Delirium Follow-up
- Author: Kannayiram Alagiakrishnan, MD, MBBS, MHA, MPH; Chief Editor: Iqbal Ahmed, MBBS, FRCPsych (UK) more...
Further Inpatient Care
Carefully assess patients to determine their level of care needs. Assessment should include behavior (24 h), daily mental status, potential for injury, and underlying medical and metabolic status.
Further Outpatient Care
- Following recovery, patient's memories of events of the delirium are variable.
- Educate the patient, family, and primary caregivers about future risk factors.
- It is not unusual for patients who are elderly to require 6-8 weeks or longer for full recovery.
Deterrence/Prevention
- Prevention should be the goal because delirium is associated with adverse outcomes and high health care costs.
- A multicomponent intervention study that targeted cognitive impairment, sleep deprivation, immobility, visual impairment, hearing impairment, and dehydration showed significant reduction in the number and duration of episodes of delirium in older patients who were hospitalized.
- Patients who are at high risk for delirium should be monitored closely as outpatients, during hospitalization, and throughout surgical procedures.
- Physicians should become familiar with prescribing practices for patients who are elderly, keeping dosages low and avoiding medications that cause delirium.
- Monitoring the patient's mental status as a vital sign helps to diagnose delirium early.
Complications
- Malnutrition, fluid and electrolyte abnormalities
- Aspiration pneumonia
- Pressure ulcers
- Weakness, decreased mobility, and decreased function
- Falls and combative behavior leading to injuries and fractures
- Wandering and getting lost
- Long-term cognitive impairment: Accumulating evidence shows that delirium is not only a transient, reversible acute confusion, but also can give rise to a persistent long-term cognitive impairment.[28]
Prognosis
- Resolution of symptoms may take longer in patients with poor premorbid cognitive function, incorrect or incomplete diagnosis of contributing factors, and structural brain diseases treated with large doses of psychoactive medications prior to the onset of acute medical illness.
- For some patients, the cognitive effects of delirium may resolve slowly or not at all.
Patient Education
Patient and family education
- Educating families and patients regarding the etiology and course of disease is an important role for physicians.
- Educate the patient, family, and primary caregivers about future risk factors.
- Families may worry that the patient has brain damage or a permanent psychiatric illness. Providing reassurance that delirium often is temporary and is the result of a medical condition may be beneficial to both patients and their families.
- Suggest that family members or friends visit the patient, usually one at a time, and provide a calm and structured environment. Encourage them to furnish some familiar objects, such as photos or a favorite blanket, to help reorient the patient and make the patient feel more secure.
White S. The neuropathogenesis of delirium. Rev Clin Gerontol. 2002;12:62-67.
Cerejeira J, Batista P, Nogueira V, et al. Low preoperative plasma cholinesterase activity as a risk marker of postoperative delirium in elderly patients. Age Ageing. Sep 2011;40(5):621-6. [Medline].
Shigeta H, Yasui A, Nimura Y, et al. Postoperative delirium and melatonin levels in elderly patients. Am J Surg. Nov 2001;182(5):449-54. [Medline].
de Rooij SE, van Munster BC, Korevaar JC, Levi M. Cytokines and acute phase response in delirium. J Psychosom Res. May 2007;62(5):521-5. [Medline].
Rudolph JL, Ramlawi B, Kuchel GA, et al. Chemokines are associated with delirium after cardiac surgery. J Gerontol A Biol Sci Med Sci. Feb 2008;63(2):184-9. [Medline].
Ebersoldt M, Sharshar T, Annane D. Sepsis-associated delirium. Intensive Care Med. Jun 2007;33(6):941-50. [Medline].
Banks WH. The aged blood- brain barrier: A substrate for CNS disease. Facts, Research and Intervention in Geriatrics. 2000;2000(2):521-530.
Brown LJ, McGrory S, McLaren L, Starr JM, Deary IJ, Maclullich AM. Cognitive visual perceptual deficits in patients with delirium. J Neurol Neurosurg Psychiatry. Jun 2009;80(6):594-9. [Medline].
Limosin F, Loze JY, Boni C, et al. The A9 allele of the dopamine transporter gene increases the risk of visual hallucinations during alcohol withdrawal in alcohol-dependent women. Neurosci Lett. May 20 2004;362(2):91-4. [Medline].
McCusker J, Cole M, Abrahamowicz M, Primeau F, Belzile E. Delirium predicts 12-month mortality. Arch Intern Med. Feb 25 2002;162(4):457-63. [Medline].
American Psychiatric Association. Practice guideline for the treatment of patients with delirium. Am J Psychiatry. May 1999;156(5 Suppl):1-20. [Medline].
Marcantonio ER, Kiely DK, Simon SE, et al. Outcomes of older people admitted to postacute facilities with delirium. J Am Geriatr Soc. Jun 2005;53(6):963-9. [Medline].
Folstein MF, Folstein SE, McGugh PR. "Mini- Mental State".A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. Nov. 1975;12(3):189-98.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). 4th ed. Washington, DC: American Psychiatric Association; 2000.
Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. Apr 1983;17:37-49.
McAvay GJ, Van Ness PH, Bogardus ST Jr, Zhang Y, Leslie DL, Leo-Summers LS. Depressive symptoms and the risk of incident delirium in older hospitalized adults. J Am Geriatr Soc. May 2007;55(5):684-91. [Medline].
Farrell KR, Ganzini L. Misdiagnosing delirium as depression in medically ill elderly patients. Arch Intern Med. Dec 11-25 1995;155(22):2459-64. [Medline].
Cole M, McCusker J, Dendukuri N, Han L. The prognostic significance of subsyndromal delirium in elderly medical inpatients. J Am Geriatr Soc. Jun 2003;51(6):754-60. [Medline].
Ouimet S, Riker R, Bergeron N, Cossette M, Kavanagh B, Skrobik Y. Subsyndromal delirium in the ICU: evidence for a disease spectrum. Intensive Care Med. Jun 2007;33(6):1007-13. [Medline].
Inouye SK, van Dyck CH, Alessi CA. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med. Dec 15 1990;113(12):941-8. [Medline].
Alagiakrishnan K, Marrie T, Rolfson D et al. Gaps in patient care practices to prevent hospital-acquired delirium. Can Fam Physician. 2009;55:e41-6. [Medline].
Rudolph JL, Jones RN, Rasmussen LS, Silverstein JH, Inouye SK, Marcantonio ER. Independent vascular and cognitive risk factors for postoperative delirium. Am J Med. Sep 2007;120(9):807-13. [Medline].
Perry SW. Organic mental disorders caused by HIV: update on early diagnosis and treatment. Am J Psychiatry. Jun 1990;147(6):696-710. [Medline].
Van Muster BC, Korevaar JC, Korse CM , Bonfer JM, Zwinderman AH, DeRooji SE. Serum S 100B in elderly patients with and without delirium. International Journal of Geriatric Psychiatry. 2010;25(3):234-239.
Van Rompaey B, Elseviers M M, Van Drom W, Fromont V, Jorens P G. The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients. Critical Care. 2012;16.
Overshott R, Karim S, Burns A. Cholinesterase inhibitors for delirium. Cochrane Database Syst Rev. Jan 23 2008;CD005317. [Medline].
van Eijk MM, Roes KC, Honing ML, Kuiper MA, Karakus A, van der Jagt M. Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. Lancet. Nov 27 2010;376(9755):1829-37. [Medline].
Maclullich AMJ, Beaglehole A, Hall RA, Meagher DJ. Delirium and long-term cognitive impairment. International Review of Psychiatry. 2009;21(1):30-42.
Alagiakrishnan K, Marrie T, Rolfson D, Coke W, Camicioli R, Duggan D. Simple cognitive testing (Mini-Cog) predicts in-hospital delirium in the elderly. J Am Geriatr Soc. Feb 2007;55(2):314-6. [Medline].
Alagiakrishnan K, Wiens CA. An approach to drug induced delirium in the elderly. Postgrad Med J. Jul 2004;80(945):388-93. [Medline].
Alsop DC, Fearing MA, Johnson K, Sperling R, Fong TG, Inouye SK. The role of neuroimaging in elucidating delirium pathophysiology. J Gerontol A Biol Sci Med Sci. Dec 2006;61(12):1287-93. [Medline].
Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med. 2001;27:859-864.
Chan D, Brennan NJ. Delirium: making the diagnosis, improving the prognosis. Geriatrics. Mar 1999;54(3):28-30, 36, 39-42. [Medline].
Day JJ, Bayer AJ, McMahon M. Thiamine status, vitamin supplements and postoperative confusion. Age Ageing. Jan 1988;17(1):29-34. [Medline].
Ely EW, Inouye SK, Bernard GR. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA. Dec 5 2001;286(21):2703-10. [Medline].
Hung OL, Lewin NA, Howland MA. Herbal preparations. In: Goldfrank LR, Flomenbaum NE, Lewin NA, et al, eds. Goldfrank's Toxicologic Emergencies. 7th ed. New York: McGraw-Hill; 2002:1129.
Inouye SK. The dilemma of delirium: clinical and research controversies regarding diagnosis and evaluation of delirium in hospitalized elderly medical patients. Am J Med. Sep 1994;97(3):278-88. [Medline].
Inouye SK, Bogardus ST, Charpentier PA, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med. Mar 4 1999;340(9):669-76. [Medline].
Inouye SK, Charpentier PA. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA. Mar 20 1996;275(11):852-7. [Medline].
Jones RN, Yang FM, Zhang Y, Kiely DK, Marcantonio ER, Inouye SK. Does educational attainment contribute to risk for delirium? A potential role for cognitive reserve. J Gerontol A Biol Sci Med Sci. Dec 2006;61(12):1307-11. [Medline].
[Best Evidence] Leslie DL, Zhang Y, Holford TR, Bogardus ST, Leo- Summers LS, Inouye SK. Premature death associated with delirium at 1-year follow-up. Arch Intern Med. July 2005;165(14):1657-62. [Medline].
Lipowski ZJ. Delirium (acute confusional states). JAMA. Oct 2 1987;258(13):1789-92. [Medline].
Lipowski ZJ. Delirium in the elderly patient. N Engl J Med. Mar 2 1989;320(9):578-82. [Medline].
Liptzin B, Levkoff SE. An empirical study of delirium subtypes. Br J Psychiatry. Dec 1992;161:843-5. [Medline].
Liptzin B, Levkoff SE, Gottlieb GL. Delirium. J Neuropsychiatry Clin Neurosci. Spring 1993;5(2):154-60. [Medline].
McAvay GJ, Van Ness PH, Bogardus ST Jr, Zhang Y, Leslie DL, Leo-Summers LS. Depressive symptoms and the risk of incident delirium in older hospitalized adults. J Am Geriatr Soc. May 2007;55(5):684-91. [Medline].
O'Keeffe ST, Ni Chonchubhair A. Postoperative delirium in the elderly. Br J Anaesth. Nov 1994;73(5):673-87. [Medline].
O'Keeffee ST. Delirium in the elderly. Age Ageing. Sep 1999;28 Suppl 2:5-8. [Medline].
Obrecht R, Okhomina FO, Scott DF. Value of EEG in acute confusional states. J Neurol Neurosurg Psychiatry. Jan 1979;42(1):75-7. [Medline].
Otter H, Martin J, Bäsell K, von Heymann C, Hein OV, Böllert P. Validity and reliability of the DDS for severity of delirium in the ICU. Neurocrit Care. 2005;2(2):150-8. [Medline].
Ouimet S, Riker R, Bergeon N, Cosette M, Kavanagh B, Skrobik Y. Subsyndromal delirium in the ICU: evidence for a disease spectrum. Intensive Care Med. Apr 3 2007;33(6):1007-1013. [Medline].
Sipahimalani A, Masand PS. Use of risperidone in delirium: case reports. Ann Clin Psychiatry. Jun 1997;9(2):105-7. [Medline].
Trzepacz PT. Delirium. Advances in diagnosis, pathophysiology, and treatment. Psychiatr Clin North Am. Sep 1996;19(3):429-48. [Medline].
| Features | Delirium | Dementia |
| Onset | Acute | Insidious |
| Course | Fluctuating | Progressive |
| Duration | Days to weeks | Months to years |
| Consciousness | Altered | Clear |
| Attention | Impaired | Normal, except in severe dementia |
| Psychomotor changes | Increased or decreased | Often normal |
| Reversibility | Usually | Rarely |

