Neuroleptic Malignant Syndrome Differential Diagnoses

  • Author: Joseph Tonkonogy, MD, PhD; Chief Editor: Iqbal Ahmed, MBBS, FRCPsych (UK)   more...
 
Updated: Oct 18, 2011
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Joseph Tonkonogy, MD, PhD  Clinical Professor of Psychiatry, University of Massachusetts Medical School; Consulting Staff, Departments of Psychiatry, University of Massachusetts Medical School

Joseph Tonkonogy, MD, PhD is a member of the following medical societies: American Academy of Neurology, American Medical Association, American Neuropsychiatric Association, International Neuropsychological Society, Massachusetts Medical Society, Royal Society of Medicine, Society for Neuroscience, and United Council for Neurologic Subspecialties, Certification Behavioral Neurology and Neuropsychiatry

Disclosure: Nothing to disclose.

Coauthor(s)

Darius P Sholevar, MD  Fellow, Cardiovascular Disease, Albert Einstein Medical Center

Disclosure: Nothing to disclose.

Specialty Editor Board

Alan D Schmetzer, MD  Professor Emeritus, Interim Chairman, Vice-Chair for Education, Associate Residency Training Director in General Psychiatry, Fellowship Training Director in Addiction Psychiatry, Department of Psychiatry, Indiana University School of Medicine; Addiction Psychiatrist, Midtown Mental Health Cener at Wishard Health Services

Alan D Schmetzer, MD is a member of the following medical societies: American Academy of Addiction Psychiatry, American Academy of Clinical Psychiatrists, American Academy of Psychiatry and the Law, American College of Physician Executives, American Medical Association, American Neuropsychiatric Association, American Psychiatric Association, and Association for Convulsive Therapy

Disclosure: Eli Lilly & Co. Grant/research funds Other

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Harold H Harsch, MD  Program Director of Geropsychiatry, Department of Geriatrics/Gerontology, Associate Professor, Department of Psychiatry and Department of Medicine, Froedtert Hospital, Medical College of Wisconsin

Harold H Harsch, MD is a member of the following medical societies: American Psychiatric Association

Disclosure: lilly Honoraria Speaking and teaching; Forest Labs None None; Pfizer Grant/research funds Speaking and teaching; Northstar None None; Novartis Grant/research funds research; Pfizer Honoraria Speaking and teaching; Sunovion Speaking and teaching; Otsuke Grant/research funds reseach; GlaxoSmithKline Grant/research funds research; Merck Honoraria Speaking and teaching

Chief Editor

Iqbal Ahmed, MBBS, FRCPsych (UK)  Faculty, Department of Psychiatry, Tripler Army Medical Center; Clinical Professor of Psychiatry, Clinical Professor of Geriatric Medicine, University of Hawaii, John A Burns School of Medicine

Iqbal Ahmed, MBBS, FRCPsych (UK) is a member of the following medical societies: Academy of Psychosomatic Medicine, American Association for Geriatric Psychiatry, American Neuropsychiatric Association, American Psychiatric Association, American Society of Clinical Psychopharmacology, and Royal College of Psychiatrists

Disclosure: Nothing to disclose.

References

  1. Delay J, Pichot P, Lemperiere T, et al. [A non-phenothiazine and non-reserpine major neuroleptic, haloperidol, in the treatment of psychoses.]. Ann Med Psychol (Paris). Jan 1960;118(1):145-52. [Medline].

  2. Trollor JN, Chen X, Sachdev PS. Neuroleptic malignant syndrome associated with atypical antipsychotic drugs. CNS Drugs. 2009;23(6):477-92. [Medline].

  3. Gurrera RJ. Sympathoadrenal hyperactivity and the etiology of neuroleptic malignant syndrome. Am J Psychiatry. Feb 1999;156(2):169-80. [Medline].

  4. Gelenberg AJ, Bellinghausen B, Wojcik JD. A prospective survey of neuroleptic malignant syndrome in a short-term psychiatric hospital. Am J Psychiatry. Apr 1988;145(4):517-8. [Medline].

  5. Deng MZ, Chen GQ, Phillips MR. Neuroleptic malignant syndrome in 12 of 9,792 Chinese inpatients exposed to neuroleptics: a prospective study. Am J Psychiatry. Sep 1990;147(9):1149-55. [Medline].

  6. Chopra MP, Prakash SS, Raguram R. The neuroleptic malignant syndrome: an Indian experience. Compr Psychiatry. Jan-Feb 1999;40(1):19-23. [Medline].

  7. Croarkin PE, Emslie GJ, Mayes TL. Neuroleptic malignant syndrome associated with atypical antipsychotics in pediatric patients: a review of published cases. J Clin Psychiatry. Jul 2008;69(7):1157-65. [Medline].

  8. Gurrera RJ, Caroff SN, Cohen A, et al. An international consensus study of neuroleptic malignant syndrome diagnostic criteria using the Delphi method. J Clin Psychiatry. Sep 2011;72(9):1222-8. [Medline].

  9. Newman EJ, Grosset DG, Kennedy PG. The parkinsonism-hyperpyrexia syndrome. Neurocrit Care. 2009;10(1):136-40. [Medline].

  10. Ward C. Neuroleptic malignant syndrome in a patient with Parkinson's disease: a case study. J Neurosci Nurs. Jun 2005;37(3):160-2. [Medline].

  11. Osman AA, Khurasani MH. Lethal catatonia and neuroleptic malignant syndrome. A dopamine receptor shut-down hypothesis. Br J Psychiatry. Oct 1994;165(4):548-50. [Medline].

  12. Martin TG. Serotonin syndrome. Ann Emerg Med. Nov 1996;28(5):520-6. [Medline].

  13. Odagaki Y. Atypical neuroleptic malignant syndrome or serotonin toxicity associated with atypical antipsychotics?. Curr Drug Saf. Jan 2009;4(1):84-93. [Medline].

  14. Oomura M, Terai T, Sueyoshi K. Reversible cardiomyopathy as the autonomic involvement of neuroleptic malignant syndrome. Intern Med. 2004;43 (12):1162-5. [Medline].

  15. Keck PE Jr, Pope HG Jr, Cohen BM. Risk factors for neuroleptic malignant syndrome. A case-control study. Arch Gen Psychiatry. Oct 1989;46(10):914-8. [Medline].

  16. Otani K, Horiuchi M, Kondo T. Is the predisposition to neuroleptic malignant syndrome genetically transmitted?. Br J Psychiatry. Jun 1991;158:850-3. [Medline].

  17. Ehara H, Maegaki Y, Takeshita K. Neuroleptic malignant syndrome and methylphenidate. Pediatr Neurol. Oct 1998;19(4):299-301. [Medline].

  18. Paparrigopoulos T, Tzavellas E, Ferentinos P, Mourikis I, Liappas J. Catatonia as a risk factor for the development of neuroleptic malignant syndrome: report of a case following treatment with clozapine. World J Biol Psychiatry. 2009;10(1):70-3. [Medline].

  19. Sachdev P, Mason C, Hadzi-Pavlovic D. Case-control study of neuroleptic malignant syndrome. Am J Psychiatry. Aug 1997;154(8):1156-8. [Medline].

  20. Alexander PJ, Thomas RM, Das A. Is risk of neuroleptic malignant syndrome increased in the postpartum period?. J Clin Psychiatry. May 1998;59(5):254-5. [Medline].

  21. Heiman-Patterson TD. Neuroleptic malignant syndrome and malignant hyperthermia. Important issues for the medical consultant. Med Clin North Am. Mar 1993;77(2):477-92. [Medline].

  22. Voros V, Osvath P, Fekete S, Tenyi T. [Antipsychotics and rhabdomyolysis. Differential diagnosis and clinical significance of elevated serum creatine kinase levels in psychiatric practice]. Psychiatr Hung. 2009;24(3):175-84. [Medline].

  23. Rosebush PI, Mazurek MF. Serum iron and neuroleptic malignant syndrome. Lancet. Jul 20 1991;338(8760):149-51. [Medline].

  24. Rosenberg MR, Green M. Neuroleptic malignant syndrome. Review of response to therapy. Arch Intern Med. Sep 1989;149(9):1927-31. [Medline].

  25. Addonizio G, Susman VL, Roth SD. Neuroleptic malignant syndrome: review and analysis of 115 cases. Biol Psychiatry. Aug 1987;22(8):1004-20. [Medline].

  26. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington, DC: American Psychiatric Association; 2000:735, 795-798.

  27. Bertorini TE. Myoglobinuria, malignant hyperthermia, neuroleptic malignant syndrome and serotonin syndrome. Neurol Clin. Aug 1997;15(3):649-71. [Medline].

  28. Borovicka MC, Bond LC, Gaughan KN. Ziprazidone and lithium-induced neuroleptic malignant syndrome. Ann Pharmacother. 2006;40 (1):139-142. [Medline].

  29. Caroff SN, Mann SC. Neuroleptic malignant syndrome. Med Clin North Am. Jan 1993;77(1):185-202. [Medline].

  30. Croarkin PE, Emslie GJ, Mayes TL. Neuroleptic malignant syndrome associated with atypical antipsychotics in pediatric patients: a review of published cases. J Clin Psychiatry. Jul 2008;69(7):1157-65. [Medline].

  31. Deuschl G, Oepen G, Hermle L. Neuroleptic malignant syndrome: observations on altered consciousness. Pharmacopsychiatry. Jul 1987;20(4):168-70. [Medline].

  32. Dickey W. The neuroleptic malignant syndrome. Prog Neurobiol. 1991;36(5):425-36. [Medline].

  33. Gurrera RJ, Chang SS, Romero JA. A comparison of diagnostic criteria for neuroleptic malignant syndrome. J Clin Psychiatry. Feb 1992;53(2):56-62. [Medline].

  34. Hammerman S, Lam C, Caroff SN. Neuroleptic malignant syndrome and aripiprazole. Journal of the American Academy of Child and Adolescent Psychiatry. June 2006;45 (6):639-41. [Medline].

  35. Kaplan HI, Sadock BJ, Grebb JA. Kaplan and Sadock's Synopsis of Psychiatry. Philadelphia, Pa: Lippincott, Williams, & Wilkins; 1994:1913, 2004-2005.

  36. Kaufman KR, Levitt MJ, Schiltz JF, Sunderram J. Neuroleptic malignant syndrome and serotonin syndrome in the critical care setting: case analysis. Ann Clin Psychiatry. Jul-Sep 2006;18(3):201-4. [Medline].

  37. Keck PE Jr, Caroff SN, McElroy SL. Neuroleptic malignant syndrome and malignant hyperthermia: end of a controversy?. J Neuropsychiatry Clin Neurosci. Spring 1995;7(2):135-44. [Medline].

  38. Keck PE Jr, Pope HG Jr, McElroy SL. Declining frequency of neuroleptic malignant syndrome in a hospital population. Am J Psychiatry. Jul 1991;148(7):880-2. [Medline].

  39. Klein JP, Fiedler U, Appel H. Massive creatine kinase elevations with quetiapine: report of two cases. Pharmacopsychiatry. 2006;39(1):39-40. [Medline].

  40. Mendhekar DN, Jiloha RC. Neuroleptic malignant syndrome precipitated by haloperidol following clozapine discontinuation. Aust N Z J Psychiatry. 2005;39 (10):947-8. [Medline].

  41. Miyaoka H, Shishikura K, Otsubo T. Diazepam-responsive neuroleptic malignant syndrome: a diagnostic subtype?. Am J Psychiatry. Jun 1997;154(6):882. [Medline].

  42. Rodriguez OP, Dowell MS. A case report of neuroleptic malignant syndrome without fever in a patient given aripiprazole. Journal-Oklahoma State Medical Association. July-August 2006;99(7):435-8. [Medline].

  43. Rosebush P, Stewart T. A prospective analysis of 24 episodes of neuroleptic malignant syndrome. Am J Psychiatry. Jun 1989;146(6):717-25. [Medline].

  44. Rosebush PI, Stewart T, Mazurek MF. The treatment of neuroleptic malignant syndrome. Are dantrolene and bromocriptine useful adjuncts to supportive care?. Br J Psychiatry. Nov 1991;159:709-12. [Medline].

  45. Rosebush PI, Stewart TD, Gelenberg AJ. Twenty neuroleptic rechallenges after neuroleptic malignant syndrome in 15 patients [published erratum appears in J Clin Psychiatry 1989 Dec;50(12):472]. J Clin Psychiatry. Aug 1989;50(8):295-8. [Medline].

  46. Seitz DP, Gill SS. Neuroleptic malignant syndrome complicating antipsychotic treatment of delirium or agitation in medical and surgical patients: case reports and a review of the literature. Psychosomatics. Jan-Feb 2009;50(1):8-15. [Medline].

  47. Shalev A, Hermesh H, Munitz H. Mortality from neuroleptic malignant syndrome. J Clin Psychiatry. Jan 1989;50(1):18-25. [Medline].

  48. Silva RR, Munoz DM, Alpert M. Neuroleptic malignant syndrome in children and adolescents. J Am Acad Child Adolesc Psychiatry. Feb 1999;38(2):187-94. [Medline].

  49. Trutia A, Bledowski J, Pandurangi A, Kahn DA. Neuroleptic rechallenge with aripiprazole in a patient with previously documented neuroleptic malignant syndrome. J Psychiatr Pract. Nov 2008;14(6):398-402. [Medline].

  50. Vancaester E, Santens P. Catatonia and neuroleptic malignant syndrome: two sides of a coine?. Acta Neurological Belgica. June 2007;107(2):47-50. [Medline].

  51. Warwick TC, Moningi V, Jami P, Lucas K, Molokwu O, Moningi S. Neuroleptic malignant syndrome variant in a patient receiving donepezil and olanzapine. Nature Clinical Practice Neurology. March 2008;4(3):170-4. [Medline].

  52. Wells AJ, Sommi RW, Crismon ML. Neuroleptic rechallenge after neuroleptic malignant syndrome: case report and literature review. Drug Intell Clin Pharm. Jun 1988;22(6):475-80. [Medline].

 
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