, long distance running, diving, and figure skating. Eating disorders are also being recognized as a problem in predominantly male sports such as cycling, weight lifting, and wrestling. Certain vocations such as acting, modeling, and ballet dancing also appear to be associated with higher risk for these disorders.
While overall epidemiological trends are difficult to assess given the changes in diagnostic criteria over time, most studies report a progressive increase in the prevalence of anorexia nervosa and bulimia nervosa in the last several decades of the 20th century, with the possibility that rates have been leveling off. However, along with increases in obesity, rates of binge eating disorder are believed to be on the rise as well.
Rates of bulimic symptoms (as distinct from the diagnosis of bulimia nervosa per se) may vary across geographic regions in the United States. In one small study, women from North Carolina and Virginia (South Atlantic region) reported more bulimic symptoms than women from Louisiana and Tennessee (South Central region) and Ohio and Missouri (Midwest region).
A meta-analysis conducted of 36 studies by Arcelus et al suggests that individuals with eating disorders have significantly elevated mortality rates. Furthermore, the patients with anorexia nervosa had the highest mortality rate.
Bulimia nervosa is a cosmopolitan disorder that has been described in all ethnic, racial, and socioeconomic groups. Literature is mixed regarding ethnic differences in eating disorders. No clear consensus exists about the relative prevalence of eating disorders and associated symptoms across ethnicities. Clinicians should remain alert for possible ethnic diversity in symptom presentation or distress that could obscure the diagnosis or need for intervention.[17, 18]
As with other eating disorders, bulimia nervosa occurs predominantly in women. Most reports suggest a female-to-male ratio of 10:1, with reported ranges from 20:1 to 7:1. In some populations (eg, active duty military) body dissatisfaction and subclinical eating disorder rates among males have been reported to be in excess of 20%.
Clinicians should remain aware that men also develop bulimia nervosa and other eating disorders. The psychopathology and attitudes of males with eating disorders appear on the whole to be similar to those of females with eating disorders; both are significantly associated with family histories of these disorders. Although few data are available, evidence suggests that men and women also share significant similarities in clinical course, complications, and response to treatment.
The mean age of onset is 19.7, slightly older than the peak age of onset for anorexia nervosa but generally lower than the age of onset for binge-eating disorder. The prevalence of bulimia nervosa in children younger than 14 years appears to be less than 5%. Bulimia nervosa has also been reported in the elderly.
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|Anorexia Nervosa||AN and BN||Bulimia Nervosa|
|Restriction of energy intake relative to requirement, leading to significantly low body weight in the context of age, sex, developmental trajectory, and physical health||Recurrent episodes of binge eating: a) eating in a discrete period of time, within a 2-hour period, an amount that is definitely larger than what most would eat in that time period; b) a sense of lack of control over eating|
|Intense fear of gaining weight or of becoming fat, or persistent behavior that interferes with weight gain, even though at a significantly low weight||Recurrent inappropriate compensatory behaviors in order to prevent weight gain, such as self-induced vomiting; misuse of laxatives, diuretics, or other medications; fasting; or excessive exercise|
|Disturbance in which one's body weight or shape is experienced, undue influence of body weight or shape on self-evaluation, or persistent lack of recognition of the seriousness of the current low body weight||The binge eating and inappropriate compensatory behaviors both occur, on average, at least once a week for 3 months|
|Two types: Restrictive and Purge/Bing-Eating type||The disturbance does not occur exclusively during episodes of AN|
|Body Dysmorphic Disorder||BDD and BN||BN|
|Preoccupation with one or more perceived defects or flaws in physical appearance that are not observable or appear slight to others||Disturbance in which one's body weight or shape is experienced, undue influence of body weight or shape on self-evaluation||Recurrent episodes of binge eating: a) eating in a discrete period of time, within a 2-hour period, an amount that is definitely larger than what most would eat in that time period; b) a sense of lack of control over eating|
|At some point during the course of the disorder, the individual has performed repetitive behaviors or mental acts in response to the appearance concerns||The preoccupation causes significant distress or impairment in social, occupational, or other important areas of functioning||Recurrent inappropriate compensatory behaviors in order to prevent weight gain, such as self-induced vomiting; misuse of laxatives, diuretics, or other medications; fasting; or excessive exercise|
|The appearance preoccupation is not better explained by concerns with body fat or weight in an individual whose symptoms meet diagnostic criteria for an eating disorder||The binge eating and inappropriate compensatory behaviors both occur, on average, at least once a week for 3 months|