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Sleep Disorders Differential Diagnoses

  • Author: Roy H Lubit, MD, PhD; Chief Editor: Iqbal Ahmed, MBBS, FRCPsych(UK)  more...
Updated: Jan 28, 2015

Diagnostic Considerations

In addition to the conditions listed in the differential diagnosis, stimulant abuse (eg, amphetamine abuse) should also be considered.

Differential Diagnoses

Contributor Information and Disclosures

Roy H Lubit, MD, PhD Private Practice

Roy H Lubit, MD, PhD is a member of the following medical societies: American Academy of Child and Adolescent Psychiatry

Disclosure: Nothing to disclose.


Curley L Bonds, II, MD Professor and Chair, Department of Psychiatry and Human Behavior, Charles Drew University of Medicine and Science; Health Sciences Clinical Professor, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, David Geffen School of Medicine

Curley L Bonds, II, MD is a member of the following medical societies: Academy of Psychosomatic Medicine, American Medical Association, National Medical Association, American Psychiatric Association

Disclosure: Nothing to disclose.

Michael A Lucia, MD, FAASM Owner/CEO, Pulmonary, Allergy and Sleep Medicine, Sierra Pulmonary and Sleep Consultants, LLC

Michael A Lucia, MD, FAASM is a member of the following medical societies: Nevada State Medical Association, American Academy of Sleep Medicine, American Association of Cardiovascular and Pulmonary Rehabilitation

Disclosure: Nothing to disclose.

Chief Editor

Iqbal Ahmed, MBBS, FRCPsych(UK) Faculty, Department of Psychiatry, Tripler Army Medical Center; Clinical Professor of Psychiatry, Uniformed Services University of the Health Sciences; Clinical Professor of Psychiatry, Clinical Professor of Geriatric Medicine, University of Hawaii, John A Burns School of Medicine

Iqbal Ahmed, MBBS, FRCPsych(UK) is a member of the following medical societies: Academy of Psychosomatic Medicine, American Neuropsychiatric Association, American Society of Clinical Psychopharmacology, Royal College of Psychiatrists, American Association for Geriatric Psychiatry, American Psychiatric Association

Disclosure: Nothing to disclose.


Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Reference Salary Employment

  1. Zammit GK, Weiner J, Damato N, et al. Quality of life in people with insomnia. Sleep. 1999 May 1. 22 Suppl 2:S379-85. [Medline].

  2. Chen Q, Hayman LL, Shmerling RH, Bean JF, Leveille SG. Characteristics of Chronic Pain Associated with Sleep Difficulty in Older Adults: The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) Boston Study. J Am Geriatr Soc. 2011 Aug. 59(8):1385-92. [Medline].

  3. Yaffe K, Laffan AM, Harrison SL, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 2011 Aug 10. 306(6):613-9. [Medline].

  4. Rajaratnam SM, Barger LK, Lockley SW, et al. Sleep disorders, health, and safety in police officers. JAMA. 2011 Dec 21. 306(23):2567-78. [Medline].

  5. Morin CM, Vallières A, Guay B, Ivers H, Savard J, Mérette C, et al. Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial. JAMA. 2009 May 20. 301(19):2005-15. [Medline].

  6. Elie R, Ruther E, Farr I, Salinas E. Sleep latency is shortened during 4 weeks of treatment with zaleplon, a novel nonbenzodiazepine hypnotic. Zaleplon Clinical Study Group. J Clin Psychiatry. 1999 Aug. 60(8):536-44. [Medline].

  7. Lockley S, Dressman M, Xiao C, Fisher D, Torres R, Lavedan C, et al. Tasimelteon treatment entrains the circadian clock and demonstrates a clinically meaningful benefit blind individuals with non-24-hour circadian rhythms. Presented at ENDO 2013: the Endocrinology Society 95th Annual Meeting. San Francisco. (SUN-134).

  8. Lockley S, Dressman M, Xiao C, Licamele L, Polymeropoulos M. RESET study demonstrates that tasimelteon maintains entrainment of melatonin and cortisol in totally blind individuals with non-24-hour circadian rhythms. Presented at ENDO 2013: the Endocrinology Society 95th Annual Meeting. San Francisco. (SUN-137).

  9. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed, Text Revision (DSM-IV-TR). Washington, DC: American Psychiatric Association; 2000.

  10. Anders TF, Eiben LA. Pediatric sleep disorders: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry. 1997 Jan. 36(1):9-20. [Medline].

  11. Benca RM, Ancoli-Israel S, Moldofsky H. Special considerations in insomnia diagnosis and management: depressed, elderly, and chronic pain populations. J Clin Psychiatry. 2004. 65 Suppl 8:26-35. [Medline].

  12. Bryant PA, Trinder J, Curtis N. Sick and tired: Does sleep have a vital role in the immune system?. Nat Rev Immunol. 2004 Jun. 4(6):457-67. [Medline].

  13. Chen W, Kushida CA. Nasal obstruction in sleep-disordered breathing. Otolaryngol Clin North Am. 2003 Jun. 36(3):437-60. [Medline].

  14. Ford DE, Kamerow DB. Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?. JAMA. 1989 Sep 15. 262(11):1479-84. [Medline].

  15. Gillin JC, Byerley WF. Drug therapy: The diagnosis and management of insomnia. N Engl J Med. 1990 Jan 25. 322(4):239-48. [Medline].

  16. Hauri PJ, Hayes B, Sateia M, et al. Effectiveness of a sleep disorders center: a 9-month follow-up. Am J Psychiatry. 1982 May. 139(5):663-6. [Medline].

  17. Kaplan HI, Sadock BJ, Grebb JA. Normal sleep and sleep disorders. Kaplan and Sadock's Synopsis of Psychiatry. 7th ed. Baltimore, Md: Williams & Wilkins; 1994. 699-716.

  18. Lamberg L. Promoting adequate sleep finds a place on the public health agenda. JAMA. 2004 May 26. 291(20):2415-7. [Medline].

  19. Lamberg L. Sleep-disordered breathing may spur behavioral, learning problems in children. JAMA. 2007 June. 27;297(24):2681-3. [Medline].

  20. Loewy DH, Black JE. Effective management of transient and chronic insomnia. CNS News. McMahon Publishing Group: New York, NY; 2000. 19-22. [Full Text].

  21. No authors listed. Beauty sleep for the heart. Harv Heart Lett. 2004 May. 14(9):7. [Medline].

  22. Richert AC, Baran AS. A review of common sleep disorders. CNS Spectr. 2003 Feb. 8(2):102-9. [Medline].

  23. Schuen JN, Millard SL. Evaluation and treatment of sleep disorders in adolescents. Adolesc Med. 2000 Oct. 11(3):605-16. [Medline].

  24. Schwab RJ. Disturbances of sleep in the intensive care unit. Crit Care Clin. 1994 Oct. 10(4):681-94. [Medline].

  25. Veasey SC. Sedating, not treating sleep apnea: hit & run in primary care. J Clin Sleep Med. 2005 Oct 15. 1(4):372-3. [Medline].

  26. Zorner D, Geisler P. [Diagnostic Spectrum and Filtration Function of Outpatient Sleep Clinics]. Psychiatr Prax. 2003 May. 30(Suppl 2):173-175. [Medline].

  27. Belsomra (survorexant) prescribing information. [package insert]. Whitehouse Station, NJ 08889: August, 2014. Available at [Full Text].

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