Cannabis Compound Abuse Treatment & Management

  • Author: Lawrence Genen, MD, MBA; Chief Editor: David Bienenfeld, MD   more...
 
Updated: Feb 2, 2012
 

Medical Care

Acute intoxication of cannabis usually resolves unremarkably within 4-6 hours and is best managed by the following measures:

  • Frequent reassurance and maintenance of a nonthreatening environment
  • Minimal stimuli
  • Use of a specifically assigned nurse to calm the patient
  • Judicious use of benzodiazepines (BZs) when significant anxiety is present
Next

Consultations

People who use marijuana and are suffering from biological, psychological, or social impairment from marijuana use should be evaluated and, if necessary, treated by a psychiatrist.

  • The treatment of marijuana abuse follows the general principals of substance abuse, with particular attention paid to psychological and social aspects.
  • Marijuana may be one of many drugs abused, and total abstinence from all psychoactive substances (with the exception of caffeine) is the treatment goal.
  • Interventions may include psychiatric evaluation, occupational and family assessment, and implementation of a comprehensive treatment plan.
    • Psychological issues (eg, denial, minimization, rationalization) must be confronted.
    • Often, cessation of drug use and subsequent cognitive improvement result in self-motivation and changes in the occupational and social well-being of the patient.
    • Lifestyle changes, such as avoiding drug-related situations, may be encouraged.
  • Identify and address low self-esteem, mood disorders, family problems, and other stresses.
  • One-to-one therapy, group therapy, and even hospitalization may be necessary components of the treatment plan. (Patients with uncomplicated marijuana use in the absence of other psychiatric or medical problems are rarely hospitalized.)
Previous
Proceed to Medication
 
 
Contributor Information and Disclosures
Author

Lawrence Genen, MD, MBA  Child & Adolescent Psychiatry Fellow, Division of Child & Adolescent Psychiatry, Department of Psychiatry, Keck School of Medicine, University of Southern California

Disclosure: Nothing to disclose.

Coauthor(s)

John Franzen, MD  Resident Physician, Department of Psychiatry, University of Nebraska-Creighton University

Disclosure: Nothing to disclose.

William F Haning III, MD, FASAM, DFAPA  Professor of Psychiatry, Director of Graduate Affairs, Office of the Dean, Program Director, Addiction Psychiatry/Medicine, Department of Psychiatry, University of Hawaii, John A Burns School of Medicine; Principal Investigator and Co-Director, Pacific Addiction Research Center

William F Haning III, MD, FASAM, DFAPA is a member of the following medical societies: Alpha Omega Alpha, American Academy of Addiction Psychiatry, American Medical Association, American Psychiatric Association, American Society of Addiction Medicine, Association of Military Surgeons of the US, and Hawaii Medical Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Barry I Liskow, MD  Professor of Psychiatry, Vice Chairman, Psychiatry Department, Director, Psychiatric Residency Program, University of Kansas School of Medicine; Director, Psychiatric Outpatient Clinic, The University of Kansas Medical Center

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Harold H Harsch, MD  Program Director of Geropsychiatry, Department of Geriatrics/Gerontology, Associate Professor, Department of Psychiatry and Department of Medicine, Froedtert Hospital, Medical College of Wisconsin

Harold H Harsch, MD is a member of the following medical societies: American Psychiatric Association

Disclosure: lilly Honoraria Speaking and teaching; Forest Labs None None; Pfizer Grant/research funds Speaking and teaching; Northstar None None; Novartis Grant/research funds research; Pfizer Honoraria Speaking and teaching; Sunovion Speaking and teaching; Otsuke Grant/research funds reseach; GlaxoSmithKline Grant/research funds research; Merck Honoraria Speaking and teaching

Chief Editor

David Bienenfeld, MD  Professor of Psychiatry, Vice-Chair and Director of Residency Training, Department of Psychiatry, Wright State University, Boonshoft School of Medicine

David Bienenfeld, MD is a member of the following medical societies: American Medical Association, American Psychiatric Association, and Association for Academic Psychiatry

Disclosure: Nothing to disclose.

Additional Contributors

The authors and editors of eMedicine gratefully acknowledge the contributions of previous authors Robert C Daly, MB, ChB, MPH, BCh; Can M Savasman, MD; Caroline Fisher, MD, PhD; and Lina Cassandra Vawter, MD to the development and writing of this article.

References
  1. Peter J. Cohen. Medical Marijuana: The Conflict Between Scientific Evidence and Political Ideology. Journal Of Pain & Palliative Care Pharmacotherapy. June 2009;23:120-140.

  2. Dan Whitcomb. Marijuana legalization will be on California ballot. Reuters. Available at http://www.reuters.com/article/idUSTRE62O08U20100325. Accessed 7/24/10.

  3. Dan Frosch. V.A. Easing Rules for Users of Medical Marijuana. The New York Times. Available at http://www.nytimes.com/2010/07/24/health/policy/24veterans.html?pagewanted=1&_r=1. Accessed 7/24/10.

  4. MacCoun R, Reuter P. Evaluating alternative cannabis regimes. Br J Psychiatry. Feb 2001;178:123-8. [Medline].

  5. Reinarman C, Cohen PD, Kaal HL. The limited relevance of drug policy: cannabis in Amsterdam and in San Francisco. Am J Public Health. May 2004;94(5):836-42. [Medline]. [Full Text].

  6. van den Brink W. Forum: Decriminalization of cannabis. Curr Opin Psychiatry. Mar 2008;21(2):122-6. [Medline].

  7. D.I. Abrams, C.A. Jay, S.B. Shade, H. Vizoso, H. Reda, S. Press, et al. Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial. Neurology. 2007;68:515-521.

  8. Michael Craig Miller, MD, et. al. Medical marijuana and the mind. Harvard Mental Health Letter. April 2010;26:1-4.

  9. Pletcher MJ, Vittinghoff E, Kalhan R, et al. Association between marijuana exposure and pulmonary function over 20 years. JAMA. Jan 11 2012;307(2):173-81. [Medline].

  10. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Washington D.C.: American Psychiatric Association; 2000.

  11. Ringen PA, Vaskinn A, Sundet K, et al. Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia. Psychol Med. Nov 6 2009;1-11. [Medline].

  12. Substance Abuse and Mental Health Services Administration. Results from the 2005 National Survey on Drug Use and Health: National Findings. Rockville, MD: Office of Applied Studies, NSDUH Series H-30;. 2006;DHHS Publication No. SMA 06-4194.

  13. InfoFacts. National Institute on Drug Abuse; January 2010. [Full Text].

  14. Stinson FS, Ruan WJ, Pickering R, Grant BF. Cannabis use disorders in the USA: prevalence, correlates and co-morbidity. Psychol Med. Oct 2006;36(10):1447-60. [Medline].

  15. Annual Report 2006: The State of the Drugs Problem in Europe. Lisbon: European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).

  16. Wilson N, Cadet JL. Comorbid mood, psychosis, and marijuana abuse disorders: a theoretical review. J Addict Dis. Oct 2009;28(4):309-19. [Medline].

  17. Maria L. Barrigon, Manuel Gurpegui, Miguel Ruiz-Veguilla, Francisco J. Diaz, Manuel Anguita, Fernando Sarramea, et al. Temporal relationship of first-episode non-affective psychosis with cannabis use: A clinical verification of an epidemiological hypothesis. Journal of Psychiatric Research. 2010;44:413-420. [Medline].

  18. Daniel J. Foti, M.A., Roman Kotov, Ph.D., Lin T. Guey, Ph.D., et al. Cannabis Use and the Course of Schizophrenia: 10-Year Follow-Up After First Hospitalization. Am J Psychiatry. May 2010;167:987-993.

  19. Kuepper R, van Os J, Lieb R, Wittchen HU, Höfler M, Henquet C. Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study. BMJ. Mar 1 2011;342:d738. [Medline]. [Full Text].

  20. Large M, Sharma S, Compton MT, Slade T, Nielssen O. Cannabis Use and Earlier Onset of Psychosis: A Systematic Meta-analysis. Arch Gen Psychiatry. Jun 2011;68(6):555-61. [Medline].

  21. Peter Hecht. Report: African-Americans disproportionately targeted for pot. The Sacramento Bee. Available at http://blogs.sacbee.com/weed-wars/2010/06/report-african-americans-disproportionately-targeted-for-pot.html. Accessed August 3, 2010.

  22. Lopez-Quintero C, Perez de los Cobos J, Hasin DS, et al. Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Drug Alcohol Depend. May 1 2011;115(1-2):120-30. [Medline]. [Full Text].

  23. U.W. Preuss, A.B. Watzke, J. Zimmermann, J.W.M. Wong, C.O. Schmidt. Cannabis withdrawal severity and short-term course among cannabis-dependent adolescent and young adult inpatients. Drug and Alcohol Dependence. 2010;106:133-141.

  24. A.J. Budney, B.A. Moore, R.G. Vandrey, J.R. Hughes. Review of the validity and significance of cannabis withdrawal syndrome. American Journal of Psychiatry. 2004;161:1967-1977.

  25. Allsop DJ, Norberg MM, Copeland J, Fu S, Budney AJ. The Cannabis Withdrawal Scale development: Patterns and predictors of cannabis withdrawal and distress. Drug Alcohol Depend. Dec 1 2011;119(1-2):123-9. [Medline].

  26. Musshoff F, Madea B. Review of biologic matrices (urine, blood, hair) as indicators of recent or ongoing cannabis use. Ther Drug Monit. Apr 2006;28(2):155-63. [Medline].

  27. Kenneth M. Carpenter, David McDowell, Daniel J. Brooks, Wendy Y. Cheng, Frances R. Levin. A Preliminary Trial: Double Blind Comparison of Nefazodone, Burproprion-SR, and Placebo in the Treatment of Cannabis Dependence. The American Journal on Addictions. 2009;18:53-64. [Medline].

  28. Louisa Degenhardt, Lisa Dierker, Wai Tat Chiu, Maria Elena Medina-Mora, Yehuda Neumark, Nancy Sampson, et al. Evaluating the drug use "gateway" theory using cross-national data: Consistency and associations of the order of initiation of drug use among participants in the WHO World Mental Health Surveys. Drug and Alcohol Dependence. 2010;108:84-97.

  29. Agrawal A, Lynskey MT. The genetic epidemiology of cannabis use, abuse and dependence. Addiction. Jun 2006;101(6):801-12. [Medline].

  30. Degenhardt L, Hall W. Is cannabis use a contributory cause of psychosis?. Can J Psychiatry. Aug 2006;51(9):556-65. [Medline].

  31. Di Forti M, Morgan C, Dazzan P, et al. High-potency cannabis and the risk of psychosis. Br J Psychiatry. Dec 2009;195(6):488-91. [Medline].

  32. Gruber SA, Yurgelun-Todd DA. Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation. Brain Res Cogn Brain Res. Apr 2005;23(1):107-18. [Medline].

  33. Haney M, Rabkin J, Gunderson E, Foltin RW. Dronabinol and marijuana in HIV(+) marijuana smokers: acute effects on caloric intake and mood. Psychopharmacology (Berl). Aug 2005;181(1):170-8. [Medline].

  34. Hurd YL, Wang X, Anderson V, Beck O, Minkoff H, Dow-Edwards D. Marijuana impairs growth in mid-gestation fetuses. Neurotoxicol Teratol. Mar-Apr 2005;27(2):221-9. [Medline].

  35. Iversen L. Cannabis and the brain. Brain. Jun 2003;126(Pt 6):1252-70. [Medline].

  36. Johnston LD, O'Malley PM, Bachman JG, Schulenberg JE. Monitoring the Future national results on adolescent drug use: Overview of key findings, 2005. Bethesday, MD: National Institute on Drug Abuse;. 2006;NIH Publication No. 06-5882.

  37. [Guideline] Kleber HD, Weiss RD, Anton RF, et al. Treatment of patients with substance use disorders, second edition. American Psychiatic Association. Am J Psychiatry. Aug 2006;163(8 Suppl):5-82. [Medline].

  38. Ramaekers JG, Moeller MR, van Ruitenbeek P, et al. Cognition and motor control as a function of Delta9-THC concentration in serum and oral fluid: limits of impairment. Drug Alcohol Depend. Nov 8 2006;85(2):114-22. [Medline].

  39. Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T. Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group. J Clin Oncol. Jul 20 2006;24(21):3394-400. [Medline].

  40. Zuardi AW, Crippa JA, Hallak JE, Moreira FA, Guimaraes FS. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res. Apr 2006;39(4):421-9. [Medline].

Previous
Next
 
Cannabis sativa.
The major psychoactive component of marijuana is tetrahydrocannabinol (THC).
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.